JP5868593B2 - Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体 - Google Patents

Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体 Download PDF

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JP5868593B2
JP5868593B2 JP2010517161A JP2010517161A JP5868593B2 JP 5868593 B2 JP5868593 B2 JP 5868593B2 JP 2010517161 A JP2010517161 A JP 2010517161A JP 2010517161 A JP2010517161 A JP 2010517161A JP 5868593 B2 JP5868593 B2 JP 5868593B2
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antibody
seq
variable region
chain variable
antigen
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JP2010533498A5 (https=
JP2010533498A (ja
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ジョナサン・アレクサンダー・ターレット
リ−シェン・ル
ハイチュン・フアン
ダペン・ヤオ
チン・パン
ヘイディ・ルブラン
ティモシー・スプロール
マーク・ヤマナカ
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ER Squibb and Sons LLC
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Medarex LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2010517161A 2007-07-17 2008-07-17 Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体 Expired - Fee Related JP5868593B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95984507P 2007-07-17 2007-07-17
US60/959,845 2007-07-17
PCT/US2008/070344 WO2009012394A1 (en) 2007-07-17 2008-07-17 Monoclonal antibodies against glypican-3

Related Child Applications (1)

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JP2014137921A Division JP2014236734A (ja) 2007-07-17 2014-07-03 Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体

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JP2010533498A JP2010533498A (ja) 2010-10-28
JP2010533498A5 JP2010533498A5 (https=) 2011-07-21
JP5868593B2 true JP5868593B2 (ja) 2016-02-24

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JP2014137921A Pending JP2014236734A (ja) 2007-07-17 2014-07-03 Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体

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US (2) US8680247B2 (https=)
EP (1) EP2178921B1 (https=)
JP (2) JP5868593B2 (https=)
KR (2) KR101570252B1 (https=)
CN (1) CN101815726B (https=)
AU (1) AU2008275985B2 (https=)
CY (1) CY1117236T1 (https=)
DK (1) DK2178921T3 (https=)
ES (1) ES2562790T3 (https=)
HR (1) HRP20160270T1 (https=)
HU (1) HUE028737T2 (https=)
ME (1) ME02345B (https=)
MX (1) MX2010000537A (https=)
PL (1) PL2178921T3 (https=)
PT (1) PT2178921E (https=)
RS (1) RS54624B1 (https=)
SI (1) SI2178921T1 (https=)
WO (1) WO2009012394A1 (https=)

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EP2178921A1 (en) 2010-04-28
HUE028737T2 (en) 2017-01-30
AU2008275985A1 (en) 2009-01-22
RS54624B1 (sr) 2016-08-31
WO2009012394A1 (en) 2009-01-22
US9217033B2 (en) 2015-12-22
JP2014236734A (ja) 2014-12-18
US8680247B2 (en) 2014-03-25
KR101570252B1 (ko) 2015-11-19
ME02345B (me) 2016-08-31
HRP20160270T1 (hr) 2016-05-06
DK2178921T3 (en) 2016-04-04
CY1117236T1 (el) 2017-04-05
KR20100056467A (ko) 2010-05-27
KR20150038732A (ko) 2015-04-08
AU2008275985B2 (en) 2013-09-19
CN101815726A (zh) 2010-08-25
PL2178921T3 (pl) 2016-06-30
EP2178921B1 (en) 2016-01-06
PT2178921E (pt) 2016-03-23
CN101815726B (zh) 2013-04-03
US20140186892A1 (en) 2014-07-03
MX2010000537A (es) 2010-03-25
KR101527342B1 (ko) 2015-06-09
JP2010533498A (ja) 2010-10-28
SI2178921T1 (sl) 2016-05-31
US20100209432A1 (en) 2010-08-19
ES2562790T3 (es) 2016-03-08

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