RU2582265C2 - АНТИТЕЛО ПРОТИВ cMet И ЕГО ПРИМЕНЕНИЕ ДЛЯ ОПРЕДЕЛЕНИЯ И ДИАГНОСТИКИ РАКА - Google Patents

АНТИТЕЛО ПРОТИВ cMet И ЕГО ПРИМЕНЕНИЕ ДЛЯ ОПРЕДЕЛЕНИЯ И ДИАГНОСТИКИ РАКА Download PDF

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RU2582265C2
RU2582265C2 RU2012109004/10A RU2012109004A RU2582265C2 RU 2582265 C2 RU2582265 C2 RU 2582265C2 RU 2012109004/10 A RU2012109004/10 A RU 2012109004/10A RU 2012109004 A RU2012109004 A RU 2012109004A RU 2582265 C2 RU2582265 C2 RU 2582265C2
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cmet
antibody
cdr
sequence
seq
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RU2012109004/10A
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Russian (ru)
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RU2012109004A (ru
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Лилиан ГЁТШ
Александра ЖУАННО
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Пьер Фабр Медикамент
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57595—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving intracellular compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2012109004/10A 2009-08-21 2010-08-23 АНТИТЕЛО ПРОТИВ cMet И ЕГО ПРИМЕНЕНИЕ ДЛЯ ОПРЕДЕЛЕНИЯ И ДИАГНОСТИКИ РАКА RU2582265C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23586409P 2009-08-21 2009-08-21
EP09305777A EP2287197A1 (en) 2009-08-21 2009-08-21 Anti-cMET antibody and its use for the detection and the diagnosis of cancer
US61/235,864 2009-08-21
EP09305777.6 2009-08-21
US34800510P 2010-05-25 2010-05-25
US61/348,005 2010-05-25
PCT/EP2010/062271 WO2011020925A1 (en) 2009-08-21 2010-08-23 Anti-cmet antibody and its use for the detection and the diagnosis of cancer

Publications (2)

Publication Number Publication Date
RU2012109004A RU2012109004A (ru) 2013-09-27
RU2582265C2 true RU2582265C2 (ru) 2016-04-20

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RU2012109004/10A RU2582265C2 (ru) 2009-08-21 2010-08-23 АНТИТЕЛО ПРОТИВ cMet И ЕГО ПРИМЕНЕНИЕ ДЛЯ ОПРЕДЕЛЕНИЯ И ДИАГНОСТИКИ РАКА

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Country Link
US (2) US8673302B2 (enExample)
EP (2) EP2287197A1 (enExample)
JP (1) JP5951486B2 (enExample)
KR (1) KR20120051734A (enExample)
CN (1) CN102639564B (enExample)
AR (1) AR077901A1 (enExample)
AU (1) AU2010284944B2 (enExample)
BR (1) BR112012003759A2 (enExample)
CA (1) CA2769427C (enExample)
ES (1) ES2692522T3 (enExample)
IL (1) IL218202A (enExample)
IN (1) IN2012DN01322A (enExample)
MX (1) MX2012002139A (enExample)
NZ (2) NZ700437A (enExample)
RU (1) RU2582265C2 (enExample)
SG (1) SG178339A1 (enExample)
TW (1) TW201111781A (enExample)
WO (1) WO2011020925A1 (enExample)
ZA (1) ZA201202076B (enExample)

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WO2019235973A1 (ru) * 2018-06-07 2019-12-12 Cherkasova Zhanneta Rashidovna Набор реагентов для выявления маркера эпителиальных карцином

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EP2287197A1 (en) * 2009-08-21 2011-02-23 Pierre Fabre Medicament Anti-cMET antibody and its use for the detection and the diagnosis of cancer
MX2013002084A (es) 2010-08-31 2013-05-09 Genentech Inc Biomarcadores y metodos de tratamiento.
KR101444837B1 (ko) 2011-06-03 2014-09-30 한국생명공학연구원 ＨＧＦ 활성을 가지는 ｃ-Ｍｅｔ에 대한 인간항체 및 이의 용도
SG11201400724SA (en) 2011-09-19 2014-04-28 Genentech Inc Combination treatments comprising c-met antagonists and b-raf antagonists
KR20130036993A (ko) * 2011-10-05 2013-04-15 삼성전자주식회사 ｃ-Ｍｅｔ의 ＳＥＭＡ 도메인 내의 에피토프에 특이적으로 결합하는 항체
SG11201402485UA (en) 2011-11-21 2014-06-27 Genentech Inc Purification of anti-c-met antibodies
ES2736999T3 (es) * 2011-11-21 2020-01-09 Taivex Therapeutics Corp Biomarcadores para cánceres que responden a moduladores de la actividad de Hec1
GB201121914D0 (en) 2011-12-20 2012-02-01 Ge Healthcare Ltd Method for patient selection
WO2013169532A1 (en) * 2012-05-09 2013-11-14 Eli Lilly And Company Anti-c-met antibodies
CN105050618B (zh) * 2012-06-21 2018-11-16 索伦托治疗有限公司 与c-Met结合的抗原结合蛋白
JP2016509045A (ja) 2013-02-22 2016-03-24 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト がんを治療し、薬剤耐性を防止する方法
US10214593B2 (en) 2013-04-02 2019-02-26 Samsung Electronics Co., Ltd. Anti-idiotype antibody against anti-c-MET antibody
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
WO2015031626A1 (en) * 2013-08-28 2015-03-05 Abbvie Inc. Soluble cmet assay
WO2015031614A1 (en) * 2013-08-28 2015-03-05 Abbvie Inc. Soluble cmet assay
WO2015032695A1 (en) * 2013-09-09 2015-03-12 Ventana Medical Systems, Inc. Scoring method for mesothelin protein expression
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
RU2016141385A (ru) 2014-03-24 2018-04-28 Дженентек, Инк. Лечение рака антагонистами с-мет и их корреляция с экспрессией hgf
RU2016144405A (ru) 2014-05-23 2018-06-26 Дженентек, Инк. MiT БИОМАРКЕРЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
JP6864953B2 (ja) 2014-12-09 2021-04-28 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Ａｘｌに対するヒトモノクローナル抗体
US10544210B2 (en) * 2015-02-03 2020-01-28 Inserm (Institut National De La Sante Et De La Recherche Medicale) Anti-Rho GTPase conformational single domain antibodies and uses thereof
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
DK3270965T3 (da) * 2015-03-18 2020-06-08 Seattle Genetics Inc Cd48-antistoffer og konjugater deraf
KR102476846B1 (ko) * 2016-02-05 2022-12-12 주식회사 헬릭스미스 항―ｃ―ＭＥＴ 항체 및 이의 용도
SI3626273T1 (sl) 2016-05-17 2021-04-30 Abbvie Biotherapeutics Inc. Konjugati protitelesa proti CMET in zdravila ter postopki za njihovo uporabo
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
EP3816186A4 (en) * 2018-06-29 2022-04-06 Suzhou Smartnuclide Biopharmaceutical Co., Ltd. PD-L1 BINDING POLYPEPTIDES AND USE THEREOF
KR102396194B1 (ko) * 2018-12-07 2022-05-10 서울대학교 산학협력단 항 c-Met 아고니스트 항체 및 이의 용도
US20220252603A1 (en) * 2019-06-06 2022-08-11 Apollomics Inc. (Hangzhou) Method for treating cancer patients using c-met inhibitor
AU2020349462A1 (en) 2019-09-16 2022-03-03 Regeneron Pharmaceuticals, Inc. Radiolabeled MET binding proteins for immuno-PET imaging
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WO2022055893A1 (en) * 2020-09-08 2022-03-17 Ideaya Biosciences Inc. Pharmaceutical combination and tumor treatment
JP2025524370A (ja) * 2022-06-09 2025-07-30 サンタ アナ バイオ インコーポレイテッド ｃ－Ｋｉｔ及び／またはｓｉｇｌｅｃを標的とする抗体ならびにその使用
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AU2024323801A1 (en) * 2023-08-14 2026-03-19 Minghui Pharmaceutical (Hangzhou) Limited Anti-c-met nanobody and use thereof

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US20080286825A1 (en) * 2005-11-08 2008-11-20 Bottaro Donald P Methods for Diagnosing and Monitoring the Progression of Cancer
WO2009007427A2 (en) * 2007-07-12 2009-01-15 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
RU2361879C2 (ru) * 2004-04-15 2009-07-20 ГЭЛЭКСИ БАЙОТЕК, ЭлЭлСи Моноклональные антитела к фактору роста гепатоцитов

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US7892770B2 (en) * 2007-08-24 2011-02-22 Van Andel Research Institute Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods
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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US20050118165A1 (en) * 2001-12-27 2005-06-02 Van Andel Institute; And The Usa As Represented By The Department Of Veterans Affairs Monoclonal antibody imaging and therapy of tumors that express met and bind hepatocyte growth factor
RU2361879C2 (ru) * 2004-04-15 2009-07-20 ГЭЛЭКСИ БАЙОТЕК, ЭлЭлСи Моноклональные антитела к фактору роста гепатоцитов
US20080286825A1 (en) * 2005-11-08 2008-11-20 Bottaro Donald P Methods for Diagnosing and Monitoring the Progression of Cancer
WO2009007427A2 (en) * 2007-07-12 2009-01-15 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019235973A1 (ru) * 2018-06-07 2019-12-12 Cherkasova Zhanneta Rashidovna Набор реагентов для выявления маркера эпителиальных карцином
EA039873B1 (ru) * 2018-06-07 2022-03-22 Общество с ограниченной ответственностью "ДЖЕЙВИС ДИАГНОСТИКС" Набор реагентов для выявления маркера эпителиальных карцином

Also Published As

Publication number Publication date
TW201111781A (en) 2011-04-01
NZ598194A (en) 2015-05-29
MX2012002139A (es) 2012-03-07
NZ700437A (en) 2016-04-29
SG178339A1 (en) 2012-03-29
ES2692522T3 (es) 2018-12-04
BR112012003759A2 (pt) 2017-07-11
US20120149031A1 (en) 2012-06-14
ZA201202076B (en) 2012-11-28
JP5951486B2 (ja) 2016-07-13
JP2013502213A (ja) 2013-01-24
IL218202A (en) 2017-07-31
EP2467402B1 (en) 2018-08-01
CN102639564A (zh) 2012-08-15
EP2287197A1 (en) 2011-02-23
IL218202A0 (en) 2012-04-30
CA2769427A1 (en) 2011-02-24
EP2467402A1 (en) 2012-06-27
WO2011020925A1 (en) 2011-02-24
KR20120051734A (ko) 2012-05-22
RU2012109004A (ru) 2013-09-27
CA2769427C (en) 2020-03-10
AU2010284944A1 (en) 2012-03-08
US20140295452A1 (en) 2014-10-02
AU2010284944B2 (en) 2016-01-28
US8673302B2 (en) 2014-03-18
AR077901A1 (es) 2011-09-28
IN2012DN01322A (enExample) 2015-06-05
CN102639564B (zh) 2015-01-07

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