JP5719301B2 - 血清不含インスリン不含で第ｖｉｉ因子を産生する方法 - Google Patents

血清不含インスリン不含で第ｖｉｉ因子を産生する方法 Download PDF

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JP5719301B2
JP5719301B2 JP2011535656A JP2011535656A JP5719301B2 JP 5719301 B2 JP5719301 B2 JP 5719301B2 JP 2011535656 A JP2011535656 A JP 2011535656A JP 2011535656 A JP2011535656 A JP 2011535656A JP 5719301 B2 JP5719301 B2 JP 5719301B2
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insulin
free
medium
serum
culture
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JP2012508562A (ja
JP2012508562A5 (https=
Inventor
フィルックス， シモン フォン
フィルックス， シモン フォン
ラス エルマー，
ラス エルマー，
マンフレット ライター，
マンフレット ライター，
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Baxter Healthcare SA
Baxter International Inc
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Baxter Healthcare SA
Baxter International Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C12N2500/95—Protein-free medium and culture conditions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011535656A 2008-11-12 2009-11-05 血清不含インスリン不含で第ｖｉｉ因子を産生する方法 Active JP5719301B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11379208P 2008-11-12 2008-11-12
US61/113,792 2008-11-12
PCT/US2009/063338 WO2010056584A1 (en) 2008-11-12 2009-11-05 Method of producing serum-free insulin-free factor vii

Publications (3)

Publication Number Publication Date
JP2012508562A JP2012508562A (ja) 2012-04-12
JP2012508562A5 JP2012508562A5 (https=) 2012-12-20
JP5719301B2 true JP5719301B2 (ja) 2015-05-13

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ID=42165541

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JP2011535656A Active JP5719301B2 (ja) 2008-11-12 2009-11-05 血清不含インスリン不含で第ｖｉｉ因子を産生する方法

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Country Link
US (1) US20100120093A1 (https=)
EP (2) EP2356247B2 (https=)
JP (1) JP5719301B2 (https=)
AU (1) AU2009314345B2 (https=)
CA (1) CA2742107A1 (https=)
DK (1) DK2356247T4 (https=)
ES (1) ES2547881T5 (https=)
HK (1) HK1219113A1 (https=)
HR (1) HRP20151054T4 (https=)
HU (1) HUE026210T2 (https=)
IL (1) IL212355A (https=)
PL (1) PL2356247T5 (https=)
PT (1) PT2356247E (https=)
SI (1) SI2356247T2 (https=)
WO (1) WO2010056584A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013535981A (ja) * 2010-08-20 2013-09-19 ワイス・エルエルシー 成長因子不含適合細胞の細胞培養
US20120076779A1 (en) 2010-09-17 2012-03-29 Baxter Healthcare S.A. STABILIZATION OF IMMUNOGLOBULINS AND OTHER PROTEINS THROUGH AQUEOUS FORMULATIONS WITH SODIUM CHLORIDE AT WEAK ACIDIC TO NEUTRAL ph
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
KR20150026024A (ko) * 2013-08-30 2015-03-11 한미약품 주식회사 인간 혈액응고 7인자 유도체의 대량 생산 방법
US11286292B2 (en) 2014-02-07 2022-03-29 Cmc Biologics A/S Bioreactor arrangement and continuous process for producing and capturing a biopolymer
NZ724826A (en) * 2014-04-16 2022-07-29 Cmc Biologics As A high cell density fill and draw fermentation process
AU2015269365A1 (en) 2014-06-04 2016-12-15 Amgen Inc. Methods for harvesting mammalian cell cultures
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456591A (en) 1981-06-25 1984-06-26 Baxter Travenol Laboratories, Inc. Therapeutic method for activating factor VII
GR860984B (en) 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
US5997864A (en) 1995-06-07 1999-12-07 Novo Nordisk A/S Modified factor VII
US5804420A (en) * 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
AT407255B (de) * 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
AT409379B (de) † 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
DK1200561T3 (da) † 1999-08-05 2006-10-16 Baxter Ag Rekombinant stabil celleklon, dens fremstilling og anvendelse
US20030204338A1 (en) 2002-04-22 2003-10-30 Peter Martinek Method and measurement probe for the performance of measurements in water supply systems
US20040185535A1 (en) † 2003-03-21 2004-09-23 Giles Wilson Industrial-scale serum-free production of recombinant FVII in mammalian cells
BR0114373A (pt) * 2000-10-02 2004-02-17 Novo Nordisk As Célula hospedeira eucariótica, métodos para a produção de fvii e de fviia ou de suas variantes, de uma proteìna dependente de vitamina k e de uma célula hospedeira eucariótica produtora de fvii ou de seu análogo, vetor recombinante, fvii e fviia recombinante ou suas variantes, e, proteìna dependente de vitamina k recombinante
EP1434857B1 (en) * 2001-10-02 2007-08-01 Novo Nordisk Health Care AG Method for production of recombinant proteins in eukaryote cells
US20050214289A1 (en) * 2004-03-26 2005-09-29 Human Genome Sciences, Inc. Antibodies against Nogo receptor
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
EP1851305B1 (en) * 2005-02-11 2012-01-18 Novo Nordisk Health Care AG Production of a polypeptide in a serum-free cell culture liquid containing plant protein hydrolysate
CN101300342A (zh) † 2005-11-02 2008-11-05 惠氏公司 用于使哺乳动物细胞具备适应性的方法
ES2474573T3 (es) † 2006-01-04 2014-07-09 Baxter International Inc Medio de cultivo celular sin oligop�ptidos

Also Published As

Publication number Publication date
PL2356247T5 (pl) 2019-10-31
SI2356247T1 (sl) 2015-11-30
HK1219113A1 (en) 2017-03-24
PT2356247E (pt) 2015-10-26
CA2742107A1 (en) 2010-05-20
EP2977461A1 (en) 2016-01-27
JP2012508562A (ja) 2012-04-12
IL212355A0 (en) 2011-06-30
US20100120093A1 (en) 2010-05-13
ES2547881T5 (es) 2019-10-16
AU2009314345B2 (en) 2015-02-12
EP2356247A4 (en) 2013-01-02
PL2356247T3 (pl) 2016-04-29
WO2010056584A1 (en) 2010-05-20
SI2356247T2 (sl) 2019-08-30
EP2356247A1 (en) 2011-08-17
IL212355A (en) 2016-04-21
HRP20151054T4 (hr) 2019-11-15
EP2356247B2 (en) 2019-05-15
EP2356247B1 (en) 2015-07-15
HRP20151054T1 (xx) 2015-11-20
HUE026210T2 (en) 2016-05-30
ES2547881T3 (es) 2015-10-09
AU2009314345A1 (en) 2011-06-30
DK2356247T3 (en) 2015-09-21
DK2356247T4 (da) 2019-06-03

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