JP5805088B2 - 遺伝子発現を阻害する組成物およびその使用 - Google Patents

遺伝子発現を阻害する組成物およびその使用 Download PDF

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Publication number
JP5805088B2
JP5805088B2 JP2012526977A JP2012526977A JP5805088B2 JP 5805088 B2 JP5805088 B2 JP 5805088B2 JP 2012526977 A JP2012526977 A JP 2012526977A JP 2012526977 A JP2012526977 A JP 2012526977A JP 5805088 B2 JP5805088 B2 JP 5805088B2
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oligonucleotide
based compound
oligonucleotides
antisense
disease
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JP2013507905A (ja
JP2013507905A5 (cg-RX-API-DMAC7.html
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アグラワル,サディール
カンディマラ,エカンバー
プッタ,マリカージュナ
ラン,タオ
バガット,ラクシュミ
ワン,ダキン
ユ,ドン
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Aceragen Inc
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Idera Pharmaceuticals Inc
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
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    • A61P33/00Antiparasitic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/15Nucleic acids forming more than 2 strands, e.g. TFOs
    • C12N2310/152Nucleic acids forming more than 2 strands, e.g. TFOs on a single-stranded target, e.g. fold-back TFOs
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/51Physical structure in polymeric form, e.g. multimers, concatemers

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2012526977A 2009-08-27 2010-08-26 遺伝子発現を阻害する組成物およびその使用 Expired - Fee Related JP5805088B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27525209P 2009-08-27 2009-08-27
US61/275,252 2009-08-27
US24055309P 2009-09-08 2009-09-08
US61/240,553 2009-09-08
PCT/US2010/046781 WO2011031520A1 (en) 2009-08-27 2010-08-26 Composition for inhibiting gene expression and uses thereof

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JP2013507905A JP2013507905A (ja) 2013-03-07
JP2013507905A5 JP2013507905A5 (cg-RX-API-DMAC7.html) 2013-10-17
JP5805088B2 true JP5805088B2 (ja) 2015-11-04

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US (3) US20110082186A1 (cg-RX-API-DMAC7.html)
EP (3) EP3272870A1 (cg-RX-API-DMAC7.html)
JP (1) JP5805088B2 (cg-RX-API-DMAC7.html)
CN (2) CN104673795A (cg-RX-API-DMAC7.html)
CA (1) CA2772352A1 (cg-RX-API-DMAC7.html)
DK (1) DK2470656T3 (cg-RX-API-DMAC7.html)
ES (2) ES2646097T3 (cg-RX-API-DMAC7.html)
HK (1) HK1210223A1 (cg-RX-API-DMAC7.html)
HR (1) HRP20150566T1 (cg-RX-API-DMAC7.html)
HU (1) HUE026020T2 (cg-RX-API-DMAC7.html)
PL (1) PL2470656T3 (cg-RX-API-DMAC7.html)
PT (1) PT2470656E (cg-RX-API-DMAC7.html)
SI (1) SI2470656T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201500140B (cg-RX-API-DMAC7.html)
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