JP5677951B2 - 抗癌活性を有する２−デオキシ単糖の新規なアセテート - Google Patents

抗癌活性を有する２−デオキシ単糖の新規なアセテート Download PDF

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JP5677951B2
JP5677951B2 JP2011517467A JP2011517467A JP5677951B2 JP 5677951 B2 JP5677951 B2 JP 5677951B2 JP 2011517467 A JP2011517467 A JP 2011517467A JP 2011517467 A JP2011517467 A JP 2011517467A JP 5677951 B2 JP5677951 B2 JP 5677951B2
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glucose
mmol
autophagy
benzyl
glucal
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Japanese (ja)
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JP2011527678A5 (enExample
JP2011527678A (ja
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プリーベ、ワルデマー
シブルスキー、マルチン
フォクト、イザベラ
スコラ、スタインスロー
コンラッド、チャールズ
マッデン、ティモシー
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University of Texas System
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University of Texas System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2011517467A 2008-07-11 2009-06-25 抗癌活性を有する２−デオキシ単糖の新規なアセテート Expired - Fee Related JP5677951B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7996808P 2008-07-11 2008-07-11
US61/079,968 2008-07-11
PCT/US2009/048675 WO2010005799A2 (en) 2008-07-11 2009-06-25 Novel acetates of 2-deoxy monosaccharides with anticancer activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015000024A Division JP5890043B2 (ja) 2008-07-11 2015-01-05 抗癌活性を有する２−デオキシ単糖の新規なアセテート

Publications (3)

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JP2011527678A JP2011527678A (ja) 2011-11-04
JP2011527678A5 JP2011527678A5 (enExample) 2012-08-09
JP5677951B2 true JP5677951B2 (ja) 2015-02-25

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Family Applications (2)

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JP2011517467A Expired - Fee Related JP5677951B2 (ja) 2008-07-11 2009-06-25 抗癌活性を有する２−デオキシ単糖の新規なアセテート
JP2015000024A Expired - Fee Related JP5890043B2 (ja) 2008-07-11 2015-01-05 抗癌活性を有する２−デオキシ単糖の新規なアセテート

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JP2015000024A Expired - Fee Related JP5890043B2 (ja) 2008-07-11 2015-01-05 抗癌活性を有する２−デオキシ単糖の新規なアセテート

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Country Link
US (1) US8927506B2 (enExample)
EP (1) EP2310020B1 (enExample)
JP (2) JP5677951B2 (enExample)
CN (1) CN102149388B (enExample)
DK (1) DK2310020T3 (enExample)
ES (1) ES2628180T3 (enExample)
HU (1) HUE033210T2 (enExample)
LT (1) LT2310020T (enExample)
PL (1) PL2310020T3 (enExample)
WO (1) WO2010005799A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9149489B2 (en) 2006-04-27 2015-10-06 Board Of Regents, University Of Texas System Inhibitors of glycolysis useful in the treatment of brain tumors
HUE033210T2 (hu) 2008-07-11 2017-11-28 Univ Texas Rákellenes aktivitású 2-dezoxi-monoszacharidok új acetátjai
JP2014505058A (ja) * 2011-01-11 2014-02-27 ザ・ユニバーシティ・オブ・テキサス・エム・ディー・アンダーソン・キャンサー 増殖性および炎症性皮膚疾患の治療用単糖ベース化合物
WO2012142615A2 (en) * 2011-04-14 2012-10-18 Board Of Regents, The University Of Texas System Auranofin and auranofin analogs useful to treat proliferative disease and disorders
CA2870248A1 (en) * 2012-04-12 2013-10-17 Gifu University Medicinal composition for treating infarction
WO2014165736A2 (en) 2013-04-05 2014-10-09 Board Of Regents, The University Of Texas System Esters of 2-deoxy-monosaccharides with anti proliferative activity
WO2020035782A1 (en) * 2018-08-13 2020-02-20 Dermin Sp. Z O.O. Molecular probes for analysis of metabolism of glycolysis inhibitors prodrugs and synthesis methods therefore
CA3170872A1 (en) 2020-03-16 2021-09-23 Board Of Regents, The University Of Texas System Method of treating viral infections with hexose type monosaccharides and analogs thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56103197A (en) * 1980-01-21 1981-08-18 Wakamoto Pharmaceut Co Ltd Novel d-glucose derivative and antitumor agent containing the same as active constitutent
JPS58167582A (ja) 1982-03-29 1983-10-03 Takeda Chem Ind Ltd 糖ケタ−ルの製造法
US6319695B1 (en) 1991-10-15 2001-11-20 The Scripps Research Insitute Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
KR19990028344A (ko) * 1995-06-23 1999-04-15 로버터 에이.커리 치료 화합물
EE200200565A (et) 2000-03-31 2004-06-15 Angiogene Pharmaceuticals Ltd. Vaskulaarse kahjustava toimega kombinatsioonravi
US6670330B1 (en) 2000-05-01 2003-12-30 Theodore J. Lampidis Cancer chemotherapy with 2-deoxy-D-glucose
CA2487039A1 (en) 2001-06-11 2002-12-19 Transition Therapeutics Inc. Combination therapies using vitamin b12 and interferon for treatment of viral, proliferative and inflammatory diseases
AU2002330717A1 (en) 2001-08-30 2003-03-10 University College Dublin Monosaccharide derivatives
AU2003230750A1 (en) 2002-03-29 2003-10-13 Threshold Pharmaceuticals, Inc. Compositions and methods for treating cancer
JP2006515883A (ja) * 2003-01-10 2006-06-08 スレッシュオールド ファーマシューティカルズ， インコーポレイテッド ２−デオキシグルコースによる癌の処置
CA2431425A1 (en) 2003-06-05 2004-12-05 Angiogene, Inc. Epas1 gene transfer to improve cell therapy
WO2005065721A2 (en) 2003-12-30 2005-07-21 Board Of Regents, The University Of Texas System Use of an anti-inflammatory compound for the reduction of inflammation secondary to the administration of a lipid-nucleic acid complex
EP1789107B1 (en) 2004-08-30 2009-05-27 Interstitial Therapeutics Medical stent provided with inhibitors of atp synthesis
EP1991056A4 (en) 2006-02-24 2009-09-02 Univ Miami MANNOSEDERIVATES FOR THE KILLING OF TUMOR CELLS
WO2007101148A2 (en) 2006-02-24 2007-09-07 Board Of Regents, The University Of Texas System Hexose compounds to treat cancer
US9149489B2 (en) 2006-04-27 2015-10-06 Board Of Regents, University Of Texas System Inhibitors of glycolysis useful in the treatment of brain tumors
EP1881000A1 (en) * 2006-07-17 2008-01-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Conjugates of 2-fluoro-2-deoxy-glucose and their uses as anti cancer agents
WO2008131024A1 (en) 2007-04-17 2008-10-30 Board Of Regents, The University Of Texas System Iodo-hexose compounds useful to treat cancer
HUE033210T2 (hu) 2008-07-11 2017-11-28 Univ Texas Rákellenes aktivitású 2-dezoxi-monoszacharidok új acetátjai
WO2012142615A2 (en) 2011-04-14 2012-10-18 Board Of Regents, The University Of Texas System Auranofin and auranofin analogs useful to treat proliferative disease and disorders

Also Published As

Publication number Publication date
DK2310020T3 (en) 2017-06-26
CN102149388B (zh) 2014-11-05
CN102149388A (zh) 2011-08-10
US8927506B2 (en) 2015-01-06
US20110160151A1 (en) 2011-06-30
HUE033210T2 (hu) 2017-11-28
JP2011527678A (ja) 2011-11-04
WO2010005799A2 (en) 2010-01-14
EP2310020A4 (en) 2012-04-25
EP2310020B1 (en) 2017-03-15
ES2628180T3 (es) 2017-08-02
WO2010005799A3 (en) 2010-04-29
EP2310020A2 (en) 2011-04-20
JP5890043B2 (ja) 2016-03-22
LT2310020T (lt) 2017-07-25
PL2310020T3 (pl) 2017-10-31
JP2015091849A (ja) 2015-05-14

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