JP5989900B2 - ２−アミノ−４−アリールチアゾール化合物のアミド及びその塩類 - Google Patents

２−アミノ−４−アリールチアゾール化合物のアミド及びその塩類 Download PDF

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Publication number
JP5989900B2
JP5989900B2 JP2015515642A JP2015515642A JP5989900B2 JP 5989900 B2 JP5989900 B2 JP 5989900B2 JP 2015515642 A JP2015515642 A JP 2015515642A JP 2015515642 A JP2015515642 A JP 2015515642A JP 5989900 B2 JP5989900 B2 JP 5989900B2
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Japan
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formula
compound
another embodiment
potassium salt
difluoro
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Japanese (ja)
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JP2015520183A (ja
Inventor
シュレス・マハデブ・カダム
アブラハム・トマス
スクマール・シンハ
スケールティ・クマル
ビピン・パルソッタム・カンサグラ
サチン・ガブハン
サンディープ・バンドゥ・ハンダガレ
シャイレス・パワセ
ジャヤント・プラカシュラオ・パティル
シャイレンドラ・バデーン
バーブナ・ミシュラ
ラジェシュ・ドウィヴェディ
Original Assignee
グレンマーク ファーマシューティカルズ， エセ．アー．
グレンマーク ファーマシューティカルズ， エセ．アー．
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Application filed by グレンマーク ファーマシューティカルズ， エセ．アー．, グレンマーク ファーマシューティカルズ， エセ．アー． filed Critical グレンマーク ファーマシューティカルズ， エセ．アー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2015515642A 2012-06-08 2013-06-08 ２−アミノ−４−アリールチアゾール化合物のアミド及びその塩類 Expired - Fee Related JP5989900B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
IN1687MU2012 2012-06-08
IN1687/MUM/2012 2012-06-08
US201261665282P 2012-06-27 2012-06-27
US61/665,282 2012-06-27
IN3519/MUM/2012 2012-12-13
IN3519MU2012 2012-12-13
US201261748016P 2012-12-31 2012-12-31
US61/748,016 2012-12-31
PCT/IB2013/054703 WO2013183035A2 (en) 2012-06-08 2013-06-08 Amides of 2-amino-4-arylthiazole compounds and their salts

Publications (2)

Publication Number Publication Date
JP2015520183A JP2015520183A (ja) 2015-07-16
JP5989900B2 true JP5989900B2 (ja) 2016-09-07

Family

ID=54193746

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JP2015515642A Expired - Fee Related JP5989900B2 (ja) 2012-06-08 2013-06-08 ２−アミノ−４−アリールチアゾール化合物のアミド及びその塩類

Country Status (22)

Country Link
US (1) US9458173B2 (enExample)
EP (1) EP2858999B1 (enExample)
JP (1) JP5989900B2 (enExample)
KR (1) KR20150015488A (enExample)
CN (1) CN104350058A (enExample)
AP (1) AP3546A (enExample)
AU (1) AU2013273118B2 (enExample)
BR (1) BR112014029155A2 (enExample)
CA (1) CA2873570C (enExample)
CL (1) CL2014003317A1 (enExample)
EA (1) EA031334B1 (enExample)
HK (1) HK1207643A1 (enExample)
IL (1) IL236084A0 (enExample)
IN (1) IN2014MN02467A (enExample)
MX (1) MX354014B (enExample)
MY (1) MY165622A (enExample)
NZ (1) NZ701721A (enExample)
PE (1) PE20142306A1 (enExample)
PH (1) PH12014502685B1 (enExample)
SG (1) SG11201408093PA (enExample)
WO (1) WO2013183035A2 (enExample)
ZA (1) ZA201500082B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
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AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
CA2875692A1 (en) 2012-06-08 2013-12-12 Selcia Limited Macrocyclic inhibitors of flaviviridae viruses
CN105307642A (zh) 2013-06-20 2016-02-03 格兰马克药品股份有限公司 包含trpa1拮抗剂的纳米颗粒制剂
JP6573968B2 (ja) * 2014-08-11 2019-09-11 ハイドラ バイオサイエンシズ インコーポレイテッドＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． ＴＲＰＣ５調節因子としての、精神神経障害の処置のためのチエノおよびフロ［２，３−ｄ］ピリミジン−２，４［１Ｈ，３Ｈ］−ジオン誘導体
US20190175599A1 (en) * 2014-09-16 2019-06-13 Glemark Pharmaceuticals S.A. Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain
TW202321229A (zh) 2021-08-18 2023-06-01 美商富曼西公司 殺真菌的取代的雜環化合物
CN114671875A (zh) * 2022-04-27 2022-06-28 成都施贝康生物医药科技有限公司 新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途

Family Cites Families (25)

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DE2248231A1 (de) 1972-10-02 1974-04-11 Basf Ag 3-aminoisothiazolo eckige klammer auf 3,4-d eckige klammer zu pyrimidine
SE9701398D0 (sv) 1997-04-15 1997-04-15 Astra Pharma Prod Novel compounds
ES2193839B1 (es) 2001-06-22 2005-02-16 Almirall Prodesfarma, S.A. Nuevos derivados de 6-fenildihidropirrolpirimidindiona.
AU2003253165A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Pyrimidine fused bicyclic metalloproteinase inhibitors
US6890923B2 (en) 2002-12-16 2005-05-10 Astrazeneca Ab Compounds
US7465581B2 (en) 2002-12-18 2008-12-16 The Scripps Research Institute ANKTM1, a cold-activated TRP-like channel expressed in nociceptive neurons
EP1657238A4 (en) * 2003-08-22 2008-12-03 Takeda Pharmaceutical CONDENSATE PYRIMIDINE DERIVATIVE AND ITS USE
JP2007522214A (ja) 2004-02-11 2007-08-09 スミスクライン・ビーチャム・コーポレイション Ｐｔｈアゴニスト
US20070196866A1 (en) 2004-03-13 2007-08-23 Irm Llc Modulators of ion channel trpa1
WO2006083005A1 (ja) 2005-02-03 2006-08-10 Takeda Pharmaceutical Company Limited 縮合ピリミジン誘導体およびその用途
CA2617788A1 (en) 2005-08-04 2007-02-15 Apogee Biotechnology Corporation Sphingosine kinase inhibitors and methods of their use
US20070105920A1 (en) 2005-11-08 2007-05-10 Akzo Nobel N.V. 2-(Benzimidazol-1-Yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives
CN101384261B (zh) * 2005-12-22 2011-12-07 海德拉生物科学公司 治疗疼痛的组合物
CN101454318A (zh) * 2006-03-22 2009-06-10 阿斯利康(瑞典)有限公司 吡啶并嘧啶衍生物及其作为pde4抑制剂的用途
TW200800997A (en) 2006-03-22 2008-01-01 Astrazeneca Ab Chemical compounds
JP2011201776A (ja) 2008-07-23 2011-10-13 Mochida Pharmaceut Co Ltd ヘテロシクリデン−ｎ−（３，４−ジヒドロ−２（１ｈ）−キナゾリノン−５−イル）アセトアミド誘導体
AR065081A1 (es) 2007-01-29 2009-05-13 Xenon Pharmaceuticals Inc Compuestos de quinazolinona y pirimidona fusionados y composicion farmaceutica
WO2009002933A1 (en) 2007-06-22 2008-12-31 Hydra Biosciences, Inc. Methods and compositions for treating disorders
WO2010004390A1 (en) * 2008-06-17 2010-01-14 Glenmark Pharmaceuticals, S.A. Quinazoline dione derivatives as trpa1 modulators
WO2009158719A2 (en) 2008-06-27 2009-12-30 Hydra Biosciences, Inc. Methods and compositions for treating disorders
US8623880B2 (en) 2009-03-23 2014-01-07 Glenmark Pharmaceuticals S.A. Fused pyrimidine-dione derivatives as TRPA1 modulators
ES2424340T3 (es) 2009-03-23 2013-10-01 Glenmark Pharmaceuticals S.A. Derivados de isotiazolo-pirimidindiona como moduladores de TRPA1
AU2010227225A1 (en) * 2009-03-23 2011-09-15 Glenmark Pharmaceuticals, S.A. Furopyrimidinedione derivatives as TRPA1 modulators
AU2010227245B2 (en) 2009-03-23 2015-09-10 Glenmark Pharmaceuticals S.A. Fused pyrimidine-dione derivatives as TRPA1 modulators
AU2011346763B2 (en) 2010-12-20 2016-01-07 Glenmark Pharmaceuticals S.A. 2-amino-4-arylthiazole compounds as TRPA1 antagonists

Also Published As

Publication number Publication date
ZA201500082B (en) 2015-12-23
AU2013273118A1 (en) 2014-11-27
EP2858999A2 (en) 2015-04-15
EP2858999B1 (en) 2017-05-10
EA201492054A1 (ru) 2016-08-31
SG11201408093PA (en) 2015-01-29
WO2013183035A2 (en) 2013-12-12
CN104350058A (zh) 2015-02-11
AP2014008076A0 (en) 2014-11-30
BR112014029155A2 (pt) 2017-06-27
MX354014B (es) 2018-02-08
NZ701721A (en) 2016-03-31
KR20150015488A (ko) 2015-02-10
PE20142306A1 (es) 2015-01-16
PH12014502685A1 (en) 2015-01-26
AP3546A (en) 2016-01-14
AU2013273118B2 (en) 2015-11-05
MY165622A (en) 2018-04-18
EA031334B1 (ru) 2018-12-28
US9458173B2 (en) 2016-10-04
JP2015520183A (ja) 2015-07-16
CA2873570C (en) 2016-11-01
CA2873570A1 (en) 2013-12-12
WO2013183035A3 (en) 2014-02-27
IN2014MN02467A (enExample) 2015-07-10
CL2014003317A1 (es) 2015-02-13
US20150111038A1 (en) 2015-04-23
HK1207643A1 (en) 2016-02-05
MX2014014482A (es) 2015-06-05
PH12014502685B1 (en) 2015-01-26
IL236084A0 (en) 2015-02-01

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