JP5896175B2 - トランスサイレチン発現の調節 - Google Patents

トランスサイレチン発現の調節 Download PDF

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JP5896175B2
JP5896175B2 JP2013508296A JP2013508296A JP5896175B2 JP 5896175 B2 JP5896175 B2 JP 5896175B2 JP 2013508296 A JP2013508296 A JP 2013508296A JP 2013508296 A JP2013508296 A JP 2013508296A JP 5896175 B2 JP5896175 B2 JP 5896175B2
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certain embodiments
seq
compound
transthyretin
antisense
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Japanese (ja)
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JP2013526860A (ja
JP2013526860A5 (https=
Inventor
モニア，ブレット・ピー
フレアー，スーザン・エム
シウコウスキー，アンドリュー・エム
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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JP2013508296A 2010-04-29 2011-04-29 トランスサイレチン発現の調節 Active JP5896175B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32953810P 2010-04-29 2010-04-29
US61/329,538 2010-04-29
US40516310P 2010-10-20 2010-10-20
US61/405,163 2010-10-20
PCT/US2011/034661 WO2011139917A1 (en) 2010-04-29 2011-04-29 Modulation of transthyretin expression

Publications (3)

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JP2013526860A JP2013526860A (ja) 2013-06-27
JP2013526860A5 JP2013526860A5 (https=) 2014-06-19
JP5896175B2 true JP5896175B2 (ja) 2016-03-30

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US (9) US20110294868A1 (https=)
EP (1) EP2563920B1 (https=)
JP (1) JP5896175B2 (https=)
KR (2) KR20180026798A (https=)
CN (1) CN103038345B (https=)
BR (1) BR112012027547B1 (https=)
CA (2) CA2994063A1 (https=)
CY (2) CY1119070T1 (https=)
DK (1) DK2563920T3 (https=)
ES (1) ES2625689T3 (https=)
HR (1) HRP20170737T1 (https=)
HU (2) HUE031909T2 (https=)
IL (1) IL222697A (https=)
LT (2) LT2563920T (https=)
LU (1) LUC00096I2 (https=)
MX (1) MX343559B (https=)
NL (1) NL300963I2 (https=)
NO (1) NO2019001I1 (https=)
NZ (1) NZ603339A (https=)
PL (1) PL2563920T3 (https=)
PT (1) PT2563920T (https=)
RS (1) RS56011B1 (https=)
RU (1) RU2592669C2 (https=)
SI (1) SI2563920T1 (https=)
SM (1) SMT201700209T1 (https=)
WO (1) WO2011139917A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
WO2019071206A1 (en) 2017-10-06 2019-04-11 Prothena Biosciences Limited METHODS OF DETECTING TRANSTHYRETIN

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EA036772B1 (ru) 2008-10-20 2020-12-18 Элнилэм Фармасьютикалз, Инк. Композиции и способы для ингибирования экспрессии транстиретина
US9101643B2 (en) 2009-11-03 2015-08-11 Alnylam Pharmaceuticals, Inc. Lipid formulated compositions and methods for inhibiting expression of transthyretin (TTR)
RS56011B1 (sr) * 2010-04-29 2017-09-29 Ionis Pharmaceuticals Inc Modulacija ekspresije transtiretina
HK1200484A1 (zh) 2011-09-14 2015-08-07 Translate Bio Ma, Inc. 多聚寡核苷酸化合物
HUE048622T2 (hu) * 2011-11-18 2020-08-28 Alnylam Pharmaceuticals Inc RNSi szerek, készítmények és alkalmazási eljárások transztiretin (TTR) asszociált betegségek kezelésére
AU2013262709A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating MECP2 expression
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
US9574193B2 (en) 2012-05-17 2017-02-21 Ionis Pharmaceuticals, Inc. Methods and compositions for modulating apolipoprotein (a) expression
US20160002624A1 (en) * 2012-05-17 2016-01-07 Isis Pharmaceuticals, Inc. Antisense oligonucleotide compositions
EP2895200B1 (en) 2012-09-14 2019-11-06 Translate Bio MA, Inc. Multimeric oligonucleotide compounds
US10077443B2 (en) 2012-11-15 2018-09-18 Roche Innovation Center Copenhagen A/S Oligonucleotide conjugates
CN104955952A (zh) 2013-01-30 2015-09-30 弗·哈夫曼-拉罗切有限公司 Lna寡核苷酸碳水化合物缀合物
DK2991656T3 (da) 2013-05-01 2020-03-23 Ionis Pharmaceuticals Inc Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression
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