CN103842362B - 用于治疗阿尔茨海默氏病的组合物和方法 - Google Patents
用于治疗阿尔茨海默氏病的组合物和方法 Download PDFInfo
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- CN103842362B CN103842362B CN201280034096.2A CN201280034096A CN103842362B CN 103842362 B CN103842362 B CN 103842362B CN 201280034096 A CN201280034096 A CN 201280034096A CN 103842362 B CN103842362 B CN 103842362B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D513/04—Ortho-condensed systems
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161483919P | 2011-05-09 | 2011-05-09 | |
| US61/483,919 | 2011-05-09 | ||
| PCT/US2012/037064 WO2012154814A1 (en) | 2011-05-09 | 2012-05-09 | Compositions and methods for treating alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103842362A CN103842362A (zh) | 2014-06-04 |
| CN103842362B true CN103842362B (zh) | 2017-05-24 |
Family
ID=47139618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280034096.2A Active CN103842362B (zh) | 2011-05-09 | 2012-05-09 | 用于治疗阿尔茨海默氏病的组合物和方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8697627B2 (enExample) |
| EP (2) | EP2707369B1 (enExample) |
| JP (3) | JP5851022B2 (enExample) |
| CN (1) | CN103842362B (enExample) |
| AU (1) | AU2012253615B2 (enExample) |
| CA (1) | CA2835707C (enExample) |
| DK (1) | DK3081568T3 (enExample) |
| ES (1) | ES2773480T3 (enExample) |
| WO (1) | WO2012154814A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011343039B2 (en) | 2010-12-14 | 2017-03-02 | Electrophoretics Limited | Casein kinase 1delta (CK1delta) inhibitors |
| JP5851022B2 (ja) | 2011-05-09 | 2016-02-03 | イーアイピー ファーマ, エルエルシー | アルツハイマー病を処置するための組成物および方法 |
| WO2013162027A1 (ja) * | 2012-04-27 | 2013-10-31 | 学校法人 慶應義塾 | 神経分化促進剤 |
| EP3842424B1 (en) | 2013-03-15 | 2024-12-11 | The Trustees of Columbia University in the City of New York | Map kinase modulators and uses thereof in the tretament of tauopathies |
| GB201319620D0 (en) * | 2013-11-06 | 2013-12-18 | Norwegian University Of Science And Technology | Immunosuppressive agents and their use in therapy |
| JP6163084B2 (ja) * | 2013-11-11 | 2017-07-12 | キリン株式会社 | 認知症の予防、治療及び/又は認知機能を改善する組成物、及びこれを用いた医薬、食品 |
| CN114010641A (zh) * | 2014-07-09 | 2022-02-08 | 爱普制药有限责任公司 | 用于治疗神经病症的方法 |
| CN106536521B (zh) | 2014-07-22 | 2018-08-03 | 葛兰素史密斯克莱知识产权发展有限公司 | 化合物 |
| JP2016193870A (ja) * | 2015-04-01 | 2016-11-17 | 国立大学法人広島大学 | 慢性骨髄性白血病治療剤 |
| EP3325992A4 (en) | 2015-07-24 | 2019-03-27 | Northeastern University | QUANTITATIVE MAGNETIC RESONANCE IMAGING VASCULATURE |
| WO2017185073A1 (en) * | 2016-04-21 | 2017-10-26 | Eip Pharma, Llc | Compositions and methods for treating dementia |
| IL294407B2 (en) * | 2016-06-03 | 2025-01-01 | Univ Columbia | Phosphodiesterase 4 inhibitor for use in the treatment of diseases associated with low levels and/or activity of PC1 |
| GB201611712D0 (en) | 2016-07-02 | 2016-08-17 | Hvivo Services Ltd | Methods and compounds for the treatment or prevention of severe or persistent influenza |
| WO2019056003A1 (en) | 2017-09-18 | 2019-03-21 | Eip Pharma, Llc | CO-CRYSTALS FROM NEFLAMAPIMOD (VX -745) |
| KR20200078513A (ko) * | 2017-10-03 | 2020-07-01 | 프리베일 테라퓨틱스, 인크. | 리소좀 장애를 위한 유전자 요법 |
| MX2020003965A (es) | 2017-10-03 | 2020-10-05 | Prevail Therapeutics Inc | Terapias genicas para los trastornos lisosomales. |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| CN114748622B (zh) | 2017-10-05 | 2024-09-24 | 弗尔康医疗公司 | P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd |
| GB201721793D0 (en) | 2017-12-22 | 2018-02-07 | Hvivo Services Ltd | Methods and compunds for the treatment or prevention of hypercytokinemia and severe influenza |
| CN111789949A (zh) * | 2019-04-08 | 2020-10-20 | 北京昱嘉科技集团有限公司 | 基于特异性趋化因子受体的阿尔兹海默病治疗靶点 |
| AU2020270984B2 (en) | 2019-04-10 | 2025-11-20 | Prevail Therapeutics, Inc. | Gene therapies for lysosomal disorders |
| WO2021216754A1 (en) * | 2020-04-21 | 2021-10-28 | Spring Discovery, Inc. | Use of p38 mapk inhibitors for prevention and treatment of aging and aging-related disorders and for boosting an immune system |
| WO2023282900A1 (en) * | 2021-07-08 | 2023-01-12 | Morehouse School Of Medicine | Method and system of diagnosing and treating neurodegenerative disease and seizures |
| US20230010690A1 (en) * | 2021-07-08 | 2023-01-12 | Morehouse School Of Medicine | Method and system of diagnosing and treating neurodegenerative disease and seizures |
| WO2023004054A1 (en) * | 2021-07-23 | 2023-01-26 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for the treatment of alzheimer's disease |
| EP4342394A1 (de) | 2022-09-23 | 2024-03-27 | MTS Medical UG | Vorrichtung und system zur behandlung von alzheimererkrankungen |
| CN115887641B (zh) * | 2022-11-23 | 2024-06-21 | 四川大学华西医院 | 他米巴罗汀在制备免疫佐剂中的应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244867A (zh) * | 1996-12-18 | 2000-02-16 | 沃泰克斯药物股份有限公司 | 作为p38蛋白激酶抑制剂的取代的含氮杂环 |
| US20050203111A1 (en) * | 2004-03-12 | 2005-09-15 | Vvii Newco 2003, Inc. | Compositions and methods for preventing and treating skin and hair conditions |
| WO2008002465A2 (en) * | 2006-06-23 | 2008-01-03 | The Feinstein Institute For Medical Research | INHIBITORS OF Aβ AND SYNUCLEIN AGGREGATION |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1740047A2 (en) | 2004-03-11 | 2007-01-10 | Kythera Biopharmaceuticals, Inc. | Compositions and methods for preventing and treating skin and hair conditions |
| JP5851022B2 (ja) | 2011-05-09 | 2016-02-03 | イーアイピー ファーマ, エルエルシー | アルツハイマー病を処置するための組成物および方法 |
-
2012
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- 2015-09-15 US US14/855,338 patent/US9427438B2/en active Active
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- 2017-02-06 JP JP2017019250A patent/JP2017075191A/ja not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244867A (zh) * | 1996-12-18 | 2000-02-16 | 沃泰克斯药物股份有限公司 | 作为p38蛋白激酶抑制剂的取代的含氮杂环 |
| US20050203111A1 (en) * | 2004-03-12 | 2005-09-15 | Vvii Newco 2003, Inc. | Compositions and methods for preventing and treating skin and hair conditions |
| WO2008002465A2 (en) * | 2006-06-23 | 2008-01-03 | The Feinstein Institute For Medical Research | INHIBITORS OF Aβ AND SYNUCLEIN AGGREGATION |
Non-Patent Citations (3)
| Title |
|---|
| Molecular Mechanisms of Amyloidosis;Giampaolo Merlini, M.D.,等;《The new england journal of medicine》;20030807;第349卷(第6期);第583-596页 * |
| Natural History and Outcome in Systemic AA Amyloidosis;Helen J. Lachmann,等;《The new england journal of medicine》;20070607;第356卷(第23期);第2361-2371页 * |
| The increased density of p38 mitogen-activated protein kinase-immunoreactive microglia in the sensorimotor cortex of aged TgCRND8 mice is associated predominantly with smaller dense-core amyloid plaques;J. Chlan-Fourney,等;《European Journal of Neuroscience》;20110216;第33卷;第1433-1444页 * |
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| WO2012154814A1 (en) | 2012-11-15 |
| EP2707369A1 (en) | 2014-03-19 |
| JP5851022B2 (ja) | 2016-02-03 |
| AU2012253615A1 (en) | 2013-12-12 |
| CA2835707C (en) | 2019-02-26 |
| EP3081568A1 (en) | 2016-10-19 |
| US20160030431A1 (en) | 2016-02-04 |
| EP3081568B1 (en) | 2019-11-13 |
| JP6114355B2 (ja) | 2017-04-12 |
| JP2017075191A (ja) | 2017-04-20 |
| ES2773480T3 (es) | 2020-07-13 |
| EP2707369A4 (en) | 2014-12-10 |
| DK3081568T3 (da) | 2020-02-24 |
| CN103842362A (zh) | 2014-06-04 |
| US8697627B2 (en) | 2014-04-15 |
| JP2015232042A (ja) | 2015-12-24 |
| US20140357638A1 (en) | 2014-12-04 |
| JP2014513694A (ja) | 2014-06-05 |
| CA2835707A1 (en) | 2012-11-15 |
| US20120289511A1 (en) | 2012-11-15 |
| US9427438B2 (en) | 2016-08-30 |
| EP2707369B1 (en) | 2016-07-27 |
| AU2012253615B2 (en) | 2017-03-02 |
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