JP5805774B2 - シクロスポリンアナログ - Google Patents

シクロスポリンアナログ Download PDF

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Publication number
JP5805774B2
JP5805774B2 JP2013533942A JP2013533942A JP5805774B2 JP 5805774 B2 JP5805774 B2 JP 5805774B2 JP 2013533942 A JP2013533942 A JP 2013533942A JP 2013533942 A JP2013533942 A JP 2013533942A JP 5805774 B2 JP5805774 B2 JP 5805774B2
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JP
Japan
Prior art keywords
cyclosporin
sar
amide
ethyl
thiomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2013533942A
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English (en)
Japanese (ja)
Other versions
JP2013540776A5 (enExample
JP2013540776A (ja
Inventor
ウィリアム・ロバート・カーリング
カトリーヌ・シモン・ヴィクトリレ・フリードリヒ
マイケル・イー・ガースト
マイケル・イー・スターン
クリストファー・エス・ショームバーグ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of JP2013540776A publication Critical patent/JP2013540776A/ja
Publication of JP2013540776A5 publication Critical patent/JP2013540776A5/ja
Application granted granted Critical
Publication of JP5805774B2 publication Critical patent/JP5805774B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Analytical Chemistry (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2013533942A 2010-10-12 2011-10-11 シクロスポリンアナログ Expired - Fee Related JP5805774B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39244910P 2010-10-12 2010-10-12
US61/392,449 2010-10-12
PCT/US2011/055791 WO2012051194A1 (en) 2010-10-12 2011-10-11 Cyclosporin analogs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015173082A Division JP6250608B2 (ja) 2010-10-12 2015-09-02 シクロスポリンアナログ

Publications (3)

Publication Number Publication Date
JP2013540776A JP2013540776A (ja) 2013-11-07
JP2013540776A5 JP2013540776A5 (enExample) 2013-12-26
JP5805774B2 true JP5805774B2 (ja) 2015-11-10

Family

ID=44883784

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013533942A Expired - Fee Related JP5805774B2 (ja) 2010-10-12 2011-10-11 シクロスポリンアナログ
JP2015173082A Expired - Fee Related JP6250608B2 (ja) 2010-10-12 2015-09-02 シクロスポリンアナログ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015173082A Expired - Fee Related JP6250608B2 (ja) 2010-10-12 2015-09-02 シクロスポリンアナログ

Country Status (13)

Country Link
US (3) US20120088734A1 (enExample)
EP (1) EP2627664B1 (enExample)
JP (2) JP5805774B2 (enExample)
KR (1) KR20140026329A (enExample)
CN (1) CN103328497A (enExample)
AU (1) AU2011316690C1 (enExample)
BR (1) BR112013008864A2 (enExample)
CA (1) CA2814192A1 (enExample)
IL (1) IL225617A0 (enExample)
MX (1) MX2013004061A (enExample)
RU (1) RU2013119869A (enExample)
SG (1) SG189880A1 (enExample)
WO (1) WO2012051194A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016029050A (ja) * 2010-10-12 2016-03-03 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンアナログ

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103153330B (zh) 2010-08-12 2017-08-18 美国科技环球有限公司 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用
EP2627663B1 (en) 2010-10-12 2018-02-21 Allergan, Inc. Cyclosporin analogs
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
AU2011342284C1 (en) * 2010-12-15 2017-07-13 Contravir Pharmaceuticals, Inc. Cyclosporine analogue molecules modified at amino acid 1 and 3
WO2013181339A2 (en) * 2012-06-01 2013-12-05 Allergan, Inc. Cyclosporin a analogs
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
WO2014138359A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Steroid antibiotic conjugates
TW201639873A (zh) 2015-01-08 2016-11-16 歐樂根公司 Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物
EP3277704A1 (en) 2015-03-31 2018-02-07 Allergan, Inc. Cyclosporins modified on the mebmt sidechain by heterocyclic rings
AU2017267560B2 (en) 2016-05-17 2022-03-24 S&T Global Inc. Novel cyclosporin derivatives and uses thereof
CA3045944A1 (en) 2016-12-07 2018-06-14 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
US11523772B2 (en) 2016-12-14 2022-12-13 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
US20230041197A1 (en) 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
WO2021173474A1 (en) * 2020-02-26 2021-09-02 Bacainn Biotherapeutics, Ltd. Cyclosporine compositions and methods of use
CN113173974B (zh) 2021-03-18 2024-09-06 北京大学深圳研究生院 环孢素衍生物的合成方法
AU2024285817A1 (en) * 2023-06-08 2026-01-08 Hepion Pharmaceuticals, Inc. Solid state forms of rencofilstat
CN118834148B (zh) * 2024-09-20 2025-01-21 天津凯莱英制药有限公司 一种l-青霉胺的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (en) 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US4839342A (en) 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
FR2757521B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757522B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2762843B1 (fr) 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
ATE254630T1 (de) * 1998-06-12 2003-12-15 Chem Ag C Cyclosporine
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
US20050059583A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7676680B2 (en) 2005-07-08 2010-03-09 Morgan Stanley Systems and methods for distributing private placement documents
US7288520B2 (en) 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
CA2652662C (en) * 2006-05-19 2015-11-03 Scynexis, Inc. Methods for the treatment and prevention of ocular disorders
CN101130058B (zh) * 2006-08-23 2011-10-05 华北制药集团新药研究开发有限责任公司 一种环孢菌素a眼用乳剂及其制备方法
CN101687013A (zh) * 2007-05-04 2010-03-31 阿勒根公司 环孢菌素在治疗具有人工晶状体的患者中的用途
US8716238B2 (en) * 2008-07-10 2014-05-06 Allergan, Inc. Cyclosporin derivatives for treating ocular and dermal diseases and conditions
US9903271B2 (en) * 2010-07-02 2018-02-27 Exxonmobil Upstream Research Company Low emission triple-cycle power generation and CO2 separation systems and methods
US8902844B2 (en) 2010-07-06 2014-12-02 Lg Electronics Inc. Method and device for allocating wireless resources for a machine type communication device in a wireless communication system
AU2011316690C1 (en) * 2010-10-12 2017-01-19 Allergan, Inc. Cyclosporin analogs
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
MX350746B (es) * 2010-12-03 2017-09-14 Hebei Kunxiangjishi Pharmaceutical Tech Co Ltd Derivados de ciclosporina novedosos para el tratamiento y la prevención de una infección viral.
CN103987399A (zh) * 2011-08-19 2014-08-13 美国科技环球有限公司 用于治疗和预防病毒感染的新型环孢菌素衍生物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016029050A (ja) * 2010-10-12 2016-03-03 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンアナログ

Also Published As

Publication number Publication date
WO2012051194A1 (en) 2012-04-19
US9493511B2 (en) 2016-11-15
JP6250608B2 (ja) 2017-12-20
US20170029469A1 (en) 2017-02-02
IL225617A0 (en) 2013-06-27
SG189880A1 (en) 2013-06-28
CA2814192A1 (en) 2012-04-19
US10065992B2 (en) 2018-09-04
US20120088734A1 (en) 2012-04-12
AU2011316690C1 (en) 2017-01-19
MX2013004061A (es) 2013-07-22
EP2627664B1 (en) 2018-04-04
KR20140026329A (ko) 2014-03-05
EP2627664A1 (en) 2013-08-21
AU2011316690B2 (en) 2016-07-07
JP2016029050A (ja) 2016-03-03
RU2013119869A (ru) 2014-11-20
US20150065433A1 (en) 2015-03-05
CN103328497A (zh) 2013-09-25
AU2011316690A1 (en) 2013-05-02
JP2013540776A (ja) 2013-11-07
BR112013008864A2 (pt) 2016-06-28

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