JP5847087B2 - オレキシン受容体調節因子としての縮合複素環式化合物 - Google Patents

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Publication number

JP5847087B2

JP5847087B2 JP2012535385A JP2012535385A JP5847087B2 JP 5847087 B2 JP5847087 B2 JP 5847087B2 JP 2012535385 A JP2012535385 A JP 2012535385A JP 2012535385 A JP2012535385 A JP 2012535385A JP 5847087 B2 JP5847087 B2 JP 5847087B2

Authority

JP

Japan

Prior art keywords

phenyl

diazabicyclo

octane

triazol

fluoro

Prior art date

2009-10-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 108050000742 Orexin Receptor Proteins 0.000 title claims description 22
• 102000008834 Orexin receptor Human genes 0.000 title claims description 21
• 150000002391 heterocyclic compounds Chemical class 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 494
• -1 2H-1,2,3-triazol-2-yl Chemical group 0.000 claims description 489
• 150000003839 salts Chemical class 0.000 claims description 59
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 55
• 125000000217 alkyl group Chemical group 0.000 claims description 48
• 102000002512 Orexin Human genes 0.000 claims description 47
• 108060005714 orexin Proteins 0.000 claims description 46
• 238000000034 method Methods 0.000 claims description 43
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 33
• 125000001072 heteroaryl group Chemical group 0.000 claims description 32
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 31
• 125000003545 alkoxy group Chemical group 0.000 claims description 28
• 239000000126 substance Substances 0.000 claims description 21
• 125000005843 halogen group Chemical group 0.000 claims description 20
• 239000008194 pharmaceutical composition Substances 0.000 claims description 20
• 230000000694 effects Effects 0.000 claims description 19
• WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims description 18
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 17
• 208000035475 disorder Diseases 0.000 claims description 17
• 201000010099 disease Diseases 0.000 claims description 16
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 16
• 230000001404 mediated effect Effects 0.000 claims description 15
• 125000001309 chloro group Chemical group Cl* 0.000 claims description 12
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 12
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 12
• 125000003118 aryl group Chemical group 0.000 claims description 10
• 230000027455 binding Effects 0.000 claims description 10
• 125000001607 1,2,3-triazol-1-yl group Chemical group [*]N1N=NC([H])=C1[H] 0.000 claims description 9
• 125000001246 bromo group Chemical group Br* 0.000 claims description 9
• 208000024891 symptom Diseases 0.000 claims description 9
• KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims description 8
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
• NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 claims description 8
• 229910052760 oxygen Inorganic materials 0.000 claims description 8
• 239000001301 oxygen Substances 0.000 claims description 8
• 125000004262 quinoxalin-2-yl group Chemical group [H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1* 0.000 claims description 8
• HWBHNCKNXGKGOR-UHFFFAOYSA-N (2-phenylphenyl)-(7-quinoxalin-2-yl-4,7-diazabicyclo[4.2.0]octan-4-yl)methanone Chemical compound C1CC2CN(C=3N=C4C=CC=CC4=NC=3)C2CN1C(=O)C1=CC=CC=C1C1=CC=CC=C1 HWBHNCKNXGKGOR-UHFFFAOYSA-N 0.000 claims description 7
• 208000019116 sleep disease Diseases 0.000 claims description 7
• MKJZIZWXDYBQGT-UHFFFAOYSA-N 2-fluoro-6-(4-methylpyridin-2-yl)benzaldehyde Chemical compound FC1=CC=CC(=C1C=O)C1=NC=CC(=C1)C MKJZIZWXDYBQGT-UHFFFAOYSA-N 0.000 claims description 6
• WXFOIFCNLHJFKL-UHFFFAOYSA-N 3-fluoro-2-(4-methylpyridin-2-yl)benzaldehyde Chemical compound CC1=CC(=NC=C1)C2=C(C=CC=C2F)C=O WXFOIFCNLHJFKL-UHFFFAOYSA-N 0.000 claims description 6
• 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims description 6
• 206010033307 Overweight Diseases 0.000 claims description 6
• JPUWQDQOTJPGPA-UHFFFAOYSA-N [6-(4-phenylpyrimidin-2-yl)-3,6-diazabicyclo[3.2.0]heptan-3-yl]-(2-thiophen-2-ylphenyl)methanone Chemical compound C=1C=CC=C(C=2SC=CC=2)C=1C(=O)N(CC12)CC1CN2C(N=1)=NC=CC=1C1=CC=CC=C1 JPUWQDQOTJPGPA-UHFFFAOYSA-N 0.000 claims description 6
• 125000004498 isoxazol-4-yl group Chemical group O1N=CC(=C1)* 0.000 claims description 6
• 125000004430 oxygen atom Chemical group O* 0.000 claims description 6
• 229910052717 sulfur Inorganic materials 0.000 claims description 6
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 6
• 206010002383 Angina Pectoris Diseases 0.000 claims description 5
• 206010020772 Hypertension Diseases 0.000 claims description 5
• 208000008589 Obesity Diseases 0.000 claims description 5
• 208000001871 Tachycardia Diseases 0.000 claims description 5
• 235000020824 obesity Nutrition 0.000 claims description 5
• TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims description 5
• 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 5
• 230000006794 tachycardia Effects 0.000 claims description 5
• DICRKFALAXMPIZ-GUYCJALGSA-N (2-bromo-5-fluorophenyl)-[(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=C(F)C=2)Br)=N1 DICRKFALAXMPIZ-GUYCJALGSA-N 0.000 claims description 4
• FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical compound N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 claims description 4
• YESCPKTWTUCNTK-UHFFFAOYSA-N 2-fluoro-6-(triazol-2-yl)benzaldehyde Chemical compound FC1=C(C(=CC=C1)N1N=CC=N1)C=O YESCPKTWTUCNTK-UHFFFAOYSA-N 0.000 claims description 4
• AVUGWWNPIYMWFM-UHFFFAOYSA-N 3-(1,2-oxazol-5-yl)-1,2-oxazole Chemical compound O1N=CC=C1C1=NOC=C1 AVUGWWNPIYMWFM-UHFFFAOYSA-N 0.000 claims description 4
• USIFEQSDNJSTEZ-UHFFFAOYSA-N 3-fluoro-2-(1,3-oxazol-2-yl)benzaldehyde Chemical compound FC=1C(=C(C=CC=1)C=O)C=1OC=CN=1 USIFEQSDNJSTEZ-UHFFFAOYSA-N 0.000 claims description 4
• RWIQUTTXNIBMEB-UHFFFAOYSA-N 3-fluoro-2-(3-fluoropyridin-2-yl)benzaldehyde Chemical compound C1=CC(=C(C(=C1)F)C2=C(C=CC=N2)F)C=O RWIQUTTXNIBMEB-UHFFFAOYSA-N 0.000 claims description 4
• AQNUMUOUDSPGFZ-UHFFFAOYSA-N 3-fluoro-2-(6-methylpyridin-2-yl)benzaldehyde Chemical compound CC1=NC(=CC=C1)C2=C(C=CC=C2F)C=O AQNUMUOUDSPGFZ-UHFFFAOYSA-N 0.000 claims description 4
• QSYWKQLZNHTFCV-UHFFFAOYSA-N 3-fluoro-2-(triazol-2-yl)benzaldehyde Chemical compound FC1=CC=CC(C=O)=C1N1N=CC=N1 QSYWKQLZNHTFCV-UHFFFAOYSA-N 0.000 claims description 4
• DHWCSMLTMQOFTF-UHFFFAOYSA-N 3-fluoro-2-pyridin-2-ylbenzaldehyde Chemical compound C1=CC=NC(=C1)C2=C(C=CC=C2F)C=O DHWCSMLTMQOFTF-UHFFFAOYSA-N 0.000 claims description 4
• VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 claims description 4
• IBBWBTSDCKSONR-UHFFFAOYSA-N 4-fluoro-2-(3-fluoropyridin-2-yl)benzaldehyde Chemical compound C1=CC(=C(N=C1)C2=C(C=CC(=C2)F)C=O)F IBBWBTSDCKSONR-UHFFFAOYSA-N 0.000 claims description 4
• QMZYMTUJIDFLAL-UHFFFAOYSA-N 4-fluoro-2-(4-methylpyridin-2-yl)benzaldehyde Chemical compound CC1=CC(=NC=C1)C2=C(C=CC(=C2)F)C=O QMZYMTUJIDFLAL-UHFFFAOYSA-N 0.000 claims description 4
• HPDVLTBRUZLFHQ-UHFFFAOYSA-N 4-fluoro-2-(6-methylpyridin-2-yl)benzaldehyde Chemical compound CC1=NC(=CC=C1)C2=C(C=CC(=C2)F)C=O HPDVLTBRUZLFHQ-UHFFFAOYSA-N 0.000 claims description 4
• WDSYURFPAZPOEH-UHFFFAOYSA-N 4-fluoro-2-(triazol-2-yl)benzaldehyde Chemical compound FC1=CC(=C(C=C1)C=O)N1N=CC=N1 WDSYURFPAZPOEH-UHFFFAOYSA-N 0.000 claims description 4
• AEHCOTWWCZSIBH-UHFFFAOYSA-N 4-fluoro-2-pyridin-2-ylbenzaldehyde Chemical compound N1=C(C=CC=C1)C1=C(C=O)C=CC(=C1)F AEHCOTWWCZSIBH-UHFFFAOYSA-N 0.000 claims description 4
• VWMQXAYLHOSRKA-UHFFFAOYSA-N 5-chloro-1,3-benzoxazole Chemical compound ClC1=CC=C2OC=NC2=C1 VWMQXAYLHOSRKA-UHFFFAOYSA-N 0.000 claims description 4
• XEHHYSIYICDBID-UHFFFAOYSA-N 5-fluoro-2-(triazol-2-yl)benzaldehyde Chemical compound Fc1ccc(c(C=O)c1)-n1nccn1 XEHHYSIYICDBID-UHFFFAOYSA-N 0.000 claims description 4
• QIADRVMTVCXFSA-UHFFFAOYSA-N C1=CC(=C(C=C1F)C2=NC=CO2)C=O Chemical compound C1=CC(=C(C=C1F)C2=NC=CO2)C=O QIADRVMTVCXFSA-UHFFFAOYSA-N 0.000 claims description 4
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 4
• 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 4
• HXGLBRDCFKNXJH-PXNSSMCTSA-N [2-(triazol-2-yl)phenyl]-[(1s,6r)-7-(4,5,6-trimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=C(C)C(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2)N2N=CC=N2)=N1 HXGLBRDCFKNXJH-PXNSSMCTSA-N 0.000 claims description 4
• ACJPUSZQFBKUFF-UHFFFAOYSA-N [6-(4,6-dimethylpyrimidin-2-yl)-3,6-diazabicyclo[3.2.0]heptan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound C=1C(C)=CC=C(N2N=CC=N2)C=1C(=O)N(CC12)CC1CN2C1=NC(C)=CC(C)=N1 ACJPUSZQFBKUFF-UHFFFAOYSA-N 0.000 claims description 4
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 4
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 4
• YLQWCDOCJODRMT-UHFFFAOYSA-N fluoren-9-one Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3C2=C1 YLQWCDOCJODRMT-UHFFFAOYSA-N 0.000 claims description 4
• 230000036512 infertility Effects 0.000 claims description 4
• 231100000535 infertility Toxicity 0.000 claims description 4
• 206010022437 insomnia Diseases 0.000 claims description 4
• 125000000842 isoxazolyl group Chemical group 0.000 claims description 4
• 125000004434 sulfur atom Chemical group 0.000 claims description 4
• 125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
• FBXAORYHONSOPH-UHFFFAOYSA-N (2-phenylphenyl)-[6-(4-phenylpyrimidin-2-yl)-3,6-diazabicyclo[3.2.0]heptan-3-yl]methanone Chemical compound C=1C=CC=C(C=2C=CC=CC=2)C=1C(=O)N(CC12)CC1CN2C(N=1)=NC=CC=1C1=CC=CC=C1 FBXAORYHONSOPH-UHFFFAOYSA-N 0.000 claims description 3
• ZYWRJPNACZTMSM-UHFFFAOYSA-N (2-phenylphenyl)-[7-(4-phenylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C=1C=CC=C(C=2C=CC=CC=2)C=1C(=O)N(CC12)CCC1CN2C(N=1)=NC=CC=1C1=CC=CC=C1 ZYWRJPNACZTMSM-UHFFFAOYSA-N 0.000 claims description 3
• HNGPNDUPZZQYMH-CYFREDJKSA-N (2-pyridin-3-ylphenyl)-[(1s,6r)-7-quinoxalin-2-yl-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C([C@@H]1N(C[C@@H]1CC1)C=2N=C3C=CC=CC3=NC=2)N1C(=O)C1=CC=CC=C1C1=CC=CN=C1 HNGPNDUPZZQYMH-CYFREDJKSA-N 0.000 claims description 3
• AOTIXDWTXAREKJ-ZFWWWQNUSA-N (3-bromopyridin-2-yl)-[(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CN=2)Br)=N1 AOTIXDWTXAREKJ-ZFWWWQNUSA-N 0.000 claims description 3
• RCPUSPJRILBGKC-LPHOPBHVSA-N (3-propoxypyridin-2-yl)-[(1s,6r)-7-quinoxalin-2-yl-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CCCOC1=CC=CN=C1C(=O)N1C[C@@H]2N(C=3N=C4C=CC=CC4=NC=3)C[C@@H]2CC1 RCPUSPJRILBGKC-LPHOPBHVSA-N 0.000 claims description 3
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• 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims description 3
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• 208000008930 Low Back Pain Diseases 0.000 claims description 3
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• 208000018737 Parkinson disease Diseases 0.000 claims description 3
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• 208000000323 Tourette Syndrome Diseases 0.000 claims description 3
• 208000016620 Tourette disease Diseases 0.000 claims description 3
• 208000025865 Ulcer Diseases 0.000 claims description 3
• ZTJVMFAEMRPFSN-YJBOKZPZSA-N [(1s,6r)-7-(3,6-dimethylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[3-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound CC1=CN=C(C)C(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=C(F)C=CC=2)N2N=CC=N2)=N1 ZTJVMFAEMRPFSN-YJBOKZPZSA-N 0.000 claims description 3
• MVCRFRYMKXDRPT-KXBFYZLASA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[4-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC(F)=CC=2)N2N=CC=N2)=N1 MVCRFRYMKXDRPT-KXBFYZLASA-N 0.000 claims description 3
• BZXSLNZHHPKYQK-YWZLYKJASA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-fluoro-2-(1h-pyrazol-5-yl)phenyl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=C(F)C=2)C2=NNC=C2)=N1 BZXSLNZHHPKYQK-YWZLYKJASA-N 0.000 claims description 3
• PMIGYMQOENSCRV-DJJJIMSYSA-N [(1s,6r)-7-(5-chloro-1,3-benzoxazol-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound C([C@@H]1N(C[C@@H]1CC1)C=2OC3=CC=C(Cl)C=C3N=2)N1C(=O)C1=CC(F)=CC=C1N1N=CC=N1 PMIGYMQOENSCRV-DJJJIMSYSA-N 0.000 claims description 3
• QZZLUCJJEVICBK-UHFFFAOYSA-N [6-(4,6-dimethoxypyrimidin-2-yl)-3,6-diazabicyclo[3.2.0]heptan-3-yl]-[3-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound COC1=CC(OC)=NC(N2C3CN(CC3C2)C(=O)C=2C(=C(F)C=CC=2)N2N=CC=N2)=N1 QZZLUCJJEVICBK-UHFFFAOYSA-N 0.000 claims description 3
• QAFFSVOOPXEZBT-UHFFFAOYSA-N [7-(4,6-dimethoxypyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone Chemical compound COC1=CC(OC)=NC(N2C3CN(CCC3C2)C(=O)C=2C(=CC=CC=2F)N2N=CC=N2)=N1 QAFFSVOOPXEZBT-UHFFFAOYSA-N 0.000 claims description 3
• 230000036506 anxiety Effects 0.000 claims description 3
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• NARYFSHFYGGAPX-RXVVDRJESA-N (1s,6r)-4-(2-phenylphenyl)sulfonyl-7-[5-(trifluoromethyl)pyridin-2-yl]-4,7-diazabicyclo[4.2.0]octane Chemical compound N1=CC(C(F)(F)F)=CC=C1N1[C@H]2CN(S(=O)(=O)C=3C(=CC=CC=3)C=3C=CC=CC=3)CC[C@H]2C1 NARYFSHFYGGAPX-RXVVDRJESA-N 0.000 claims description 2
• XMGUPEFWVBGCFK-PXNSSMCTSA-N (1s,6r)-4-(2-phenylphenyl)sulfonyl-7-[5-(trifluoromethyl)pyrimidin-2-yl]-4,7-diazabicyclo[4.2.0]octane Chemical compound N1=CC(C(F)(F)F)=CN=C1N1[C@H]2CN(S(=O)(=O)C=3C(=CC=CC=3)C=3C=CC=CC=3)CC[C@H]2C1 XMGUPEFWVBGCFK-PXNSSMCTSA-N 0.000 claims description 2
• WCUGSLIJJFPUGV-HOTGVXAUSA-N (1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4-(2-methoxyphenyl)sulfonyl-4,7-diazabicyclo[4.2.0]octane Chemical compound COC1=CC=CC=C1S(=O)(=O)N1C[C@@H]2N(C=3N=C(C)C=C(C)N=3)C[C@@H]2CC1 WCUGSLIJJFPUGV-HOTGVXAUSA-N 0.000 claims description 2
• LQLJXTVERMXZOQ-UNMCSNQZSA-N (1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4-(2-phenylphenyl)sulfonyl-4,7-diazabicyclo[4.2.0]octane Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)S(=O)(=O)C=2C(=CC=CC=2)C=2C=CC=CC=2)=N1 LQLJXTVERMXZOQ-UNMCSNQZSA-N 0.000 claims description 2
• QIBAJUSGSRFHMG-UHFFFAOYSA-N (2,6-dimethoxyphenyl)-(7-quinoxalin-2-yl-4,7-diazabicyclo[4.2.0]octan-4-yl)methanone Chemical compound COC1=CC=CC(OC)=C1C(=O)N1CC2N(C=3N=C4C=CC=CC4=NC=3)CC2CC1 QIBAJUSGSRFHMG-UHFFFAOYSA-N 0.000 claims description 2
• JONOPNXFMMCQAM-ZFWWWQNUSA-N (2,6-dimethoxyphenyl)-[(1s,6r)-7-[5-(trifluoromethyl)pyridin-2-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound COC1=CC=CC(OC)=C1C(=O)N1C[C@@H]2N(C=3N=CC(=CC=3)C(F)(F)F)C[C@@H]2CC1 JONOPNXFMMCQAM-ZFWWWQNUSA-N 0.000 claims description 2
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• QIBAJUSGSRFHMG-YJBOKZPZSA-N (2,6-dimethoxyphenyl)-[(1s,6r)-7-quinoxalin-2-yl-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound COC1=CC=CC(OC)=C1C(=O)N1C[C@@H]2N(C=3N=C4C=CC=CC4=NC=3)C[C@@H]2CC1 QIBAJUSGSRFHMG-YJBOKZPZSA-N 0.000 claims description 2
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• GATCPBZBYFRAAH-UHFFFAOYSA-N (2-bromophenyl)-[6-(4-methylpyrimidin-2-yl)-3,6-diazabicyclo[3.2.0]heptan-3-yl]methanone Chemical compound CC1=CC=NC(N2C3CN(CC3C2)C(=O)C=2C(=CC=CC=2)Br)=N1 GATCPBZBYFRAAH-UHFFFAOYSA-N 0.000 claims description 2
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• GFFAVKDUYBZUHO-PXNSSMCTSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-(2-thiophen-2-ylphenyl)methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2)C=2SC=CC=2)=N1 GFFAVKDUYBZUHO-PXNSSMCTSA-N 0.000 claims description 2
• MEURXDCKHZIQND-LPHOPBHVSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-(3-fluoro-2-pyrazol-1-ylphenyl)methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=C(F)C=CC=2)N2N=CC=C2)=N1 MEURXDCKHZIQND-LPHOPBHVSA-N 0.000 claims description 2
• ADBOZGRDDFIONY-LPHOPBHVSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-(3-fluoro-2-pyrimidin-2-ylphenyl)methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=C(F)C=CC=2)C=2N=CC=CN=2)=N1 ADBOZGRDDFIONY-LPHOPBHVSA-N 0.000 claims description 2
• FXJOBYDZYVFQIS-ICSRJNTNSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-(3-methyl-2-pyrazol-1-ylphenyl)methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=C(C)C=CC=2)N2N=CC=C2)=N1 FXJOBYDZYVFQIS-ICSRJNTNSA-N 0.000 claims description 2
• URROPVKRCHCUOU-JXFKEZNVSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-(5-fluoro-2-pyrimidin-2-ylphenyl)methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=C(F)C=2)C=2N=CC=CN=2)=N1 URROPVKRCHCUOU-JXFKEZNVSA-N 0.000 claims description 2
• XUPCMGYHEMYXNZ-KKSFZXQISA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-(5-fluoro-2-pyrimidin-5-ylphenyl)methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=C(F)C=2)C=2C=NC=NC=2)=N1 XUPCMGYHEMYXNZ-KKSFZXQISA-N 0.000 claims description 2
• VUJVKLDUMVARNX-GJZGRUSLSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-(5-methoxy-2-methylpyrimidin-4-yl)methanone Chemical compound COC1=CN=C(C)N=C1C(=O)N1C[C@@H]2N(C=3N=C(C)C=C(C)N=3)C[C@@H]2CC1 VUJVKLDUMVARNX-GJZGRUSLSA-N 0.000 claims description 2
• COALYLDHKMSPID-RXVVDRJESA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-(5-methyl-2-pyrimidin-2-ylphenyl)methanone Chemical compound C([C@@H]1N(C[C@@H]1CC1)C=2N=C(C)C=C(C)N=2)N1C(=O)C1=CC(C)=CC=C1C1=NC=CC=N1 COALYLDHKMSPID-RXVVDRJESA-N 0.000 claims description 2
• SCQSUMNRDUQLMN-REWPJTCUSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-(9h-fluoren-4-yl)methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C=3C4=CC=CC=C4CC=3C=CC=2)=N1 SCQSUMNRDUQLMN-REWPJTCUSA-N 0.000 claims description 2
• SALFTRQLKHQRSL-YJBOKZPZSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(1h-1,2,4-triazol-5-yl)phenyl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2)C=2NN=CN=2)=N1 SALFTRQLKHQRSL-YJBOKZPZSA-N 0.000 claims description 2
• MHLPBRRUNHDHLH-LPHOPBHVSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]methanone Chemical compound CC1=NOC(C=2C(=CC=CC=2)C(=O)N2C[C@@H]3N(C[C@@H]3CC2)C=2N=C(C)C=C(C)N=2)=N1 MHLPBRRUNHDHLH-LPHOPBHVSA-N 0.000 claims description 2
• WNWUDGHZOXYLNZ-PXNSSMCTSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(furan-2-yl)phenyl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2)C=2OC=CC=2)=N1 WNWUDGHZOXYLNZ-PXNSSMCTSA-N 0.000 claims description 2
• OUVHNDWXWOLNTO-HOCLYGCPSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(triazol-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=NC(=CC=2)C(F)(F)F)N2N=NC=C2)=N1 OUVHNDWXWOLNTO-HOCLYGCPSA-N 0.000 claims description 2
• GCJLLSZIAIAWSK-LPHOPBHVSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2)N2N=CC=N2)=N1 GCJLLSZIAIAWSK-LPHOPBHVSA-N 0.000 claims description 2
• LJZIGRNYUYTLML-ZFWWWQNUSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(trifluoromethyl)pyridin-3-yl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=NC=CC=2)C(F)(F)F)=N1 LJZIGRNYUYTLML-ZFWWWQNUSA-N 0.000 claims description 2
• SJCRTLFZMYFXRM-YJBOKZPZSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2F)N2N=CC=N2)=N1 SJCRTLFZMYFXRM-YJBOKZPZSA-N 0.000 claims description 2
• CHLFYOFERFUEBH-RDJZCZTQSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[3-(triazol-1-yl)pyridin-2-yl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CN=2)N2N=NC=C2)=N1 CHLFYOFERFUEBH-RDJZCZTQSA-N 0.000 claims description 2
• REZXBSRYXSQAPC-RDJZCZTQSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[3-(triazol-2-yl)pyridin-2-yl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CN=2)N2N=CC=N2)=N1 REZXBSRYXSQAPC-RDJZCZTQSA-N 0.000 claims description 2
• ZLZXBOCSKUBSRY-KXBFYZLASA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[3-fluoro-2-(1h-pyrazol-5-yl)phenyl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=C(F)C=CC=2)C2=NNC=C2)=N1 ZLZXBOCSKUBSRY-KXBFYZLASA-N 0.000 claims description 2
• RHFCEWQBBZIMDX-HKUYNNGSSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[3-methyl-2-(triazol-1-yl)phenyl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=C(C)C=CC=2)N2N=NC=C2)=N1 RHFCEWQBBZIMDX-HKUYNNGSSA-N 0.000 claims description 2
• WNFPOORBCVZXSS-HKUYNNGSSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[3-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=C(C)C=CC=2)N2N=CC=N2)=N1 WNFPOORBCVZXSS-HKUYNNGSSA-N 0.000 claims description 2
• OBZDRYNAXVTAJE-GJZGRUSLSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[3-methyl-5-(4-methylthiadiazol-5-yl)-1,2-oxazol-4-yl]methanone Chemical compound N1=NSC(C2=C(C(C)=NO2)C(=O)N2C[C@@H]3N(C[C@@H]3CC2)C=2N=C(C)C=C(C)N=2)=C1C OBZDRYNAXVTAJE-GJZGRUSLSA-N 0.000 claims description 2
• CGLXSGZQQIHPAY-JXFKEZNVSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[4-methoxy-2-(triazol-2-yl)phenyl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C2=CC=C(C=C2N2N=CC=N2)OC)N1C1=NC(C)=CC(C)=N1 CGLXSGZQQIHPAY-JXFKEZNVSA-N 0.000 claims description 2
• FTOSJNYBIZILBH-HKUYNNGSSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5,6-dimethyl-2-(triazol-1-yl)pyridin-3-yl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=NC(C)=C(C)C=2)N2N=NC=C2)=N1 FTOSJNYBIZILBH-HKUYNNGSSA-N 0.000 claims description 2
• SHGQBCFNKNAGOO-HKUYNNGSSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5,6-dimethyl-2-(triazol-2-yl)pyridin-3-yl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=NC(C)=C(C)C=2)N2N=CC=N2)=N1 SHGQBCFNKNAGOO-HKUYNNGSSA-N 0.000 claims description 2
• ADLJMXGXMGUKOJ-YJBOKZPZSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-(2-fluorophenyl)-1,3-oxazol-4-yl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C2=C(OC=N2)C=2C(=CC=CC=2)F)=N1 ADLJMXGXMGUKOJ-YJBOKZPZSA-N 0.000 claims description 2
• KOAPULRKKGIKLA-HKUYNNGSSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C=2N=C(SC=2C=2C=CC(F)=CC=2)C)N1C1=NC(C)=CC(C)=N1 KOAPULRKKGIKLA-HKUYNNGSSA-N 0.000 claims description 2
• GWDTVNMVFNQNIK-KKSFZXQISA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-fluoro-2-(1-methylpyrazol-3-yl)phenyl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=C(F)C=2)C2=NN(C)C=C2)=N1 GWDTVNMVFNQNIK-KKSFZXQISA-N 0.000 claims description 2
• AIJWSTPDSILCOZ-KXBFYZLASA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=C(F)C=2)N2N=CC=N2)=N1 AIJWSTPDSILCOZ-KXBFYZLASA-N 0.000 claims description 2
• QRPNMNBKGFDZLV-XIJCICFPSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-fluoro-2-[2-(oxan-2-yl)pyrazol-3-yl]phenyl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=C(F)C=2)C=2N(N=CC=2)C2OCCCC2)=N1 QRPNMNBKGFDZLV-XIJCICFPSA-N 0.000 claims description 2
• HNIYDSMNVPLFOY-JXFKEZNVSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-methoxy-2-(triazol-2-yl)phenyl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C=2C(=CC=C(C=2)OC)N2N=CC=N2)N1C1=NC(C)=CC(C)=N1 HNIYDSMNVPLFOY-JXFKEZNVSA-N 0.000 claims description 2
• NEMWYHPNGUVQCK-WMZOPIPTSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-methyl-2-(triazol-1-yl)pyridin-3-yl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C=2C(=NC=C(C=2)C)N2N=NC=C2)N1C1=NC(C)=CC(C)=N1 NEMWYHPNGUVQCK-WMZOPIPTSA-N 0.000 claims description 2
• OQHCXNWWBQRUSP-PXNSSMCTSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C=2C(=CC=C(C=2)C)N2N=CC=N2)N1C1=NC(C)=CC(C)=N1 OQHCXNWWBQRUSP-PXNSSMCTSA-N 0.000 claims description 2
• TWRZQMSBBKPDSB-WMZOPIPTSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-methyl-2-(triazol-2-yl)pyridin-3-yl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C=2C(=NC=C(C=2)C)N2N=CC=N2)N1C1=NC(C)=CC(C)=N1 TWRZQMSBBKPDSB-WMZOPIPTSA-N 0.000 claims description 2
• IIGDQSZHCOLSQF-RDJZCZTQSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[6-methoxy-2-(triazol-1-yl)pyridin-3-yl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C2=CC=C(N=C2N2N=NC=C2)OC)N1C1=NC(C)=CC(C)=N1 IIGDQSZHCOLSQF-RDJZCZTQSA-N 0.000 claims description 2
• BBZMSEWQYBHXNQ-WMZOPIPTSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[6-methyl-2-(triazol-1-yl)pyridin-3-yl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C2=CC=C(N=C2N2N=NC=C2)C)N1C1=NC(C)=CC(C)=N1 BBZMSEWQYBHXNQ-WMZOPIPTSA-N 0.000 claims description 2
• PBKCYYYZPATVTR-FPOVZHCZSA-N [(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[6-methyl-3-(3-methylpyridin-2-yl)pyridin-2-yl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C=2C(=CC=C(N=2)C)C=2C(=CC=CN=2)C)N1C1=NC(C)=CC(C)=N1 PBKCYYYZPATVTR-FPOVZHCZSA-N 0.000 claims description 2
• ASFFYKJYANXDAE-LIRRHRJNSA-N [(1s,6r)-7-(5-chloro-1,3-benzoxazol-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound C([C@H]1CN([C@H]1C1)C=2OC3=CC=C(C=C3N=2)Cl)CN1C(=O)C1=CC=CC=C1N1N=CC=N1 ASFFYKJYANXDAE-LIRRHRJNSA-N 0.000 claims description 2
• MUXDWBWGCFZGSS-UGSOOPFHSA-N [(1s,6r)-7-(5-chloro-1,3-benzoxazol-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone Chemical compound C([C@@H]1N(C[C@@H]1CC1)C=2OC3=CC=C(Cl)C=C3N=2)N1C(=O)C=1C(F)=CC=CC=1N1N=CC=N1 MUXDWBWGCFZGSS-UGSOOPFHSA-N 0.000 claims description 2
• KQVOXYJJSWYBFV-UGSOOPFHSA-N [(1s,6r)-7-(5-chloro-1,3-benzoxazol-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[3-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound FC1=CC=CC(C(=O)N2C[C@@H]3N(C[C@@H]3CC2)C=2OC3=CC=C(Cl)C=C3N=2)=C1N1N=CC=N1 KQVOXYJJSWYBFV-UGSOOPFHSA-N 0.000 claims description 2
• UGARRAULODPKDT-DJJJIMSYSA-N [(1s,6r)-7-(5-chloro-1,3-benzoxazol-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[4-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound C=1C(F)=CC=C(C(=O)N2C[C@@H]3N(C[C@@H]3CC2)C=2OC3=CC=C(Cl)C=C3N=2)C=1N1N=CC=N1 UGARRAULODPKDT-DJJJIMSYSA-N 0.000 claims description 2
• JOUNIVHBRMXUIX-YJBOKZPZSA-N [(1s,6r)-7-(5-methylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound C1=NC(C)=CN=C1N1[C@H]2CN(C(=O)C=3C(=CC=CC=3)N3N=CC=N3)CC[C@H]2C1 JOUNIVHBRMXUIX-YJBOKZPZSA-N 0.000 claims description 2
• PAMNCOGCSYQICN-GUYCJALGSA-N [(1s,6r)-7-(6-amino-2-methylpyrimidin-4-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound CC1=NC(N)=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=C(F)C=2)N2N=CC=N2)=N1 PAMNCOGCSYQICN-GUYCJALGSA-N 0.000 claims description 2
• LYHAZJWDNSWOIJ-SJCJKPOMSA-N [(1s,6r)-7-(6-chloropyridazin-4-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C=2C(=CC=C(C=2)F)N2N=CC=N2)N1C1=CN=NC(Cl)=C1 LYHAZJWDNSWOIJ-SJCJKPOMSA-N 0.000 claims description 2
• LQRWGYPSUWDZTR-YJBOKZPZSA-N [(1s,6r)-7-(6-methylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound CC1=CN=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2)N2N=CC=N2)=N1 LQRWGYPSUWDZTR-YJBOKZPZSA-N 0.000 claims description 2
• HOQLYDYVYPJRAF-LPHOPBHVSA-N [(1s,6r)-7-(6-methylpyridin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound CC1=CC=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2)N2N=CC=N2)=N1 HOQLYDYVYPJRAF-LPHOPBHVSA-N 0.000 claims description 2
• PKOGXQBGKRIGPC-YOEHRIQHSA-N [(1s,6r)-7-[2-(dimethylamino)-6-(trifluoromethyl)pyrimidin-4-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound FC(F)(F)C1=NC(N(C)C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2)N2N=CC=N2)=C1 PKOGXQBGKRIGPC-YOEHRIQHSA-N 0.000 claims description 2
• BWMDAFIQDYRKHB-BBRMVZONSA-N [(1s,6r)-7-[2-(dimethylamino)-6-(trifluoromethyl)pyrimidin-4-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone Chemical compound FC(F)(F)C1=NC(N(C)C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2F)N2N=CC=N2)=C1 BWMDAFIQDYRKHB-BBRMVZONSA-N 0.000 claims description 2
• JHGJXSYUJSBXDY-GUYCJALGSA-N [(1s,6r)-7-[2-(dimethylamino)-6-(trifluoromethyl)pyrimidin-4-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[4-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound FC(F)(F)C1=NC(N(C)C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC(F)=CC=2)N2N=CC=N2)=C1 JHGJXSYUJSBXDY-GUYCJALGSA-N 0.000 claims description 2
• COQAGPWIRBBDQU-GUYCJALGSA-N [(1s,6r)-7-[2-(dimethylamino)-6-(trifluoromethyl)pyrimidin-4-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound FC(F)(F)C1=NC(N(C)C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=C(F)C=2)N2N=CC=N2)=C1 COQAGPWIRBBDQU-GUYCJALGSA-N 0.000 claims description 2
• REABRJLCUXPAHI-LPHOPBHVSA-N [(1s,6r)-7-[2-(dimethylamino)-6-methylpyrimidin-4-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound CN(C)C1=NC(C)=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2)N2N=CC=N2)=N1 REABRJLCUXPAHI-LPHOPBHVSA-N 0.000 claims description 2
• ICTFOQORRSBYLJ-YJBOKZPZSA-N [(1s,6r)-7-[2-(dimethylamino)-6-methylpyrimidin-4-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone Chemical compound CN(C)C1=NC(C)=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2F)N2N=CC=N2)=N1 ICTFOQORRSBYLJ-YJBOKZPZSA-N 0.000 claims description 2
• NMXLIXYKBDZGLU-KXBFYZLASA-N [(1s,6r)-7-[2-(dimethylamino)-6-methylpyrimidin-4-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[4-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound CN(C)C1=NC(C)=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC(F)=CC=2)N2N=CC=N2)=N1 NMXLIXYKBDZGLU-KXBFYZLASA-N 0.000 claims description 2
• WTHWKCWNBUNRAF-KXBFYZLASA-N [(1s,6r)-7-[2-(dimethylamino)-6-methylpyrimidin-4-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound CN(C)C1=NC(C)=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=C(F)C=2)N2N=CC=N2)=N1 WTHWKCWNBUNRAF-KXBFYZLASA-N 0.000 claims description 2
• PGQUWZXMFPXHSD-JXFKEZNVSA-N [(1s,6r)-7-[4-(dimethylamino)pyridin-2-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-(3-fluoro-2-pyrimidin-2-ylphenyl)methanone Chemical compound CN(C)C1=CC=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=C(F)C=CC=2)C=2N=CC=CN=2)=C1 PGQUWZXMFPXHSD-JXFKEZNVSA-N 0.000 claims description 2
• SEGXJUXXZMKYLL-KXBFYZLASA-N [(1s,6r)-7-[4-(dimethylamino)pyridin-2-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[3-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound CN(C)C1=CC=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=C(F)C=CC=2)N2N=CC=N2)=C1 SEGXJUXXZMKYLL-KXBFYZLASA-N 0.000 claims description 2
• RMVQTFNCMRGHFJ-PXNSSMCTSA-N [(1s,6r)-7-[4-(dimethylamino)pyridin-2-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[3-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CN(C)C1=CC=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=C(C)C=CC=2)N2N=CC=N2)=C1 RMVQTFNCMRGHFJ-PXNSSMCTSA-N 0.000 claims description 2
• QTRSJWYRFYJLCQ-KKSFZXQISA-N [(1s,6r)-7-[4-(dimethylamino)pyridin-2-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[4-methoxy-2-(triazol-2-yl)phenyl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C2=CC=C(C=C2N2N=CC=N2)OC)N1C1=CC(N(C)C)=CC=N1 QTRSJWYRFYJLCQ-KKSFZXQISA-N 0.000 claims description 2
• KNIWFTMZQQINOZ-KKSFZXQISA-N [(1s,6r)-7-[4-(dimethylamino)pyridin-2-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-methoxy-2-(triazol-2-yl)phenyl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C=2C(=CC=C(C=2)OC)N2N=CC=N2)N1C1=CC(N(C)C)=CC=N1 KNIWFTMZQQINOZ-KKSFZXQISA-N 0.000 claims description 2
• OMIGRHBORNOVFI-LIRRHRJNSA-N [(1s,6r)-7-[6-(cyclopropylamino)pyrimidin-4-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C=2C(=CC=C(C=2)F)N2N=CC=N2)N1C(N=CN=1)=CC=1NC1CC1 OMIGRHBORNOVFI-LIRRHRJNSA-N 0.000 claims description 2
• CWGQURLFXHAFQD-KSSFIOAISA-N [(1s,6r)-7-[6-(dimethylamino)pyrimidin-4-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[5-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound C1=NC(N(C)C)=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=C(F)C=2)N2N=CC=N2)=N1 CWGQURLFXHAFQD-KSSFIOAISA-N 0.000 claims description 2
• XVYQCSDBLWBGHX-YOEHRIQHSA-N [(1s,6r)-7-[6-methyl-2-(trifluoromethyl)pyrimidin-4-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound FC(F)(F)C1=NC(C)=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2)N2N=CC=N2)=N1 XVYQCSDBLWBGHX-YOEHRIQHSA-N 0.000 claims description 2
• FKBFJEQPIKTRPN-JTSKRJEESA-N [(1s,6r)-7-quinoxalin-2-yl-4,7-diazabicyclo[4.2.0]octan-4-yl]-(2-thiophen-2-ylphenyl)methanone Chemical compound C([C@@H]1N(C[C@@H]1CC1)C=2N=C3C=CC=CC3=NC=2)N1C(=O)C1=CC=CC=C1C1=CC=CS1 FKBFJEQPIKTRPN-JTSKRJEESA-N 0.000 claims description 2
• NULXWPZWUYBRCG-KKSFZXQISA-N [(1s,6r)-7-quinoxalin-2-yl-4,7-diazabicyclo[4.2.0]octan-4-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound C([C@@H]1N(C[C@@H]1CC1)C=2N=C3C=CC=CC3=NC=2)N1C(=O)C1=CC=CC=C1N1N=CC=N1 NULXWPZWUYBRCG-KKSFZXQISA-N 0.000 claims description 2
• UDMDCPSUOZRRMH-JXFKEZNVSA-N [2-(3-chloropyridin-2-yl)-3-fluorophenyl]-[(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=C(F)C=CC=2)C=2C(=CC=CN=2)Cl)=N1 UDMDCPSUOZRRMH-JXFKEZNVSA-N 0.000 claims description 2
• WBLFAGDVIJVAMF-LVXARBLLSA-N [2-(4-methylphenyl)phenyl]-[(1s,6r)-7-quinoxalin-2-yl-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C1=CC(C)=CC=C1C1=CC=CC=C1C(=O)N1C[C@@H]2N(C=3N=C4C=CC=CC4=NC=3)C[C@@H]2CC1 WBLFAGDVIJVAMF-LVXARBLLSA-N 0.000 claims description 2
• CJWALWGZPZBUMF-JTSKRJEESA-N [2-(furan-2-yl)phenyl]-[(1s,6r)-7-quinoxalin-2-yl-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C([C@@H]1N(C[C@@H]1CC1)C=2N=C3C=CC=CC3=NC=2)N1C(=O)C1=CC=CC=C1C1=CC=CO1 CJWALWGZPZBUMF-JTSKRJEESA-N 0.000 claims description 2
• ICXYSAINLSBCNE-CVDCTZTESA-N [2-[6-(dimethylamino)pyridin-3-yl]-5-fluorophenyl]-[(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C1=NC(N(C)C)=CC=C1C1=CC=C(F)C=C1C(=O)N1C[C@@H]2N(C=3N=C(C)C=C(C)N=3)C[C@@H]2CC1 ICXYSAINLSBCNE-CVDCTZTESA-N 0.000 claims description 2
• QZHNTBOGFBBQGE-YOEHRIQHSA-N [2-fluoro-6-(triazol-2-yl)phenyl]-[(1s,6r)-7-(3-methylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=NC=CN=C1N1[C@H]2CN(C(=O)C=3C(=CC=CC=3F)N3N=CC=N3)CC[C@H]2C1 QZHNTBOGFBBQGE-YOEHRIQHSA-N 0.000 claims description 2
• CKERJJVSZPKSBU-YOEHRIQHSA-N [2-fluoro-6-(triazol-2-yl)phenyl]-[(1s,6r)-7-(5-methylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C1=NC(C)=CN=C1N1[C@H]2CN(C(=O)C=3C(=CC=CC=3F)N3N=CC=N3)CC[C@H]2C1 CKERJJVSZPKSBU-YOEHRIQHSA-N 0.000 claims description 2
• HTDGQXHMLMPQGX-YOEHRIQHSA-N [2-fluoro-6-(triazol-2-yl)phenyl]-[(1s,6r)-7-(6-methylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=CN=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2F)N2N=CC=N2)=N1 HTDGQXHMLMPQGX-YOEHRIQHSA-N 0.000 claims description 2
• IYROBDHTCYCLKD-YJBOKZPZSA-N [2-fluoro-6-(triazol-2-yl)phenyl]-[(1s,6r)-7-(6-methylpyridin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=CC=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=CC=2F)N2N=CC=N2)=N1 IYROBDHTCYCLKD-YJBOKZPZSA-N 0.000 claims description 2
• WZFWVFYIORTRAG-WFASDCNBSA-N [2-fluoro-6-(triazol-2-yl)phenyl]-[(1s,6r)-7-[4-(trifluoromethyl)pyrimidin-2-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C2=C(C=CC=C2F)N2N=CC=N2)N1C1=NC=CC(C(F)(F)F)=N1 WZFWVFYIORTRAG-WFASDCNBSA-N 0.000 claims description 2
• NOAUFFLMJAOCOG-YWZLYKJASA-N [2-fluoro-6-(triazol-2-yl)phenyl]-[(1s,6r)-7-quinoxalin-2-yl-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C([C@@H]1N(C[C@@H]1CC1)C=2N=C3C=CC=CC3=NC=2)N1C(=O)C=1C(F)=CC=CC=1N1N=CC=N1 NOAUFFLMJAOCOG-YWZLYKJASA-N 0.000 claims description 2
• HUDRHGDADFZPAQ-YOEHRIQHSA-N [3-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-(3-methylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=NC=CN=C1N1[C@H]2CN(C(=O)C=3C(=C(F)C=CC=3)N3N=CC=N3)CC[C@H]2C1 HUDRHGDADFZPAQ-YOEHRIQHSA-N 0.000 claims description 2
• ZQOKMPIGADWQHE-YOEHRIQHSA-N [3-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-(5-methylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C1=NC(C)=CN=C1N1[C@H]2CN(C(=O)C=3C(=C(F)C=CC=3)N3N=CC=N3)CC[C@H]2C1 ZQOKMPIGADWQHE-YOEHRIQHSA-N 0.000 claims description 2
• WQEUMTUNQPIOJK-GUYCJALGSA-N [3-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-[4-(trifluoromethyl)pyridin-2-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C=2C=CC=C(C=2N2N=CC=N2)F)N1C1=CC(C(F)(F)F)=CC=N1 WQEUMTUNQPIOJK-GUYCJALGSA-N 0.000 claims description 2
• FLOMBNYPQJLSQF-YWZLYKJASA-N [3-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-quinoxalin-2-yl-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound FC1=CC=CC(C(=O)N2C[C@@H]3N(C[C@@H]3CC2)C=2N=C3C=CC=CC3=NC=2)=C1N1N=CC=N1 FLOMBNYPQJLSQF-YWZLYKJASA-N 0.000 claims description 2
• UOIWGXKIAIQMDU-YJBOKZPZSA-N [3-methyl-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-[4-(trifluoromethyl)pyridin-2-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C=2C=CC=C(C=2N2N=CC=N2)C)N1C1=CC(C(F)(F)F)=CC=N1 UOIWGXKIAIQMDU-YJBOKZPZSA-N 0.000 claims description 2
• OOVZFBIAAYGBMA-KSSFIOAISA-N [4-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-(3-methylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=NC=CN=C1N1[C@H]2CN(C(=O)C=3C(=CC(F)=CC=3)N3N=CC=N3)CC[C@H]2C1 OOVZFBIAAYGBMA-KSSFIOAISA-N 0.000 claims description 2
• RNFZYXHJPPPWIF-KSSFIOAISA-N [4-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-(5-methylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C1=NC(C)=CN=C1N1[C@H]2CN(C(=O)C=3C(=CC(F)=CC=3)N3N=CC=N3)CC[C@H]2C1 RNFZYXHJPPPWIF-KSSFIOAISA-N 0.000 claims description 2
• MQUOGPOCGAQVDA-KSSFIOAISA-N [4-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-(6-methylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=CN=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC(F)=CC=2)N2N=CC=N2)=N1 MQUOGPOCGAQVDA-KSSFIOAISA-N 0.000 claims description 2
• FUVWHKNIXNMRLW-GUYCJALGSA-N [4-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-[6-methyl-2-(trifluoromethyl)pyrimidin-4-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound FC(F)(F)C1=NC(C)=CC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC(F)=CC=2)N2N=CC=N2)=N1 FUVWHKNIXNMRLW-GUYCJALGSA-N 0.000 claims description 2
• UQLKAWXIWWVWLO-BTYIYWSLSA-N [4-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-quinoxalin-2-yl-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C=1C(F)=CC=C(C(=O)N2C[C@@H]3N(C[C@@H]3CC2)C=2N=C3C=CC=CC3=NC=2)C=1N1N=CC=N1 UQLKAWXIWWVWLO-BTYIYWSLSA-N 0.000 claims description 2
• VSHKXJBZUXATST-LIRRHRJNSA-N [4-methoxy-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-[4-(trifluoromethyl)pyridin-2-yl]-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C([C@@H]1CCN(C[C@@H]11)C(=O)C2=CC=C(C=C2N2N=CC=N2)OC)N1C1=CC(C(F)(F)F)=CC=N1 VSHKXJBZUXATST-LIRRHRJNSA-N 0.000 claims description 2
• JANFKWUUXNFEKA-UHFFFAOYSA-N [5-(2-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]-[6-(4-phenylpyrimidin-2-yl)-3,6-diazabicyclo[3.2.0]heptan-3-yl]methanone Chemical compound C=1C=CC=C(F)C=1C=1SC(C)=NC=1C(=O)N(CC12)CC1CN2C(N=1)=NC=CC=1C1=CC=CC=C1 JANFKWUUXNFEKA-UHFFFAOYSA-N 0.000 claims description 2
• VGVHYZBJMGKIJW-WMZOPIPTSA-N [5-(3-chlorophenyl)-1,3-oxazol-4-yl]-[(1s,6r)-7-(4,6-dimethylpyrimidin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=CC(C)=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C2=C(OC=N2)C=2C=C(Cl)C=CC=2)=N1 VGVHYZBJMGKIJW-WMZOPIPTSA-N 0.000 claims description 2
• BQLBIUMHDBUEDU-KSSFIOAISA-N [5-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-(3-methylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=NC=CN=C1N1[C@H]2CN(C(=O)C=3C(=CC=C(F)C=3)N3N=CC=N3)CC[C@H]2C1 BQLBIUMHDBUEDU-KSSFIOAISA-N 0.000 claims description 2
• IWLOIZWVNYUPSQ-KXBFYZLASA-N [5-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-(4-methylpyridin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound CC1=CC=NC(N2[C@H]3CN(CC[C@H]3C2)C(=O)C=2C(=CC=C(F)C=2)N2N=CC=N2)=C1 IWLOIZWVNYUPSQ-KXBFYZLASA-N 0.000 claims description 2
• AXKXZMMWINVUTB-KSSFIOAISA-N [5-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-(5-methylpyrazin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound C1=NC(C)=CN=C1N1[C@H]2CN(C(=O)C=3C(=CC=C(F)C=3)N3N=CC=N3)CC[C@H]2C1 AXKXZMMWINVUTB-KSSFIOAISA-N 0.000 claims description 2
• LRUPPXLBYVSMRB-KXBFYZLASA-N [5-fluoro-2-(triazol-2-yl)phenyl]-[(1s,6r)-7-(5-methylpyridin-2-yl)-4,7-diazabicyclo[4.2.0]octan-4-yl]methanone Chemical compound N1=CC(C)=CC=C1N1[C@H]2CN(C(=O)C=3C(=CC=C(F)C=3)N3N=CC=N3)CC[C@H]2C1 LRUPPXLBYVSMRB-KXBFYZLASA-N 0.000 claims description 2
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