JP5907990B2 - 核酸増幅のための方法、組成物、システム、装置およびキット - Google Patents
核酸増幅のための方法、組成物、システム、装置およびキット Download PDFInfo
- Publication number
- JP5907990B2 JP5907990B2 JP2013544833A JP2013544833A JP5907990B2 JP 5907990 B2 JP5907990 B2 JP 5907990B2 JP 2013544833 A JP2013544833 A JP 2013544833A JP 2013544833 A JP2013544833 A JP 2013544833A JP 5907990 B2 JP5907990 B2 JP 5907990B2
- Authority
- JP
- Japan
- Prior art keywords
- primer
- nucleic acid
- strand
- reverse
- template
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
- C12Q1/46—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase involving cholinesterase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6846—Common amplification features
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2531/00—Reactions of nucleic acids characterised by
- C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
- C12Q2531/119—Strand displacement amplification [SDA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/50—Detection characterised by immobilisation to a surface
- C12Q2565/537—Detection characterised by immobilisation to a surface characterised by the capture oligonucleotide acting as a primer
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424599P | 2010-12-17 | 2010-12-17 | |
| US61/424,599 | 2010-12-17 | ||
| US201161445324P | 2011-02-22 | 2011-02-22 | |
| US61/445,324 | 2011-02-22 | ||
| US201161451919P | 2011-03-11 | 2011-03-11 | |
| US61/451,919 | 2011-03-11 | ||
| US201161526478P | 2011-08-23 | 2011-08-23 | |
| US61/526,478 | 2011-08-23 | ||
| US201161552660P | 2011-10-28 | 2011-10-28 | |
| US61/552,660 | 2011-10-28 | ||
| PCT/US2011/065535 WO2012083189A2 (en) | 2010-12-17 | 2011-12-16 | Methods, compositions, systems, apparatuses and kits for nucleic acid amplification |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503207A JP2014503207A (ja) | 2014-02-13 |
| JP2014503207A5 JP2014503207A5 (enExample) | 2014-11-06 |
| JP5907990B2 true JP5907990B2 (ja) | 2016-05-11 |
Family
ID=45478545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013544833A Active JP5907990B2 (ja) | 2010-12-17 | 2011-12-16 | 核酸増幅のための方法、組成物、システム、装置およびキット |
Country Status (5)
| Country | Link |
|---|---|
| US (10) | US20120156728A1 (enExample) |
| EP (3) | EP2652148B1 (enExample) |
| JP (1) | JP5907990B2 (enExample) |
| CN (3) | CN110079588B (enExample) |
| WO (1) | WO2012083189A2 (enExample) |
Families Citing this family (148)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090047673A1 (en) | 2006-08-22 | 2009-02-19 | Cary Robert B | Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| WO2009137059A1 (en) | 2008-05-05 | 2009-11-12 | Los Alamos National Security, Llc | Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control |
| EP3216874A1 (en) | 2008-09-05 | 2017-09-13 | TOMA Biosciences, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| US9309566B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Methods, compositions, systems, apparatuses and kits for nucleic acid amplification |
| US9309557B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Nucleic acid amplification |
| US9334531B2 (en) | 2010-12-17 | 2016-05-10 | Life Technologies Corporation | Nucleic acid amplification |
| US10030045B2 (en) | 2010-02-19 | 2018-07-24 | Ohio State Innovation Foundation | Primers and methods for nucleic acid amplification |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| KR20130113447A (ko) | 2010-09-24 | 2013-10-15 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화 |
| US9184099B2 (en) | 2010-10-04 | 2015-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Biosensor devices, systems and methods therefor |
| GB2499340B (en) | 2010-10-04 | 2015-10-28 | Genapsys Inc | Methods for sequencing nucleic acids |
| US9399217B2 (en) | 2010-10-04 | 2016-07-26 | Genapsys, Inc. | Chamber free nanoreactor system |
| CN110079588B (zh) | 2010-12-17 | 2024-03-15 | 生命技术公司 | 用于核酸扩增的方法、组合物、系统、仪器和试剂盒 |
| WO2012099832A2 (en) | 2011-01-17 | 2012-07-26 | Life Technologies Corporation | Enzymatic ligation of nucleic acids |
| WO2012099896A2 (en) | 2011-01-17 | 2012-07-26 | Life Technologies Corporation | Workflow for detection of ligands using nucleic acids |
| BR112013020220B1 (pt) | 2011-02-09 | 2020-03-17 | Natera, Inc. | Método para determinar o estado de ploidia de um cromossomo em um feto em gestação |
| CA2856304C (en) | 2011-04-20 | 2017-05-16 | Mesa Tech International, Inc. | Oscillating amplification reaction for nucleic acids |
| US9926596B2 (en) | 2011-05-27 | 2018-03-27 | Genapsys, Inc. | Systems and methods for genetic and biological analysis |
| US8585973B2 (en) | 2011-05-27 | 2013-11-19 | The Board Of Trustees Of The Leland Stanford Junior University | Nano-sensor array |
| WO2013082619A1 (en) | 2011-12-01 | 2013-06-06 | Genapsys, Inc. | Systems and methods for high efficiency electronic sequencing and detection |
| WO2013112923A1 (en) | 2012-01-26 | 2013-08-01 | Nugen Technologies, Inc. | Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation |
| EP3461910B1 (en) * | 2012-04-19 | 2020-08-26 | Life Technologies Corporation | Nucleic acid amplification |
| SG11201406717RA (en) | 2012-04-19 | 2014-11-27 | Life Technologies Corp | Nucleic acid amplification |
| KR20150011359A (ko) | 2012-04-19 | 2015-01-30 | 라이프 테크놀로지스 코포레이션 | 디지털 pcr을 수행하는 방법 |
| WO2013191775A2 (en) | 2012-06-18 | 2013-12-27 | Nugen Technologies, Inc. | Compositions and methods for negative selection of non-desired nucleic acid sequences |
| US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
| KR101890466B1 (ko) * | 2012-07-24 | 2018-08-21 | 내테라, 인코포레이티드 | 고도의 다중 pcr 방법 및 조성물 |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| WO2014031163A1 (en) * | 2012-08-24 | 2014-02-27 | Life Technologies Corporation | Methods, compositions, systems, apparatuses and kits for nucleic acid paired end sequencing |
| WO2014043143A1 (en) * | 2012-09-11 | 2014-03-20 | Life Technologies Corporation | Nucleic acid amplification |
| EP2895620B1 (en) | 2012-09-11 | 2017-08-02 | Life Technologies Corporation | Nucleic acid amplification |
| EP2964789A4 (en) * | 2013-03-06 | 2016-11-02 | Ohio State Innovation Foundation | ISOTHERMIC NUCLEIC ACID AMPLIFICATION AND LIBRARY GENERATION AND CLONING GENERATION IN SEQUENCING |
| US10590474B2 (en) * | 2013-03-11 | 2020-03-17 | Elitechgroup B.V. | Methods for true isothermal strand displacement amplification |
| US20140255928A1 (en) * | 2013-03-11 | 2014-09-11 | Elitech Holding B.V. | Methods for true isothermal strand displacement amplification |
| US10975423B2 (en) * | 2013-03-11 | 2021-04-13 | Elitechgroup, Inc. | Methods for true isothermal strand displacement amplification |
| CN110066853B (zh) | 2013-03-14 | 2023-03-28 | 生命技术公司 | 基质阵列和其制备方法 |
| WO2014144092A1 (en) | 2013-03-15 | 2014-09-18 | Nugen Technologies, Inc. | Sequential sequencing |
| CA2896879C (en) | 2013-03-15 | 2020-09-22 | Genapsys, Inc. | Systems and methods for biological analysis |
| US9409139B2 (en) | 2013-08-05 | 2016-08-09 | Twist Bioscience Corporation | De novo synthesized gene libraries |
| WO2015073711A1 (en) | 2013-11-13 | 2015-05-21 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
| EP3792921A1 (en) | 2013-12-11 | 2021-03-17 | Genapsys, Inc. | Systems and methods for biological analysis and computation |
| WO2015131107A1 (en) | 2014-02-28 | 2015-09-03 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
| WO2015161054A2 (en) | 2014-04-18 | 2015-10-22 | Genapsys, Inc. | Methods and systems for nucleic acid amplification |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| EP3134541B1 (en) | 2014-04-21 | 2020-08-19 | Natera, Inc. | Detecting copy number variations (cnv) of chromosomal segments in cancer |
| SG10202004286UA (en) | 2014-05-08 | 2020-06-29 | Fluidigm Corp | Integrated single cell sequencing |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| EP3155127B1 (en) | 2014-06-13 | 2020-07-22 | Life Technologies Corporation | Multiplex nucleic acid amplification |
| CN107002071A (zh) | 2014-11-27 | 2017-08-01 | 株式会社日立高新技术 | 光点阵列基板、其制造方法、核酸聚合物解析方法以及装置 |
| CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| CA3253836A1 (en) | 2015-02-04 | 2025-12-01 | Twist Bioscience Corp | Compositions and methods for synthetic gene assembly |
| AU2016220404B2 (en) * | 2015-02-17 | 2021-05-27 | Mgi Tech Co., Ltd. | DNA sequencing using controlled strand displacement |
| GB201502645D0 (en) * | 2015-02-17 | 2015-04-01 | Touchlight Genetics Ltd | Method |
| ES2924907T3 (es) | 2015-03-05 | 2022-10-11 | Life Technologies Corp | Estabilización superficial de biosensores |
| EP4119677B1 (en) | 2015-04-10 | 2023-06-28 | Spatial Transcriptomics AB | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| JP6830443B2 (ja) | 2015-04-24 | 2021-02-17 | メサ バイオテック,インク. | 流体検査用カセット |
| WO2016170179A1 (en) | 2015-04-24 | 2016-10-27 | Qiagen Gmbh | Method for immobilizing a nucleic acid molecule on solid support |
| WO2016170182A1 (en) | 2015-04-24 | 2016-10-27 | Qiagen Gmbh | Method for immobilizing a nucleic acid molecule on a solid support |
| EP3289105B1 (en) | 2015-04-29 | 2021-01-20 | The Regents of The University of California | Compositions and methods for constructing strand specific cdna libraries |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| CA2985545C (en) | 2015-05-29 | 2021-02-09 | Illumina Cambridge Limited | Enhanced utilization of surface primers in clusters |
| US10344336B2 (en) | 2015-06-09 | 2019-07-09 | Life Technologies Corporation | Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging |
| AU2016324296A1 (en) | 2015-09-18 | 2018-04-12 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
| CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
| US20180291413A1 (en) | 2015-10-06 | 2018-10-11 | Thermo Fisher Scientific Geneart Gmbh | Devices and methods for producing nucleic acids and proteins |
| CN108603307A (zh) | 2015-12-01 | 2018-09-28 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
| AU2017218431B2 (en) | 2016-02-08 | 2022-08-04 | RGENE, Inc. | Multiple ligase compositions, systems, and methods |
| RU2760913C2 (ru) | 2016-04-15 | 2021-12-01 | Натера, Инк. | Способы выявления рака легкого |
| JP2017209051A (ja) * | 2016-05-25 | 2017-11-30 | 株式会社ニコン | 標的生体分子の検出方法、標的生体分子検出用基板、及び標的生体分子検出装置 |
| FI3464628T3 (fi) | 2016-06-06 | 2024-05-03 | Redvault Biosciences Lp | Kohdereportterikonstruktit ja niiden käyttö |
| US11268117B2 (en) | 2016-06-10 | 2022-03-08 | Life Technologies Corporation | Methods and compositions for nucleic acid amplification |
| GB201611469D0 (en) | 2016-06-30 | 2016-08-17 | Lumiradx Tech Ltd | Improvements in or relating to nucleic acid amplification processes |
| CN109790575A (zh) | 2016-07-20 | 2019-05-21 | 吉纳普赛斯股份有限公司 | 用于核酸测序的系统和方法 |
| EP4039824A1 (en) * | 2016-08-15 | 2022-08-10 | Pacific Biosciences of California, Inc. | Method and system for sequencing nucleic acids |
| CA3034769A1 (en) | 2016-08-22 | 2018-03-01 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
| CN110248724B (zh) | 2016-09-21 | 2022-11-18 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
| JP7018940B2 (ja) * | 2016-10-05 | 2022-02-14 | エフ.ホフマン-ラ ロシュ アーゲー | ナノトランジスタを使用した核酸配列決定 |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| CN110366613A (zh) | 2016-12-16 | 2019-10-22 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
| CN114958998A (zh) * | 2017-01-10 | 2022-08-30 | 深圳华大智造科技股份有限公司 | 一种提高核酸聚合测序质量的方法、反应体系和试剂盒 |
| WO2018137826A1 (en) | 2017-01-26 | 2018-08-02 | Qiagen Gmbh | Method for enriching template nucleic acids |
| WO2018156792A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
| CN110913865A (zh) | 2017-03-15 | 2020-03-24 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
| EP3607087A4 (en) | 2017-04-04 | 2020-12-30 | Omniome, Inc. | FLUIDIC APPARATUS AND USEFUL METHODS FOR CHEMICAL AND BIOLOGICAL REACTIONS |
| US12492430B2 (en) | 2017-04-11 | 2025-12-09 | Tecan Genomics, Inc. | Library quantitation and qualification |
| IL271205B2 (en) | 2017-06-12 | 2025-02-01 | Twist Bioscience Corp | Methods for assembling continuous nucleic acids |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| KR20200075814A (ko) | 2017-08-15 | 2020-06-26 | 옴니옴 인코포레이티드 | 화학적 및 생물학적 분석물의 검출에 유용한 스캐닝 장치 및 방법 |
| US11407837B2 (en) | 2017-09-11 | 2022-08-09 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
| EP3684951A4 (en) | 2017-09-21 | 2021-06-16 | Genapsys, Inc. | NUCLEIC ACID SEQUENCING SYSTEMS AND METHODS |
| US11414687B2 (en) * | 2017-10-04 | 2022-08-16 | Centrillion Technology Holdings Corporation | Method and system for enzymatic synthesis of oligonucleotides |
| EP3697932A1 (en) | 2017-10-19 | 2020-08-26 | Omniome, Inc. | Simultaneous background reduction and complex stabilization in binding assay workflows |
| KR102637566B1 (ko) | 2017-10-20 | 2024-02-16 | 트위스트 바이오사이언스 코포레이션 | 폴리뉴클레오타이드 합성을 위한 가열된 나노웰 |
| US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
| US12226745B2 (en) | 2017-11-07 | 2025-02-18 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| EP4310196A3 (en) | 2017-11-07 | 2024-04-24 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| CN112041438B (zh) | 2018-01-04 | 2025-05-23 | 特韦斯特生物科学公司 | 基于dna的数字信息存储 |
| GB2569965A (en) | 2018-01-04 | 2019-07-10 | Lumiradx Uk Ltd | Improvements in or relating to amplification of nucleic acids |
| GB201804585D0 (en) * | 2018-03-22 | 2018-05-09 | Dnae Diagnostics Ltd | Methods for amplication of nucleic acids with Endonuclease-Mediated shifting equilibrium amplification (EM-SEq) |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| AU2019255987A1 (en) | 2018-04-19 | 2020-12-10 | Pacific Biosciences Of California, Inc. | Improving accuracy of base calls in nucleic acid sequencing methods |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| WO2020018824A1 (en) * | 2018-07-19 | 2020-01-23 | Ultima Genomics, Inc. | Nucleic acid clonal amplification and sequencing methods, systems, and kits |
| US12421628B2 (en) | 2018-07-23 | 2025-09-23 | Dna Script | Massively parallel enzymatic synthesis of nucleic acid strands |
| WO2020076976A1 (en) | 2018-10-10 | 2020-04-16 | Readcoor, Inc. | Three-dimensional spatial molecular indexing |
| WO2020101795A1 (en) | 2018-11-15 | 2020-05-22 | Omniome, Inc. | Electronic detection of nucleic acid structure |
| CN113166805B (zh) | 2018-12-04 | 2024-07-16 | 加利福尼亚太平洋生物科学股份有限公司 | 用于核酸测序和其他分析测定的混合相流体 |
| KR102872251B1 (ko) | 2018-12-05 | 2025-10-16 | 일루미나 케임브리지 리미티드 | 브릿지 증폭에 의한 클러스터 생성을 위한 방법 및 조성물 |
| US12385083B2 (en) | 2018-12-10 | 2025-08-12 | 10X Genomics, Inc. | Methods of using master / copy arrays for spatial detection |
| EP3899036A1 (en) * | 2018-12-17 | 2021-10-27 | Illumina Cambridge Limited | Primer oligonucleotide for sequencing |
| WO2020126602A1 (en) | 2018-12-18 | 2020-06-25 | Illumina Cambridge Limited | Methods and compositions for paired end sequencing using a single surface primer |
| EP3899032A2 (en) | 2018-12-20 | 2021-10-27 | Omniome, Inc. | Temperature control for analysis of nucleic acids and other analytes |
| CA3124980A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| KR20210138017A (ko) | 2019-02-11 | 2021-11-18 | 울티마 제노믹스, 인크. | 핵산 분석 방법 |
| WO2020172444A1 (en) | 2019-02-20 | 2020-08-27 | Omniome, Inc. | Scanning apparatus and methods for detecting chemical and biological analytes |
| KR20210143766A (ko) | 2019-02-26 | 2021-11-29 | 트위스트 바이오사이언스 코포레이션 | Glp1 수용체에 대한 변이체 핵산 라이브러리 |
| CN113785057A (zh) | 2019-02-26 | 2021-12-10 | 特韦斯特生物科学公司 | 用于抗体优化的变异核酸文库 |
| GB201905303D0 (en) | 2019-04-15 | 2019-05-29 | Thermo Fisher Scient Geneart Gmbh | Multiplex assembly of nucleic acid molecules |
| EP4403648B1 (en) | 2019-05-03 | 2025-08-20 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| US11644406B2 (en) | 2019-06-11 | 2023-05-09 | Pacific Biosciences Of California, Inc. | Calibrated focus sensing |
| JP2022550497A (ja) | 2019-06-21 | 2022-12-02 | ツイスト バイオサイエンス コーポレーション | バーコードに基づいた核酸配列アセンブリ |
| US10656368B1 (en) | 2019-07-24 | 2020-05-19 | Omniome, Inc. | Method and system for biological imaging using a wide field objective lens |
| KR20220062302A (ko) | 2019-08-21 | 2022-05-16 | 라이프 테크놀로지스 코포레이션 | 시퀀싱을 위한 시스템 및 방법 |
| TW202124406A (zh) | 2019-09-10 | 2021-07-01 | 美商歐姆尼歐美公司 | 核苷酸之可逆修飾 |
| AU2020355027A1 (en) | 2019-09-23 | 2022-04-21 | Twist Bioscience Corporation | Antibodies that bind CD3 Epsilon |
| CA3155629A1 (en) | 2019-09-23 | 2021-04-01 | Twist Bioscience Corporation | Variant nucleic acid libraries for crth2 |
| US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| CN113275053A (zh) | 2020-02-03 | 2021-08-20 | 帝肯基因组学公司 | 试剂存储系统 |
| US20230054204A1 (en) | 2020-02-04 | 2023-02-23 | Pacific Biosciences Of California, Inc. | Flow cells and methods for their manufacture and use |
| US20220049303A1 (en) | 2020-08-17 | 2022-02-17 | Readcoor, Llc | Methods and systems for spatial mapping of genetic variants |
| US20220170093A1 (en) | 2020-11-16 | 2022-06-02 | Life Technologies Corporation | System and method for sequencing |
| MX2023007842A (es) | 2021-01-08 | 2023-09-19 | Cellanome Inc | Dispositivos y metodos para analizar muestras biologicas. |
| US11859241B2 (en) | 2021-06-17 | 2024-01-02 | Element Biosciences, Inc. | Compositions and methods for pairwise sequencing |
| US11236388B1 (en) | 2021-06-17 | 2022-02-01 | Element Biosciences, Inc. | Compositions and methods for pairwise sequencing |
| GB202215624D0 (en) | 2022-10-21 | 2022-12-07 | Dnae Diagnostics Ltd | Clonal amplification |
Family Cites Families (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1009396A (en) | 1911-06-03 | 1911-11-21 | Arthur E Fahrman | Perforating-machine. |
| US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| US5223414A (en) | 1990-05-07 | 1993-06-29 | Sri International | Process for nucleic acid hybridization and amplification |
| US5426180A (en) | 1991-03-27 | 1995-06-20 | Research Corporation Technologies, Inc. | Methods of making single-stranded circular oligonucleotides |
| WO1994003624A1 (en) | 1992-08-04 | 1994-02-17 | Auerbach Jeffrey I | Methods for the isothermal amplification of nucleic acid molecules |
| RU2048522C1 (ru) | 1992-10-14 | 1995-11-20 | Институт белка РАН | Способ размножения нуклеиновых кислот, способ их экспрессии и среда для их осуществления |
| US6001568A (en) | 1992-10-26 | 1999-12-14 | Institut Belka | Solid medium for amplification and expression of nucleic acids as colonies |
| US5593826A (en) | 1993-03-22 | 1997-01-14 | Perkin-Elmer Corporation, Applied Biosystems, Inc. | Enzymatic ligation of 3'amino-substituted oligonucleotides |
| AU684279B2 (en) | 1993-04-12 | 1997-12-11 | Northwestern University | Method of forming oligonucleotides |
| SE9400522D0 (sv) | 1994-02-16 | 1994-02-16 | Ulf Landegren | Method and reagent for detecting specific nucleotide sequences |
| AT402203B (de) | 1995-06-13 | 1997-03-25 | Himmler Gottfried Dipl Ing Dr | Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren |
| US5773258A (en) * | 1995-08-25 | 1998-06-30 | Roche Molecular Systems, Inc. | Nucleic acid amplification using a reversibly inactivated thermostable enzyme |
| US5670325A (en) | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
| EP2368897B1 (en) | 1996-02-09 | 2016-10-19 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US5928870A (en) | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| WO1998008975A1 (en) | 1996-08-29 | 1998-03-05 | Daikin Industries, Ltd. | Methods for targeting, enriching, detecting and/or isolating target nucleic acid sequence using reca-like recombinase |
| US5948653A (en) | 1997-03-21 | 1999-09-07 | Pati; Sushma | Sequence alterations using homologous recombination |
| ATE364718T1 (de) | 1997-04-01 | 2007-07-15 | Solexa Ltd | Verfahren zur vervielfältigung von nukleinsäure |
| WO1999019341A1 (en) | 1997-10-10 | 1999-04-22 | President & Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
| US6511803B1 (en) * | 1997-10-10 | 2003-01-28 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
| US6306590B1 (en) | 1998-06-08 | 2001-10-23 | Caliper Technologies Corp. | Microfluidic matrix localization apparatus and methods |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| GB9902970D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Novel matrix |
| US6531302B1 (en) * | 1999-04-12 | 2003-03-11 | Nanogen/Becton Dickinson Partnership | Anchored strand displacement amplification on an electronically addressable microchip |
| AUPQ008799A0 (en) * | 1999-04-30 | 1999-05-27 | Tillett, Daniel | Genome sequencing |
| US6300070B1 (en) * | 1999-06-04 | 2001-10-09 | Mosaic Technologies, Inc. | Solid phase methods for amplifying multiple nucleic acids |
| US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
| US6413792B1 (en) | 2000-04-24 | 2002-07-02 | Eagle Research Development, Llc | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
| EP1313880A2 (en) | 2000-05-30 | 2003-05-28 | PE Corporation (NY) | Methods for detecting target nucleic acids using coupled ligation and amplification |
| AR031640A1 (es) * | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
| WO2002072772A2 (en) * | 2001-03-09 | 2002-09-19 | Nugen Technologies, Inc. | Methods and compositions for amplification of rna sequences |
| DE60226856D1 (de) | 2001-04-20 | 2008-07-10 | Penn State Res Found | Verfahren zur manipulation von nukleinsäuren |
| AU2002258997A1 (en) | 2001-04-24 | 2002-11-05 | Li-Cor, Inc. | Polymerases with charge-switch activity and methods of generating such polymerases |
| US20040161741A1 (en) * | 2001-06-30 | 2004-08-19 | Elazar Rabani | Novel compositions and processes for analyte detection, quantification and amplification |
| AU2003215391B2 (en) | 2002-02-21 | 2007-05-24 | Abbott Diagnostics Scarborough, Inc. | Recombinase Polymerase Amplification |
| US8030000B2 (en) | 2002-02-21 | 2011-10-04 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| US7399590B2 (en) | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US20050118616A1 (en) * | 2002-08-16 | 2005-06-02 | Kawashima Tadashi R. | Amplification of target nucleotide sequence without polymerase chain reaction |
| JP2006500959A (ja) | 2002-09-30 | 2006-01-12 | パラレル バイオサイエンス, インコーポレイテッド | 動的サンプリング結合によるポリヌクレオチド合成および標識化 |
| US7255994B2 (en) | 2003-06-10 | 2007-08-14 | Applera Corporation | Ligation assay |
| EP1664265A4 (en) | 2003-07-21 | 2009-11-25 | Seng Entpr Ltd | IMPROVED MULTIPLAY PLATE |
| US7432055B2 (en) | 2004-03-05 | 2008-10-07 | Uchicago Argonne Llc | Dual phase multiplex polymerase chain reaction |
| JP5026958B2 (ja) | 2004-06-01 | 2012-09-19 | アリーア サン ディエゴ, インコーポレイテッド | リコンビナーゼポリメラーゼ増幅 |
| CN101189345A (zh) | 2005-02-01 | 2008-05-28 | Ab先进基因分析公司 | 珠基测序的试剂、方法和文库 |
| WO2006099579A2 (en) * | 2005-03-16 | 2006-09-21 | Applera Corporation | Compositions and methods for clonal amplification and analysis of polynucleotides |
| US7604940B1 (en) | 2005-03-16 | 2009-10-20 | Applied Biosystems, Llc | Compositions and methods for analyzing isolated polynucleotides |
| GB0514910D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Method for sequencing a polynucleotide template |
| GB0514936D0 (en) * | 2005-07-20 | 2005-08-24 | Solexa Ltd | Preparation of templates for nucleic acid sequencing |
| CA2616241C (en) | 2005-07-25 | 2012-02-07 | Asm Scientific, Inc. | Methods for multiplexing recombinase polymerase amplification |
| JP2009506788A (ja) * | 2005-09-06 | 2009-02-19 | ジェン−プローブ・インコーポレーテッド | 核酸の等温増幅のための方法、組成物及びキット |
| CA2641851A1 (en) | 2006-02-08 | 2007-08-16 | Eric Hans Vermaas | Method for sequencing a polynucleotide template |
| EP2021503A1 (en) * | 2006-03-17 | 2009-02-11 | Solexa Ltd. | Isothermal methods for creating clonal single molecule arrays |
| US7282337B1 (en) | 2006-04-14 | 2007-10-16 | Helicos Biosciences Corporation | Methods for increasing accuracy of nucleic acid sequencing |
| AU2007237909A1 (en) | 2006-04-19 | 2007-10-25 | Applied Biosystems, Llc. | Reagents, methods, and libraries for gel-free bead-based sequencing |
| CA2650993C (en) | 2006-05-04 | 2015-06-16 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| WO2008015396A2 (en) | 2006-07-31 | 2008-02-07 | Solexa Limited | Method of library preparation avoiding the formation of adaptor dimers |
| US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
| US20080118917A1 (en) | 2006-11-21 | 2008-05-22 | Applera Corporation | Isothermal SNP Detection Method |
| US8262900B2 (en) * | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| AU2007334393A1 (en) | 2006-12-14 | 2008-06-26 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| US7932034B2 (en) | 2006-12-20 | 2011-04-26 | The Board Of Trustees Of The Leland Stanford Junior University | Heat and pH measurement for sequencing of DNA |
| CN101743319B (zh) | 2007-03-02 | 2013-03-06 | Dna电子有限公司 | 使用固态pH传感器的qPCR |
| WO2008109176A2 (en) | 2007-03-07 | 2008-09-12 | President And Fellows Of Harvard College | Assays and other reactions involving droplets |
| EP2191011B1 (en) | 2007-08-29 | 2017-03-29 | Illumina Cambridge Limited | Method for sequencing a polynucleotide template |
| AU2008307617B2 (en) | 2007-09-28 | 2013-05-23 | Pacific Biosciences Of California, Inc. | Error-free amplification of DNA for clonal sequencing |
| US20090286286A1 (en) | 2007-11-06 | 2009-11-19 | Ambergen , Inc. | Methods for controlling amplification |
| US20090171078A1 (en) | 2007-11-20 | 2009-07-02 | Applied Biosystems Inc. | Method of sequencing nucleic acids using elaborated nucleotide phosphorotiolate compounds |
| EP2242855A1 (en) | 2008-02-05 | 2010-10-27 | Roche Diagnostics GmbH | Paired end sequencing |
| US8034568B2 (en) * | 2008-02-12 | 2011-10-11 | Nugen Technologies, Inc. | Isothermal nucleic acid amplification methods and compositions |
| EP2247727A4 (en) * | 2008-02-12 | 2011-08-03 | Nugen Technologies Inc | PROCESS FOR ARCHIVING AND CLONING EXPANSION |
| GB0810573D0 (en) | 2008-06-10 | 2008-07-16 | Univ Westminster | Anti-bacterial ligase inhibitors |
| CN102119225B (zh) * | 2008-06-11 | 2015-04-08 | 基因排列技术有限公司 | 等温核酸扩增 |
| US8198028B2 (en) | 2008-07-02 | 2012-06-12 | Illumina Cambridge Limited | Using populations of beads for the fabrication of arrays on surfaces |
| US8530156B2 (en) * | 2008-08-08 | 2013-09-10 | President And Fellows Of Harvard College | Chemically cleavable phosphoramidite linkers for sequencing by ligation |
| CN101413034B (zh) | 2008-11-21 | 2011-02-09 | 东南大学 | 高通量核酸分子克隆制备分子克隆芯片的方法 |
| EP2607496B1 (en) | 2008-12-23 | 2014-07-16 | Illumina, Inc. | Methods useful in nucleic acid sequencing protocols |
| US9447461B2 (en) | 2009-03-24 | 2016-09-20 | California Institute Of Technology | Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes |
| US20100261185A1 (en) * | 2009-03-27 | 2010-10-14 | Life Technologies Corporation | Labeled enzyme compositions, methods and systems |
| US9309557B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Nucleic acid amplification |
| US9309566B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Methods, compositions, systems, apparatuses and kits for nucleic acid amplification |
| US9334531B2 (en) | 2010-12-17 | 2016-05-10 | Life Technologies Corporation | Nucleic acid amplification |
| EP2435461B1 (en) | 2009-05-29 | 2017-08-09 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
| US8574835B2 (en) | 2009-05-29 | 2013-11-05 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
| EP2438196B1 (en) | 2009-06-05 | 2016-12-21 | Alere San Diego, Inc. | Recombinase polymerase amplification reagents and kits |
| US8574864B2 (en) * | 2009-11-05 | 2013-11-05 | Epicentre Technologies Corporation | Methods and kits for 3'-end-tagging of RNA |
| US8759037B2 (en) | 2010-02-23 | 2014-06-24 | Illumina Cambridge Limited | Amplification methods to minimise sequence specific bias |
| US20110257385A1 (en) | 2010-02-23 | 2011-10-20 | Life Technologies Corporation | Methods for flip-strand immobilizing and sequencing nucleic acids |
| AU2011220536B2 (en) | 2010-02-26 | 2012-05-24 | Life Technologies Corporation | Modified proteins and methods of making and using same |
| US9029103B2 (en) | 2010-08-27 | 2015-05-12 | Illumina Cambridge Limited | Methods for sequencing polynucleotides |
| EP2426214A1 (en) | 2010-09-01 | 2012-03-07 | Koninklijke Philips Electronics N.V. | Method for amplifying nucleic acids |
| US9618475B2 (en) | 2010-09-15 | 2017-04-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
| CN110079588B (zh) | 2010-12-17 | 2024-03-15 | 生命技术公司 | 用于核酸扩增的方法、组合物、系统、仪器和试剂盒 |
| WO2012099832A2 (en) | 2011-01-17 | 2012-07-26 | Life Technologies Corporation | Enzymatic ligation of nucleic acids |
| WO2012106072A2 (en) | 2011-02-03 | 2012-08-09 | Illumina, Inc. | Methods for minimizing sequence specific bias |
| JP5961247B2 (ja) | 2011-04-07 | 2016-08-02 | アリーア サン ディエゴ, インコーポレイテッド | リコンビナーゼポリメラーゼ増幅混合物のモニタリング |
| US9139874B2 (en) | 2011-07-07 | 2015-09-22 | Life Technologies Corporation | Bi-directional sequencing compositions and methods |
| DE102011054101A1 (de) | 2011-09-30 | 2013-04-04 | Albert-Ludwigs-Universität Freiburg | Verfahren zur räumlichen Anordnung von Probenfragmenten zur Amplifikation und Immobilisierung für weitere Derivatisierungen |
| SG11201406717RA (en) | 2012-04-19 | 2014-11-27 | Life Technologies Corp | Nucleic acid amplification |
| EP3461910B1 (en) | 2012-04-19 | 2020-08-26 | Life Technologies Corporation | Nucleic acid amplification |
| US8895249B2 (en) | 2012-06-15 | 2014-11-25 | Illumina, Inc. | Kinetic exclusion amplification of nucleic acid libraries |
| WO2014031163A1 (en) | 2012-08-24 | 2014-02-27 | Life Technologies Corporation | Methods, compositions, systems, apparatuses and kits for nucleic acid paired end sequencing |
| WO2014043143A1 (en) | 2012-09-11 | 2014-03-20 | Life Technologies Corporation | Nucleic acid amplification |
| EP2895620B1 (en) | 2012-09-11 | 2017-08-02 | Life Technologies Corporation | Nucleic acid amplification |
| CN110066853B (zh) | 2013-03-14 | 2023-03-28 | 生命技术公司 | 基质阵列和其制备方法 |
-
2011
- 2011-12-16 CN CN201910119594.0A patent/CN110079588B/zh active Active
- 2011-12-16 EP EP11808489.6A patent/EP2652148B1/en active Active
- 2011-12-16 EP EP16196078.6A patent/EP3147374B1/en active Active
- 2011-12-16 WO PCT/US2011/065535 patent/WO2012083189A2/en not_active Ceased
- 2011-12-16 EP EP19154117.6A patent/EP3564392B1/en active Active
- 2011-12-16 CN CN202410224895.0A patent/CN118086471A/zh active Pending
- 2011-12-16 JP JP2013544833A patent/JP5907990B2/ja active Active
- 2011-12-16 CN CN201180067596.1A patent/CN103370425B/zh active Active
- 2011-12-16 US US13/328,844 patent/US20120156728A1/en not_active Abandoned
-
2012
- 2012-11-28 US US14/360,892 patent/US9315861B2/en active Active
-
2015
- 2015-04-21 US US14/692,706 patent/US9476080B2/en active Active
-
2016
- 2016-03-15 US US15/071,086 patent/US9765388B2/en active Active
- 2016-09-26 US US15/276,713 patent/US10233488B2/en active Active
-
2017
- 2017-09-05 US US15/695,244 patent/US10093969B2/en active Active
-
2018
- 2018-10-08 US US16/154,529 patent/US10597705B2/en active Active
-
2019
- 2019-03-12 US US16/351,194 patent/US10913976B2/en active Active
-
2020
- 2020-10-13 US US16/949,083 patent/US11578360B2/en active Active
-
2023
- 2023-02-01 US US18/104,548 patent/US12351865B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5907990B2 (ja) | 核酸増幅のための方法、組成物、システム、装置およびキット | |
| CN104781418B (zh) | 用于核酸配对末端测序的方法、组合物、系统、仪器和试剂盒 | |
| US9309566B2 (en) | Methods, compositions, systems, apparatuses and kits for nucleic acid amplification | |
| CN111094584B (zh) | 用于改进编索引的核酸文库中的样品鉴定的组合物和方法 | |
| WO2017214561A1 (en) | Methods and compositions for nucleic acid amplification | |
| JP2022546485A (ja) | 腫瘍高精度アッセイのための組成物および方法 | |
| US20100151473A1 (en) | Methods and compositions for hybridizing nucleic acids | |
| HK40049316A (en) | Compositions and methods for improving sample identification in indexed nucleic acid libraries | |
| HK40049316B (en) | Compositions and methods for improving sample identification in indexed nucleic acid libraries | |
| HK40015459A (en) | Compositions and methods for improving sample identification in indexed nucleic acid libraries | |
| HK40015459B (en) | Compositions and methods for improving sample identification in indexed nucleic acid libraries | |
| HK1245843A1 (en) | Dna sequencing using controlled strand displacement | |
| HK1245843B (en) | Dna sequencing using controlled strand displacement |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131111 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140605 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140919 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20140919 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20150324 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150928 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20151228 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160126 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160222 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160322 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5907990 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |