JP5820813B2 - インドール化合物を含む医薬組成物 - Google Patents
インドール化合物を含む医薬組成物 Download PDFInfo
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- JP5820813B2 JP5820813B2 JP2012536664A JP2012536664A JP5820813B2 JP 5820813 B2 JP5820813 B2 JP 5820813B2 JP 2012536664 A JP2012536664 A JP 2012536664A JP 2012536664 A JP2012536664 A JP 2012536664A JP 5820813 B2 JP5820813 B2 JP 5820813B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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- Neurosurgery (AREA)
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- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Birds (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20090101978 | 2009-10-26 | ||
| KR10-2009-0101978 | 2009-10-26 | ||
| KR20100098511 | 2010-10-08 | ||
| KR10-2010-0098511 | 2010-10-08 | ||
| PCT/KR2010/007344 WO2011052950A2 (en) | 2009-10-26 | 2010-10-25 | Pharmaceutical composition comprising indole compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013508452A JP2013508452A (ja) | 2013-03-07 |
| JP2013508452A5 JP2013508452A5 (enExample) | 2015-04-30 |
| JP5820813B2 true JP5820813B2 (ja) | 2015-11-24 |
Family
ID=43922791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012536664A Active JP5820813B2 (ja) | 2009-10-26 | 2010-10-25 | インドール化合物を含む医薬組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20120214804A1 (enExample) |
| EP (1) | EP2493469A4 (enExample) |
| JP (1) | JP5820813B2 (enExample) |
| KR (1) | KR101325272B1 (enExample) |
| CN (1) | CN102596198B (enExample) |
| AR (1) | AR078775A1 (enExample) |
| BR (1) | BR112012009894A2 (enExample) |
| MX (1) | MX338807B (enExample) |
| RU (1) | RU2557243C2 (enExample) |
| TR (1) | TR201204895T1 (enExample) |
| TW (2) | TW201119651A (enExample) |
| WO (1) | WO2011052950A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101304772B1 (ko) * | 2011-04-11 | 2013-09-05 | 인제대학교 산학협력단 | NecroX―5를 유효성분으로 포함하는 미토콘드리아 기능 조절용 조성물 |
| WO2013115457A1 (ko) * | 2012-01-31 | 2013-08-08 | 인제대학교 산학협력단 | NecroX를 함유하는 암 전이 억제용 조성물 |
| KR101400346B1 (ko) * | 2012-01-31 | 2014-05-30 | 인제대학교 산학협력단 | NecroX를 함유하는 암 전이 억제용 조성물 |
| CN113967215A (zh) * | 2014-04-18 | 2022-01-25 | Lg 化学株式会社 | 用于预防或治疗脂肪肝疾病的组合物 |
| CA2953387C (en) * | 2014-06-30 | 2023-11-28 | The Regents Of The University Of California | Ketobutyrate compounds and compositions for treating age-related symptoms and diseases |
| KR101633703B1 (ko) * | 2014-12-30 | 2016-06-27 | 한국원자력의학원 | necro X-5를 유효성분으로 포함하는 방사선 조사에 의한 세포손상 예방 또는 치료용 조성물 |
| CN107434819B (zh) * | 2017-02-15 | 2020-03-17 | 河北医科大学第二医院 | 吲哚-tempo缀合物及其在保护远隔器官对抗缺血再灌注损伤中的用途 |
| CN111278807B (zh) | 2017-08-17 | 2022-07-22 | 凯瑞康宁生物工程(武汉)有限公司 | 活性氧清除剂衍生物的制备及用途 |
| CN111356699B (zh) | 2017-09-04 | 2022-08-23 | 凯瑞康宁生物工程(武汉)有限公司 | 活性氧清除剂的制备及用途 |
| KR20200069259A (ko) | 2018-12-06 | 2020-06-16 | 국립암센터 | nc886을 포함하는 암살상 바이러스 활성 증진 또는 생산 증진용 조성물 |
| US11795147B2 (en) | 2019-08-26 | 2023-10-24 | Boehringer Ingelheim International Gmbh | Modulators of complex I |
| US20240009202A1 (en) | 2020-08-19 | 2024-01-11 | Mitoimmune Therapeutics Inc. | Mitochondria-targeted antioxidant as agent for treating pathologic inflammation caused by mabc-r infection |
| US20240043409A1 (en) | 2021-04-12 | 2024-02-08 | Mitoimmune Therapeutics Inc. | Crystalline forms of 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-n-(tetrahydro-2h-pyran-4-yl)-1h-indol-7-amine |
| EP4324829A4 (en) | 2021-04-12 | 2025-04-23 | MitoImmune Therapeutics Inc. | 5-[(1,1-DIOXIDO-4-THIOMORPHOLINYL)METHYL]-2-PHENYL-N-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-INDOL-7-AMINE SULFATE AND A NEW CRYSTALLINE FORM THEREOF |
| WO2023182840A1 (ko) * | 2022-03-25 | 2023-09-28 | 주식회사 미토이뮨테라퓨틱스 | 항바이러스용 약학적 조성물 및 이의 용도 |
| DE102023204801A1 (de) * | 2023-05-23 | 2024-11-28 | Continental Reifen Deutschland Gmbh | Verbindung als Alterungsschutzmittel in Kautschukmischungen und Fahrzeugreifen |
Family Cites Families (12)
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| US6420429B1 (en) * | 1997-12-23 | 2002-07-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Brain targeted low molecular weight hydrophobic antioxidant compounds |
| RU2182908C2 (ru) * | 1997-09-05 | 2002-05-27 | Лид Кемикал Ко., Лтд. | Стереоизомерные индольные соединения, способ их получения и их использование |
| EP1133487B1 (en) * | 1998-11-25 | 2004-09-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Antioxidants |
| IL130169A (en) * | 1999-05-27 | 2006-08-20 | Neurim Pharma 1991 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
| AR039209A1 (es) * | 2002-04-03 | 2005-02-09 | Novartis Ag | Derivados de indolilmaleimida |
| DE10217006A1 (de) * | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
| WO2006112549A1 (ja) * | 2005-04-20 | 2006-10-26 | Takeda Pharmaceutical Company Limited | 縮合複素環化合物 |
| JP2008538586A (ja) * | 2005-04-21 | 2008-10-30 | グレン エー. ゴールドスタイン, | 酸化ストレスに関連する疾患および病気の処置のためのn−アセチルシステインアミド(nacアミド) |
| US20070161609A1 (en) * | 2006-01-10 | 2007-07-12 | Charles Buck | Use of mitochondrially targeted antioxidant in treatment and prevention of drug-induced liver disease |
| KR20090018593A (ko) * | 2007-08-17 | 2009-02-20 | 주식회사 엘지생명과학 | 세포괴사 저해제로서의 인돌 및 인다졸 화합물 |
| RU2450001C2 (ru) * | 2007-12-20 | 2012-05-10 | Эл Джи Лайф Сайенсиз Лтд. | Активаторы глюкокиназы и фармацевтические композиции, содержащие их в качестве активного ингредиента |
| WO2009088192A2 (ko) * | 2008-01-04 | 2009-07-16 | Lg Life Sciences Ltd. | 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체 |
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| EP2493469A2 (en) | 2012-09-05 |
| MX338807B (es) | 2016-05-02 |
| TR201204895T1 (tr) | 2013-01-21 |
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| EP2493469A4 (en) | 2013-05-29 |
| AR078775A1 (es) | 2011-11-30 |
| TW201119651A (en) | 2011-06-16 |
| RU2557243C2 (ru) | 2015-07-20 |
| TW201414473A (zh) | 2014-04-16 |
| BR112012009894A2 (pt) | 2016-11-29 |
| KR20110046321A (ko) | 2011-05-04 |
| MX2012004504A (es) | 2012-09-07 |
| JP2013508452A (ja) | 2013-03-07 |
| WO2011052950A2 (en) | 2011-05-05 |
| US20170165272A1 (en) | 2017-06-15 |
| CN102596198A (zh) | 2012-07-18 |
| TWI535440B (zh) | 2016-06-01 |
| US20120214804A1 (en) | 2012-08-23 |
| CN102596198B (zh) | 2016-01-27 |
| KR101325272B1 (ko) | 2013-11-05 |
| WO2011052950A3 (en) | 2011-11-24 |
| US10322135B2 (en) | 2019-06-18 |
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