ES2547881T5 - Método de producción de factor VII libre de suero y libre de insulina - Google Patents
Método de producción de factor VII libre de suero y libre de insulina Download PDFInfo
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- ES2547881T5 ES2547881T5 ES09826577T ES09826577T ES2547881T5 ES 2547881 T5 ES2547881 T5 ES 2547881T5 ES 09826577 T ES09826577 T ES 09826577T ES 09826577 T ES09826577 T ES 09826577T ES 2547881 T5 ES2547881 T5 ES 2547881T5
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Classifications
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2009/063338 WO2010056584A1 (en) | 2008-11-12 | 2009-11-05 | Method of producing serum-free insulin-free factor vii |
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| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| KR20150026024A (ko) * | 2013-08-30 | 2015-03-11 | 한미약품 주식회사 | 인간 혈액응고 7인자 유도체의 대량 생산 방법 |
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| NZ724826A (en) * | 2014-04-16 | 2022-07-29 | Cmc Biologics As | A high cell density fill and draw fermentation process |
| AU2015269365A1 (en) | 2014-06-04 | 2016-12-15 | Amgen Inc. | Methods for harvesting mammalian cell cultures |
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| US4456591A (en) | 1981-06-25 | 1984-06-26 | Baxter Travenol Laboratories, Inc. | Therapeutic method for activating factor VII |
| GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| GB9022545D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| US5997864A (en) | 1995-06-07 | 1999-12-07 | Novo Nordisk A/S | Modified factor VII |
| US5804420A (en) * | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| AT407255B (de) * | 1997-06-20 | 2001-02-26 | Immuno Ag | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
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| US20030204338A1 (en) | 2002-04-22 | 2003-10-30 | Peter Martinek | Method and measurement probe for the performance of measurements in water supply systems |
| US20040185535A1 (en) † | 2003-03-21 | 2004-09-23 | Giles Wilson | Industrial-scale serum-free production of recombinant FVII in mammalian cells |
| BR0114373A (pt) * | 2000-10-02 | 2004-02-17 | Novo Nordisk As | Célula hospedeira eucariótica, métodos para a produção de fvii e de fviia ou de suas variantes, de uma proteìna dependente de vitamina k e de uma célula hospedeira eucariótica produtora de fvii ou de seu análogo, vetor recombinante, fvii e fviia recombinante ou suas variantes, e, proteìna dependente de vitamina k recombinante |
| EP1434857B1 (en) * | 2001-10-02 | 2007-08-01 | Novo Nordisk Health Care AG | Method for production of recombinant proteins in eukaryote cells |
| US20050214289A1 (en) * | 2004-03-26 | 2005-09-29 | Human Genome Sciences, Inc. | Antibodies against Nogo receptor |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| EP1851305B1 (en) * | 2005-02-11 | 2012-01-18 | Novo Nordisk Health Care AG | Production of a polypeptide in a serum-free cell culture liquid containing plant protein hydrolysate |
| CN101300342A (zh) † | 2005-11-02 | 2008-11-05 | 惠氏公司 | 用于使哺乳动物细胞具备适应性的方法 |
| ES2474573T3 (es) † | 2006-01-04 | 2014-07-09 | Baxter International Inc | Medio de cultivo celular sin oligop�ptidos |
-
2009
- 2009-11-05 PT PT98265770T patent/PT2356247E/pt unknown
- 2009-11-05 WO PCT/US2009/063338 patent/WO2010056584A1/en not_active Ceased
- 2009-11-05 EP EP09826577.0A patent/EP2356247B2/en not_active Not-in-force
- 2009-11-05 JP JP2011535656A patent/JP5719301B2/ja active Active
- 2009-11-05 CA CA2742107A patent/CA2742107A1/en not_active Abandoned
- 2009-11-05 EP EP15169975.8A patent/EP2977461A1/en not_active Withdrawn
- 2009-11-05 ES ES09826577T patent/ES2547881T5/es active Active
- 2009-11-05 HU HUE09826577A patent/HUE026210T2/en unknown
- 2009-11-05 SI SI200931283T patent/SI2356247T2/sl unknown
- 2009-11-05 PL PL09826577T patent/PL2356247T5/pl unknown
- 2009-11-05 HR HRP20151054T patent/HRP20151054T4/hr unknown
- 2009-11-05 US US12/612,752 patent/US20100120093A1/en not_active Abandoned
- 2009-11-05 AU AU2009314345A patent/AU2009314345B2/en not_active Ceased
- 2009-11-05 DK DK09826577.0T patent/DK2356247T4/da active
-
2011
- 2011-04-14 IL IL212355A patent/IL212355A/en not_active IP Right Cessation
-
2016
- 2016-06-14 HK HK16106839.4A patent/HK1219113A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2356247T5 (pl) | 2019-10-31 |
| SI2356247T1 (sl) | 2015-11-30 |
| HK1219113A1 (en) | 2017-03-24 |
| PT2356247E (pt) | 2015-10-26 |
| CA2742107A1 (en) | 2010-05-20 |
| EP2977461A1 (en) | 2016-01-27 |
| JP2012508562A (ja) | 2012-04-12 |
| IL212355A0 (en) | 2011-06-30 |
| US20100120093A1 (en) | 2010-05-13 |
| JP5719301B2 (ja) | 2015-05-13 |
| AU2009314345B2 (en) | 2015-02-12 |
| EP2356247A4 (en) | 2013-01-02 |
| PL2356247T3 (pl) | 2016-04-29 |
| WO2010056584A1 (en) | 2010-05-20 |
| SI2356247T2 (sl) | 2019-08-30 |
| EP2356247A1 (en) | 2011-08-17 |
| IL212355A (en) | 2016-04-21 |
| HRP20151054T4 (hr) | 2019-11-15 |
| EP2356247B2 (en) | 2019-05-15 |
| EP2356247B1 (en) | 2015-07-15 |
| HRP20151054T1 (xx) | 2015-11-20 |
| HUE026210T2 (en) | 2016-05-30 |
| ES2547881T3 (es) | 2015-10-09 |
| AU2009314345A1 (en) | 2011-06-30 |
| DK2356247T3 (en) | 2015-09-21 |
| DK2356247T4 (da) | 2019-06-03 |
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