JP5951486B2 - 癌の検出および診断のための抗ｃＭｅｔ抗体およびその使用 - Google Patents
癌の検出および診断のための抗ｃＭｅｔ抗体およびその使用 Download PDFInfo
- Publication number
- JP5951486B2 JP5951486B2 JP2012525183A JP2012525183A JP5951486B2 JP 5951486 B2 JP5951486 B2 JP 5951486B2 JP 2012525183 A JP2012525183 A JP 2012525183A JP 2012525183 A JP2012525183 A JP 2012525183A JP 5951486 B2 JP5951486 B2 JP 5951486B2
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- seq
- cdr
- antibody
- cmet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/57595—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving intracellular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23586409P | 2009-08-21 | 2009-08-21 | |
| US61/235,864 | 2009-08-21 | ||
| EP09305777A EP2287197A1 (en) | 2009-08-21 | 2009-08-21 | Anti-cMET antibody and its use for the detection and the diagnosis of cancer |
| EP09305777.6 | 2009-08-21 | ||
| US34800510P | 2010-05-25 | 2010-05-25 | |
| US61/348,005 | 2010-05-25 | ||
| PCT/EP2010/062271 WO2011020925A1 (en) | 2009-08-21 | 2010-08-23 | Anti-cmet antibody and its use for the detection and the diagnosis of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013502213A JP2013502213A (ja) | 2013-01-24 |
| JP5951486B2 true JP5951486B2 (ja) | 2016-07-13 |
Family
ID=41571045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012525183A Active JP5951486B2 (ja) | 2009-08-21 | 2010-08-23 | 癌の検出および診断のための抗ｃＭｅｔ抗体およびその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8673302B2 (enExample) |
| EP (2) | EP2287197A1 (enExample) |
| JP (1) | JP5951486B2 (enExample) |
| KR (1) | KR20120051734A (enExample) |
| CN (1) | CN102639564B (enExample) |
| AR (1) | AR077901A1 (enExample) |
| AU (1) | AU2010284944B2 (enExample) |
| BR (1) | BR112012003759A2 (enExample) |
| CA (1) | CA2769427C (enExample) |
| ES (1) | ES2692522T3 (enExample) |
| IL (1) | IL218202A (enExample) |
| IN (1) | IN2012DN01322A (enExample) |
| MX (1) | MX2012002139A (enExample) |
| NZ (2) | NZ700437A (enExample) |
| RU (1) | RU2582265C2 (enExample) |
| SG (1) | SG178339A1 (enExample) |
| TW (1) | TW201111781A (enExample) |
| WO (1) | WO2011020925A1 (enExample) |
| ZA (1) | ZA201202076B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2287197A1 (en) * | 2009-08-21 | 2011-02-23 | Pierre Fabre Medicament | Anti-cMET antibody and its use for the detection and the diagnosis of cancer |
| SG10201408229WA (en) | 2010-08-31 | 2015-02-27 | Genentech Inc | Biomarkers and methods of treatment |
| KR101444837B1 (ko) | 2011-06-03 | 2014-09-30 | 한국생명공학연구원 | ＨＧＦ 활성을 가지는 ｃ-Ｍｅｔ에 대한 인간항체 및 이의 용도 |
| AU2012312515A1 (en) | 2011-09-19 | 2014-03-13 | Genentech, Inc. | Combination treatments comprising c-met antagonists and B-raf antagonists |
| KR20130036993A (ko) * | 2011-10-05 | 2013-04-15 | 삼성전자주식회사 | ｃ-Ｍｅｔ의 ＳＥＭＡ 도메인 내의 에피토프에 특이적으로 결합하는 항체 |
| SG10201506881PA (en) * | 2011-11-21 | 2015-10-29 | Taivex Therapeutics Corp | Biomarkers for cancers responsive to modulators of hec1 activity |
| SG11201402485UA (en) | 2011-11-21 | 2014-06-27 | Genentech Inc | Purification of anti-c-met antibodies |
| GB201121914D0 (en) | 2011-12-20 | 2012-02-01 | Ge Healthcare Ltd | Method for patient selection |
| CA2869316C (en) * | 2012-05-09 | 2016-12-20 | Eli Lilly And Company | Anti-c-met antibodies |
| HK1208181A1 (en) * | 2012-06-21 | 2016-02-26 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind c-met |
| WO2014128235A1 (en) | 2013-02-22 | 2014-08-28 | F. Hoffmann-La Roche Ag | Methods of treating cancer and preventing drug resistance |
| US10214593B2 (en) | 2013-04-02 | 2019-02-26 | Samsung Electronics Co., Ltd. | Anti-idiotype antibody against anti-c-MET antibody |
| GB201314936D0 (en) | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| WO2015031626A1 (en) * | 2013-08-28 | 2015-03-05 | Abbvie Inc. | Soluble cmet assay |
| WO2015031614A1 (en) * | 2013-08-28 | 2015-03-05 | Abbvie Inc. | Soluble cmet assay |
| WO2015032695A1 (en) * | 2013-09-09 | 2015-03-12 | Ventana Medical Systems, Inc. | Scoring method for mesothelin protein expression |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| EP3122900A1 (en) | 2014-03-24 | 2017-02-01 | F. Hoffmann-La Roche AG | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression |
| KR20170005016A (ko) | 2014-05-23 | 2017-01-11 | 제넨테크, 인크. | MiT 바이오마커 및 그의 사용 방법 |
| EP3229836B1 (en) | 2014-12-09 | 2019-11-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Human monoclonal antibodies against axl |
| US10544210B2 (en) * | 2015-02-03 | 2020-01-28 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anti-Rho GTPase conformational single domain antibodies and uses thereof |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| KR20170128256A (ko) * | 2015-03-18 | 2017-11-22 | 시애틀 지네틱스, 인크. | Cd48 항체 및 이의 접합체 |
| EP3411067B1 (en) | 2016-02-05 | 2021-10-20 | Helixmith Co., Ltd | Anti-c-met antibodies and uses thereof |
| RS61659B1 (sr) | 2016-05-17 | 2021-04-29 | Abbvie Biotherapeutics Inc | Konjugati antitelo lek anti-cmet i metode za njihovu upotrebu |
| TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法 |
| RU2735918C2 (ru) * | 2018-06-07 | 2020-11-10 | Общество с ограниченной ответственностью "ДЖЕЙВИС ДИАГНОСТИКС" | Набор реагентов для выявления маркера эпителиальных карцином |
| CN112351998B (zh) * | 2018-06-29 | 2022-07-22 | 苏州智核生物医药科技有限公司 | Pd-l1结合多肽及其用途 |
| KR102396194B1 (ko) * | 2018-12-07 | 2022-05-10 | 서울대학교 산학협력단 | 항 c-Met 아고니스트 항체 및 이의 용도 |
| US20220252603A1 (en) * | 2019-06-06 | 2022-08-11 | Apollomics Inc. (Hangzhou) | Method for treating cancer patients using c-met inhibitor |
| CN114340684B (zh) | 2019-09-16 | 2025-09-12 | 瑞泽恩制药公司 | 用于免疫pet成像的放射性标记的met结合蛋白 |
| JP7510518B2 (ja) | 2020-09-01 | 2024-07-03 | レメゲン シーオー．，エルティーディー． | 抗ｃ－Ｍｅｔ抗体薬物複合体及びその応用 |
| CA3191363A1 (en) * | 2020-09-08 | 2022-03-17 | Ideaya Biosciences, Inc. | Pharmaceutical combination and tumor treatment |
| IL315960A (en) | 2022-03-30 | 2024-11-01 | Pinetree Therapeutics Inc | Bispecific antibodies comprising an nrp1 binding domain and methods of use thereof |
| CA3251953A1 (en) * | 2022-06-09 | 2023-12-14 | Santa Ana Bio, Inc. | C-KIT AND/OR SIGLEC TARGETING ANTIBODIES AND THEIR USES |
| AU2023317484A1 (en) | 2022-07-30 | 2025-03-13 | Pinetree Therapeutics, Inc. | Compositions for targeted lysosomal degradaton and methods of use thereof |
| EP4763865A1 (en) * | 2023-08-14 | 2026-06-24 | Minghui Pharmaceutical (Hangzhou) Limited | Anti-c-met nanobody and use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214344B1 (en) * | 1995-06-02 | 2001-04-10 | Genetech, Inc. | Hepatocyte growth factor receptor antagonists and uses thereof |
| WO2003057155A2 (en) * | 2001-12-27 | 2003-07-17 | Van Andel Research Institute | Monoclonal antibody imaging and therapy of tumors that express met and bind hepatocyte growth factor |
| US20040208876A1 (en) * | 2003-04-18 | 2004-10-21 | Kim Kyung Jin | Monoclonal antibodies to hepatocyte growth factor |
| WO2007056523A2 (en) * | 2005-11-08 | 2007-05-18 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Methods for diagnosing and monitoring the progression of cancer |
| ES2368864T3 (es) * | 2006-02-06 | 2011-11-23 | Metheresis Translational Research Sa | Anticuerpos monoclonales anti-met, sus fragmentos y vectores para el tratamiento de tumores y productos correspondientes. |
| EP2014681A1 (en) * | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| US7892770B2 (en) * | 2007-08-24 | 2011-02-22 | Van Andel Research Institute | Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods |
| AR074439A1 (es) * | 2008-12-02 | 2011-01-19 | Pf Medicament | Anticuerpo anti-cmet (receptor c-met) |
| US8545839B2 (en) * | 2008-12-02 | 2013-10-01 | Pierre Fabre Medicament | Anti-c-Met antibody |
| EP2287197A1 (en) * | 2009-08-21 | 2011-02-23 | Pierre Fabre Medicament | Anti-cMET antibody and its use for the detection and the diagnosis of cancer |
-
2009
- 2009-08-21 EP EP09305777A patent/EP2287197A1/en not_active Withdrawn
-
2010
- 2010-08-23 KR KR1020127005757A patent/KR20120051734A/ko not_active Withdrawn
- 2010-08-23 TW TW099128075A patent/TW201111781A/zh unknown
- 2010-08-23 CA CA2769427A patent/CA2769427C/en active Active
- 2010-08-23 CN CN201080036635.7A patent/CN102639564B/zh active Active
- 2010-08-23 AU AU2010284944A patent/AU2010284944B2/en active Active
- 2010-08-23 SG SG2012009106A patent/SG178339A1/en unknown
- 2010-08-23 ES ES10744608.0T patent/ES2692522T3/es active Active
- 2010-08-23 WO PCT/EP2010/062271 patent/WO2011020925A1/en not_active Ceased
- 2010-08-23 EP EP10744608.0A patent/EP2467402B1/en active Active
- 2010-08-23 BR BR112012003759A patent/BR112012003759A2/pt not_active Application Discontinuation
- 2010-08-23 IN IN1322DEN2012 patent/IN2012DN01322A/en unknown
- 2010-08-23 JP JP2012525183A patent/JP5951486B2/ja active Active
- 2010-08-23 AR ARP100103069A patent/AR077901A1/es not_active Application Discontinuation
- 2010-08-23 NZ NZ700437A patent/NZ700437A/en unknown
- 2010-08-23 NZ NZ598194A patent/NZ598194A/en unknown
- 2010-08-23 RU RU2012109004/10A patent/RU2582265C2/ru active
- 2010-08-23 US US13/391,435 patent/US8673302B2/en active Active
- 2010-08-23 MX MX2012002139A patent/MX2012002139A/es not_active Application Discontinuation
-
2012
- 2012-02-19 IL IL218202A patent/IL218202A/en active IP Right Grant
- 2012-03-20 ZA ZA2012/02076A patent/ZA201202076B/en unknown
-
2014
- 2014-01-24 US US14/163,501 patent/US20140295452A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2769427C (en) | 2020-03-10 |
| US8673302B2 (en) | 2014-03-18 |
| AR077901A1 (es) | 2011-09-28 |
| IL218202A (en) | 2017-07-31 |
| SG178339A1 (en) | 2012-03-29 |
| MX2012002139A (es) | 2012-03-07 |
| TW201111781A (en) | 2011-04-01 |
| EP2467402A1 (en) | 2012-06-27 |
| WO2011020925A1 (en) | 2011-02-24 |
| KR20120051734A (ko) | 2012-05-22 |
| CN102639564A (zh) | 2012-08-15 |
| NZ700437A (en) | 2016-04-29 |
| CA2769427A1 (en) | 2011-02-24 |
| US20140295452A1 (en) | 2014-10-02 |
| EP2467402B1 (en) | 2018-08-01 |
| JP2013502213A (ja) | 2013-01-24 |
| RU2012109004A (ru) | 2013-09-27 |
| CN102639564B (zh) | 2015-01-07 |
| AU2010284944A1 (en) | 2012-03-08 |
| IN2012DN01322A (enExample) | 2015-06-05 |
| ES2692522T3 (es) | 2018-12-04 |
| EP2287197A1 (en) | 2011-02-23 |
| IL218202A0 (en) | 2012-04-30 |
| AU2010284944B2 (en) | 2016-01-28 |
| BR112012003759A2 (pt) | 2017-07-11 |
| US20120149031A1 (en) | 2012-06-14 |
| ZA201202076B (en) | 2012-11-28 |
| NZ598194A (en) | 2015-05-29 |
| RU2582265C2 (ru) | 2016-04-20 |
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