JP5980689B2 - 安定な成長ホルモン化合物 - Google Patents

安定な成長ホルモン化合物 Download PDF

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Publication number
JP5980689B2
JP5980689B2 JP2012549376A JP2012549376A JP5980689B2 JP 5980689 B2 JP5980689 B2 JP 5980689B2 JP 2012549376 A JP2012549376 A JP 2012549376A JP 2012549376 A JP2012549376 A JP 2012549376A JP 5980689 B2 JP5980689 B2 JP 5980689B2
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growth hormone
seq
hgh
hormone compound
additional
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JP2013518037A (ja
JP2013518037A5 (cg-RX-API-DMAC10.html
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ヘレ・デムート
クリスティーネ・ブルーン・シュット・シュット
ライフ・ナアスコウ−ラウリトスン
ジャンヘ・チェン
ピーター・テューイェスン
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ノヴォ・ノルディスク・ヘルス・ケア・アーゲー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2012549376A 2010-01-22 2011-01-24 安定な成長ホルモン化合物 Expired - Fee Related JP5980689B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US29730510P 2010-01-22 2010-01-22
EP10151405.7 2010-01-22
US61/297,305 2010-01-22
EP10151405 2010-01-22
CNPCT/CN2010/001120 2010-07-23
CN2010001120 2010-07-23
US37860210P 2010-08-31 2010-08-31
US61/378,602 2010-08-31
PCT/EP2011/050909 WO2011089250A2 (en) 2010-01-22 2011-01-24 Stable growth hormone compounds

Publications (3)

Publication Number Publication Date
JP2013518037A JP2013518037A (ja) 2013-05-20
JP2013518037A5 JP2013518037A5 (cg-RX-API-DMAC10.html) 2014-03-06
JP5980689B2 true JP5980689B2 (ja) 2016-08-31

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Family Applications (1)

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JP2012549376A Expired - Fee Related JP5980689B2 (ja) 2010-01-22 2011-01-24 安定な成長ホルモン化合物

Country Status (11)

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US (1) US9211342B2 (cg-RX-API-DMAC10.html)
EP (1) EP2525833A2 (cg-RX-API-DMAC10.html)
JP (1) JP5980689B2 (cg-RX-API-DMAC10.html)
AU (1) AU2011208620B2 (cg-RX-API-DMAC10.html)
BR (1) BR112012018162A2 (cg-RX-API-DMAC10.html)
CA (1) CA2787895A1 (cg-RX-API-DMAC10.html)
IL (1) IL220648A0 (cg-RX-API-DMAC10.html)
MX (1) MX338357B (cg-RX-API-DMAC10.html)
RU (1) RU2012134974A (cg-RX-API-DMAC10.html)
WO (1) WO2011089250A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA201205385B (cg-RX-API-DMAC10.html)

Families Citing this family (11)

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RU2012134974A (ru) 2010-01-22 2014-02-27 Ново Нордиск Хелс Кеа Аг Стабилизированное соединение гормона роста
PL2525834T3 (pl) 2010-01-22 2020-10-19 Novo Nordisk Health Care Ag Hormony wzrostu o przedłużonej skuteczności in-vivo
CN103269720A (zh) * 2010-07-22 2013-08-28 诺沃—诺迪斯克保健股份有限公司 生长激素缀合物
JP2016511275A (ja) 2013-03-11 2016-04-14 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 成長ホルモン化合物
ES2841123T3 (es) 2013-04-05 2021-07-07 Formulacion Del Compuesto De La Hormona De Crecimiento Formulación del compuesto de la hormona de crecimiento
WO2015036553A1 (en) 2013-09-16 2015-03-19 Novo Nordisk Health Care Ag Thiol functionalized polymers
EP3079722B1 (en) 2013-12-13 2021-03-24 Novo Nordisk Health Care AG Method for thioether conjugation of proteins
MY193776A (en) 2015-09-22 2022-10-27 Univ California Modified cytotoxins and their therapeutics use
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WO2017055582A1 (en) 2015-10-01 2017-04-06 Novo Nordisk A/S Protein conjugates
KR20180003677A (ko) * 2016-06-30 2018-01-10 주식회사 크레아플래닛 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물

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MX2012007999A (es) 2012-08-03
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US9211342B2 (en) 2015-12-15
EP2525833A2 (en) 2012-11-28
MX338357B (es) 2016-04-13
CA2787895A1 (en) 2011-07-28
BR112012018162A2 (pt) 2017-10-03
AU2011208620A1 (en) 2012-07-19
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