CN103328497A - 环孢菌素类似物 - Google Patents

环孢菌素类似物 Download PDF

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Publication number
CN103328497A
CN103328497A CN2011800596461A CN201180059646A CN103328497A CN 103328497 A CN103328497 A CN 103328497A CN 2011800596461 A CN2011800596461 A CN 2011800596461A CN 201180059646 A CN201180059646 A CN 201180059646A CN 103328497 A CN103328497 A CN 103328497A
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CN
China
Prior art keywords
cyclosporin
sar
methyl
ethyl
chr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800596461A
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English (en)
Chinese (zh)
Inventor
W·R·卡林
C·S·V·弗里德里希
M·E·贾斯特
M·E·斯特恩
C·S·绍姆博格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of CN103328497A publication Critical patent/CN103328497A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Analytical Chemistry (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2011800596461A 2010-10-12 2011-10-11 环孢菌素类似物 Pending CN103328497A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39244910P 2010-10-12 2010-10-12
US61/392,449 2010-10-12
PCT/US2011/055791 WO2012051194A1 (en) 2010-10-12 2011-10-11 Cyclosporin analogs

Publications (1)

Publication Number Publication Date
CN103328497A true CN103328497A (zh) 2013-09-25

Family

ID=44883784

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800596461A Pending CN103328497A (zh) 2010-10-12 2011-10-11 环孢菌素类似物

Country Status (13)

Country Link
US (3) US20120088734A1 (enExample)
EP (1) EP2627664B1 (enExample)
JP (2) JP5805774B2 (enExample)
KR (1) KR20140026329A (enExample)
CN (1) CN103328497A (enExample)
AU (1) AU2011316690C1 (enExample)
BR (1) BR112013008864A2 (enExample)
CA (1) CA2814192A1 (enExample)
IL (1) IL225617A0 (enExample)
MX (1) MX2013004061A (enExample)
RU (1) RU2013119869A (enExample)
SG (1) SG189880A1 (enExample)
WO (1) WO2012051194A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022193482A1 (zh) * 2021-03-18 2022-09-22 北京大学深圳研究生院 环孢素衍生物的合成方法
CN118834148A (zh) * 2024-09-20 2024-10-25 天津凯莱英制药有限公司 一种l-青霉胺的制备方法

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9573978B2 (en) 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
CA2814191A1 (en) 2010-10-12 2012-04-19 Allergan, Inc. Cyclosporin analogs
RU2013119869A (ru) * 2010-10-12 2014-11-20 Аллерган, Инк. Аналоги циклоспорина
US9890198B2 (en) * 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
CN107496902B (zh) * 2010-12-15 2022-01-18 康卓维尔制药公司 在氨基酸1和3位修改的环孢菌素类似分子
US9266927B2 (en) 2012-06-01 2016-02-23 Allergan, Inc. Cyclosporin A analogs
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
SG11201507241UA (en) 2013-03-08 2015-10-29 Allergan Inc Cyclosporine a-steroid conjugates
WO2016112321A1 (en) 2015-01-08 2016-07-14 Allergan, Inc. Cyclosporin derivatives wherein the mebmt sidechain has been cyclized
EP3277704A1 (en) 2015-03-31 2018-02-07 Allergan, Inc. Cyclosporins modified on the mebmt sidechain by heterocyclic rings
EP3458470A4 (en) 2016-05-17 2020-04-22 S&T Global Inc. NEW CYCLOSPOR DERIVATIVES AND USES THEREOF
WO2018106931A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
WO2018112255A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
WO2021173474A1 (en) * 2020-02-26 2021-09-02 Bacainn Biotherapeutics, Ltd. Cyclosporine compositions and methods of use
WO2024254480A2 (en) * 2023-06-08 2024-12-12 Hepion Pharmaceuticals, Inc. Solid state forms of rencofilstat

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101130058A (zh) * 2006-08-23 2008-02-27 华北制药集团新药研究开发有限责任公司 一种环孢菌素a眼用乳剂及其制备方法
CN101511357A (zh) * 2006-05-19 2009-08-19 西尼克斯公司 治疗和预防眼部疾病的方法
CN101687013A (zh) * 2007-05-04 2010-03-31 阿勒根公司 环孢菌素在治疗具有人工晶状体的患者中的用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
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EP0194972B1 (en) 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US4839342A (en) 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US5474979A (en) * 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
FR2757522B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2762843B1 (fr) 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
BR9911160A (pt) * 1998-06-12 2001-04-03 Chem Ag C Ciclosporinas
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
US20050059583A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7676680B2 (en) 2005-07-08 2010-03-09 Morgan Stanley Systems and methods for distributing private placement documents
US7288520B2 (en) 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
CA2730108A1 (en) * 2008-07-10 2010-01-14 Allergan, Inc. Cyclosporin derivatives for treating ocular and dermal diseases and conditions
CN102985665A (zh) * 2010-07-02 2013-03-20 埃克森美孚上游研究公司 低排放三循环动力产生系统和方法
WO2012005494A2 (ko) 2010-07-06 2012-01-12 엘지전자 주식회사 무선 통신 시스템에서 머신형 통신 장치를 위한 무선 자원 할당 방법 및 장치
RU2013119869A (ru) * 2010-10-12 2014-11-20 Аллерган, Инк. Аналоги циклоспорина
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
EP2646043B1 (en) * 2010-12-03 2017-02-15 S&T Global Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
HK1201181A1 (en) * 2011-08-19 2015-08-28 美国科技环球有限公司 Novel cyclosporin derivatives for the treatment and prevention of viral infections

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101511357A (zh) * 2006-05-19 2009-08-19 西尼克斯公司 治疗和预防眼部疾病的方法
CN101130058A (zh) * 2006-08-23 2008-02-27 华北制药集团新药研究开发有限责任公司 一种环孢菌素a眼用乳剂及其制备方法
CN101687013A (zh) * 2007-05-04 2010-03-31 阿勒根公司 环孢菌素在治疗具有人工晶状体的患者中的用途

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022193482A1 (zh) * 2021-03-18 2022-09-22 北京大学深圳研究生院 环孢素衍生物的合成方法
US11840582B2 (en) 2021-03-18 2023-12-12 Peking University Shenzhen Graduate School Synthesis method of cyclosporine derivatives
CN118834148A (zh) * 2024-09-20 2024-10-25 天津凯莱英制药有限公司 一种l-青霉胺的制备方法
CN118834148B (zh) * 2024-09-20 2025-01-21 天津凯莱英制药有限公司 一种l-青霉胺的制备方法

Also Published As

Publication number Publication date
MX2013004061A (es) 2013-07-22
US20120088734A1 (en) 2012-04-12
AU2011316690B2 (en) 2016-07-07
US20150065433A1 (en) 2015-03-05
US20170029469A1 (en) 2017-02-02
JP5805774B2 (ja) 2015-11-10
JP2013540776A (ja) 2013-11-07
WO2012051194A1 (en) 2012-04-19
JP2016029050A (ja) 2016-03-03
US9493511B2 (en) 2016-11-15
RU2013119869A (ru) 2014-11-20
SG189880A1 (en) 2013-06-28
BR112013008864A2 (pt) 2016-06-28
AU2011316690A1 (en) 2013-05-02
KR20140026329A (ko) 2014-03-05
IL225617A0 (en) 2013-06-27
JP6250608B2 (ja) 2017-12-20
CA2814192A1 (en) 2012-04-19
EP2627664A1 (en) 2013-08-21
US10065992B2 (en) 2018-09-04
EP2627664B1 (en) 2018-04-04
AU2011316690C1 (en) 2017-01-19

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