TR201204895T1 - İndol bileşiği içeren bir farmasötik kompozisyon. - Google Patents
İndol bileşiği içeren bir farmasötik kompozisyon.Info
- Publication number
- TR201204895T1 TR201204895T1 TR2012/04895T TR201204895T TR201204895T1 TR 201204895 T1 TR201204895 T1 TR 201204895T1 TR 2012/04895 T TR2012/04895 T TR 2012/04895T TR 201204895 T TR201204895 T TR 201204895T TR 201204895 T1 TR201204895 T1 TR 201204895T1
- Authority
- TR
- Turkey
- Prior art keywords
- pharmaceutical composition
- indole compound
- compound
- indole
- injury
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title abstract 2
- -1 indole compound Chemical class 0.000 title abstract 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001146 hypoxic effect Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 230000002438 mitochondrial effect Effects 0.000 abstract 1
- 230000017074 necrotic cell death Effects 0.000 abstract 1
- 230000036542 oxidative stress Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract
Mevcut buluş oksidatif stres, mitokondri yetmezliği, hipoksik incinme, nekroz ve/veya iskemik reperfüzyon zedelenmesi ile ilgili hastalıkların önlenmesi veya tedavisine yönelik tarifnamede açıklanan formül (1), (2), veya (3)'e ait bir bileşik içeren farmasötik bir bileşik, ve antioksidan etkisi olan bir indol bileşiği içeren bir kozmetik kompozisyon ile ilgilidir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20090101978 | 2009-10-26 | ||
KR20100098511 | 2010-10-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201204895T1 true TR201204895T1 (tr) | 2013-01-21 |
Family
ID=43922791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2012/04895T TR201204895T1 (tr) | 2009-10-26 | 2010-10-25 | İndol bileşiği içeren bir farmasötik kompozisyon. |
Country Status (12)
Country | Link |
---|---|
US (2) | US20120214804A1 (tr) |
EP (1) | EP2493469A4 (tr) |
JP (1) | JP5820813B2 (tr) |
KR (1) | KR101325272B1 (tr) |
CN (1) | CN102596198B (tr) |
AR (1) | AR078775A1 (tr) |
BR (1) | BR112012009894A2 (tr) |
MX (1) | MX338807B (tr) |
RU (1) | RU2557243C2 (tr) |
TR (1) | TR201204895T1 (tr) |
TW (2) | TWI535440B (tr) |
WO (1) | WO2011052950A2 (tr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101304772B1 (ko) * | 2011-04-11 | 2013-09-05 | 인제대학교 산학협력단 | NecroX―5를 유효성분으로 포함하는 미토콘드리아 기능 조절용 조성물 |
WO2013115457A1 (ko) * | 2012-01-31 | 2013-08-08 | 인제대학교 산학협력단 | NecroX를 함유하는 암 전이 억제용 조성물 |
KR101400346B1 (ko) * | 2012-01-31 | 2014-05-30 | 인제대학교 산학협력단 | NecroX를 함유하는 암 전이 억제용 조성물 |
CN106659722A (zh) * | 2014-04-18 | 2017-05-10 | 株式会社Lg生命科学 | 用于预防或治疗脂肪肝疾病的组合物 |
CA2953387C (en) | 2014-06-30 | 2023-11-28 | The Regents Of The University Of California | Ketobutyrate compounds and compositions for treating age-related symptoms and diseases |
KR101633703B1 (ko) * | 2014-12-30 | 2016-06-27 | 한국원자력의학원 | necro X-5를 유효성분으로 포함하는 방사선 조사에 의한 세포손상 예방 또는 치료용 조성물 |
CN107434819B (zh) * | 2017-02-15 | 2020-03-17 | 河北医科大学第二医院 | 吲哚-tempo缀合物及其在保护远隔器官对抗缺血再灌注损伤中的用途 |
CN111278807B (zh) | 2017-08-17 | 2022-07-22 | 凯瑞康宁生物工程(武汉)有限公司 | 活性氧清除剂衍生物的制备及用途 |
CN115475229A (zh) | 2017-09-04 | 2022-12-16 | 凯瑞康宁生物工程(武汉)有限公司 | 活性氧清除剂的制备及用途 |
US11795147B2 (en) | 2019-08-26 | 2023-10-24 | Boehringer Ingelheim International Gmbh | Modulators of complex I |
WO2022039506A1 (ko) | 2020-08-19 | 2022-02-24 | 주식회사 미토이뮨테라퓨틱스 | Mabc-r 감염에 의한 병적 염증 치료제로서의 미토콘드리아 표적 항산화제 |
JP2024515630A (ja) | 2021-04-12 | 2024-04-10 | ミトイミューン・セラピューティクス・インコーポレイテッド | 5-[(1,1-ジオキシド-4-チオモルホリニル)メチル]-2-フェニル-n-(テトラヒドロ-2h-ピラン-4-イル)-1h-インドール-7-アミンの新規結晶形 |
EP4324829A1 (en) | 2021-04-12 | 2024-02-21 | MitoImmune Therapeutics Inc. | Sulfate of 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-n-(tetrahydro-2h-pyran-4-yl)-1h-indole-7-amine, and novel crystal form thereof |
WO2023182840A1 (ko) * | 2022-03-25 | 2023-09-28 | 주식회사 미토이뮨테라퓨틱스 | 항바이러스용 약학적 조성물 및 이의 용도 |
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US6420429B1 (en) * | 1997-12-23 | 2002-07-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Brain targeted low molecular weight hydrophobic antioxidant compounds |
CA2302402C (en) * | 1997-09-05 | 2008-12-02 | Lead Chemical Co., Ltd. | Stereoisomeric indole compounds, process for the preparation of the same, and use thereof |
CA2352144A1 (en) * | 1998-11-25 | 2000-06-02 | Yissum Research Development Company Of The Hebrew University In Jerusale M | Scavenger compounds |
IL130169A (en) * | 1999-05-27 | 2006-08-20 | Neurim Pharma 1991 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
TW200918046A (en) * | 2002-04-03 | 2009-05-01 | Novartis Ag | Indolylmaleimide derivatives |
DE10217006A1 (de) * | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
JP5094394B2 (ja) * | 2005-04-20 | 2012-12-12 | 武田薬品工業株式会社 | 縮合複素環化合物 |
RU2007143040A (ru) * | 2005-04-21 | 2009-05-27 | Гленн А. ГОЛДШТЕЙН (US) | Амид n-ацетилцистеина (амид nac) в лечении заболеваний и состояний, связанных с окислительным стрессом |
US20070161609A1 (en) * | 2006-01-10 | 2007-07-12 | Charles Buck | Use of mitochondrially targeted antioxidant in treatment and prevention of drug-induced liver disease |
DK2178870T3 (en) * | 2007-08-17 | 2018-10-22 | Lg Chemical Ltd | INDOLE AND INDAZOLIC COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSE |
WO2009082152A2 (en) * | 2007-12-20 | 2009-07-02 | Lg Life Sciences Ltd. | Glucokinase activators and pharmaceutical compositions containing the same as an active ingredient |
CN101952281B (zh) | 2008-01-04 | 2014-04-02 | 株式会社Lg生命科学 | 具有细胞、组织及器官保存效果的吲哚及吲唑衍生物 |
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- 2010-10-22 TW TW099136045A patent/TW201119651A/zh unknown
- 2010-10-25 KR KR1020100104175A patent/KR101325272B1/ko active IP Right Grant
- 2010-10-25 US US13/503,857 patent/US20120214804A1/en not_active Abandoned
- 2010-10-25 CN CN201080048324.2A patent/CN102596198B/zh active Active
- 2010-10-25 TR TR2012/04895T patent/TR201204895T1/tr unknown
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- 2010-10-25 MX MX2012004504A patent/MX338807B/es active IP Right Grant
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CN102596198B (zh) | 2016-01-27 |
AR078775A1 (es) | 2011-11-30 |
JP2013508452A (ja) | 2013-03-07 |
MX2012004504A (es) | 2012-09-07 |
TWI535440B (zh) | 2016-06-01 |
TW201119651A (en) | 2011-06-16 |
CN102596198A (zh) | 2012-07-18 |
US10322135B2 (en) | 2019-06-18 |
RU2557243C2 (ru) | 2015-07-20 |
RU2012121815A (ru) | 2013-12-10 |
KR101325272B1 (ko) | 2013-11-05 |
MX338807B (es) | 2016-05-02 |
US20170165272A1 (en) | 2017-06-15 |
JP5820813B2 (ja) | 2015-11-24 |
US20120214804A1 (en) | 2012-08-23 |
BR112012009894A2 (pt) | 2016-11-29 |
EP2493469A4 (en) | 2013-05-29 |
WO2011052950A3 (en) | 2011-11-24 |
EP2493469A2 (en) | 2012-09-05 |
KR20110046321A (ko) | 2011-05-04 |
TW201414473A (zh) | 2014-04-16 |
WO2011052950A2 (en) | 2011-05-05 |
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