JP5941558B2 - シルデナフィルを有効成分として含有し、且つ、苦味の隠蔽された高含量速溶フィルム - Google Patents
シルデナフィルを有効成分として含有し、且つ、苦味の隠蔽された高含量速溶フィルム Download PDFInfo
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- JP5941558B2 JP5941558B2 JP2014554675A JP2014554675A JP5941558B2 JP 5941558 B2 JP5941558 B2 JP 5941558B2 JP 2014554675 A JP2014554675 A JP 2014554675A JP 2014554675 A JP2014554675 A JP 2014554675A JP 5941558 B2 JP5941558 B2 JP 5941558B2
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- sildenafil
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020120020316A KR101328350B1 (ko) | 2012-02-28 | 2012-02-28 | 실데나필 또는 이의 약제학적으로 허용되는 염을 유효성분으로 함유하는 고미가 은폐된 약제학적 조성물 |
| KR10-2012-0020316 | 2012-02-28 | ||
| KR10-2012-0117233 | 2012-10-22 | ||
| KR1020120117233A KR101440808B1 (ko) | 2012-10-22 | 2012-10-22 | 실데나필 또는 이의 약제학적으로 허용되는 염을 고함량으로 포함하는 속용필름 |
| PCT/KR2013/001679 WO2013129889A2 (ko) | 2012-02-28 | 2013-02-28 | 실데나필을 유효성분으로 함유하며 고미가 은폐된 고함량 속용필름 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015504916A JP2015504916A (ja) | 2015-02-16 |
| JP5941558B2 true JP5941558B2 (ja) | 2016-06-29 |
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| JP2014554675A Active JP5941558B2 (ja) | 2012-02-28 | 2013-02-28 | シルデナフィルを有効成分として含有し、且つ、苦味の隠蔽された高含量速溶フィルム |
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|---|---|---|---|---|
| CN103989661B (zh) * | 2014-05-26 | 2016-04-20 | 苏州大学 | 西地那非口腔速溶膜剂及其制备方法 |
| KR101538985B1 (ko) * | 2014-09-02 | 2015-07-24 | 주식회사 서울제약 | 타다라필 구강붕해필름 및 이의 제조방법 |
| KR20240036586A (ko) * | 2014-12-09 | 2024-03-20 | 어퀘스티브 테라퓨틱스, 인크. | 선형 다당류-기반 필름 생성물 |
| CN104586820B (zh) * | 2015-01-13 | 2021-04-09 | 齐鲁制药有限公司 | 具有高载药量的西地那非口腔速溶薄膜组合物 |
| CN104546807B (zh) * | 2015-01-21 | 2020-09-01 | 齐鲁制药有限公司 | 奥氮平口腔速溶膜剂 |
| BR112017017428A2 (pt) | 2015-02-25 | 2018-04-03 | Eisai R&D Management Co., Ltd. | ?método para supressão do amargor de derivado de quinolina? |
| RU2718048C2 (ru) | 2015-08-20 | 2020-03-30 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Противоопухолевое терапевтическое средство |
| EP3463317A4 (en) * | 2016-06-07 | 2020-01-08 | Aridis Pharmaceuticals, Inc. | PROCESS FOR THE PREPARATION OF FAST-DISSOLVING THIN FILMS CONTAINING A BIOLOGICALLY ACTIVE SUBSTANCE WITH IMPROVED THERMAL STABILITY |
| AU2018219637B2 (en) | 2017-02-08 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Tumor-treating pharmaceutical composition |
| US11096892B2 (en) * | 2017-03-13 | 2021-08-24 | Nano And Advanced Materials Institute Limited | High loading and fast disintegration film for fast drug absorption |
| CN106860404A (zh) * | 2017-04-13 | 2017-06-20 | 中国药科大学 | 一种枸橼酸西地那非掩味树脂复合物及其应用 |
| US20200197384A1 (en) | 2017-05-16 | 2020-06-25 | Eisai R&D Management Co., Ltd. | Treatment of hepatocellular carcinoma |
| CN109717282A (zh) * | 2017-10-30 | 2019-05-07 | 上海冠生园食品有限公司 | 一种富含花青素的糖果及其制备方法 |
| WO2019161322A1 (en) * | 2018-02-19 | 2019-08-22 | Monell Chemical Senses Center | Compositions and methods of ameliorating pharmaceutical aversiveness with salts |
| CN109010324B (zh) * | 2018-08-30 | 2021-07-02 | 南京康川济医药科技有限公司 | 一种西地那非口溶膜剂及其制备方法 |
| CN111466564A (zh) * | 2019-01-24 | 2020-07-31 | 甄崇礼 | 含有天然活性多糖的口腔速溶膜剂及其制备方法 |
| CN110128429A (zh) * | 2019-04-30 | 2019-08-16 | 孙常全 | 一种西地那非-安赛蜜盐型及其制备方法和用途 |
| US20220249466A1 (en) * | 2019-09-04 | 2022-08-11 | Seasons Biotechnology (Taizhou) Co., Ltd. | Coated granule, solid dispersion, and preparation containing vortioxetine hydrobromide for oral taste masking |
| US11179331B1 (en) | 2020-04-21 | 2021-11-23 | Cure Pharmaceutcai Holding Corp | Oral soluble film containing sildenafil citrate |
| GR20200100430A (el) * | 2020-06-01 | 2022-01-13 | Κυριακος Ηλια Κυπραιος | Ταχεως διαλυομενες στοματικες ταινιες για τη χορηγηση δια της στοματικης οδου φαρμακων και λοιπων βιοδραστικων ουσιων σε ανθρωπους |
| US20240065303A1 (en) * | 2020-12-22 | 2024-02-29 | Solugen, Inc. | Bitter masking agent |
| CN115252587A (zh) * | 2022-08-19 | 2022-11-01 | 南京泛太化工医药研究所 | 一种口腔速溶膜及其制备方法 |
| CN116270553B (zh) * | 2023-02-01 | 2024-05-07 | 北京悦康科创医药科技股份有限公司 | 一种爱地那非口溶膜剂及其制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US652024A (en) | 1898-12-08 | 1900-06-19 | James Gray | Valve mechanism for automatic water-heaters. |
| TW271400B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1992-07-30 | 1996-03-01 | Pfizer | |
| GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| GB9401090D0 (en) | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
| US5605889A (en) | 1994-04-29 | 1997-02-25 | Pfizer Inc. | Method of administering azithromycin |
| IL135462A0 (en) | 1997-11-12 | 2001-05-20 | Bayer Ag | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
| KR100353014B1 (ko) | 1998-11-11 | 2002-09-18 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물 |
| US6552024B1 (en) | 1999-01-21 | 2003-04-22 | Lavipharm Laboratories Inc. | Compositions and methods for mucosal delivery |
| US7067116B1 (en) | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
| CA2417736A1 (en) * | 2000-07-19 | 2002-01-24 | Lavipharm Laboratories, Inc. | Sildenafil citrate solid dispersions having high water solubility |
| DE10207394B4 (de) | 2002-02-21 | 2007-03-29 | Lts Lohmann Therapie-Systeme Ag | Geschmacksmaskierte oblatenförmige Arzneizubereitung |
| GB0219516D0 (en) * | 2002-08-21 | 2002-10-02 | Phoqus Ltd | Fast dissolving and taste masked oral dosage form comprising sildenafil |
| KR20060031552A (ko) | 2004-10-08 | 2006-04-12 | 박영국 | 취수선을 이용한 해양 심층수 취수 방법 |
| US20070092553A1 (en) | 2005-10-21 | 2007-04-26 | Pfab Lp | Compositions and methods of making rapidly dissolving lonically masked formulations |
| WO2007059591A1 (en) * | 2005-11-28 | 2007-05-31 | Imaginot Pty Ltd | Oral therapeutic compound delivery system |
| MX2008011823A (es) * | 2006-03-16 | 2008-10-31 | Novartis Ag | Forma de dosificacion solida que contiene un agente activo de sabor encubierto. |
| KR101304343B1 (ko) | 2006-04-06 | 2013-09-11 | 한미사이언스 주식회사 | Ｐｄｅ-5 억제제의 경구용 속용제형 |
| MX2009003372A (es) * | 2006-10-02 | 2009-09-24 | Labtec Gmbh | Formas de dosificacion de pelicula no mucoadhesiva. |
| CA2675356A1 (en) | 2007-01-12 | 2008-07-24 | Monosol Rx, Llc | High dose film compositions and methods of preparation |
| US20080220029A1 (en) | 2007-03-05 | 2008-09-11 | Charlene Ng | Fast-dissolving/disintegrating film preparation having high proportion of active |
| US20090047330A1 (en) * | 2007-08-17 | 2009-02-19 | Ramesh Bangalore | Oral fast dissolving films for erectile dysfunction bioactive agents |
| US20100297232A1 (en) * | 2009-05-19 | 2010-11-25 | Monosol Rx, Llc | Ondansetron film compositions |
| KR101074271B1 (ko) * | 2009-06-25 | 2011-10-17 | (주)차바이오앤디오스텍 | 불쾌한 맛을 효과적으로 은폐한 경구용 속용 필름 |
| DE102010049708A1 (de) * | 2010-10-28 | 2012-05-03 | Hexal Ag | Orale pharmazeutische Filmformulierung für bitter schmeckende Arzneistoffe |
| EA201500604A1 (ru) | 2011-02-11 | 2015-09-30 | СиТиСи БАЙО, ИНК. | Пленочная лекарственная форма, содержащая свободное основание силденафила, и способ ее получения |
| KR101188594B1 (ko) | 2011-12-06 | 2012-10-08 | (주)씨엘팜 | 쓴맛이 차단된 실데나필 시트르산의 구강내 속붕해 필름제형 |
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| WO2013129889A2 (ko) | 2013-09-06 |
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| CN104168895B (zh) | 2020-02-21 |
| CA2864322C (en) | 2016-08-09 |
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