JP5785687B2 - 急性虚血性脳卒中を処置するためのテネクテプラーゼの使用 - Google Patents

急性虚血性脳卒中を処置するためのテネクテプラーゼの使用 Download PDF

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Publication number
JP5785687B2
JP5785687B2 JP2009526788A JP2009526788A JP5785687B2 JP 5785687 B2 JP5785687 B2 JP 5785687B2 JP 2009526788 A JP2009526788 A JP 2009526788A JP 2009526788 A JP2009526788 A JP 2009526788A JP 5785687 B2 JP5785687 B2 JP 5785687B2
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Prior art keywords
tenecteplase
dose
minutes
bolus
stroke
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Japanese (ja)
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JP2010502629A5 (enExample
JP2010502629A (ja
Inventor
ピーター キューブラー，
ピーター キューブラー，
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Genentech Inc
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Genentech Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2009526788A 2006-08-29 2007-08-01 急性虚血性脳卒中を処置するためのテネクテプラーゼの使用 Active JP5785687B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82386806P 2006-08-29 2006-08-29
US60/823,868 2006-08-29
PCT/US2007/074997 WO2008027687A2 (en) 2006-08-29 2007-08-01 Use of tenecteplase for treating acute ischemic stroke

Publications (3)

Publication Number Publication Date
JP2010502629A JP2010502629A (ja) 2010-01-28
JP2010502629A5 JP2010502629A5 (enExample) 2011-08-18
JP5785687B2 true JP5785687B2 (ja) 2015-09-30

Family

ID=38835003

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009526788A Active JP5785687B2 (ja) 2006-08-29 2007-08-01 急性虚血性脳卒中を処置するためのテネクテプラーゼの使用

Country Status (21)

Country Link
US (2) US20080107641A1 (enExample)
EP (1) EP2056856B1 (enExample)
JP (1) JP5785687B2 (enExample)
KR (1) KR20090045405A (enExample)
CN (1) CN101505785A (enExample)
AU (1) AU2007290277B2 (enExample)
BR (1) BRPI0716143A2 (enExample)
CA (1) CA2661012C (enExample)
CO (1) CO6150188A2 (enExample)
EA (1) EA015573B1 (enExample)
EC (1) ECSP099178A (enExample)
IL (2) IL196987A (enExample)
MX (1) MX2009001918A (enExample)
MY (1) MY163119A (enExample)
NO (1) NO342302B1 (enExample)
NZ (1) NZ574767A (enExample)
SG (3) SG10201501498VA (enExample)
TW (1) TWI439282B (enExample)
UA (1) UA97486C2 (enExample)
WO (1) WO2008027687A2 (enExample)
ZA (1) ZA200900957B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
US8030350B2 (en) 2005-02-24 2011-10-04 Diffusion Pharmaceuticals Llc Trans carotenoids, their synthesis, formulation and uses
TWI439282B (zh) 2006-08-29 2014-06-01 Genentech Inc 以血栓溶解劑治療中風之方法
MX2009010988A (es) 2007-04-13 2010-03-15 Diffusion Pharmaceuticals Llc Uso de trans-carotenoides bipolares como un tratamiento previo y en el tratamiento de una enfermedad vascular periferica.
US9034007B2 (en) 2007-09-21 2015-05-19 Insera Therapeutics, Inc. Distal embolic protection devices with a variable thickness microguidewire and methods for their use
JP2012513812A (ja) * 2008-12-24 2012-06-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Ｍｒ卒中検出および処置による心臓介入のシステム、方法および装置
EP2445339B1 (en) 2009-06-22 2019-08-07 Diffusion Pharmaceuticals LLC Diffusion enhancing compound and its use with a thrombolytic
JP5762414B2 (ja) * 2009-08-24 2015-08-12 ハフ イヤ インスティテュート 急性音響外傷の治療方法
ES2654945T3 (es) 2010-06-02 2018-02-15 Diffusion Pharmaceuticals Llc Formulaciones orales de carotenoides trans bipolares
MY171723A (en) * 2010-12-23 2019-10-24 Gennova Biopharmaceuticals Ltd Pharmaceutical compositions of tenecteplase
WO2014062888A1 (en) 2012-10-18 2014-04-24 University Of South Florida Compositions and methods for treating stroke
US8715315B1 (en) 2013-03-15 2014-05-06 Insera Therapeutics, Inc. Vascular treatment systems
US8679150B1 (en) 2013-03-15 2014-03-25 Insera Therapeutics, Inc. Shape-set textile structure based mechanical thrombectomy methods
JP6437517B2 (ja) 2013-03-15 2018-12-12 インセラ セラピューティクス，インク． 血管治療装置及び方法
US8715314B1 (en) 2013-03-15 2014-05-06 Insera Therapeutics, Inc. Vascular treatment measurement methods
US10220008B2 (en) 2013-08-14 2019-03-05 Stc.Unm Treatment and prevention of stroke and other neurological disorders
MX383595B (es) * 2014-10-21 2025-03-14 Gennova Biopharmaceuticals Ltd Proceso novedoso de purificacion para el aislamiento y produccion comercial de tnk-tpa recombinante (tenecteplasa)
CN108697423A (zh) 2016-02-16 2018-10-23 伊瑟拉医疗公司 抽吸装置和锚定的分流装置
WO2017165667A1 (en) 2016-03-24 2017-09-28 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
EP3573635B1 (en) * 2017-01-24 2021-05-12 Ekos Corporation Method for the treatment of thromboembolism
EP3624832B1 (en) * 2017-05-16 2025-08-20 Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for the treatment of acute ischemic stroke
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
WO2021158799A1 (en) * 2020-02-04 2021-08-12 The Regents Of The University Of Colorado, A Body Corporate Prophylactic uses of annexin a2
MX2022010160A (es) * 2020-02-19 2022-10-10 Nono Inc Tratamiento de combinación de apoplejia con inhibidor de psd-95 escindible por plasmina y reperfusión.
CN114984197A (zh) * 2022-07-01 2022-09-02 江苏丰华生物制药有限公司 替奈普酶在制备用于治疗急性缺血性卒中的药物组合物中的应用
CN115487294A (zh) * 2022-07-12 2022-12-20 上海丰华天力通生物医药有限公司 替奈普酶在制备用于治疗轻型缺血性卒中的药物组合物中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
EP0786257B1 (en) 1992-06-03 2003-07-30 Genentech, Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
JP2002173447A (ja) * 2000-09-29 2002-06-21 Yamanouchi Pharmaceut Co Ltd 脳塞栓症治療用医薬組成物
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
US20030180282A1 (en) * 2002-03-25 2003-09-25 Victor Serebruany Method of treatment of thrombotic events
US20070014779A1 (en) * 2002-11-14 2007-01-18 Genentech, Inc. Plasminogen activator variant formulations
WO2006094120A2 (en) * 2005-03-02 2006-09-08 The Regents Of The University Of California Treatment for embolic stroke
TWI439282B (zh) 2006-08-29 2014-06-01 Genentech Inc 以血栓溶解劑治療中風之方法

Also Published As

Publication number Publication date
NZ574767A (en) 2012-02-24
HK1131054A1 (en) 2010-01-15
TW200817033A (en) 2008-04-16
NO342302B1 (no) 2018-04-30
WO2008027687A3 (en) 2008-05-22
UA97486C2 (ru) 2012-02-27
ECSP099178A (es) 2009-06-30
IL196987A (en) 2016-10-31
NO20091296L (no) 2009-05-28
CO6150188A2 (es) 2010-04-20
MX2009001918A (es) 2009-03-06
US9023346B2 (en) 2015-05-05
ZA200900957B (en) 2010-05-26
WO2008027687A2 (en) 2008-03-06
BRPI0716143A2 (pt) 2013-11-26
MY163119A (en) 2017-08-15
TWI439282B (zh) 2014-06-01
AU2007290277B2 (en) 2013-04-11
US20080107641A1 (en) 2008-05-08
EA200970237A1 (ru) 2009-08-28
CA2661012A1 (en) 2008-03-06
IL196987A0 (en) 2011-08-01
KR20090045405A (ko) 2009-05-07
EP2056856B1 (en) 2015-01-14
US20120164157A1 (en) 2012-06-28
SG174753A1 (en) 2011-10-28
EP2056856A2 (en) 2009-05-13
JP2010502629A (ja) 2010-01-28
IL248176A0 (en) 2016-11-30
SG10201501498VA (en) 2015-04-29
CN101505785A (zh) 2009-08-12
AU2007290277A1 (en) 2008-03-06
EA015573B1 (ru) 2011-10-31
CA2661012C (en) 2019-03-19
SG10201804944XA (en) 2018-07-30

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