KR20140026329A - 사이클로스포린 유사체 - Google Patents
사이클로스포린 유사체 Download PDFInfo
- Publication number
- KR20140026329A KR20140026329A KR1020137012145A KR20137012145A KR20140026329A KR 20140026329 A KR20140026329 A KR 20140026329A KR 1020137012145 A KR1020137012145 A KR 1020137012145A KR 20137012145 A KR20137012145 A KR 20137012145A KR 20140026329 A KR20140026329 A KR 20140026329A
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- KR
- South Korea
- Prior art keywords
- sar
- cyclosporin
- compound
- amide
- chr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims abstract description 133
- 108010036949 Cyclosporine Proteins 0.000 claims abstract description 129
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Analytical Chemistry (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39244910P | 2010-10-12 | 2010-10-12 | |
| US61/392,449 | 2010-10-12 | ||
| PCT/US2011/055791 WO2012051194A1 (en) | 2010-10-12 | 2011-10-11 | Cyclosporin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20140026329A true KR20140026329A (ko) | 2014-03-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137012145A Withdrawn KR20140026329A (ko) | 2010-10-12 | 2011-10-11 | 사이클로스포린 유사체 |
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| Country | Link |
|---|---|
| US (3) | US20120088734A1 (enExample) |
| EP (1) | EP2627664B1 (enExample) |
| JP (2) | JP5805774B2 (enExample) |
| KR (1) | KR20140026329A (enExample) |
| CN (1) | CN103328497A (enExample) |
| AU (1) | AU2011316690C1 (enExample) |
| BR (1) | BR112013008864A2 (enExample) |
| CA (1) | CA2814192A1 (enExample) |
| IL (1) | IL225617A0 (enExample) |
| MX (1) | MX2013004061A (enExample) |
| RU (1) | RU2013119869A (enExample) |
| SG (1) | SG189880A1 (enExample) |
| WO (1) | WO2012051194A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103153330B (zh) | 2010-08-12 | 2017-08-18 | 美国科技环球有限公司 | 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用 |
| EP2627663B1 (en) | 2010-10-12 | 2018-02-21 | Allergan, Inc. | Cyclosporin analogs |
| AU2011316690C1 (en) * | 2010-10-12 | 2017-01-19 | Allergan, Inc. | Cyclosporin analogs |
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| AU2011342284C1 (en) * | 2010-12-15 | 2017-07-13 | Contravir Pharmaceuticals, Inc. | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
| WO2013181339A2 (en) * | 2012-06-01 | 2013-12-05 | Allergan, Inc. | Cyclosporin a analogs |
| GB201222455D0 (en) * | 2012-12-13 | 2013-01-30 | Perioc Ltd | Novel pharmaceutical formulations and their use in the treatment of periodontaldisease |
| WO2014138359A1 (en) | 2013-03-08 | 2014-09-12 | Allergan, Inc. | Steroid antibiotic conjugates |
| TW201639873A (zh) | 2015-01-08 | 2016-11-16 | 歐樂根公司 | Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物 |
| EP3277704A1 (en) | 2015-03-31 | 2018-02-07 | Allergan, Inc. | Cyclosporins modified on the mebmt sidechain by heterocyclic rings |
| AU2017267560B2 (en) | 2016-05-17 | 2022-03-24 | S&T Global Inc. | Novel cyclosporin derivatives and uses thereof |
| CA3045944A1 (en) | 2016-12-07 | 2018-06-14 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| US11523772B2 (en) | 2016-12-14 | 2022-12-13 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an immunosuppressant |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| WO2021173474A1 (en) * | 2020-02-26 | 2021-09-02 | Bacainn Biotherapeutics, Ltd. | Cyclosporine compositions and methods of use |
| CN113173974B (zh) | 2021-03-18 | 2024-09-06 | 北京大学深圳研究生院 | 环孢素衍生物的合成方法 |
| AU2024285817A1 (en) * | 2023-06-08 | 2026-01-08 | Hepion Pharmaceuticals, Inc. | Solid state forms of rencofilstat |
| CN118834148B (zh) * | 2024-09-20 | 2025-01-21 | 天津凯莱英制药有限公司 | 一种l-青霉胺的制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0194972B1 (en) | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
| US4649047A (en) * | 1985-03-19 | 1987-03-10 | University Of Georgia Research Foundation, Inc. | Ophthalmic treatment by topical administration of cyclosporin |
| US4839342A (en) | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
| US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| FR2757521B1 (fr) | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2757522B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2762843B1 (fr) | 1997-04-30 | 1999-12-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| ATE254630T1 (de) * | 1998-06-12 | 2003-12-15 | Chem Ag C | Cyclosporine |
| US6254860B1 (en) * | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
| US20050059583A1 (en) * | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| US7676680B2 (en) | 2005-07-08 | 2010-03-09 | Morgan Stanley | Systems and methods for distributing private placement documents |
| US7288520B2 (en) | 2005-07-13 | 2007-10-30 | Allergan, Inc. | Cyclosporin compositions |
| CA2652662C (en) * | 2006-05-19 | 2015-11-03 | Scynexis, Inc. | Methods for the treatment and prevention of ocular disorders |
| CN101130058B (zh) * | 2006-08-23 | 2011-10-05 | 华北制药集团新药研究开发有限责任公司 | 一种环孢菌素a眼用乳剂及其制备方法 |
| CN101687013A (zh) * | 2007-05-04 | 2010-03-31 | 阿勒根公司 | 环孢菌素在治疗具有人工晶状体的患者中的用途 |
| US8716238B2 (en) * | 2008-07-10 | 2014-05-06 | Allergan, Inc. | Cyclosporin derivatives for treating ocular and dermal diseases and conditions |
| US9903271B2 (en) * | 2010-07-02 | 2018-02-27 | Exxonmobil Upstream Research Company | Low emission triple-cycle power generation and CO2 separation systems and methods |
| US8902844B2 (en) | 2010-07-06 | 2014-12-02 | Lg Electronics Inc. | Method and device for allocating wireless resources for a machine type communication device in a wireless communication system |
| AU2011316690C1 (en) * | 2010-10-12 | 2017-01-19 | Allergan, Inc. | Cyclosporin analogs |
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| MX350746B (es) * | 2010-12-03 | 2017-09-14 | Hebei Kunxiangjishi Pharmaceutical Tech Co Ltd | Derivados de ciclosporina novedosos para el tratamiento y la prevención de una infección viral. |
| CN103987399A (zh) * | 2011-08-19 | 2014-08-13 | 美国科技环球有限公司 | 用于治疗和预防病毒感染的新型环孢菌素衍生物 |
-
2011
- 2011-10-11 AU AU2011316690A patent/AU2011316690C1/en not_active Ceased
- 2011-10-11 MX MX2013004061A patent/MX2013004061A/es unknown
- 2011-10-11 EP EP11770985.7A patent/EP2627664B1/en not_active Not-in-force
- 2011-10-11 CA CA2814192A patent/CA2814192A1/en not_active Abandoned
- 2011-10-11 KR KR1020137012145A patent/KR20140026329A/ko not_active Withdrawn
- 2011-10-11 US US13/270,964 patent/US20120088734A1/en not_active Abandoned
- 2011-10-11 RU RU2013119869/04A patent/RU2013119869A/ru not_active Application Discontinuation
- 2011-10-11 JP JP2013533942A patent/JP5805774B2/ja not_active Expired - Fee Related
- 2011-10-11 WO PCT/US2011/055791 patent/WO2012051194A1/en not_active Ceased
- 2011-10-11 BR BR112013008864A patent/BR112013008864A2/pt not_active Application Discontinuation
- 2011-10-11 CN CN2011800596461A patent/CN103328497A/zh active Pending
- 2011-10-11 SG SG2013027339A patent/SG189880A1/en unknown
-
2013
- 2013-04-07 IL IL225617A patent/IL225617A0/en unknown
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2014
- 2014-11-06 US US14/534,677 patent/US9493511B2/en active Active
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2015
- 2015-09-02 JP JP2015173082A patent/JP6250608B2/ja not_active Expired - Fee Related
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2016
- 2016-10-11 US US15/290,171 patent/US10065992B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012051194A1 (en) | 2012-04-19 |
| US9493511B2 (en) | 2016-11-15 |
| JP6250608B2 (ja) | 2017-12-20 |
| US20170029469A1 (en) | 2017-02-02 |
| IL225617A0 (en) | 2013-06-27 |
| SG189880A1 (en) | 2013-06-28 |
| CA2814192A1 (en) | 2012-04-19 |
| US10065992B2 (en) | 2018-09-04 |
| US20120088734A1 (en) | 2012-04-12 |
| AU2011316690C1 (en) | 2017-01-19 |
| MX2013004061A (es) | 2013-07-22 |
| EP2627664B1 (en) | 2018-04-04 |
| EP2627664A1 (en) | 2013-08-21 |
| AU2011316690B2 (en) | 2016-07-07 |
| JP2016029050A (ja) | 2016-03-03 |
| JP5805774B2 (ja) | 2015-11-10 |
| RU2013119869A (ru) | 2014-11-20 |
| US20150065433A1 (en) | 2015-03-05 |
| CN103328497A (zh) | 2013-09-25 |
| AU2011316690A1 (en) | 2013-05-02 |
| JP2013540776A (ja) | 2013-11-07 |
| BR112013008864A2 (pt) | 2016-06-28 |
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| PA0105 | International application |
Patent event date: 20130510 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |