JP5805774B2 - シクロスポリンアナログ - Google Patents

シクロスポリンアナログ Download PDF

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Publication number
JP5805774B2
JP5805774B2 JP2013533942A JP2013533942A JP5805774B2 JP 5805774 B2 JP5805774 B2 JP 5805774B2 JP 2013533942 A JP2013533942 A JP 2013533942A JP 2013533942 A JP2013533942 A JP 2013533942A JP 5805774 B2 JP5805774 B2 JP 5805774B2
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JP
Japan
Prior art keywords
cyclosporin
sar
amide
ethyl
thiomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2013533942A
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English (en)
Japanese (ja)
Other versions
JP2013540776A5 (enExample
JP2013540776A (ja
Inventor
ウィリアム・ロバート・カーリング
カトリーヌ・シモン・ヴィクトリレ・フリードリヒ
マイケル・イー・ガースト
マイケル・イー・スターン
クリストファー・エス・ショームバーグ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of JP2013540776A publication Critical patent/JP2013540776A/ja
Publication of JP2013540776A5 publication Critical patent/JP2013540776A5/ja
Application granted granted Critical
Publication of JP5805774B2 publication Critical patent/JP5805774B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2013533942A 2010-10-12 2011-10-11 シクロスポリンアナログ Expired - Fee Related JP5805774B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39244910P 2010-10-12 2010-10-12
US61/392,449 2010-10-12
PCT/US2011/055791 WO2012051194A1 (en) 2010-10-12 2011-10-11 Cyclosporin analogs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015173082A Division JP6250608B2 (ja) 2010-10-12 2015-09-02 シクロスポリンアナログ

Publications (3)

Publication Number Publication Date
JP2013540776A JP2013540776A (ja) 2013-11-07
JP2013540776A5 JP2013540776A5 (enExample) 2013-12-26
JP5805774B2 true JP5805774B2 (ja) 2015-11-10

Family

ID=44883784

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013533942A Expired - Fee Related JP5805774B2 (ja) 2010-10-12 2011-10-11 シクロスポリンアナログ
JP2015173082A Expired - Fee Related JP6250608B2 (ja) 2010-10-12 2015-09-02 シクロスポリンアナログ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015173082A Expired - Fee Related JP6250608B2 (ja) 2010-10-12 2015-09-02 シクロスポリンアナログ

Country Status (13)

Country Link
US (3) US20120088734A1 (enExample)
EP (1) EP2627664B1 (enExample)
JP (2) JP5805774B2 (enExample)
KR (1) KR20140026329A (enExample)
CN (1) CN103328497A (enExample)
AU (1) AU2011316690C1 (enExample)
BR (1) BR112013008864A2 (enExample)
CA (1) CA2814192A1 (enExample)
IL (1) IL225617A0 (enExample)
MX (1) MX2013004061A (enExample)
RU (1) RU2013119869A (enExample)
SG (1) SG189880A1 (enExample)
WO (1) WO2012051194A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016029050A (ja) * 2010-10-12 2016-03-03 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンアナログ

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9573978B2 (en) 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
CA2814191A1 (en) 2010-10-12 2012-04-19 Allergan, Inc. Cyclosporin analogs
US9890198B2 (en) * 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
BR112013014890B1 (pt) * 2010-12-15 2023-10-24 Contravir Pharmaceuticals, Inc Composto análogo de moléculas pertencentes à família ciclosporina, composição farmacêutica compreendendo o mesmo, uso terapêutico ou profilático do referido composto e processos para a preparação dos mesmos
JP2015519368A (ja) * 2012-06-01 2015-07-09 アラーガン インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａ類似体
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
BR112015021388A2 (pt) 2013-03-08 2017-07-18 Allergan Inc conjugados esteroides de ciclosporina a
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
EP3277704A1 (en) 2015-03-31 2018-02-07 Allergan, Inc. Cyclosporins modified on the mebmt sidechain by heterocyclic rings
CN118324867A (zh) 2016-05-17 2024-07-12 美国科技环球有限公司 新型环孢菌素衍生物及其用途
WO2018106945A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
JP2020513280A (ja) 2016-12-14 2020-05-14 プロジェニティ， インコーポレイテッド 消化管疾病の免疫抑制剤による治療
WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
WO2021173474A1 (en) * 2020-02-26 2021-09-02 Bacainn Biotherapeutics, Ltd. Cyclosporine compositions and methods of use
CN113173974B (zh) * 2021-03-18 2024-09-06 北京大学深圳研究生院 环孢素衍生物的合成方法
EP4724081A2 (en) * 2023-06-08 2026-04-15 Hepion Pharmaceuticals, Inc. Solid state forms of rencofilstat
CN118834148B (zh) * 2024-09-20 2025-01-21 天津凯莱英制药有限公司 一种l-青霉胺的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (en) 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US4839342A (en) 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
FR2757522B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757521B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2762843B1 (fr) 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
CN1205220C (zh) * 1998-06-12 2005-06-08 斯－凯穆公司 新颖的环孢菌素
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
US20050059583A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7676680B2 (en) 2005-07-08 2010-03-09 Morgan Stanley Systems and methods for distributing private placement documents
US7288520B2 (en) 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
EP2023918B1 (en) 2006-05-19 2011-03-23 Scynexis, Inc. Cyclosporins for the treatment and prevention of ocular disorders
CN101130058B (zh) * 2006-08-23 2011-10-05 华北制药集团新药研究开发有限责任公司 一种环孢菌素a眼用乳剂及其制备方法
RU2009144186A (ru) * 2007-05-04 2011-06-10 Аллерган, Инк. (Us) Применение циклоспоринов при лечении пациентов с интраокулярными линзами
JP5661035B2 (ja) * 2008-07-10 2015-01-28 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 眼および皮膚の疾患および症状の治療用のシクロスポリン誘導体
EA029301B1 (ru) * 2010-07-02 2018-03-30 Эксонмобил Апстрим Рисерч Компани Интегрированные системы для получения со(варианты) и способ производства электроэнергии
WO2012005494A2 (ko) 2010-07-06 2012-01-12 엘지전자 주식회사 무선 통신 시스템에서 머신형 통신 장치를 위한 무선 자원 할당 방법 및 장치
JP5805774B2 (ja) * 2010-10-12 2015-11-10 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンアナログ
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
ES2625502T3 (es) * 2010-12-03 2017-07-19 S&T Global Inc Nuevos derivados de ciclosporina para el tratamiento y prevención de una infección vírica
WO2013028615A2 (en) * 2011-08-19 2013-02-28 S&T Golbal Inc. Novel cyclosporin derivatives for the treatment and prevention of viral infections

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016029050A (ja) * 2010-10-12 2016-03-03 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンアナログ

Also Published As

Publication number Publication date
AU2011316690A1 (en) 2013-05-02
US9493511B2 (en) 2016-11-15
EP2627664A1 (en) 2013-08-21
WO2012051194A1 (en) 2012-04-19
SG189880A1 (en) 2013-06-28
AU2011316690C1 (en) 2017-01-19
RU2013119869A (ru) 2014-11-20
CN103328497A (zh) 2013-09-25
US20150065433A1 (en) 2015-03-05
JP2016029050A (ja) 2016-03-03
JP6250608B2 (ja) 2017-12-20
BR112013008864A2 (pt) 2016-06-28
CA2814192A1 (en) 2012-04-19
EP2627664B1 (en) 2018-04-04
IL225617A0 (en) 2013-06-27
US20170029469A1 (en) 2017-02-02
US20120088734A1 (en) 2012-04-12
JP2013540776A (ja) 2013-11-07
US10065992B2 (en) 2018-09-04
MX2013004061A (es) 2013-07-22
KR20140026329A (ko) 2014-03-05
AU2011316690B2 (en) 2016-07-07

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