FR2952072B1 - Procede de production de triptolide - Google Patents

Procede de production de triptolide

Info

Publication number
FR2952072B1
FR2952072B1 FR0957847A FR0957847A FR2952072B1 FR 2952072 B1 FR2952072 B1 FR 2952072B1 FR 0957847 A FR0957847 A FR 0957847A FR 0957847 A FR0957847 A FR 0957847A FR 2952072 B1 FR2952072 B1 FR 2952072B1
Authority
FR
France
Prior art keywords
triptolide
producing
producing triptolide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0957847A
Other languages
English (en)
French (fr)
Other versions
FR2952072A1 (fr
Inventor
Nicolas Steward
Nadine Chomarat
Guyen Ngoc Thien N
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to FR0957847A priority Critical patent/FR2952072B1/fr
Priority to EP10781460.0A priority patent/EP2496708B1/fr
Priority to US13/508,068 priority patent/US9228209B2/en
Priority to JP2012537406A priority patent/JP5951491B2/ja
Priority to PCT/EP2010/066916 priority patent/WO2011054929A2/fr
Publication of FR2952072A1 publication Critical patent/FR2952072A1/fr
Application granted granted Critical
Publication of FR2952072B1 publication Critical patent/FR2952072B1/fr
Priority to US14/950,685 priority patent/US20160143975A1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Rheumatology (AREA)
  • Birds (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR0957847A 2009-11-05 2009-11-05 Procede de production de triptolide Expired - Fee Related FR2952072B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR0957847A FR2952072B1 (fr) 2009-11-05 2009-11-05 Procede de production de triptolide
EP10781460.0A EP2496708B1 (fr) 2009-11-05 2010-11-05 Procede de production de triptolide
US13/508,068 US9228209B2 (en) 2009-11-05 2010-11-05 Method for producing triptolide
JP2012537406A JP5951491B2 (ja) 2009-11-05 2010-11-05 トリプトリドの製造方法
PCT/EP2010/066916 WO2011054929A2 (fr) 2009-11-05 2010-11-05 Procede de production de triptolide
US14/950,685 US20160143975A1 (en) 2009-11-05 2015-11-24 Method for producing triptolide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0957847A FR2952072B1 (fr) 2009-11-05 2009-11-05 Procede de production de triptolide

Publications (2)

Publication Number Publication Date
FR2952072A1 FR2952072A1 (fr) 2011-05-06
FR2952072B1 true FR2952072B1 (fr) 2013-09-27

Family

ID=42316019

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0957847A Expired - Fee Related FR2952072B1 (fr) 2009-11-05 2009-11-05 Procede de production de triptolide

Country Status (5)

Country Link
US (2) US9228209B2 (cg-RX-API-DMAC7.html)
EP (1) EP2496708B1 (cg-RX-API-DMAC7.html)
JP (1) JP5951491B2 (cg-RX-API-DMAC7.html)
FR (1) FR2952072B1 (cg-RX-API-DMAC7.html)
WO (1) WO2011054929A2 (cg-RX-API-DMAC7.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103159822B (zh) * 2013-03-04 2016-05-18 华侨大学 雷公藤甲素及其衍生物组合物的制备方法
ES2806553T3 (es) * 2013-12-02 2021-02-18 Phyton Holdings Llc Producción de tapsigarginas por cultivo en suspensión de células de Thapsia
FR3031900A1 (fr) 2015-01-22 2016-07-29 Pf Medicament Triptolide et ses derives dans le traitement des tumeurs et pathologies pre-cancereuses cutanees
US10406232B2 (en) * 2015-06-29 2019-09-10 Vets Plus, Inc. Oral delivery compositions for treating dermatitis disorders in mammals
CN109311930B (zh) * 2016-03-31 2023-02-24 伯克利之光生命科技公司 核酸稳定试剂、试剂盒及其使用方法
FR3051116B1 (fr) * 2016-05-12 2019-06-07 Pierre Fabre Dermo-Cosmetique Procede de production du celastrol et de derives triterpeniques pentacycliques
CN111132685A (zh) * 2017-04-25 2020-05-08 瑞阳公司 五味子提取物的组合物和其方法
WO2022081767A1 (en) * 2020-10-13 2022-04-21 Phytotech Labs, Inc. Methods and compositions for axillary shoot micropropagation of cannabis and related plants
CN114642171B (zh) * 2022-03-30 2023-04-25 华侨大学 一种高活性雷公藤代谢产物的诱导方法及雷公藤活性代谢组合物
CN119386082A (zh) * 2024-11-05 2025-02-07 广西壮族自治区亚热带作物研究所（广西亚热带农产品加工研究所） 睡莲提取物在制备抗硫酸铜诱导的斑马鱼氧化和炎症损伤产品中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5940440B2 (ja) * 1980-06-05 1984-09-29 協和醗酵工業株式会社 抗腫瘍性物質の製造法
US4328309A (en) * 1980-07-02 1982-05-04 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Method for producing tripdiolide, triptolide and celastrol
JPS585196A (ja) * 1981-06-30 1983-01-12 Kyowa Hakko Kogyo Co Ltd 抗腫瘍性物質の製造法
HU223267B1 (hu) * 1996-05-24 2004-04-28 Phyton, Inc. Eljárás taxánok elõállítására Taxus fajok sejtjeinek tenyésztésével
EP1007066B1 (en) 1996-09-27 2005-11-16 The Board Of Regents, The University Of Texas System Screening methods for glucocorticoid receptor binding substances using trypterygium wilfordii preparations
ATE258594T1 (de) * 1997-02-19 2004-02-15 Phytobiotech Inc Verfahren zur steigerung des wachstums von pflanzenzellkulturen
US6303589B1 (en) * 1998-12-08 2001-10-16 Micro Flo Company Pentacyclic triterpenes
CN1184309C (zh) * 2002-01-25 2005-01-12 北京达科豪科技有限公司 植物悬浮培养细胞生产雷公藤总生物碱的方法
AU2003903909A0 (en) * 2003-07-25 2003-08-07 Albright & Wilson (Australia) Limited Production methods
US7879369B2 (en) * 2007-09-18 2011-02-01 Selvamedica, Llc Combretum laurifolium Mart. extract and methods of extracting and using such extract
CN100593367C (zh) * 2008-03-13 2010-03-10 西北农林科技大学无公害农药研究服务中心 一种由雷公藤悬浮细胞诱导不定根的方法
CN101358180B (zh) 2008-08-25 2010-09-08 西北农林科技大学无公害农药研究服务中心 一种由雷公藤细胞培养法生产雷公藤甲素和生物碱的方法

Also Published As

Publication number Publication date
WO2011054929A2 (fr) 2011-05-12
JP5951491B2 (ja) 2016-07-13
US20160143975A1 (en) 2016-05-26
JP2013510127A (ja) 2013-03-21
WO2011054929A3 (fr) 2011-12-01
EP2496708B1 (fr) 2017-03-01
FR2952072A1 (fr) 2011-05-06
US9228209B2 (en) 2016-01-05
US20120225936A1 (en) 2012-09-06
EP2496708A2 (fr) 2012-09-12

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Effective date: 20180731