BR112014029155A2 - amidas de compostos de 2-amino-4-ariltiazol e respectivos sais e processos de preparação - Google Patents
amidas de compostos de 2-amino-4-ariltiazol e respectivos sais e processos de preparaçãoInfo
- Publication number
- BR112014029155A2 BR112014029155A2 BR112014029155A BR112014029155A BR112014029155A2 BR 112014029155 A2 BR112014029155 A2 BR 112014029155A2 BR 112014029155 A BR112014029155 A BR 112014029155A BR 112014029155 A BR112014029155 A BR 112014029155A BR 112014029155 A2 BR112014029155 A2 BR 112014029155A2
- Authority
- BR
- Brazil
- Prior art keywords
- salts
- amino
- processes
- amides
- arylthiazole compounds
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- -1 compounds amides Chemical class 0.000 title 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XOPMVFNBFICPDB-UHFFFAOYSA-N n-[4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,4-dioxothieno[2,3-d]pyrimidin-5-yl)acetamide Chemical class C1=2C(=O)N(C)C(=O)N(C)C=2SC=C1CC(=O)NC(SC=1)=NC=1C1=CC=C(F)C(C(F)(F)F)=C1F XOPMVFNBFICPDB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1687MU2012 | 2012-06-08 | ||
| US201261665282P | 2012-06-27 | 2012-06-27 | |
| IN3519MU2012 | 2012-12-13 | ||
| US201261748016P | 2012-12-31 | 2012-12-31 | |
| PCT/IB2013/054703 WO2013183035A2 (en) | 2012-06-08 | 2013-06-08 | Amides of 2-amino-4-arylthiazole compounds and their salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014029155A2 true BR112014029155A2 (pt) | 2017-06-27 |
Family
ID=54193746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014029155A BR112014029155A2 (pt) | 2012-06-08 | 2013-06-08 | amidas de compostos de 2-amino-4-ariltiazol e respectivos sais e processos de preparação |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9458173B2 (enExample) |
| EP (1) | EP2858999B1 (enExample) |
| JP (1) | JP5989900B2 (enExample) |
| KR (1) | KR20150015488A (enExample) |
| CN (1) | CN104350058A (enExample) |
| AP (1) | AP3546A (enExample) |
| AU (1) | AU2013273118B2 (enExample) |
| BR (1) | BR112014029155A2 (enExample) |
| CA (1) | CA2873570C (enExample) |
| CL (1) | CL2014003317A1 (enExample) |
| EA (1) | EA031334B1 (enExample) |
| HK (1) | HK1207643A1 (enExample) |
| IL (1) | IL236084A0 (enExample) |
| IN (1) | IN2014MN02467A (enExample) |
| MX (1) | MX354014B (enExample) |
| MY (1) | MY165622A (enExample) |
| NZ (1) | NZ701721A (enExample) |
| PE (1) | PE20142306A1 (enExample) |
| PH (1) | PH12014502685B1 (enExample) |
| SG (1) | SG11201408093PA (enExample) |
| WO (1) | WO2013183035A2 (enExample) |
| ZA (1) | ZA201500082B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ724503A (en) | 2012-06-08 | 2017-12-22 | Gilead Sciences Inc | Macrocyclic inhibitors of flaviviridae viruses |
| AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| CA2912578A1 (en) * | 2013-06-20 | 2014-12-24 | Glenmark Pharmaceuticals S.A. | Nanoparticulate formulation comprising a trpa1 antagonist |
| EP3180345B1 (en) * | 2014-08-11 | 2018-10-10 | Hydra Biosciences, Inc. | Thieno- and furo[2,3-d]pyrimidine-2,4[1h,3h]-dione derivatives as trpc5 modulators for the treatment of neuropsychiatric disorders |
| WO2016042501A1 (en) * | 2014-09-16 | 2016-03-24 | Glenmark Pharmaceuticals S.A. | Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain |
| TW202321229A (zh) | 2021-08-18 | 2023-06-01 | 美商富曼西公司 | 殺真菌的取代的雜環化合物 |
| CN114671875A (zh) * | 2022-04-27 | 2022-06-28 | 成都施贝康生物医药科技有限公司 | 新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2248231A1 (de) | 1972-10-02 | 1974-04-11 | Basf Ag | 3-aminoisothiazolo eckige klammer auf 3,4-d eckige klammer zu pyrimidine |
| SE9701398D0 (sv) | 1997-04-15 | 1997-04-15 | Astra Pharma Prod | Novel compounds |
| ES2193839B1 (es) * | 2001-06-22 | 2005-02-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de 6-fenildihidropirrolpirimidindiona. |
| AU2003253165A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| US6890923B2 (en) | 2002-12-16 | 2005-05-10 | Astrazeneca Ab | Compounds |
| US7465581B2 (en) | 2002-12-18 | 2008-12-16 | The Scripps Research Institute | ANKTM1, a cold-activated TRP-like channel expressed in nociceptive neurons |
| EP1657238A4 (en) | 2003-08-22 | 2008-12-03 | Takeda Pharmaceutical | CONDENSATE PYRIMIDINE DERIVATIVE AND ITS USE |
| EP1713815A4 (en) | 2004-02-11 | 2009-03-11 | Smithkline Beecham Corp | PTH AGONISTS |
| US20070196866A1 (en) | 2004-03-13 | 2007-08-23 | Irm Llc | Modulators of ion channel trpa1 |
| EP1847541A4 (en) | 2005-02-03 | 2009-12-30 | Takeda Pharmaceutical | CONDENSED PYRIMIDINE DERIVATIVE AND USE THEREOF |
| AU2006278592A1 (en) | 2005-08-04 | 2007-02-15 | Apogee Biotechnology Corporation | Sphingosine kinase inhibitors and methods of their use |
| US20070105920A1 (en) | 2005-11-08 | 2007-05-10 | Akzo Nobel N.V. | 2-(Benzimidazol-1-Yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives |
| TW201900217A (zh) | 2005-12-22 | 2019-01-01 | 美商海卓勒生物科學公司 | 用於調節ｔｒｐａ１功能之化合物 |
| TW200800997A (en) | 2006-03-22 | 2008-01-01 | Astrazeneca Ab | Chemical compounds |
| CN101454318A (zh) * | 2006-03-22 | 2009-06-10 | 阿斯利康(瑞典)有限公司 | 吡啶并嘧啶衍生物及其作为pde4抑制剂的用途 |
| JP2011201776A (ja) | 2008-07-23 | 2011-10-13 | Mochida Pharmaceut Co Ltd | ヘテロシクリデン−ｎ−（３，４−ジヒドロ−２（１ｈ）−キナゾリノン−５−イル）アセトアミド誘導体 |
| CL2008000252A1 (es) | 2007-01-29 | 2008-03-14 | Xenon Pharmaceuticals Inc | Compuestos derivados de quinazolinona o pirimidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades mediadas por los canales de calcio, tales como dolor, depresion, enfermedades cardiovasculares, respir |
| SI3184527T1 (sl) | 2007-06-22 | 2020-03-31 | Eli Lilly And Company | Spojine 2,6-diokso,-2,3-dihidro-1H-purina uporabne za zdravljenje stanj povezanih z aktivnostjo TRPA1 kanala |
| WO2010004390A1 (en) * | 2008-06-17 | 2010-01-14 | Glenmark Pharmaceuticals, S.A. | Quinazoline dione derivatives as trpa1 modulators |
| WO2009158719A2 (en) | 2008-06-27 | 2009-12-30 | Hydra Biosciences, Inc. | Methods and compositions for treating disorders |
| EP2411395B1 (en) * | 2009-03-23 | 2013-05-29 | Glenmark Pharmaceuticals S.A. | Furopyrimidinedione derivatives as trpa1 modulators |
| DK2411397T3 (da) | 2009-03-23 | 2013-08-05 | Glenmark Pharmaceuticals Sa | Isothiazol-pyrimidindionderivater som modulatorer af TRPA1 |
| US8623880B2 (en) | 2009-03-23 | 2014-01-07 | Glenmark Pharmaceuticals S.A. | Fused pyrimidine-dione derivatives as TRPA1 modulators |
| BRPI1013559A2 (pt) | 2009-03-23 | 2016-04-12 | Glenmark Pharmaceuticals Sa | compostos, composição farmacêutica, método de tratamento de doença ou condição associada à função trpa1 e respectivos usos |
| AR084294A1 (es) | 2010-12-20 | 2013-05-08 | Glenmark Pharmaceuticals Sa | Compuestos de 2-amino-4-ariltiazol, metodos para su sintesis y uso como antagonista de trpa1 |
-
2013
- 2013-06-08 IN IN2467MUN2014 patent/IN2014MN02467A/en unknown
- 2013-06-08 WO PCT/IB2013/054703 patent/WO2013183035A2/en not_active Ceased
- 2013-06-08 EA EA201492054A patent/EA031334B1/ru unknown
- 2013-06-08 PE PE2014002226A patent/PE20142306A1/es not_active Application Discontinuation
- 2013-06-08 BR BR112014029155A patent/BR112014029155A2/pt not_active Application Discontinuation
- 2013-06-08 US US14/402,608 patent/US9458173B2/en not_active Expired - Fee Related
- 2013-06-08 NZ NZ701721A patent/NZ701721A/en not_active IP Right Cessation
- 2013-06-08 SG SG11201408093PA patent/SG11201408093PA/en unknown
- 2013-06-08 EP EP13742279.6A patent/EP2858999B1/en active Active
- 2013-06-08 CN CN201380030184.XA patent/CN104350058A/zh active Pending
- 2013-06-08 AP AP2014008076A patent/AP3546A/xx active
- 2013-06-08 JP JP2015515642A patent/JP5989900B2/ja not_active Expired - Fee Related
- 2013-06-08 HK HK15108333.2A patent/HK1207643A1/xx unknown
- 2013-06-08 KR KR1020147033855A patent/KR20150015488A/ko not_active Abandoned
- 2013-06-08 AU AU2013273118A patent/AU2013273118B2/en not_active Ceased
- 2013-06-08 MY MYPI2014003389A patent/MY165622A/en unknown
- 2013-06-08 MX MX2014014482A patent/MX354014B/es active IP Right Grant
- 2013-06-08 CA CA2873570A patent/CA2873570C/en active Active
-
2014
- 2014-12-02 PH PH12014502685A patent/PH12014502685B1/en unknown
- 2014-12-04 IL IL236084A patent/IL236084A0/en unknown
- 2014-12-04 CL CL2014003317A patent/CL2014003317A1/es unknown
-
2015
- 2015-01-07 ZA ZA2015/00082A patent/ZA201500082B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150015488A (ko) | 2015-02-10 |
| MY165622A (en) | 2018-04-18 |
| PE20142306A1 (es) | 2015-01-16 |
| SG11201408093PA (en) | 2015-01-29 |
| HK1207643A1 (en) | 2016-02-05 |
| IN2014MN02467A (enExample) | 2015-07-10 |
| AP3546A (en) | 2016-01-14 |
| JP5989900B2 (ja) | 2016-09-07 |
| MX354014B (es) | 2018-02-08 |
| AU2013273118B2 (en) | 2015-11-05 |
| WO2013183035A2 (en) | 2013-12-12 |
| IL236084A0 (en) | 2015-02-01 |
| CN104350058A (zh) | 2015-02-11 |
| MX2014014482A (es) | 2015-06-05 |
| US20150111038A1 (en) | 2015-04-23 |
| CA2873570A1 (en) | 2013-12-12 |
| WO2013183035A3 (en) | 2014-02-27 |
| EA201492054A1 (ru) | 2016-08-31 |
| AU2013273118A1 (en) | 2014-11-27 |
| PH12014502685A1 (en) | 2015-01-26 |
| ZA201500082B (en) | 2015-12-23 |
| PH12014502685B1 (en) | 2015-01-26 |
| NZ701721A (en) | 2016-03-31 |
| JP2015520183A (ja) | 2015-07-16 |
| CA2873570C (en) | 2016-11-01 |
| CL2014003317A1 (es) | 2015-02-13 |
| EP2858999A2 (en) | 2015-04-15 |
| EP2858999B1 (en) | 2017-05-10 |
| AP2014008076A0 (en) | 2014-11-30 |
| US9458173B2 (en) | 2016-10-04 |
| EA031334B1 (ru) | 2018-12-28 |
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Legal Events
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B25D | Requested change of name of applicant approved |
Owner name: ICHNOS SCIENCES SA (CH) |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 495/04 Ipc: C07D 495/04 (2006.01), A61K 31/519 (2006.01), A61P |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
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Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |