JP5951491B2 - トリプトリドの製造方法 - Google Patents

トリプトリドの製造方法 Download PDF

Info

Publication number
JP5951491B2
JP5951491B2 JP2012537406A JP2012537406A JP5951491B2 JP 5951491 B2 JP5951491 B2 JP 5951491B2 JP 2012537406 A JP2012537406 A JP 2012537406A JP 2012537406 A JP2012537406 A JP 2012537406A JP 5951491 B2 JP5951491 B2 JP 5951491B2
Authority
JP
Japan
Prior art keywords
triptolide
medium
acid
culture
extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2012537406A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013510127A5 (cg-RX-API-DMAC7.html
JP2013510127A (ja
Inventor
ニコラ、スチュワード
ナディーヌ、ショマラ
ゴク、ティエン、グエン
Original Assignee
ピエール、ファーブル、メディカマン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ピエール、ファーブル、メディカマン filed Critical ピエール、ファーブル、メディカマン
Publication of JP2013510127A publication Critical patent/JP2013510127A/ja
Publication of JP2013510127A5 publication Critical patent/JP2013510127A5/ja
Application granted granted Critical
Publication of JP5951491B2 publication Critical patent/JP5951491B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Rheumatology (AREA)
  • Birds (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012537406A 2009-11-05 2010-11-05 トリプトリドの製造方法 Expired - Fee Related JP5951491B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0957847A FR2952072B1 (fr) 2009-11-05 2009-11-05 Procede de production de triptolide
FR0957847 2009-11-05
PCT/EP2010/066916 WO2011054929A2 (fr) 2009-11-05 2010-11-05 Procede de production de triptolide

Publications (3)

Publication Number Publication Date
JP2013510127A JP2013510127A (ja) 2013-03-21
JP2013510127A5 JP2013510127A5 (cg-RX-API-DMAC7.html) 2015-07-02
JP5951491B2 true JP5951491B2 (ja) 2016-07-13

Family

ID=42316019

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012537406A Expired - Fee Related JP5951491B2 (ja) 2009-11-05 2010-11-05 トリプトリドの製造方法

Country Status (5)

Country Link
US (2) US9228209B2 (cg-RX-API-DMAC7.html)
EP (1) EP2496708B1 (cg-RX-API-DMAC7.html)
JP (1) JP5951491B2 (cg-RX-API-DMAC7.html)
FR (1) FR2952072B1 (cg-RX-API-DMAC7.html)
WO (1) WO2011054929A2 (cg-RX-API-DMAC7.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103159822B (zh) * 2013-03-04 2016-05-18 华侨大学 雷公藤甲素及其衍生物组合物的制备方法
ES2806553T3 (es) * 2013-12-02 2021-02-18 Phyton Holdings Llc Producción de tapsigarginas por cultivo en suspensión de células de Thapsia
FR3031900A1 (fr) 2015-01-22 2016-07-29 Pf Medicament Triptolide et ses derives dans le traitement des tumeurs et pathologies pre-cancereuses cutanees
US10406232B2 (en) * 2015-06-29 2019-09-10 Vets Plus, Inc. Oral delivery compositions for treating dermatitis disorders in mammals
CN109311930B (zh) * 2016-03-31 2023-02-24 伯克利之光生命科技公司 核酸稳定试剂、试剂盒及其使用方法
FR3051116B1 (fr) * 2016-05-12 2019-06-07 Pierre Fabre Dermo-Cosmetique Procede de production du celastrol et de derives triterpeniques pentacycliques
CN111132685A (zh) * 2017-04-25 2020-05-08 瑞阳公司 五味子提取物的组合物和其方法
WO2022081767A1 (en) * 2020-10-13 2022-04-21 Phytotech Labs, Inc. Methods and compositions for axillary shoot micropropagation of cannabis and related plants
CN114642171B (zh) * 2022-03-30 2023-04-25 华侨大学 一种高活性雷公藤代谢产物的诱导方法及雷公藤活性代谢组合物
CN119386082A (zh) * 2024-11-05 2025-02-07 广西壮族自治区亚热带作物研究所（广西亚热带农产品加工研究所） 睡莲提取物在制备抗硫酸铜诱导的斑马鱼氧化和炎症损伤产品中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5940440B2 (ja) * 1980-06-05 1984-09-29 協和醗酵工業株式会社 抗腫瘍性物質の製造法
US4328309A (en) * 1980-07-02 1982-05-04 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Method for producing tripdiolide, triptolide and celastrol
JPS585196A (ja) * 1981-06-30 1983-01-12 Kyowa Hakko Kogyo Co Ltd 抗腫瘍性物質の製造法
HU223267B1 (hu) * 1996-05-24 2004-04-28 Phyton, Inc. Eljárás taxánok elõállítására Taxus fajok sejtjeinek tenyésztésével
EP1007066B1 (en) 1996-09-27 2005-11-16 The Board Of Regents, The University Of Texas System Screening methods for glucocorticoid receptor binding substances using trypterygium wilfordii preparations
ATE258594T1 (de) * 1997-02-19 2004-02-15 Phytobiotech Inc Verfahren zur steigerung des wachstums von pflanzenzellkulturen
US6303589B1 (en) * 1998-12-08 2001-10-16 Micro Flo Company Pentacyclic triterpenes
CN1184309C (zh) * 2002-01-25 2005-01-12 北京达科豪科技有限公司 植物悬浮培养细胞生产雷公藤总生物碱的方法
AU2003903909A0 (en) * 2003-07-25 2003-08-07 Albright & Wilson (Australia) Limited Production methods
US7879369B2 (en) * 2007-09-18 2011-02-01 Selvamedica, Llc Combretum laurifolium Mart. extract and methods of extracting and using such extract
CN100593367C (zh) * 2008-03-13 2010-03-10 西北农林科技大学无公害农药研究服务中心 一种由雷公藤悬浮细胞诱导不定根的方法
CN101358180B (zh) 2008-08-25 2010-09-08 西北农林科技大学无公害农药研究服务中心 一种由雷公藤细胞培养法生产雷公藤甲素和生物碱的方法

Also Published As

Publication number Publication date
WO2011054929A2 (fr) 2011-05-12
US20160143975A1 (en) 2016-05-26
JP2013510127A (ja) 2013-03-21
WO2011054929A3 (fr) 2011-12-01
EP2496708B1 (fr) 2017-03-01
FR2952072A1 (fr) 2011-05-06
US9228209B2 (en) 2016-01-05
US20120225936A1 (en) 2012-09-06
FR2952072B1 (fr) 2013-09-27
EP2496708A2 (fr) 2012-09-12

Similar Documents

Publication Publication Date Title
JP5951491B2 (ja) トリプトリドの製造方法
ES2834978T3 (es) Proceso de fermentación de dos fases para la producción de un isoprenoide
KR102513830B1 (ko) 셀라스트롤 및 펜타사이클릭 트리테르펜 유도체를 제조하기 위한 방법
Cheng et al. Production of flavonoids and terpene lactones from optimized Ginkgo biloba tissue culture
TW201201864A (en) Preparation derived from an in vitro culture of dedifferentiated non-elicited argan cells, their use for the treatment of skin aging, inflammation and healing, and method for obtaining them
KR20140122533A (ko) 아스트라갈로사이드 iv의 함량이 증가된 황기 부정근의 대량생산방법
Romero et al. Alkamide production from hairy root cultures of Echinacea
Aljibouri et al. Alkaloids production from callus of Hyoscyamus niger L. in vitro
Laurain-Mattar et al. Amaryllidaceae alkaloid accumulation by plant in vitro systems
Musbah et al. Effects of feeding tyrosine or phenylalanine on the accumulation of polyphenols in Coleus Blumei in Vivo and in Vitro.
WO2017144065A1 (en) Sustainable and industrial production of guaianolides based on organ tissue culture
TWI384993B (zh) 可用於保護肝臟及／或降脂肪之枇杷葉細胞之萃取物及其製備方法與用途
US20050255569A1 (en) Method for producing triterpene composition
Bandhakavi et al. Production of oleanolic acid by plant tissue culture‐A Review
Czerpak et al. The Effect of β-estradiol and Corticosteroids on Chlorophylls and Carotenoids Content in Wolffia arrhiza (L.) Wimm.(Lemnaceae Growing in Municipal Bialystok Tap Tap T Water.
Pandey et al. In vitro culture of moss Bryum coronatum Schwaegr.(Bryaceae) and it’s phytochemical analysis
Lee et al. Effect of culture conditions on the biosynthesis of gagaminine, a potent antioxidant from the roots of Cynanchum wilfordii
US20100215625A1 (en) Efficient preparation of naphthoquinone anticancer active ingredients
DOUGUE KENTSOP Biotechnology applied to aromatic plants for the controlled production of bioactive compounds
KR20150056741A (ko) 식물성장조절물질을 함유하는 미세조류 클라미도모나스의 배양 배지 및 이를 활용한 배양방법
TW200829699A (en) Method of producting resveratrol through tissue culture and tissues and culturing method thereof
Sahu et al. Bioproduction and optimization of rosmarinic acid production in Solenostemon scutellarioides through media manipulation and conservation of high yielding clone via encapsulation
HK40002512B (en) Method for producing celastrol and pentacyclic triterpene derivatives
HK40002512A (en) Method for producing celastrol and pentacyclic triterpene derivatives
Khojasteh Biotechnological production of rosmarinic acid and ruscogenins. Scaling up the optimized processes to benchtop bioreactors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131029

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20131029

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20141107

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150206

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150303

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150407

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20150501

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20151009

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160108

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160205

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160513

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160608

R150 Certificate of patent or registration of utility model

Ref document number: 5951491

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees