JP5756850B2 - フロピリジン化合物およびその使用 - Google Patents

フロピリジン化合物およびその使用 Download PDF

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Publication number
JP5756850B2
JP5756850B2 JP2013505470A JP2013505470A JP5756850B2 JP 5756850 B2 JP5756850 B2 JP 5756850B2 JP 2013505470 A JP2013505470 A JP 2013505470A JP 2013505470 A JP2013505470 A JP 2013505470A JP 5756850 B2 JP5756850 B2 JP 5756850B2
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Japan
Prior art keywords
methylsulfonamido
cyclopropyl
methyl
pyridin
furo
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Expired - Fee Related
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JP2013505470A
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Japanese (ja)
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JP2013527842A5 (cg-RX-API-DMAC7.html
JP2013527842A (ja
Inventor
デイビッド・バーンズ
ラジブ・チョプラ
スコット・ルイス・コーヘン
フ・ジピン
充典 加藤
充典 加藤
ル・ペイチャオ
モヒンドラ・シーパーサウド
ジャン・ウェイ
Original Assignee
ノバルティス アーゲー
ノバルティス アーゲー
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2013505470A 2010-04-21 2011-04-20 フロピリジン化合物およびその使用 Expired - Fee Related JP5756850B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32649110P 2010-04-21 2010-04-21
US61/326,491 2010-04-21
PCT/EP2011/056304 WO2011131709A1 (en) 2010-04-21 2011-04-20 Furopyridine compounds and uses thereof

Publications (3)

Publication Number Publication Date
JP2013527842A JP2013527842A (ja) 2013-07-04
JP2013527842A5 JP2013527842A5 (cg-RX-API-DMAC7.html) 2014-05-08
JP5756850B2 true JP5756850B2 (ja) 2015-07-29

Family

ID=44010017

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013505470A Expired - Fee Related JP5756850B2 (ja) 2010-04-21 2011-04-20 フロピリジン化合物およびその使用

Country Status (9)

Country Link
US (1) US8324239B2 (cg-RX-API-DMAC7.html)
EP (1) EP2560976B9 (cg-RX-API-DMAC7.html)
JP (1) JP5756850B2 (cg-RX-API-DMAC7.html)
CN (1) CN103025738B (cg-RX-API-DMAC7.html)
AR (1) AR082453A1 (cg-RX-API-DMAC7.html)
ES (1) ES2605039T3 (cg-RX-API-DMAC7.html)
TW (1) TW201139446A (cg-RX-API-DMAC7.html)
UY (1) UY33348A (cg-RX-API-DMAC7.html)
WO (1) WO2011131709A1 (cg-RX-API-DMAC7.html)

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AU2016258192B2 (en) 2015-05-06 2021-07-29 Leidos Biomedical Research, Inc. K-Ras modulators
EP3612526A2 (en) 2017-04-20 2020-02-26 The Regents of the University of California K-ras modulators
JP7237941B2 (ja) * 2017-05-19 2023-03-13 エヌフレクション セラピューティクス インコーポレイテッド 皮膚障害の処置用の融合複素環式芳香族アニリン化合物
WO2019204449A1 (en) * 2018-04-18 2019-10-24 Theras, Inc. K-ras modulators with a vinyl sulfone moiety
CN108727309B (zh) * 2018-06-20 2023-04-07 天津全和诚科技有限责任公司 一种3-氧杂环丁烷羧酸的合成方法

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Also Published As

Publication number Publication date
CN103025738A (zh) 2013-04-03
UY33348A (es) 2011-12-01
EP2560976A1 (en) 2013-02-27
US20120015907A1 (en) 2012-01-19
JP2013527842A (ja) 2013-07-04
TW201139446A (en) 2011-11-16
US8324239B2 (en) 2012-12-04
AR082453A1 (es) 2012-12-12
ES2605039T3 (es) 2017-03-10
EP2560976B9 (en) 2017-06-07
WO2011131709A1 (en) 2011-10-27
EP2560976B1 (en) 2016-08-24
CN103025738B (zh) 2015-08-19

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