JP5749009B2 - ＥｐｈＢ４に結合するヒト化抗体を利用する癌治療剤 - Google Patents

ＥｐｈＢ４に結合するヒト化抗体を利用する癌治療剤 Download PDF

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Publication number
JP5749009B2
JP5749009B2 JP2010521005A JP2010521005A JP5749009B2 JP 5749009 B2 JP5749009 B2 JP 5749009B2 JP 2010521005 A JP2010521005 A JP 2010521005A JP 2010521005 A JP2010521005 A JP 2010521005A JP 5749009 B2 JP5749009 B2 JP 5749009B2
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antibody
antigen
binding fragment
seq
ephb4
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Expired - Fee Related
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Japanese (ja)
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JP2010536751A5 (enExample
JP2010536751A (ja
Inventor
ジョセフ・フランシス・カー
パルカシュ・ギル
ティモシー・デイビッド・ジョーンズ
シモン・ウィリアム・キーン
バレリー・クラスノペロフ
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Vasgene Therapeutics Inc
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Vasgene Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2010521005A 2007-08-13 2008-08-11 ＥｐｈＢ４に結合するヒト化抗体を利用する癌治療剤 Expired - Fee Related JP5749009B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96449607P 2007-08-13 2007-08-13
US60/964,496 2007-08-13
PCT/US2008/009619 WO2009023185A1 (en) 2007-08-13 2008-08-11 Cancer treatment using humanized antibodies that bind to ephb4

Publications (3)

Publication Number Publication Date
JP2010536751A JP2010536751A (ja) 2010-12-02
JP2010536751A5 JP2010536751A5 (enExample) 2012-09-27
JP5749009B2 true JP5749009B2 (ja) 2015-07-15

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JP2010521005A Expired - Fee Related JP5749009B2 (ja) 2007-08-13 2008-08-11 ＥｐｈＢ４に結合するヒト化抗体を利用する癌治療剤

Country Status (8)

Country Link
US (1) US8975377B2 (enExample)
EP (1) EP2185594B1 (enExample)
JP (1) JP5749009B2 (enExample)
CN (1) CN102083861B (enExample)
AU (1) AU2008287427B2 (enExample)
BR (1) BRPI0815399A2 (enExample)
CA (1) CA2696164C (enExample)
WO (1) WO2009023185A1 (enExample)

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WO2012054438A1 (en) * 2010-10-22 2012-04-26 Schering Corporation Anti-pcsk9
JOP20200043A1 (ar) 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
EA039663B1 (ru) 2012-05-03 2022-02-24 Амген Инк. Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств
HRP20210680T1 (hr) * 2014-07-10 2021-06-11 Bioarctic Ab POBOLJŠANA PROTUTIJELA KOJA VEŽU Aβ PROTOFIBRIL
ES2882276T3 (es) * 2015-04-14 2021-12-01 Academia Sinica Anticuerpo humano anti-VEGFR2 para terapia antiangiogénica y terapia dirigida contra el cáncer
KR20240056644A (ko) * 2018-05-10 2024-04-30 주식회사 뉴라클사이언스 서열 유사성 19, 멤버 a5 항체를 갖는 항-패밀리 및 그의 사용 방법
CN114409792B (zh) * 2021-12-01 2022-08-12 中山大学附属第五医院 抗EphB4纳米抗体
KR20240163163A (ko) * 2022-03-28 2024-11-18 코히러스 바이오사이언시스, 인크. 항-ilt4 조성물 및 방법

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Also Published As

Publication number Publication date
EP2185594B1 (en) 2016-04-06
WO2009023185A1 (en) 2009-02-19
CN102083861A (zh) 2011-06-01
US8975377B2 (en) 2015-03-10
AU2008287427B2 (en) 2014-10-09
CA2696164A1 (en) 2009-02-19
JP2010536751A (ja) 2010-12-02
HK1157798A1 (zh) 2012-07-06
AU2008287427A1 (en) 2009-02-19
CN102083861B (zh) 2016-04-13
US20090196880A1 (en) 2009-08-06
EP2185594A1 (en) 2010-05-19
BRPI0815399A2 (pt) 2019-09-24
CA2696164C (en) 2018-06-12

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