JP5851022B2 - アルツハイマー病を処置するための組成物および方法 - Google Patents

アルツハイマー病を処置するための組成物および方法 Download PDF

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JP5851022B2
JP5851022B2 JP2014510427A JP2014510427A JP5851022B2 JP 5851022 B2 JP5851022 B2 JP 5851022B2 JP 2014510427 A JP2014510427 A JP 2014510427A JP 2014510427 A JP2014510427 A JP 2014510427A JP 5851022 B2 JP5851022 B2 JP 5851022B2
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inhibitor
patient
disease
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alzheimer
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JP2014513694A5 (enExample
JP2014513694A (ja
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ジョン ジャハンガー アラム，
ジョン ジャハンガー アラム，
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イーアイピー ファーマ， エルエルシー
イーアイピー ファーマ， エルエルシー
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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JP2014510427A 2011-05-09 2012-05-09 アルツハイマー病を処置するための組成物および方法 Expired - Fee Related JP5851022B2 (ja)

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PCT/US2012/037064 WO2012154814A1 (en) 2011-05-09 2012-05-09 Compositions and methods for treating alzheimer's disease

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JP2015186148A Active JP6114355B2 (ja) 2011-05-09 2015-09-22 アルツハイマー病を処置するための組成物および方法
JP2017019250A Withdrawn JP2017075191A (ja) 2011-05-09 2017-02-06 アルツハイマー病を処置するための組成物および方法

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US (3) US8697627B2 (enExample)
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CN (1) CN103842362B (enExample)
AU (1) AU2012253615B2 (enExample)
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DK (1) DK3081568T3 (enExample)
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EP2651405A2 (en) 2010-12-14 2013-10-23 Electrophoretics Limited Casein kinase 1 (ck1 ) inhibitors
CA2835707C (en) 2011-05-09 2019-02-26 Eip Pharma, Llc Compositions and methods for treating alzheimer's disease
US20150104870A1 (en) * 2012-04-27 2015-04-16 Keio University Neuronal differentiation promoter
EP2968322B1 (en) 2013-03-15 2018-12-26 The Trustees of Columbia University in the City of New York Map kinase modulators and uses thereof
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