JP5779091B2 - Ｉａｐ阻害剤による免疫調節 - Google Patents

Ｉａｐ阻害剤による免疫調節 Download PDF

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JP5779091B2
JP5779091B2 JP2011509678A JP2011509678A JP5779091B2 JP 5779091 B2 JP5779091 B2 JP 5779091B2 JP 2011509678 A JP2011509678 A JP 2011509678A JP 2011509678 A JP2011509678 A JP 2011509678A JP 5779091 B2 JP5779091 B2 JP 5779091B2
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cells
iap
antigen
alkyl
cancer
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JP2011524339A5 (enExample
JP2011524339A (ja
Inventor
リー ザウエル，
リー ザウエル，
マイケル ドゥーガン，
マイケル ドゥーガン，
グレン ドラノフ，
グレン ドラノフ，
ブラント， ジー． ファイアストーン，
ブラント， ジー． ファイアストーン，
クリストファー， エス． ストラウブ，
クリストファー， エス． ストラウブ，
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40823320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5779091(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
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    • A61P31/10—Antimycotics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011509678A 2008-05-16 2009-05-14 Ｉａｐ阻害剤による免疫調節 Active JP5779091B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5394708P 2008-05-16 2008-05-16
US61/053,947 2008-05-16
PCT/US2009/043874 WO2009140447A1 (en) 2008-05-16 2009-05-14 Immunomodulation by iap inhibitors

Related Child Applications (1)

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JP2015040113A Division JP5986655B2 (ja) 2008-05-16 2015-03-02 Ｉａｐ阻害剤による免疫調節

Publications (3)

Publication Number Publication Date
JP2011524339A JP2011524339A (ja) 2011-09-01
JP2011524339A5 JP2011524339A5 (enExample) 2014-04-24
JP5779091B2 true JP5779091B2 (ja) 2015-09-16

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JP2011509678A Active JP5779091B2 (ja) 2008-05-16 2009-05-14 Ｉａｐ阻害剤による免疫調節
JP2015040113A Active JP5986655B2 (ja) 2008-05-16 2015-03-02 Ｉａｐ阻害剤による免疫調節
JP2015236482A Active JP6030739B2 (ja) 2008-05-16 2015-12-03 Ｉａｐ阻害剤による免疫調節

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JP2015040113A Active JP5986655B2 (ja) 2008-05-16 2015-03-02 Ｉａｐ阻害剤による免疫調節
JP2015236482A Active JP6030739B2 (ja) 2008-05-16 2015-12-03 Ｉａｐ阻害剤による免疫調節

Country Status (17)

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US (4) US9750729B2 (enExample)
EP (3) EP2296650B1 (enExample)
JP (3) JP5779091B2 (enExample)
KR (1) KR20110022608A (enExample)
CN (1) CN102099035A (enExample)
AU (1) AU2009246347A1 (enExample)
BR (1) BRPI0912692A2 (enExample)
CA (1) CA2724720A1 (enExample)
CL (1) CL2009001195A1 (enExample)
EA (1) EA201071316A1 (enExample)
ES (2) ES2882855T3 (enExample)
IL (1) IL209203A0 (enExample)
MA (1) MA32388B1 (enExample)
MX (1) MX2010012231A (enExample)
TW (1) TW201006834A (enExample)
WO (1) WO2009140447A1 (enExample)
ZA (1) ZA201008176B (enExample)

Families Citing this family (12)

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WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
AU2006308453B9 (en) 2005-10-25 2011-12-01 Pharmascience Inc. IAP BIR domain binding compounds
EP2296650B1 (en) * 2008-05-16 2020-05-06 Novartis AG Immunomodulation by iap inhibitors
JP4995211B2 (ja) * 2008-09-29 2012-08-08 キヤノン株式会社 電子写真画像形成装置
NZ602368A (en) 2010-02-12 2014-10-31 Pharmascience Inc Iap bir domain binding compounds
KR20160030099A (ko) * 2013-06-25 2016-03-16 더 월터 앤드 엘리자 홀 인스티튜트 오브 메디컬 리서치 세포내 감염의 치료 방법
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
AU2017253560B2 (en) * 2016-04-20 2019-03-21 Glaxosmithkline Intellectual Property Development Limited Conjugates comprising RIPK2 inhibitors
CN106496213B (zh) * 2016-09-30 2019-08-20 东南大学 Lcl161前药及其制备方法和应用
WO2020027225A1 (ja) * 2018-07-31 2020-02-06 ファイメクス株式会社 複素環化合物
JP2022511437A (ja) 2018-11-26 2022-01-31 デバイオファーム インターナショナル エス．エー． Ｈｉｖ感染の組み合わせ治療
AU2020356356A1 (en) 2019-09-25 2022-05-12 Debiopharm International S.A. Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma

Family Cites Families (18)

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FR2610934B1 (fr) * 1987-02-13 1989-05-05 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6133437A (en) * 1997-02-13 2000-10-17 Apoptogen, Inc. Modulation of IAPs for the treatment of proliferative diseases
ES2415336T3 (es) * 2003-04-11 2013-07-25 Survac Aps Vacuna terapéutica contra el cáncer
EP1711515A2 (en) 2004-02-04 2006-10-18 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
EP1723122B1 (en) * 2004-03-01 2014-11-19 Board of Regents, The University of Texas System Dimeric small molecule potentiators of apoptosis
US7345081B2 (en) 2004-03-23 2008-03-18 Genentech, Inc. Azabicyclo-octane inhibitors of IAP
PL2253614T3 (pl) * 2004-04-07 2013-03-29 Novartis Ag Inhibitory IAP
EP1749558A4 (en) 2004-05-02 2008-03-12 Sega Corp GAME SYSTEM
EA012810B1 (ru) 2005-02-25 2009-12-30 Тетралоджик Фармасеутикалс Димерные ингибиторы ингибиторов белков апоптоза (iap)
US20090005411A1 (en) 2005-12-20 2009-01-01 Novartic Ag Combinations of Organic Compounds
US20100056495A1 (en) * 2006-07-24 2010-03-04 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
PE20110217A1 (es) 2006-08-02 2011-04-01 Novartis Ag DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS
AU2007307763A1 (en) 2006-10-12 2008-04-17 Novartis Ag Pyrrolydine derivatives as IAP inhibitors
RU2009118487A (ru) * 2006-10-19 2010-11-27 Новартис АГ (CH) Органические соединения
KR20090087094A (ko) * 2006-11-28 2009-08-14 노파르티스 아게 Ｉａｐ 억제제 및 ｆｌｔ3 억제제의 조합물
EP2126188A1 (en) 2006-12-26 2009-12-02 Arçelik Anonim Sirketi A washer / dryer with output from humidity sensor selectively input to control unit
WO2008109057A1 (en) * 2007-03-02 2008-09-12 Dana-Farber Cancer Institute, Inc. Organic compounds and their uses
EP2296650B1 (en) * 2008-05-16 2020-05-06 Novartis AG Immunomodulation by iap inhibitors

Also Published As

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EA201071316A1 (ru) 2011-06-30
US20110135691A1 (en) 2011-06-09
MA32388B1 (fr) 2011-06-01
AU2009246347A1 (en) 2009-11-19
MX2010012231A (es) 2011-02-18
EP2296650A1 (en) 2011-03-23
ZA201008176B (en) 2011-08-31
US20200345714A1 (en) 2020-11-05
JP2016094429A (ja) 2016-05-26
US9750729B2 (en) 2017-09-05
CN102099035A (zh) 2011-06-15
BRPI0912692A2 (pt) 2017-03-21
EP2698158A1 (en) 2014-02-19
EP2698158B1 (en) 2021-06-30
JP2011524339A (ja) 2011-09-01
US20220296581A1 (en) 2022-09-22
JP5986655B2 (ja) 2016-09-06
EP2296650B1 (en) 2020-05-06
WO2009140447A1 (en) 2009-11-19
KR20110022608A (ko) 2011-03-07
ES2882855T3 (es) 2021-12-02
CA2724720A1 (en) 2009-11-19
US11382905B2 (en) 2022-07-12
JP2015129170A (ja) 2015-07-16
IL209203A0 (en) 2011-01-31
CL2009001195A1 (es) 2010-06-11
EP3701947A1 (en) 2020-09-02
JP6030739B2 (ja) 2016-11-24
US10786491B2 (en) 2020-09-29
TW201006834A (en) 2010-02-16
US20170368047A1 (en) 2017-12-28
ES2791957T3 (es) 2020-11-06

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