SG189880A1 - Cyclosporin analogs - Google Patents
Cyclosporin analogs Download PDFInfo
- Publication number
- SG189880A1 SG189880A1 SG2013027339A SG2013027339A SG189880A1 SG 189880 A1 SG189880 A1 SG 189880A1 SG 2013027339 A SG2013027339 A SG 2013027339A SG 2013027339 A SG2013027339 A SG 2013027339A SG 189880 A1 SG189880 A1 SG 189880A1
- Authority
- SG
- Singapore
- Prior art keywords
- sar
- cyclosporin
- amide
- chr
- ethyl
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- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims abstract description 114
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- C07K7/645—Cyclosporins; Related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39244910P | 2010-10-12 | 2010-10-12 | |
| PCT/US2011/055791 WO2012051194A1 (en) | 2010-10-12 | 2011-10-11 | Cyclosporin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG189880A1 true SG189880A1 (en) | 2013-06-28 |
Family
ID=44883784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013027339A SG189880A1 (en) | 2010-10-12 | 2011-10-11 | Cyclosporin analogs |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20120088734A1 (enExample) |
| EP (1) | EP2627664B1 (enExample) |
| JP (2) | JP5805774B2 (enExample) |
| KR (1) | KR20140026329A (enExample) |
| CN (1) | CN103328497A (enExample) |
| AU (1) | AU2011316690C1 (enExample) |
| BR (1) | BR112013008864A2 (enExample) |
| CA (1) | CA2814192A1 (enExample) |
| IL (1) | IL225617A0 (enExample) |
| MX (1) | MX2013004061A (enExample) |
| RU (1) | RU2013119869A (enExample) |
| SG (1) | SG189880A1 (enExample) |
| WO (1) | WO2012051194A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012021796A2 (en) | 2010-08-12 | 2012-02-16 | S&T Global, Inc. | Novel cyclosporin derivatives for the treatment and prevention of a viral infection |
| BR112013008864A2 (pt) * | 2010-10-12 | 2016-06-28 | Allergan Inc | análogos d ciclosporina |
| US9175042B2 (en) | 2010-10-12 | 2015-11-03 | Allergan, Inc. | Cyclosporin analogs |
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| PL2651965T3 (pl) * | 2010-12-15 | 2019-04-30 | Contravir Pharmaceuticals Inc | Cząsteczki analogów cyklosporyny modyfikowane w aminokwasach 1 i 3 |
| AU2013267435B2 (en) | 2012-06-01 | 2017-11-09 | Allergan, Inc. | Cyclosporin A analogs |
| GB201222455D0 (en) * | 2012-12-13 | 2013-01-30 | Perioc Ltd | Novel pharmaceutical formulations and their use in the treatment of periodontaldisease |
| WO2014138437A1 (en) | 2013-03-08 | 2014-09-12 | Allergan, Inc. | Steroid conjugates |
| WO2016112321A1 (en) | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Cyclosporin derivatives wherein the mebmt sidechain has been cyclized |
| WO2016160362A1 (en) | 2015-03-31 | 2016-10-06 | Allergan, Inc. | Cyclosporins modified on the mebmt sidechain by heterocyclic rings |
| CN118324867A (zh) * | 2016-05-17 | 2024-07-12 | 美国科技环球有限公司 | 新型环孢菌素衍生物及其用途 |
| EP3551047A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3046023A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunosuppressant |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| WO2021173474A1 (en) * | 2020-02-26 | 2021-09-02 | Bacainn Biotherapeutics, Ltd. | Cyclosporine compositions and methods of use |
| CN113173974B (zh) | 2021-03-18 | 2024-09-06 | 北京大学深圳研究生院 | 环孢素衍生物的合成方法 |
| WO2024254480A2 (en) * | 2023-06-08 | 2024-12-12 | Hepion Pharmaceuticals, Inc. | Solid state forms of rencofilstat |
| CN118834148B (zh) * | 2024-09-20 | 2025-01-21 | 天津凯莱英制药有限公司 | 一种l-青霉胺的制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0194972B1 (en) | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
| US4649047A (en) * | 1985-03-19 | 1987-03-10 | University Of Georgia Research Foundation, Inc. | Ophthalmic treatment by topical administration of cyclosporin |
| US4839342A (en) | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
| US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| FR2757521B1 (fr) | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2757522B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2762843B1 (fr) | 1997-04-30 | 1999-12-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| CA2334730C (en) * | 1998-06-12 | 2009-09-29 | C-Chem Ag | Novel cyclosporins |
| US6254860B1 (en) * | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
| US20050059583A1 (en) * | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| US7676680B2 (en) | 2005-07-08 | 2010-03-09 | Morgan Stanley | Systems and methods for distributing private placement documents |
| US7288520B2 (en) | 2005-07-13 | 2007-10-30 | Allergan, Inc. | Cyclosporin compositions |
| CA2652662C (en) | 2006-05-19 | 2015-11-03 | Scynexis, Inc. | Methods for the treatment and prevention of ocular disorders |
| CN101130058B (zh) * | 2006-08-23 | 2011-10-05 | 华北制药集团新药研究开发有限责任公司 | 一种环孢菌素a眼用乳剂及其制备方法 |
| BRPI0811538A2 (pt) * | 2007-05-04 | 2015-08-11 | Allergan Inc | Uso de ciclosporinas no tratamento de pacientes com lentes intraoculares. |
| JP5661035B2 (ja) * | 2008-07-10 | 2015-01-28 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 眼および皮膚の疾患および症状の治療用のシクロスポリン誘導体 |
| AU2011271633B2 (en) * | 2010-07-02 | 2015-06-11 | Exxonmobil Upstream Research Company | Low emission triple-cycle power generation systems and methods |
| US8902844B2 (en) | 2010-07-06 | 2014-12-02 | Lg Electronics Inc. | Method and device for allocating wireless resources for a machine type communication device in a wireless communication system |
| BR112013008864A2 (pt) * | 2010-10-12 | 2016-06-28 | Allergan Inc | análogos d ciclosporina |
| AU2011336266B2 (en) * | 2010-12-03 | 2017-04-06 | S&T Global Inc. | Novel cyclosporin derivatives for the treatment and prevention of a viral infection |
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| HK1201181A1 (en) * | 2011-08-19 | 2015-08-28 | 美国科技环球有限公司 | Novel cyclosporin derivatives for the treatment and prevention of viral infections |
-
2011
- 2011-10-11 BR BR112013008864A patent/BR112013008864A2/pt not_active Application Discontinuation
- 2011-10-11 RU RU2013119869/04A patent/RU2013119869A/ru not_active Application Discontinuation
- 2011-10-11 US US13/270,964 patent/US20120088734A1/en not_active Abandoned
- 2011-10-11 JP JP2013533942A patent/JP5805774B2/ja not_active Expired - Fee Related
- 2011-10-11 CA CA2814192A patent/CA2814192A1/en not_active Abandoned
- 2011-10-11 KR KR1020137012145A patent/KR20140026329A/ko not_active Withdrawn
- 2011-10-11 AU AU2011316690A patent/AU2011316690C1/en not_active Ceased
- 2011-10-11 WO PCT/US2011/055791 patent/WO2012051194A1/en not_active Ceased
- 2011-10-11 SG SG2013027339A patent/SG189880A1/en unknown
- 2011-10-11 EP EP11770985.7A patent/EP2627664B1/en not_active Not-in-force
- 2011-10-11 CN CN2011800596461A patent/CN103328497A/zh active Pending
- 2011-10-11 MX MX2013004061A patent/MX2013004061A/es unknown
-
2013
- 2013-04-07 IL IL225617A patent/IL225617A0/en unknown
-
2014
- 2014-11-06 US US14/534,677 patent/US9493511B2/en active Active
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2015
- 2015-09-02 JP JP2015173082A patent/JP6250608B2/ja not_active Expired - Fee Related
-
2016
- 2016-10-11 US US15/290,171 patent/US10065992B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL225617A0 (en) | 2013-06-27 |
| AU2011316690C1 (en) | 2017-01-19 |
| CA2814192A1 (en) | 2012-04-19 |
| US20170029469A1 (en) | 2017-02-02 |
| EP2627664A1 (en) | 2013-08-21 |
| WO2012051194A1 (en) | 2012-04-19 |
| JP6250608B2 (ja) | 2017-12-20 |
| EP2627664B1 (en) | 2018-04-04 |
| AU2011316690A1 (en) | 2013-05-02 |
| KR20140026329A (ko) | 2014-03-05 |
| US20120088734A1 (en) | 2012-04-12 |
| JP2013540776A (ja) | 2013-11-07 |
| US9493511B2 (en) | 2016-11-15 |
| JP2016029050A (ja) | 2016-03-03 |
| JP5805774B2 (ja) | 2015-11-10 |
| BR112013008864A2 (pt) | 2016-06-28 |
| US20150065433A1 (en) | 2015-03-05 |
| US10065992B2 (en) | 2018-09-04 |
| MX2013004061A (es) | 2013-07-22 |
| RU2013119869A (ru) | 2014-11-20 |
| AU2011316690B2 (en) | 2016-07-07 |
| CN103328497A (zh) | 2013-09-25 |
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