JP5755881B2 - ミトコンドリア病を治療するための４−（ｐ−キノリル）−２−ヒドロキシブタンアミド誘導体 - Google Patents

ミトコンドリア病を治療するための４−（ｐ−キノリル）−２−ヒドロキシブタンアミド誘導体 Download PDF

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JP5755881B2
JP5755881B2 JP2010532329A JP2010532329A JP5755881B2 JP 5755881 B2 JP5755881 B2 JP 5755881B2 JP 2010532329 A JP2010532329 A JP 2010532329A JP 2010532329 A JP2010532329 A JP 2010532329A JP 5755881 B2 JP5755881 B2 JP 5755881B2
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hydroxy
methyl
alkyl
trimethyl
dienyl
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JP2011503005A (ja
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オリオン ディー． ヤンコウスキー，
オリオン ディー． ヤンコウスキー，
キーロン イー． ウェッソン，
キーロン イー． ウェッソン，
ポール モーラード，
ポール モーラード，
ウィリアム ディー． シュレーダー，
ウィリアム ディー． シュレーダー，
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エジソン ファーマシューティカルズ， インコーポレイテッド
エジソン ファーマシューティカルズ， インコーポレイテッド
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    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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