CA2873570C - Amides of 2-amino-4-arylthiazole compounds and their salts as trpa1 modulators - Google Patents

Amides of 2-amino-4-arylthiazole compounds and their salts as trpa1 modulators Download PDF

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Publication number
CA2873570C
CA2873570C CA2873570A CA2873570A CA2873570C CA 2873570 C CA2873570 C CA 2873570C CA 2873570 A CA2873570 A CA 2873570A CA 2873570 A CA2873570 A CA 2873570A CA 2873570 C CA2873570 C CA 2873570C
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CA
Canada
Prior art keywords
formula
compound
another embodiment
potassium salt
trifluoromethyl
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CA2873570A
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English (en)
French (fr)
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CA2873570A1 (en
Inventor
Suresh Mahadev Kadam
Abraham Thomas
Sukumar Sinha
Sukeerthi Kumar
Bipin Parsottam Kansagra
Sachin Gavhane
Sandeep Bandu Khandagale
Shailesh Pawase
Jayant Prakashrao Patil
Shailendra Bhadane
Bhavna Mishra
Rajesh Dwivedi
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Ichnos Sciences SA
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Publication of CA2873570A1 publication Critical patent/CA2873570A1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2873570A 2012-06-08 2013-06-08 Amides of 2-amino-4-arylthiazole compounds and their salts as trpa1 modulators Active CA2873570C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
IN1687/MUM/2012 2012-06-08
IN1687MU2012 2012-06-08
US201261665282P 2012-06-27 2012-06-27
US61/665,282 2012-06-27
IN3519MU2012 2012-12-13
IN3519/MUM/2012 2012-12-13
US201261748016P 2012-12-31 2012-12-31
US61/748,016 2012-12-31
PCT/IB2013/054703 WO2013183035A2 (en) 2012-06-08 2013-06-08 Amides of 2-amino-4-arylthiazole compounds and their salts

Publications (2)

Publication Number Publication Date
CA2873570A1 CA2873570A1 (en) 2013-12-12
CA2873570C true CA2873570C (en) 2016-11-01

Family

ID=54193746

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2873570A Active CA2873570C (en) 2012-06-08 2013-06-08 Amides of 2-amino-4-arylthiazole compounds and their salts as trpa1 modulators

Country Status (22)

Country Link
US (1) US9458173B2 (enExample)
EP (1) EP2858999B1 (enExample)
JP (1) JP5989900B2 (enExample)
KR (1) KR20150015488A (enExample)
CN (1) CN104350058A (enExample)
AP (1) AP3546A (enExample)
AU (1) AU2013273118B2 (enExample)
BR (1) BR112014029155A2 (enExample)
CA (1) CA2873570C (enExample)
CL (1) CL2014003317A1 (enExample)
EA (1) EA031334B1 (enExample)
HK (1) HK1207643A1 (enExample)
IL (1) IL236084A0 (enExample)
IN (1) IN2014MN02467A (enExample)
MX (1) MX354014B (enExample)
MY (1) MY165622A (enExample)
NZ (1) NZ701721A (enExample)
PE (1) PE20142306A1 (enExample)
PH (1) PH12014502685A1 (enExample)
SG (1) SG11201408093PA (enExample)
WO (1) WO2013183035A2 (enExample)
ZA (1) ZA201500082B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
WO2013185103A1 (en) 2012-06-08 2013-12-12 Gilead Sciences, Inc. Macrocyclic inhibitors of flaviviridae viruses
EP3010489A1 (en) 2013-06-20 2016-04-27 Glenmark Pharmaceuticals S.A. Nanoparticulate formulation comprising a trpa1 antagonist
WO2016023832A1 (en) * 2014-08-11 2016-02-18 Hydra Biosciences, Inc. Thieno- and furo[2,3-d]pyrimidine-2,4[1h,3h]-dione derivatives as trpc5 modulators for the treatment of neuropsychiatric disorders
WO2016042501A1 (en) * 2014-09-16 2016-03-24 Glenmark Pharmaceuticals S.A. Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain
TW202321229A (zh) 2021-08-18 2023-06-01 美商富曼西公司 殺真菌的取代的雜環化合物
CN114671875A (zh) * 2022-04-27 2022-06-28 成都施贝康生物医药科技有限公司 新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途

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DE2248231A1 (de) 1972-10-02 1974-04-11 Basf Ag 3-aminoisothiazolo eckige klammer auf 3,4-d eckige klammer zu pyrimidine
SE9701398D0 (sv) 1997-04-15 1997-04-15 Astra Pharma Prod Novel compounds
ES2193839B1 (es) 2001-06-22 2005-02-16 Almirall Prodesfarma, S.A. Nuevos derivados de 6-fenildihidropirrolpirimidindiona.
AU2003253165A1 (en) * 2002-08-13 2004-02-25 Warner-Lambert Company Llc Pyrimidine fused bicyclic metalloproteinase inhibitors
US6890923B2 (en) 2002-12-16 2005-05-10 Astrazeneca Ab Compounds
AU2003290066A1 (en) 2002-12-18 2004-07-09 Novartis Ag Anktm1, a cold-activated trp-like channel expressed in nociceptive neurons
WO2005019188A1 (ja) 2003-08-22 2005-03-03 Takeda Pharmaceutical Company Limited 縮合ピリミジン誘導体およびその用途
WO2005077959A1 (en) 2004-02-11 2005-08-25 Smithkline Beecham Corporation Pth agonists
WO2005089206A2 (en) 2004-03-13 2005-09-29 Irm Llc Modulators of ion channel trpa1
EP1847541A4 (en) 2005-02-03 2009-12-30 Takeda Pharmaceutical CONDENSED PYRIMIDINE DERIVATIVE AND USE THEREOF
CA2617788A1 (en) 2005-08-04 2007-02-15 Apogee Biotechnology Corporation Sphingosine kinase inhibitors and methods of their use
US20070105920A1 (en) 2005-11-08 2007-05-10 Akzo Nobel N.V. 2-(Benzimidazol-1-Yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives
AU2006327181A1 (en) 2005-12-22 2007-06-28 Hydra Biosciences, Inc. TRPA1 inhibitors for treating pain
TW200800997A (en) 2006-03-22 2008-01-01 Astrazeneca Ab Chemical compounds
CN101454318A (zh) * 2006-03-22 2009-06-10 阿斯利康(瑞典)有限公司 吡啶并嘧啶衍生物及其作为pde4抑制剂的用途
JP2011201776A (ja) 2008-07-23 2011-10-13 Mochida Pharmaceut Co Ltd ヘテロシクリデン−ｎ−（３，４−ジヒドロ−２（１ｈ）−キナゾリノン−５−イル）アセトアミド誘導体
CL2008000252A1 (es) 2007-01-29 2008-03-14 Xenon Pharmaceuticals Inc Compuestos derivados de quinazolinona o pirimidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades mediadas por los canales de calcio, tales como dolor, depresion, enfermedades cardiovasculares, respir
CN101801362B (zh) * 2007-06-22 2014-01-22 海德拉生物科学公司 用于治疗病症的方法和组合物
WO2010004390A1 (en) * 2008-06-17 2010-01-14 Glenmark Pharmaceuticals, S.A. Quinazoline dione derivatives as trpa1 modulators
WO2009158719A2 (en) 2008-06-27 2009-12-30 Hydra Biosciences, Inc. Methods and compositions for treating disorders
BRPI1009372A2 (pt) 2009-03-23 2016-05-31 Glenmark Pharmaceuticals Sa compostos, composição farmacêutica e respectivos usos
US8623880B2 (en) 2009-03-23 2014-01-07 Glenmark Pharmaceuticals S.A. Fused pyrimidine-dione derivatives as TRPA1 modulators
EA023857B1 (ru) 2009-03-23 2016-07-29 Гленмарк Фармасеутикалс С.А. Сочлененные производные пиримидиндионов в качестве модуляторов trpa1
SG174398A1 (en) * 2009-03-23 2011-10-28 Glenmark Pharmaceuticals Sa Furopyrimidinedione derivatives as trpa1 modulators
EP2655377B1 (en) 2010-12-20 2016-03-30 Glenmark Pharmaceuticals S.A. 2-amino-4-arylthiazole compounds as trpa1 antagonists

Also Published As

Publication number Publication date
IL236084A0 (en) 2015-02-01
WO2013183035A2 (en) 2013-12-12
KR20150015488A (ko) 2015-02-10
BR112014029155A2 (pt) 2017-06-27
MX354014B (es) 2018-02-08
JP5989900B2 (ja) 2016-09-07
US9458173B2 (en) 2016-10-04
CA2873570A1 (en) 2013-12-12
NZ701721A (en) 2016-03-31
PE20142306A1 (es) 2015-01-16
CN104350058A (zh) 2015-02-11
SG11201408093PA (en) 2015-01-29
AP2014008076A0 (en) 2014-11-30
HK1207643A1 (en) 2016-02-05
PH12014502685B1 (en) 2015-01-26
US20150111038A1 (en) 2015-04-23
EP2858999A2 (en) 2015-04-15
EP2858999B1 (en) 2017-05-10
EA031334B1 (ru) 2018-12-28
AU2013273118A1 (en) 2014-11-27
AP3546A (en) 2016-01-14
ZA201500082B (en) 2015-12-23
CL2014003317A1 (es) 2015-02-13
AU2013273118B2 (en) 2015-11-05
EA201492054A1 (ru) 2016-08-31
JP2015520183A (ja) 2015-07-16
MX2014014482A (es) 2015-06-05
IN2014MN02467A (enExample) 2015-07-10
WO2013183035A3 (en) 2014-02-27
MY165622A (en) 2018-04-18
PH12014502685A1 (en) 2015-01-26

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