ES2692522T3 - Anticuerpo anti-cMet y su utilización para la detección y el diagnóstico del cáncer - Google Patents

Anticuerpo anti-cMet y su utilización para la detección y el diagnóstico del cáncer Download PDF

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Publication number
ES2692522T3
ES2692522T3 ES10744608.0T ES10744608T ES2692522T3 ES 2692522 T3 ES2692522 T3 ES 2692522T3 ES 10744608 T ES10744608 T ES 10744608T ES 2692522 T3 ES2692522 T3 ES 2692522T3
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antibody
cdr
met
sequence seq
sequence
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ES10744608.0T
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English (en)
Spanish (es)
Inventor
Liliane Goetsch
Alexandra Jouhanneaud
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Pierre Fabre Medicament SA
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Pierre Fabre Medicament SA
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES10744608.0T 2009-08-21 2010-08-23 Anticuerpo anti-cMet y su utilización para la detección y el diagnóstico del cáncer Active ES2692522T3 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23586409P 2009-08-21 2009-08-21
EP09305777A EP2287197A1 (en) 2009-08-21 2009-08-21 Anti-cMET antibody and its use for the detection and the diagnosis of cancer
EP09305777 2009-08-21
US235864P 2009-08-21
US34800510P 2010-05-25 2010-05-25
US348005P 2010-05-25
PCT/EP2010/062271 WO2011020925A1 (en) 2009-08-21 2010-08-23 Anti-cmet antibody and its use for the detection and the diagnosis of cancer

Publications (1)

Publication Number Publication Date
ES2692522T3 true ES2692522T3 (es) 2018-12-04

Family

ID=41571045

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10744608.0T Active ES2692522T3 (es) 2009-08-21 2010-08-23 Anticuerpo anti-cMet y su utilización para la detección y el diagnóstico del cáncer

Country Status (19)

Country Link
US (2) US8673302B2 (enExample)
EP (2) EP2287197A1 (enExample)
JP (1) JP5951486B2 (enExample)
KR (1) KR20120051734A (enExample)
CN (1) CN102639564B (enExample)
AR (1) AR077901A1 (enExample)
AU (1) AU2010284944B2 (enExample)
BR (1) BR112012003759A2 (enExample)
CA (1) CA2769427C (enExample)
ES (1) ES2692522T3 (enExample)
IL (1) IL218202A (enExample)
IN (1) IN2012DN01322A (enExample)
MX (1) MX2012002139A (enExample)
NZ (2) NZ598194A (enExample)
RU (1) RU2582265C2 (enExample)
SG (1) SG178339A1 (enExample)
TW (1) TW201111781A (enExample)
WO (1) WO2011020925A1 (enExample)
ZA (1) ZA201202076B (enExample)

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EP2287197A1 (en) * 2009-08-21 2011-02-23 Pierre Fabre Medicament Anti-cMET antibody and its use for the detection and the diagnosis of cancer
EP3264089A1 (en) 2010-08-31 2018-01-03 Genentech, Inc. Biomarkers and methods of treatment
KR101444837B1 (ko) * 2011-06-03 2014-09-30 한국생명공학연구원 HGF 활성을 가지는 c-Met에 대한 인간항체 및 이의 용도
KR20140064971A (ko) 2011-09-19 2014-05-28 제넨테크, 인크. c-met 길항제 및 B-raf 길항제를 포함하는 조합 치료
KR20130036993A (ko) * 2011-10-05 2013-04-15 삼성전자주식회사 c-Met의 SEMA 도메인 내의 에피토프에 특이적으로 결합하는 항체
AU2012340826A1 (en) 2011-11-21 2014-05-29 Genentech, Inc. Purification of anti-c-met antibodies
WO2013078145A1 (en) * 2011-11-21 2013-05-30 Taivex Therapeutics Corporation Biomarkers for cancers responsive to modulators of hec1 activity
GB201121914D0 (en) 2011-12-20 2012-02-01 Ge Healthcare Ltd Method for patient selection
EP2870178B1 (en) * 2012-05-09 2017-07-12 Eli Lilly and Company Anti-c-met antibodies
WO2013192594A2 (en) * 2012-06-21 2013-12-27 Sorrento Therapeutics Inc. Antigen binding proteins that bind c-met
CN104994879A (zh) 2013-02-22 2015-10-21 霍夫曼-拉罗奇有限公司 治疗癌症和预防药物抗性的方法
US10214593B2 (en) 2013-04-02 2019-02-26 Samsung Electronics Co., Ltd. Anti-idiotype antibody against anti-c-MET antibody
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
WO2015031614A1 (en) * 2013-08-28 2015-03-05 Abbvie Inc. Soluble cmet assay
WO2015031626A1 (en) * 2013-08-28 2015-03-05 Abbvie Inc. Soluble cmet assay
WO2015032695A1 (en) * 2013-09-09 2015-03-12 Ventana Medical Systems, Inc. Scoring method for mesothelin protein expression
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
EP3122900A1 (en) * 2014-03-24 2017-02-01 F. Hoffmann-La Roche AG Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
JP2017524371A (ja) 2014-05-23 2017-08-31 ジェネンテック, インコーポレイテッド Mitバイオマーカーとその使用方法
ES2764299T3 (es) 2014-12-09 2020-06-02 Inst Nat Sante Rech Med Anticuerpos monoclonales humanos contra AXL
WO2016124568A1 (en) * 2015-02-03 2016-08-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-rho gtpase conformational single domain antibodies and uses thereof
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
DK3270965T3 (da) * 2015-03-18 2020-06-08 Seattle Genetics Inc Cd48-antistoffer og konjugater deraf
ES2896709T3 (es) 2016-02-05 2022-02-25 Helixmith Co Ltd Anticuerpos anti-c-Met y usos de los mismos
KR20230028574A (ko) 2016-05-17 2023-02-28 애브비 바이오테라퓨틱스 인크. 항-cMet 항체 약물 컨쥬게이트 및 그들의 이용 방법
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法
RU2735918C2 (ru) * 2018-06-07 2020-11-10 Общество с ограниченной ответственностью "ДЖЕЙВИС ДИАГНОСТИКС" Набор реагентов для выявления маркера эпителиальных карцином
WO2020001526A1 (zh) * 2018-06-29 2020-01-02 苏州智核生物医药科技有限公司 Pd-l1结合多肽及其用途
KR102396194B1 (ko) * 2018-12-07 2022-05-10 서울대학교 산학협력단 항 c-Met 아고니스트 항체 및 이의 용도
JP2022535880A (ja) * 2019-06-06 2022-08-10 アポロミクス インコーポレイテッド(ハンジョウ) c-MET阻害剤を使用して癌患者を処置するための方法
KR20220063185A (ko) 2019-09-16 2022-05-17 리제너론 파마슈티칼스 인코포레이티드 면역-pet 영상화를 위한 방사성 표지된 met 결합 단백질
CA3161919A1 (en) 2020-09-01 2022-03-10 Remegen Co., Ltd. Anti-c-met antibody-drug conjugate and applications thereof
EP4210704A4 (en) * 2020-09-08 2024-08-28 Ideaya Biosciences, Inc. PHARMACEUTICAL COMBINATION AND ANTITUMOR TREATMENT
AU2023283550A1 (en) * 2022-06-09 2024-11-21 Santa Ana Bio, Inc. Antibodies targeting c-kit and/or siglec and uses thereof
MA71625A (fr) 2022-07-30 2025-05-30 Pinetree Therapeutics, Inc. Compositions pour la dégradation lysosomale ciblée et leurs procédés d'utilisation
WO2025036355A1 (zh) * 2023-08-14 2025-02-20 明慧医药(杭州)有限公司 抗c-MET纳米抗体及其用途

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CA2472383A1 (en) * 2001-12-27 2003-07-17 Van Andel Research Institute Monoclonal antibody imaging and therapy of tumors that express met and bind hepatocyte growth factor
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KR101429297B1 (ko) * 2006-02-06 2014-08-12 메테레시스 트랜스레이셔날 리서치 에스.에이. 종양 치료를 위한 항-Met 단클론 항체, 이의 단편과벡터 및 상응하는 산물
EP2014681A1 (en) * 2007-07-12 2009-01-14 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
US7892770B2 (en) * 2007-08-24 2011-02-22 Van Andel Research Institute Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods
AR074439A1 (es) * 2008-12-02 2011-01-19 Pf Medicament Anticuerpo anti-cmet (receptor c-met)
US8545839B2 (en) * 2008-12-02 2013-10-01 Pierre Fabre Medicament Anti-c-Met antibody
EP2287197A1 (en) * 2009-08-21 2011-02-23 Pierre Fabre Medicament Anti-cMET antibody and its use for the detection and the diagnosis of cancer

Also Published As

Publication number Publication date
EP2467402A1 (en) 2012-06-27
CN102639564A (zh) 2012-08-15
IL218202A (en) 2017-07-31
EP2287197A1 (en) 2011-02-23
RU2582265C2 (ru) 2016-04-20
ZA201202076B (en) 2012-11-28
NZ700437A (en) 2016-04-29
AU2010284944A1 (en) 2012-03-08
CA2769427A1 (en) 2011-02-24
IL218202A0 (en) 2012-04-30
AR077901A1 (es) 2011-09-28
NZ598194A (en) 2015-05-29
US20120149031A1 (en) 2012-06-14
WO2011020925A1 (en) 2011-02-24
JP2013502213A (ja) 2013-01-24
CN102639564B (zh) 2015-01-07
AU2010284944B2 (en) 2016-01-28
US8673302B2 (en) 2014-03-18
TW201111781A (en) 2011-04-01
KR20120051734A (ko) 2012-05-22
RU2012109004A (ru) 2013-09-27
EP2467402B1 (en) 2018-08-01
MX2012002139A (es) 2012-03-07
BR112012003759A2 (pt) 2017-07-11
US20140295452A1 (en) 2014-10-02
JP5951486B2 (ja) 2016-07-13
SG178339A1 (en) 2012-03-29
IN2012DN01322A (enExample) 2015-06-05
CA2769427C (en) 2020-03-10

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