AU2011248464B2 - Metabolic biomarkers of autism - Google Patents

Metabolic biomarkers of autism Download PDF

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Publication number
AU2011248464B2
AU2011248464B2 AU2011248464A AU2011248464A AU2011248464B2 AU 2011248464 B2 AU2011248464 B2 AU 2011248464B2 AU 2011248464 A AU2011248464 A AU 2011248464A AU 2011248464 A AU2011248464 A AU 2011248464A AU 2011248464 B2 AU2011248464 B2 AU 2011248464B2
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metabolites
autistic
autism
acid
samples
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AU2011248464A
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AU2011248464A1 (en
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Gabriela Gebrin Cezar
Alan M. Smith
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Wisconsin Alumni Research Foundation
Stemina Biomarker Discovery Inc
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Wisconsin Alumni Research Foundation
Stemina Biomarker Discovery Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/9426—GABA, i.e. gamma-amino-butyrate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AU2011248464A 2010-04-29 2011-04-29 Metabolic biomarkers of autism Active AU2011248464B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016204969A AU2016204969B2 (en) 2010-04-29 2016-07-15 Metabolic biomarkers of autism

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32951510P 2010-04-29 2010-04-29
US61/329,515 2010-04-29
PCT/US2011/034654 WO2011139914A1 (en) 2010-04-29 2011-04-29 Metabolic biomarkers of autism

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016204969A Division AU2016204969B2 (en) 2010-04-29 2016-07-15 Metabolic biomarkers of autism

Publications (2)

Publication Number Publication Date
AU2011248464A1 AU2011248464A1 (en) 2012-11-22
AU2011248464B2 true AU2011248464B2 (en) 2016-08-11

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AU2011248464A Active AU2011248464B2 (en) 2010-04-29 2011-04-29 Metabolic biomarkers of autism
AU2016204969A Active AU2016204969B2 (en) 2010-04-29 2016-07-15 Metabolic biomarkers of autism

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US (2) US9547013B2 (enExample)
EP (1) EP2564194B1 (enExample)
JP (2) JP6021187B2 (enExample)
AU (2) AU2011248464B2 (enExample)
CA (1) CA2797787C (enExample)
WO (1) WO2011139914A1 (enExample)

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KR101322695B1 (ko) * 2010-08-25 2013-10-25 주식회사 엘지화학 케이블형 이차전지
LT3072524T (lt) 2010-10-07 2018-03-26 California Institute Of Technology Probiotikai, skirti autizmo gydymui
EP2890808A4 (en) * 2012-08-29 2016-09-28 California Inst Of Techn DIAGNOSIS AND TREATMENT OF AUTISTICAL DISEASES
MX2016000293A (es) * 2013-07-09 2016-06-21 Stemina Biomarker Discovery Inc Biomarcadores del trastrono del espectro autista.
US20160209428A1 (en) * 2013-08-21 2016-07-21 The Regents Of The University Of California Diagnostic and predictive metabolite patterns for disorders affecting the brain and nervous system
AU2015243857A1 (en) * 2014-04-08 2016-10-20 Metabolon, Inc. Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment
US9176113B1 (en) 2014-04-11 2015-11-03 Synapdx Corporation Methods and systems for determining autism spectrum disorder risk
US20150294081A1 (en) 2014-04-11 2015-10-15 Synapdx Corporation Methods and systems for determining autism spectrum disorder risk
EP3212207A4 (en) 2014-10-30 2018-06-13 California Institute of Technology Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders
JP6800846B2 (ja) 2014-10-30 2020-12-16 カリフォルニア インスティチュート オブ テクノロジー 神経発達症群における行動の改善のための細菌含有組成物、及び細菌を使用することを含む、神経発達症群における行動の改善のための方法
EP3265820B1 (en) 2015-03-06 2023-12-13 Micromass UK Limited Spectrometric analysis of microbes
CA2978042A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
CN112557491B (zh) * 2015-03-06 2024-06-28 英国质谱公司 光谱分析
GB2556436B (en) 2015-03-06 2022-01-26 Micromass Ltd Cell population analysis
JP6421742B2 (ja) 2015-11-27 2018-11-14 株式会社デンソー 車両制御装置
WO2017178833A1 (en) 2016-04-14 2017-10-19 Micromass Uk Limited Spectrometric analysis of plants
CN109642904A (zh) 2016-05-23 2019-04-16 加州理工学院 调节肠微生物群来治疗神经退行性病症
CN107064340A (zh) * 2017-03-13 2017-08-18 瀚盟测试科技（天津）有限公司 一种检测茶叶中gaba含量的方法
WO2018213204A1 (en) 2017-05-15 2018-11-22 Axial Biotherapeutics, Inc. Inhibitors of microbially induced amyloid
GB201802116D0 (en) 2018-02-09 2018-03-28 Univ Warwick Methods for diagnosing an autistic spectrum disorder
CN109030665A (zh) * 2018-10-08 2018-12-18 黑龙江大学 亲水性液相色谱串联质谱法测定红甜菜中甜菜碱含量的检测方法
KR102550459B1 (ko) 2018-11-06 2023-07-03 스탈리클라 에스에이 특발성 자폐 스펙트럼 장애 환자의 하위 집단, asd 표현형 1의 진단을 위한 대사 프로파일링
EP4012414A1 (en) 2020-12-11 2022-06-15 Stalicla S.A. Diagnosis of autism spectrum disorder phenotype 1
CN113960200B (zh) * 2021-10-19 2023-06-20 首都医科大学附属北京儿童医院 代谢标志物在诊断儿童adhd合并抽动障碍中的应用
CN114705775B (zh) * 2022-03-31 2023-09-12 广东省结核病控制中心 一种肺结核评价的血清代谢标志物及其应用
CN115326953A (zh) * 2022-08-02 2022-11-11 云谱康(大连)生物科技有限公司 一种代谢物组合及应用和检测试剂盒与使用

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WO2006090185A1 (en) * 2005-02-28 2006-08-31 Tipogen As Method of prognosis of mental diseases, e. g. autism and cerebral palsy
WO2006121952A2 (en) * 2005-05-05 2006-11-16 The Regents Of The University Of California Diagnostic biomarkers for neurodevelopmental disorders

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EP2183589A4 (en) * 2007-07-26 2011-03-16 Phenomenome Discoveries Inc METHODS FOR THE DIAGNOSIS, RISK ASSESSMENT AND MONITORING OF AUTISM SPECTRUM DISORDERS
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WO2006090185A1 (en) * 2005-02-28 2006-08-31 Tipogen As Method of prognosis of mental diseases, e. g. autism and cerebral palsy
WO2006121952A2 (en) * 2005-05-05 2006-11-16 The Regents Of The University Of California Diagnostic biomarkers for neurodevelopmental disorders

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DATABASE HUMAN METABOLOME DATABASE, 16 November 2005, Database accession no. HMDB00099 *
GEIER D.A et al., Neurochemical Research, 2009, Vol. 34, pages 386-393 *
JAEKEN, J. et al., The Lancet, 1984, Vol. 2, pages 1058-1061 *
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Also Published As

Publication number Publication date
JP2015231392A (ja) 2015-12-24
CA2797787C (en) 2019-07-09
CA2797787A1 (en) 2011-11-10
EP2564194B1 (en) 2019-07-10
JP2013525801A (ja) 2013-06-20
US20120190055A1 (en) 2012-07-26
JP6021187B2 (ja) 2016-11-09
AU2011248464A1 (en) 2012-11-22
US9547013B2 (en) 2017-01-17
EP2564194A1 (en) 2013-03-06
AU2016204969A1 (en) 2016-08-04
US20170192019A1 (en) 2017-07-06
WO2011139914A1 (en) 2011-11-10
AU2016204969B2 (en) 2018-05-17
US10330688B2 (en) 2019-06-25

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