JP5687201B2 - 組み合わせ顕微鏡検査法 - Google Patents
組み合わせ顕微鏡検査法 Download PDFInfo
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- JP5687201B2 JP5687201B2 JP2011535029A JP2011535029A JP5687201B2 JP 5687201 B2 JP5687201 B2 JP 5687201B2 JP 2011535029 A JP2011535029 A JP 2011535029A JP 2011535029 A JP2011535029 A JP 2011535029A JP 5687201 B2 JP5687201 B2 JP 5687201B2
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- G02B27/64—Imaging systems using optical elements for stabilisation of the lateral and angular position of the image
- G02B27/642—Optical derotators, i.e. systems for compensating for image rotation, e.g. using rotating prisms, mirrors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
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- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
- G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/58—Optics for apodization or superresolution; Optical synthetic aperture systems
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- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
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- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
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- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008054317A DE102008054317A1 (de) | 2008-11-03 | 2008-11-03 | Kombinationsmikroskopie |
| DE102008054317.9 | 2008-11-03 | ||
| PCT/EP2009/007693 WO2010060515A1 (de) | 2008-11-03 | 2009-10-28 | Kombinationsmikroskopie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012507756A JP2012507756A (ja) | 2012-03-29 |
| JP2012507756A5 JP2012507756A5 (enExample) | 2012-12-13 |
| JP5687201B2 true JP5687201B2 (ja) | 2015-03-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535029A Active JP5687201B2 (ja) | 2008-11-03 | 2009-10-28 | 組み合わせ顕微鏡検査法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8704196B2 (enExample) |
| EP (2) | EP3206070B1 (enExample) |
| JP (1) | JP5687201B2 (enExample) |
| DE (1) | DE102008054317A1 (enExample) |
| WO (1) | WO2010060515A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010140609A1 (ja) * | 2009-06-02 | 2010-12-09 | 株式会社ニコン | 画像処理装置、プログラム、および、顕微鏡 |
| DE102009031231A1 (de) | 2009-06-26 | 2010-12-30 | Carl Zeiss Microlmaging Gmbh | Verfahren und Anordnungen für die Fluoreszenzmikroskopie |
| DE102010028138A1 (de) * | 2010-04-22 | 2011-10-27 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Bestimmen der Verteilung einer Substanz durch Abtasten mit einer Messfront |
| DE102010036709A1 (de) * | 2010-07-28 | 2012-02-02 | Leica Microsystems Cms Gmbh | Einrichtung und Verfahren zur mikroskopischen Bildaufnahme einer Probenstruktur |
| JP2013539074A (ja) | 2010-09-24 | 2013-10-17 | カール・ツァイス・マイクロスコピー・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ３ｄ局在顕微鏡法並びに４ｄ局在顕微鏡法及び追跡方法並びに追跡システム |
| DE102010041426A1 (de) * | 2010-09-27 | 2012-05-03 | Siemens Aktiengesellschaft | Messeinheit und Verfahren zur optischen Untersuchung einer Flüssigkeit zur Bestimmung einer Analyt-Konzentration |
| CN103477267B (zh) * | 2011-03-01 | 2016-09-14 | 通用电气医疗集团生物科学公司 | 可变取向照明模式旋转器 |
| DE102011007751B4 (de) * | 2011-04-20 | 2023-10-19 | Carl Zeiss Microscopy Gmbh | Weitfeldmikroskop und Verfahren zur Weitfeldmikroskopie |
| DE102011100507B4 (de) * | 2011-04-29 | 2020-05-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Tragbares optisches Analysegerät |
| DE102011077269A1 (de) * | 2011-06-09 | 2012-12-13 | Carl Zeiss Microimaging Gmbh | Hochauflösende Lumineszenzmikroskopie |
| DE102011083847A1 (de) | 2011-09-30 | 2013-04-04 | Carl Zeiss Microscopy Gmbh | Mikroskop für die Weitfeldmikroskopie |
| DE102011084315A1 (de) | 2011-10-12 | 2013-04-18 | Carl Zeiss Microscopy Gmbh | Hochauflösende Lumineszenzmikroskopie |
| DE102011087196A1 (de) * | 2011-11-28 | 2013-05-29 | Leica Microsystems Cms Gmbh | Mikroskopbeleuchtungssystem und -verfahren |
| US8755122B2 (en) * | 2011-12-12 | 2014-06-17 | Corning Incorporated | Laser pulse stretching unit and method for using same |
| US8724203B2 (en) * | 2011-12-12 | 2014-05-13 | Corning Incorporated | Variable pulse stretching length by variable beamsplitter reflectivity |
| JP5878756B2 (ja) | 2011-12-28 | 2016-03-08 | 浜松ホトニクス株式会社 | 画像処理装置、撮像装置、顕微鏡装置、画像処理方法、及び画像処理プログラム |
| DE102012007045B4 (de) | 2012-04-05 | 2023-03-16 | Carl Zeiss Microscopy Gmbh | Vorrichtung und Verfahren zur Mikroskopie |
| DE102013100172A1 (de) * | 2013-01-09 | 2014-07-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zum räumlich hochaufgelösten Abbilden einer einen Luminophor aufweisenden Struktur einer Probe |
| CN105144237B (zh) | 2013-03-15 | 2018-09-18 | 卢米耐克斯公司 | 微球的实时跟踪和关联 |
| EP2801854B1 (en) | 2013-05-10 | 2017-07-19 | Ruprecht-Karls-Universität Heidelberg | Method and apparatus for combination of localization microscopy and structured illumination microscopy |
| CN104516098B (zh) * | 2013-09-30 | 2017-04-12 | 西门子公司 | 一种显微装置及成像方法 |
| DE102013114860B3 (de) | 2013-12-23 | 2015-05-28 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren und Vorrichtung zur Bestimmung der Orte einzelner Moleküle einer Substanz in einer Probe |
| DE102014107606A1 (de) * | 2014-05-28 | 2015-12-03 | Carl Zeiss Ag | Funktionsintegriertes Laser-Scanning-Mikroskop |
| DE102016117096C5 (de) * | 2015-09-22 | 2023-11-30 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zum hochaufgelösten lokalen Abbilden einer Struktur in einer Probe |
| LU92924B1 (de) * | 2015-12-23 | 2017-08-07 | Leica Microsystems | Abtastvorrichtung zum Abtasten eines Objekts für den Einsatz in einem Rastermikroskop |
| US10648924B2 (en) * | 2016-01-04 | 2020-05-12 | Kla-Tencor Corp. | Generating high resolution images from low resolution images for semiconductor applications |
| JP7027316B2 (ja) | 2016-03-07 | 2022-03-01 | マックス－プランク－ゲゼルシャフト ツア フェルデルング デア ヴィッセンシャフテン イー．ヴイ． | 多数の対象の対象固有の場所間の輸送方法 |
| US10969573B2 (en) | 2016-03-24 | 2021-04-06 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Spatio-temporally light modulated imaging system, method for confocal imaging an object and carrier wheel device |
| EP3252512A1 (en) | 2016-06-03 | 2017-12-06 | Leica Instruments (Singapore) Pte. Ltd. | Interchangeable optical module and microscopic apparatus |
| DE102016120683A1 (de) * | 2016-10-28 | 2018-05-03 | Carl Zeiss Microscopy Gmbh | Lichtblattmikroskop |
| US10324041B2 (en) | 2016-12-21 | 2019-06-18 | Abbott Japan Co., Ltd. | Optical imaging system using lateral illumination for digital assays |
| WO2018131172A1 (ja) | 2017-01-16 | 2018-07-19 | 株式会社ニコン | 画像処理装置、顕微鏡システム、画像処理方法、及びプログラム |
| US11047854B2 (en) | 2017-02-06 | 2021-06-29 | Abbott Japan Llc | Methods for reducing noise in signal-generating digital assays |
| DE102017102604B4 (de) * | 2017-02-09 | 2023-12-14 | Abberior Instruments Gmbh | Verfahren zum Steuern eines Laserscanning-Mikroskops beim Abtasten einer Probe und Laserscanning-Mikroskop |
| EP3610313B1 (en) * | 2017-04-11 | 2022-03-02 | Calico Life Sciences LLC | Fluorescence microscopy system and methods based on stimulated emission |
| CN109724951A (zh) * | 2017-10-27 | 2019-05-07 | 黄晓淳 | 一种动态超分辨荧光成像技术 |
| JP7039261B2 (ja) * | 2017-11-17 | 2022-03-22 | 株式会社日立製作所 | 組織切片の特定領域からの生体分子採取方法および装置 |
| DE102018105442A1 (de) * | 2018-03-09 | 2019-09-12 | Carl Zeiss Microscopy Gmbh | Kameramodul für ein Mikroskop und Verfahren zu dessen Betrieb |
| WO2020205952A1 (en) | 2019-04-02 | 2020-10-08 | Thermo Electron Scientific Instruments Llc | Enhanced sample imaging using structured illumination microscopy |
| GB201907953D0 (en) | 2019-06-04 | 2019-07-17 | Smi Drug Discovery Ltd | An optical microscope |
| EP3822687A1 (en) * | 2019-11-15 | 2021-05-19 | Leica Microsystems CMS GmbH | Optical imaging device for a microscope |
| DE102019218912A1 (de) * | 2019-12-04 | 2021-06-10 | Carl Zeiss Microscopy Gmbh | Verfahren und Vorrichtung zur Beleuchtung einer Probenebene |
| DE102019008989B3 (de) * | 2019-12-21 | 2021-06-24 | Abberior Instruments Gmbh | Verfahren zur Störungskorrektur und Laserscanningmikroskop mit Störungskorrektur |
| CN114076750B (zh) * | 2020-08-20 | 2024-05-10 | 深圳华大智造科技股份有限公司 | 超分辨成像装置与方法、生物样品识别系统与识别方法 |
| DE102020122535B4 (de) * | 2020-08-28 | 2022-08-11 | Carl Zeiss Microscopy Gmbh | Verfahren zum Betrieb eines Strahlgeräts, Computerprogrammprodukt und Strahlgerät zum Durchführen des Verfahrens |
| CN114755200B (zh) * | 2022-03-21 | 2022-11-08 | 北京大学长三角光电科学研究院 | 基于光动力治疗的可视化监测系统及方法 |
| EP4253942A1 (en) | 2022-03-31 | 2023-10-04 | Abberior GmbH | Method and apparatus for optical imaging with a high number of imaging samples |
| EP4253941A1 (en) * | 2022-03-31 | 2023-10-04 | Abberior GmbH | Method and apparatus for optical imaging with a high number of imaging samples |
| DE102022208620A1 (de) * | 2022-08-19 | 2024-02-22 | Carl Zeiss Microscopy Gmbh | Mikroskopieverfahren, insbesondere für die Fluoreszenzkorrelationsspektroskopie |
| DE102023119977A1 (de) * | 2023-07-27 | 2025-01-30 | Abberior Instruments Gmbh | Verfahren, Computerprogramm und Vorrichtung zum Schätzen einer Lage eines Emitters in einer Probe |
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| US23686A (en) | 1859-04-19 | Coen-shellek | ||
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| JP4602731B2 (ja) * | 2004-10-05 | 2010-12-22 | オリンパス株式会社 | 顕微鏡システム |
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| ATE441103T1 (de) | 2005-07-22 | 2009-09-15 | Zeiss Carl Microimaging Gmbh | Auflísungsgesteigerte lumineszenz-mikroskopie |
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| US7679741B2 (en) | 2006-03-01 | 2010-03-16 | Leica Microsystems Cms Gmbh | Method and microscope for high spatial resolution examination of samples |
| DE102006009831B4 (de) * | 2006-03-01 | 2013-07-04 | Leica Microsystems Cms Gmbh | Verfahren und Mikroskop zur räumlich hochauflösenden Untersuchung von Proben |
| DE102006021317B3 (de) | 2006-05-06 | 2007-10-11 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren und Fluoreszenzlichtmikroskop zum räumlich hochauflösenden Abbilden einer Struktur einer Probe |
| US8421035B2 (en) | 2006-08-11 | 2013-04-16 | The Regents Of The University Of California | High-resolution microscope using optical amplification |
| DE102006046369A1 (de) | 2006-09-29 | 2008-04-03 | Carl Zeiss Microimaging Gmbh | Auflösungsgesteigerte Lumineszenzmikroskopie |
| DE102006047912A1 (de) | 2006-10-06 | 2008-04-10 | Carl Zeiss Microimaging Gmbh | Verfahren und Anordnung zur parallelisierten mikroskopischen Bildgebung |
| DE102006060180B9 (de) | 2006-12-18 | 2013-08-08 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren und Vorrichtung zum räumlich hochaufgelösten Abbilden einer mit einer Substanz markierten Struktur |
| DE102008009216A1 (de) | 2008-02-13 | 2009-08-20 | Carl Zeiss Microimaging Gmbh | Vorrichtung und Verfahren zum räumlich hochauflösenden Abbilden einer Struktur einer Probe |
-
2008
- 2008-11-03 DE DE102008054317A patent/DE102008054317A1/de not_active Withdrawn
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2009
- 2009-10-28 EP EP17162704.5A patent/EP3206070B1/de active Active
- 2009-10-28 US US13/127,427 patent/US8704196B2/en active Active
- 2009-10-28 EP EP09743876.6A patent/EP2350726B1/de not_active Not-in-force
- 2009-10-28 JP JP2011535029A patent/JP5687201B2/ja active Active
- 2009-10-28 WO PCT/EP2009/007693 patent/WO2010060515A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010060515A1 (de) | 2010-06-03 |
| US8704196B2 (en) | 2014-04-22 |
| EP3206070A1 (de) | 2017-08-16 |
| JP2012507756A (ja) | 2012-03-29 |
| DE102008054317A1 (de) | 2010-05-06 |
| EP3206070B1 (de) | 2018-05-23 |
| EP2350726B1 (de) | 2017-04-19 |
| US20110284767A1 (en) | 2011-11-24 |
| EP2350726A1 (de) | 2011-08-03 |
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