IN2014MN01706A - - Google Patents

Info

Publication number
IN2014MN01706A
IN2014MN01706A IN1706MUN2014A IN2014MN01706A IN 2014MN01706 A IN2014MN01706 A IN 2014MN01706A IN 1706MUN2014 A IN1706MUN2014 A IN 1706MUN2014A IN 2014MN01706 A IN2014MN01706 A IN 2014MN01706A
Authority
IN
India
Prior art keywords
bitter taste
active ingredient
fast dissolving
film composition
dissolving film
Prior art date
Application number
Inventor
Hyun Jun Jeong
Ik Hyeon Chang
Dal Geun Kim
Jin Hoo Lee
Jin Hee Um
Hyun Soo Kim
Kyung Tae Jung
Kyu Jeong Yeon
Jin Gyu Park
Original Assignee
Seoul Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020120020316A external-priority patent/KR101328350B1/en
Priority claimed from KR1020120117233A external-priority patent/KR101440808B1/en
Application filed by Seoul Pharma Co Ltd filed Critical Seoul Pharma Co Ltd
Publication of IN2014MN01706A publication Critical patent/IN2014MN01706A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided is a fast dissolving film composition comprising a medically active component as an active ingredient in which the bitter taste of the active ingredient is masked and the fast dissolving film composition has a high content of 50% or higher. More particularly provided is a pharmaceutical composition which comprises sildenafil or pharmaceutically acceptable salts thereof as an active ingredient and which comprises a combination of a specific bitter taste masking agent to achieve masking of a bitter taste. Further provided is a fast dissolving film composition which comprises a combination of a specific plasticizer to mask a bitter taste and in which the physical properties of the high content film are excellent.
IN1706MUN2014 2012-02-28 2013-02-28 IN2014MN01706A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020120020316A KR101328350B1 (en) 2012-02-28 2012-02-28 Taste masked pharmaceutical composition comprising sildenafil or pharmaceutically acceptable salts thereof as an active ingredient
KR1020120117233A KR101440808B1 (en) 2012-10-22 2012-10-22 Fast dissolving film comprising high dose of sildenafil or pharmaceutically acceptable salts thereof
PCT/KR2013/001679 WO2013129889A2 (en) 2012-02-28 2013-02-28 High-content fast dissolving film with masking of bitter taste comprising sildenafil as active ingredient

Publications (1)

Publication Number Publication Date
IN2014MN01706A true IN2014MN01706A (en) 2015-05-29

Family

ID=49083410

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1706MUN2014 IN2014MN01706A (en) 2012-02-28 2013-02-28

Country Status (7)

Country Link
US (1) US10092651B2 (en)
EP (1) EP2821066B1 (en)
JP (1) JP5941558B2 (en)
CN (1) CN104168895B (en)
CA (1) CA2864322C (en)
IN (1) IN2014MN01706A (en)
WO (1) WO2013129889A2 (en)

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CN103989661B (en) * 2014-05-26 2016-04-20 苏州大学 Sldenafil oral instant membrane and preparation method thereof
KR101538985B1 (en) * 2014-09-02 2015-07-24 주식회사 서울제약 Tadalafil Orally Disintegrating Film and Precess For Producing thereof
KR20170117374A (en) * 2014-12-09 2017-10-23 모노졸 알엑스, 엘엘씨 Linear polysaccharide based film products
CN104586820B (en) * 2015-01-13 2021-04-09 齐鲁制药有限公司 Sildenafil oral fast dissolving film composition with high drug loading
CN104546807B (en) * 2015-01-21 2020-09-01 齐鲁制药有限公司 Olanzapine oral instant film agent
LT3263106T (en) 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. METHOD OF REDUCING BITTERNESS OF QUINOLINE DERIVATIVES
RU2718048C2 (en) 2015-08-20 2020-03-30 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Antitumour therapeutic agent
WO2017214187A1 (en) * 2016-06-07 2017-12-14 Aridis Pharmaceuticals, Inc. Method for preparation of quick dissolving thin films containing bioactive material with enhanced thermal stability
WO2018147275A1 (en) 2017-02-08 2018-08-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 Tumor-treating pharmaceutical composition
WO2018166432A1 (en) * 2017-03-13 2018-09-20 Nano And Advanced Materials Institute Limited High loading and fast disintegration film for fast drug absorption
CN106860404A (en) * 2017-04-13 2017-06-20 中国药科大学 A kind of sildenafil citrate taste masking resin complexes and its application
RU2019134940A (en) 2017-05-16 2021-06-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. TREATMENT OF HEPATOCELLULAR CARCINOMA
CN109717282A (en) * 2017-10-30 2019-05-07 上海冠生园食品有限公司 A kind of candy and preparation method thereof rich in anthocyanidin
US20210007977A1 (en) * 2018-02-19 2021-01-14 Monell Chemical Senses Center Compositions and methods of ameliorating pharmaceutical aversiveness with salts
CN109010324B (en) * 2018-08-30 2021-07-02 南京康川济医药科技有限公司 Sildenafil oral dissolving film agent and preparation method thereof
CN111466564A (en) * 2019-01-24 2020-07-31 甄崇礼 Oral instant film containing natural active polysaccharide and preparation method thereof
CN110128429A (en) * 2019-04-30 2019-08-16 孙常全 A kind of silaenafil-acesulfame potassium salt form and its preparation method and application
MX2022002444A (en) * 2019-09-04 2022-03-22 Seasons Biotechnology Taizhou Co Ltd Coated granule, solid dispersion, and preparation containing vortioxetine hydrobromide for oral taste masking.
US11179331B1 (en) 2020-04-21 2021-11-23 Cure Pharmaceutcai Holding Corp Oral soluble film containing sildenafil citrate
GR20200100430A (en) * 2020-06-01 2022-01-13 Κυριακος Ηλια Κυπραιος Rapidly dissolving oral strips for per os administration of drugs and other bioactive compounds to humans
EP4266902A4 (en) * 2020-12-22 2024-11-20 Solugen, Inc. Bitter masking agent
CN115252587A (en) * 2022-08-19 2022-11-01 南京泛太化工医药研究所 Oral instant film and preparation method thereof
CN116270553B (en) * 2023-02-01 2024-05-07 北京悦康科创医药科技股份有限公司 A kind of edenafil orodispersible film and preparation method thereof
CN119280194B (en) * 2024-09-06 2025-10-28 广州朗圣药业有限公司 Sildenafil oral film-dissolving agent, and preparation method and application thereof

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Also Published As

Publication number Publication date
US20150025084A1 (en) 2015-01-22
CA2864322A1 (en) 2013-09-06
US10092651B2 (en) 2018-10-09
CN104168895B (en) 2020-02-21
WO2013129889A3 (en) 2013-10-24
CA2864322C (en) 2016-08-09
CN104168895A (en) 2014-11-26
EP2821066A2 (en) 2015-01-07
JP2015504916A (en) 2015-02-16
JP5941558B2 (en) 2016-06-29
EP2821066B1 (en) 2018-04-25
WO2013129889A2 (en) 2013-09-06
WO2013129889A9 (en) 2014-10-16
EP2821066A4 (en) 2015-10-21

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