RU2557243C2 - Фармацевтическая композиция, содержащая индольное соединение - Google Patents

Фармацевтическая композиция, содержащая индольное соединение Download PDF

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RU2557243C2
RU2557243C2 RU2012121815/04A RU2012121815A RU2557243C2 RU 2557243 C2 RU2557243 C2 RU 2557243C2 RU 2012121815/04 A RU2012121815/04 A RU 2012121815/04A RU 2012121815 A RU2012121815 A RU 2012121815A RU 2557243 C2 RU2557243 C2 RU 2557243C2
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compound
formula
hydrogen
alkyl
cells
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RU2012121815/04A
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Russian (ru)
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RU2012121815A (ru
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Соон Ха КИМ
Хиоунг Дзин КИМ
Хеуи Сул Парк
Сеон Ионг ГУ
Хио Шин КВАК
Ду Хее ПАРК
Хио Соо КИМ
Хиун Дзай ЧО
Дзи Хиун КИМ
Дзу Иоунг КИМ
Кванг Мин ПАРК
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Эл Джи Лайф Сайенсиз Лтд.
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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RU2012121815/04A 2009-10-26 2010-10-25 Фармацевтическая композиция, содержащая индольное соединение RU2557243C2 (ru)

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Application Number Priority Date Filing Date Title
KR10-2009-0101978 2009-10-26
KR20090101978 2009-10-26
KR20100098511 2010-10-08
KR10-2010-0098511 2010-10-08
PCT/KR2010/007344 WO2011052950A2 (en) 2009-10-26 2010-10-25 Pharmaceutical composition comprising indole compound

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RU2012121815A RU2012121815A (ru) 2013-12-10
RU2557243C2 true RU2557243C2 (ru) 2015-07-20

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US (2) US20120214804A1 (enExample)
EP (1) EP2493469A4 (enExample)
JP (1) JP5820813B2 (enExample)
KR (1) KR101325272B1 (enExample)
CN (1) CN102596198B (enExample)
AR (1) AR078775A1 (enExample)
BR (1) BR112012009894A2 (enExample)
MX (1) MX338807B (enExample)
RU (1) RU2557243C2 (enExample)
TR (1) TR201204895T1 (enExample)
TW (2) TW201119651A (enExample)
WO (1) WO2011052950A2 (enExample)

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Publication number Priority date Publication date Assignee Title
KR101304772B1 (ko) * 2011-04-11 2013-09-05 인제대학교 산학협력단 NecroX―5를 유효성분으로 포함하는 미토콘드리아 기능 조절용 조성물
WO2013115457A1 (ko) * 2012-01-31 2013-08-08 인제대학교 산학협력단 NecroX를 함유하는 암 전이 억제용 조성물
KR101400346B1 (ko) * 2012-01-31 2014-05-30 인제대학교 산학협력단 NecroX를 함유하는 암 전이 억제용 조성물
KR102006247B1 (ko) * 2014-04-18 2019-08-01 주식회사 엘지화학 지방간 질환의 예방 또는 치료용 조성물
AU2015284409B2 (en) * 2014-06-30 2020-06-25 The Regents Of The University Of California Ketobutyrate compounds and compositions for treating age-related symptoms and diseases
KR101633703B1 (ko) * 2014-12-30 2016-06-27 한국원자력의학원 necro X-5를 유효성분으로 포함하는 방사선 조사에 의한 세포손상 예방 또는 치료용 조성물
CN107434819B (zh) * 2017-02-15 2020-03-17 河北医科大学第二医院 吲哚-tempo缀合物及其在保护远隔器官对抗缺血再灌注损伤中的用途
EP3668837B1 (en) * 2017-08-17 2022-07-06 XWPharma Ltd. Preparation and uses of reactive oxygen species scavenger derivatives
EP3988561B1 (en) 2017-09-04 2023-06-07 XWPharma Ltd. Preparation and use of reactive oxygen species scavenger
CN113692443B (zh) 2018-12-06 2024-08-06 国立癌症中心 包含nc886的用于增强溶瘤病毒活性或用于促进溶瘤病毒生产的组合物
US11795147B2 (en) 2019-08-26 2023-10-24 Boehringer Ingelheim International Gmbh Modulators of complex I
EP4201407A4 (en) 2020-08-19 2024-07-31 MitoImmune Therapeutics Inc. ANTIOXIDANT TARGETING MITOCHONDRIA AS AN AGENT FOR THE TREATMENT OF PATHOLOGICAL INFLAMMATION CAUSED BY MABC-R INFECTION
EP4324830A4 (en) 2021-04-12 2025-04-16 MitoImmune Therapeutics Inc. NEW CRYSTAL FORM OF 5-[(1,1-DIOXIDO-4-THIOMORPHOLINYL)METHYL)-2-PHENYL-N-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-INDOLE-7-AMINE
KR20220141252A (ko) 2021-04-12 2022-10-19 주식회사 미토이뮨테라퓨틱스 5-[(1,1-디옥시도-4-티오몰포리닐)메틸]-2-페닐-n-(테트라하이드로-2h-피란-4-일)-1h-인돌-7-아민 황산염 및 이의 신규 결정형
US20250213583A1 (en) * 2022-03-25 2025-07-03 Mitoimmune Therapeutics Inc. Antiviral pharmaceutical composition and use thereof
DE102023204801A1 (de) * 2023-05-23 2024-11-28 Continental Reifen Deutschland Gmbh Verbindung als Alterungsschutzmittel in Kautschukmischungen und Fahrzeugreifen

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000072815A1 (en) * 1999-05-27 2000-12-07 Neurim Pharmaceuticals (1991) Ltd. Indole derivatives
RU2182908C2 (ru) * 1997-09-05 2002-05-27 Лид Кемикал Ко., Лтд. Стереоизомерные индольные соединения, способ их получения и их использование
WO2003082859A1 (en) * 2002-04-03 2003-10-09 Novartis Ag Indolylmaleimide derivatives
WO2003087086A3 (de) * 2002-04-16 2004-07-22 Merck Patent Gmbh Substituierte indole und deren verwendung als 5ht-wiederaufnahme inhibitoren und als 5ht liganden
WO2009025478A1 (en) * 2007-08-17 2009-02-26 Lg Life Sciences Ltd. Indole and indazole compounds as an inhibitor of cellular necrosis
WO2009088192A2 (ko) * 2008-01-04 2009-07-16 Lg Life Sciences Ltd. 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420429B1 (en) * 1997-12-23 2002-07-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Brain targeted low molecular weight hydrophobic antioxidant compounds
US6900338B1 (en) * 1998-11-25 2005-05-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Scavenger compounds
JP5094394B2 (ja) * 2005-04-20 2012-12-12 武田薬品工業株式会社 縮合複素環化合物
EP1877044A4 (en) * 2005-04-21 2009-09-02 Glenn A Goldstein AMIDE N-ACETYLCYSTEINE (AMIDE NAC) FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH OXIDATIVE STRESS
US20070161609A1 (en) * 2006-01-10 2007-07-12 Charles Buck Use of mitochondrially targeted antioxidant in treatment and prevention of drug-induced liver disease
JP5364103B2 (ja) * 2007-12-20 2013-12-11 エルジー・ライフ・サイエンシーズ・リミテッド グルコキナーゼ活性化剤およびそれを活性成分として含有する医薬組成物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2182908C2 (ru) * 1997-09-05 2002-05-27 Лид Кемикал Ко., Лтд. Стереоизомерные индольные соединения, способ их получения и их использование
WO2000072815A1 (en) * 1999-05-27 2000-12-07 Neurim Pharmaceuticals (1991) Ltd. Indole derivatives
WO2003082859A1 (en) * 2002-04-03 2003-10-09 Novartis Ag Indolylmaleimide derivatives
WO2003087086A3 (de) * 2002-04-16 2004-07-22 Merck Patent Gmbh Substituierte indole und deren verwendung als 5ht-wiederaufnahme inhibitoren und als 5ht liganden
WO2009025478A1 (en) * 2007-08-17 2009-02-26 Lg Life Sciences Ltd. Indole and indazole compounds as an inhibitor of cellular necrosis
WO2009025477A1 (en) * 2007-08-17 2009-02-26 Lg Life Sciences Ltd. Indole compounds as an inhibitor of cellular necrosis
WO2009088192A2 (ko) * 2008-01-04 2009-07-16 Lg Life Sciences Ltd. 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체

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