JP5681698B2 - クルクミノイドを含む栄養組成物および製造方法 - Google Patents
クルクミノイドを含む栄養組成物および製造方法 Download PDFInfo
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- JP5681698B2 JP5681698B2 JP2012502100A JP2012502100A JP5681698B2 JP 5681698 B2 JP5681698 B2 JP 5681698B2 JP 2012502100 A JP2012502100 A JP 2012502100A JP 2012502100 A JP2012502100 A JP 2012502100A JP 5681698 B2 JP5681698 B2 JP 5681698B2
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- bisdemethoxycurcumin
- curcuminoid
- curcumin
- solubilized
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- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
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- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
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- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
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- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pediatric Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Edible Oils And Fats (AREA)
- Medicinal Preparation (AREA)
Description
一実施形態は、クルクミン、デメトキシクルクミンおよびビスデメトキシクルクミンの組合せが、約0.7から約14のHLB値を有する極性油に可溶化されており、ビスデメトキシクルクミン対クルクミンの重量比が約1:1から約1:7であり、ビスデメトキシクルクミン対デメトキシクルクミンの重量比が約1:1から約1:2.5である、クルクミン、デメトキシクルクミンおよびビスデメトキシクルクミンの組合せを含む、脂肪、タンパク質および炭水化物を含む組成物を対象とする。
栄養組成物は、任意の公知のまたはその他で適切な経口形態に配合し、投与することができる。固体、液体または粉末形態の組合せまたは変形形態を含む任意の固体、液体または粉末形態は、かかる形態によって、やはり本明細書に定義の必須成分を安全で有効に個体に経口送達することができるならば、本明細書における使用に適している。
栄養組成物は極性油を含み、この極性油は組成物中の全脂肪のすべてまたは一部であってよい。極性油は、最終的には適切な処理温度の場合による選択と共に、本明細書に記載の個々の有益な比のクルクミノイドの溶解にとって有利な選択されたHLB値によって定義される。
栄養組成物は、クルクミン、デメトキシクルクミン(DMC)およびビスデメトキシクルクミン(BDMC)の組合せを含み、これらは組成物の極性油成分または極性油成分を含む油相に、選択された比で可溶化されている。
栄養組成物は、脂肪、タンパク質および炭水化物の主要栄養素を含む。公知の、またはその他で経口栄養製品における使用に適したかかる栄養分の任意の供給源も、かかる栄養分が組成物中の選択された成分と相溶性があり、脂肪成分が本明細書に記載の極性油を含むならば、本明細書における使用に適している。
栄養組成物はさらに、製品の物理的、化学的、審美的もしくは処理的な特徴を改変することができ、または標的集団において使用される場合には医薬品用の成分もしくは追加の栄養成分として働くことができる場合による他の成分を含むことができる。多くのかかる場合による成分は公知であり、またはその他で栄養製品における使用に適しており、かかる場合による成分が投与にとって安全で有効であり、組成物中の必須成分および他の選択された成分と相容性があるならば、本明細書の組成物において使用することができる。
栄養組成物は、本明細書の方法に従って調製することができ、または個々の構成成分、成分および/もしくは特徴を、最終的な栄養製品にまとめ上げるための任意の公知のもしくはその他で適切な技術によって調製することができる。
(a)クルクミン、デメトキシクルクミン(DMC)およびビスデメトキシクルクミン(BDMC)を含むクルクミノイドを、本明細書に定義の極性油と組み合わせるステップ、
(b)クルクミノイドと極性油との組合せを、極性油中のクルクミノイドのすべてではないが一部分を可溶化させるのに十分な温度に加熱するステップ(加熱して得られる組合せは、可溶化クルクミノイドおよび非可溶化クルクミノイドを含む)、
(c)この組合せから、非可溶化クルクミノイド部分の少なくとも一部、最も一般的には、約75重量%から約100重量%、および80重量%から95重量%を含む、約25重量%から100重量%除去して、極性油ならびに可溶化クルクミン、可溶化デメトキシクルクミンおよび可溶化ビスデメトキシクルクミンを本明細書に定義の重量比以内で含む溶液を形成するステップ、
(d)極性油および可溶化クルクミノイドを含む溶液を、本明細書に定義の栄養組成物に導入、添加またはその他の方法で配合するステップを含むことができる。
NEOBEE(登録商標)1053(イリノイ州ノースフィールド、Stepan Company製のMCT油)中、CURCUMIN C3 COMPLEX(登録商標)(ユタ州ペイスン、Sabinsa Corporation)を2.4重量%含む懸濁液を調製する。懸濁液を55℃から165℃の温度に加熱し、その間に温度をそれぞれ55℃、65℃、75℃、85℃、95℃および165℃で約2分間維持する。2分間の定常温度のそれぞれの懸濁液から一定分量を採取し、15,000×gで5分間遠心分離機にかけることによって、懸濁液から非可溶化固体を除去する。ここで遠心分離機にかけた一定分量は、可溶化クルクミノイドを含む溶液であり、これをジメチルスルホキシドで2:100の体積比に希釈し、高圧液体クロマトグラフィー(HPLC)を使用してクルクミノイド含量について試験する。結果を以下に概説する。
実施例2−5は、水中油エマルジョンとして配合した本開示の栄養組成物を例示するものである。各例示的な組成物の成分を、以下の表に記載する。すべての成分量は、別段特定されない限り製品の1000kgバッチ当たりのkgとして列挙する。
Claims (17)
- クルクミン、デメトキシクルクミンおよびビスデメトキシクルクミンの組合せが、1から8のHLB値を有する中鎖トリグリセリド油に可溶化されており、ビスデメトキシクルクミン対クルクミンの重量比が1:1から1:7であり、ビスデメトキシクルクミン対デメトキシクルクミンの重量比が1:1から1:2.5である、クルクミン、デメトキシクルクミンおよびビスデメトキシクルクミンの組合せを含む、脂肪、タンパク質および炭水化物を含む組成物。
- 中鎖トリグリセリド油が、組成物中の脂肪の10重量%から100重量%である、請求項1に記載の組成物。
- 水性エマルジョンである、請求項2に記載の組成物。
- クルクミン、デメトキシクルクミンおよびビスデメトキシクルクミンの組合せが、組成物の0.002重量%から1.0重量%である、請求項3に記載の組成物。
- 中鎖トリグリセリド油を0.1重量%から17重量%含む、請求項3に記載の組成物。
- ビスデメトキシクルクミン対クルクミンの重量比が1:3から1:7である、請求項3に記載の組成物。
- ビスデメトキシクルクミン対デメトキシクルクミンの重量比が1:1から1:2.0である、請求項3に記載の組成物。
- 非可溶化クルクミン、非可溶化デメトキシクルクミン、および非可溶化ビスデメトキシクルクミンを含まない、請求項3に記載の組成物。
- デメトキシクルクミン、ビスデメトキシクルクミンおよびクルクミン以外のクルクミノイドを含まない、請求項3に記載の組成物。
- (a)クルクミン、デメトキシクルクミンおよびビスデメトキシクルクミンを含むクルクミノイドを、1から8のHLB値を有する中鎖トリグリセリド油と組み合わせるステップ、
(b)クルクミノイドと中鎖トリグリセリド油との組合せを、中鎖トリグリセリド油にクルクミノイドの一部分を可溶化させるのに十分な温度に加熱するステップ、
(c)加熱した組合せから、非可溶化クルクミノイド部分を除去するステップ、次いで
(d)中鎖トリグリセリド油と可溶化クルクミノイド部分との組合せを、脂肪、タンパク質および炭水化物と配合して、栄養組成物を形成するステップ、を含み、
可溶化ビスデメトキシクルクミン対可溶化クルクミンの重量比が1:1から1:7、およびビスデメトキシクルクミン対デメトキシクルクミンの重量比が1:1から1:2.5である、栄養組成物の生成方法。 - クルクミノイドと中鎖トリグリセリド油との組合せが、22℃から90℃の温度に加熱される、請求項10に記載の方法。
- クルクミノイドと中鎖トリグリセリド油との組合せが、40℃から65℃の温度に加熱される、請求項10に記載の方法。
- クルクミノイドと中鎖トリグリセリド油との組合せが、クルクミノイドを0.4重量%から17重量%含む、請求項10に記載の方法。
- 中鎖トリグリセリド油が、栄養組成物中の脂肪の10重量%から100重量%である、請求項10に記載の方法。
- 栄養組成物が、中鎖トリグリセリド油を0.1重量%から5重量%含む、請求項10に記載の方法。
- ビスデメトキシクルクミン対クルクミンの重量比が1:3から1:7である、請求項10に記載の方法。
- ビスデメトキシクルクミン対デメトキシクルクミンの重量比が1:1から1:2.0である、請求項10に記載の方法。
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