JP5815237B2 - 核内受容体結合剤 - Google Patents
核内受容体結合剤 Download PDFInfo
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- JP5815237B2 JP5815237B2 JP2010504079A JP2010504079A JP5815237B2 JP 5815237 B2 JP5815237 B2 JP 5815237B2 JP 2010504079 A JP2010504079 A JP 2010504079A JP 2010504079 A JP2010504079 A JP 2010504079A JP 5815237 B2 JP5815237 B2 JP 5815237B2
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Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2824517A1 (en) * | 2005-11-28 | 2007-05-31 | Gtx, Inc. | Nuclear receptor binding agents |
| US8637706B2 (en) | 2005-11-28 | 2014-01-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9409856B2 (en) | 2005-11-28 | 2016-08-09 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| US8546451B2 (en) * | 2005-11-28 | 2013-10-01 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| SI3345607T1 (sl) * | 2006-12-29 | 2023-03-31 | Ossifi-Mab Llc | Postopki spreminjanja rasti kosti z dajanjem antagonista ali agonista SOST ali WISE |
| US20090130232A1 (en) * | 2007-11-20 | 2009-05-21 | Mohammed Zahra | Composition and method for treatment of oral inflammation an ulceration |
| WO2009076548A1 (en) * | 2007-12-13 | 2009-06-18 | Cytori Therapeutics, Inc. | Methods of inhibiting tumor development using adipose-derived regenerative cells |
| US8871751B2 (en) * | 2008-01-18 | 2014-10-28 | The Board Of Trustees Of The University Of Illinois | Compositions and methods relating to nuclear hormone and steroid hormone receptors including inhibitors of estrogen receptor alpha-mediated gene expression and inhibition of breast cancer |
| US20100130457A1 (en) * | 2008-11-14 | 2010-05-27 | Immune Control, Inc. | Phenothiazine Derivatives for Treatment of Asthma |
| US8870876B2 (en) | 2009-02-13 | 2014-10-28 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| US20140057946A1 (en) * | 2012-08-23 | 2014-02-27 | Gtx | Estrogen receptor ligands and methods of use thereof |
| WO2010096801A1 (en) * | 2009-02-23 | 2010-08-26 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| US9427418B2 (en) | 2009-02-23 | 2016-08-30 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| WO2013043304A1 (en) * | 2009-02-23 | 2013-03-28 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| US9624161B2 (en) | 2009-02-23 | 2017-04-18 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| US8277459B2 (en) | 2009-09-25 | 2012-10-02 | Tarsus Medical Inc. | Methods and devices for treating a structural bone and joint deformity |
| US10640457B2 (en) | 2009-12-10 | 2020-05-05 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase activators and uses thereof |
| EP2509590B1 (en) * | 2009-12-10 | 2019-10-30 | The Trustees of Columbia University in the City of New York | Histone acetyltransferase activators and uses thereof |
| US8652141B2 (en) | 2010-01-21 | 2014-02-18 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| US8696719B2 (en) | 2010-06-03 | 2014-04-15 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| US9969677B2 (en) | 2010-12-22 | 2018-05-15 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase modulators and uses thereof |
| CN107095864A (zh) | 2011-06-10 | 2017-08-29 | 纽约市哥伦比亚大学理事会 | 组蛋白乙酰转移酶激活剂的用途 |
| MX2014002105A (es) * | 2011-08-23 | 2014-09-25 | Gtx Inc | Ligandos de receptor de estrogeno y metodos de uso de los mismos. |
| JP6239522B2 (ja) * | 2011-11-01 | 2017-11-29 | メルク パテント ゲーエムベーハー | 有機エレクトロルミネッセンス素子 |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US12685719B2 (en) | 2012-07-13 | 2026-07-21 | University Of Tennessee Research Foundation | Treatment of breast cancer with selective androgen receptor modulators and cyclin-dependent kinase 4/6 inhibitors |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| EP3733170A1 (en) | 2012-07-13 | 2020-11-04 | Oncternal Therapeutics, Inc. | A method of treating androgen receptor (ar) -positive breast cancers with selective androgen receptor modulator (sarms) |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| HK1212448A1 (en) | 2012-09-07 | 2016-06-10 | The Governors Of The University Of Alberta | Methods and compositions for diagnosis of inflammatory liver disease |
| EP2994133A4 (en) | 2013-05-08 | 2016-11-16 | Univ Howard | COMPOSITIONS AND METHOD FOR TREATING NEURONAL ISCHEMIC REPERFUSION DAMAGE |
| ES2828305T3 (es) * | 2014-07-24 | 2021-05-26 | Aspen Park Pharmaceuticals Inc | Tratamiento de sofocos y pérdida ósea inducidos por tratamiento de privación de andrógenos utilizando cis-clomifeno |
| US20220054429A1 (en) * | 2015-10-27 | 2022-02-24 | Jay Pharma, Inc. | Compositions comprising cannabidiol and second therapeutic agents for the treatment of cancer |
| WO2018208633A1 (en) * | 2017-05-07 | 2018-11-15 | China Medical University | Methods and compositions for treating withdrawal syndrome |
| US12383547B2 (en) | 2020-07-01 | 2025-08-12 | Vanderbilt University | Methods of treatment for a kidney disease |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE269213C (enExample) | ||||
| US3413339A (en) * | 1964-06-18 | 1968-11-26 | Parke Davis & Co | Amine compounds and methods for their production |
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| US3960886A (en) * | 1968-07-03 | 1976-06-01 | Sterling Drug Inc. | Substituted N-arylanilines |
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| US3838131A (en) * | 1972-04-03 | 1974-09-24 | Pfizer | Di(dialkylamino alkoxy)phenanthridines as antiviral agents |
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| ES2190788T3 (es) * | 1994-09-16 | 2003-08-16 | Harvard College | Utilizacion de halogenuros aromaticos para tratar la proliferacion de celulas mamarias. |
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| JPH1171332A (ja) * | 1997-06-17 | 1999-03-16 | Sumitomo Chem Co Ltd | トリフェニルメタン誘導体およびその用途 |
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| JP4320089B2 (ja) * | 1999-07-06 | 2009-08-26 | あすか製薬株式会社 | フェニルスルファメート誘導体 |
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| US7601739B2 (en) * | 2003-08-08 | 2009-10-13 | Virgina Commonwealth University | Compounds having antiestrogenic and tissue selective estrogenic properties, and compounds with anti-androgenic properties for treatment of prostate cancer and androgen receptor dependent diseases |
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Cited By (1)
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|---|---|---|---|---|
| JP2014166996A (ja) * | 2007-04-16 | 2014-09-11 | Gtx Inc | 核内受容体結合剤 |
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| US20070265296A1 (en) | 2007-11-15 |
| JP2014166996A (ja) | 2014-09-11 |
| JP5913400B2 (ja) | 2016-04-27 |
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| US8158828B2 (en) | 2012-04-17 |
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| KR101519456B1 (ko) | 2015-05-15 |
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