CN102149388B - 具有抗癌活性的新型2-脱氧单糖乙酸酯 - Google Patents

具有抗癌活性的新型2-脱氧单糖乙酸酯 Download PDF

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Publication number
CN102149388B
CN102149388B CN200980135924.XA CN200980135924A CN102149388B CN 102149388 B CN102149388 B CN 102149388B CN 200980135924 A CN200980135924 A CN 200980135924A CN 102149388 B CN102149388 B CN 102149388B
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Prior art keywords
autophagy
glucose
ddd
cancer
mmol
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Expired - Fee Related
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CN200980135924.XA
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English (en)
Chinese (zh)
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CN102149388A (zh
Inventor
W·普里布
M·塞布尔斯基
I·富克特
S·斯科拉
C·康拉德
T·马登
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The University of Texas System
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The University of Texas System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN200980135924.XA 2008-07-11 2009-06-25 具有抗癌活性的新型2-脱氧单糖乙酸酯 Expired - Fee Related CN102149388B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7996808P 2008-07-11 2008-07-11
US61/079968 2008-07-11
PCT/US2009/048675 WO2010005799A2 (en) 2008-07-11 2009-06-25 Novel acetates of 2-deoxy monosaccharides with anticancer activity

Publications (2)

Publication Number Publication Date
CN102149388A CN102149388A (zh) 2011-08-10
CN102149388B true CN102149388B (zh) 2014-11-05

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Family Applications (1)

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CN200980135924.XA Expired - Fee Related CN102149388B (zh) 2008-07-11 2009-06-25 具有抗癌活性的新型2-脱氧单糖乙酸酯

Country Status (10)

Country Link
US (1) US8927506B2 (enExample)
EP (1) EP2310020B1 (enExample)
JP (2) JP5677951B2 (enExample)
CN (1) CN102149388B (enExample)
DK (1) DK2310020T3 (enExample)
ES (1) ES2628180T3 (enExample)
HU (1) HUE033210T2 (enExample)
LT (1) LT2310020T (enExample)
PL (1) PL2310020T3 (enExample)
WO (1) WO2010005799A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9149489B2 (en) 2006-04-27 2015-10-06 Board Of Regents, University Of Texas System Inhibitors of glycolysis useful in the treatment of brain tumors
US8927506B2 (en) 2008-07-11 2015-01-06 Board Of Regents, The University Of Texas System Acetates of 2-deoxy monosaccharides with anticancer activity
WO2012097052A2 (en) * 2011-01-11 2012-07-19 Intertech Bio, Llc Monosaccharide-based compounds for the treatment of proliferative and inflammatory dermatological diseases
WO2012142615A2 (en) * 2011-04-14 2012-10-18 Board Of Regents, The University Of Texas System Auranofin and auranofin analogs useful to treat proliferative disease and disorders
CN104470543A (zh) * 2012-04-12 2015-03-25 国立大学法人岐阜大学 梗塞治疗用医药组合物
ES2897699T3 (es) 2013-04-05 2022-03-02 Univ Texas Esteres de 2-desoxi-monosacáridos con actividad antiproliferativa
WO2020035782A1 (en) * 2018-08-13 2020-02-20 Dermin Sp. Z O.O. Molecular probes for analysis of metabolism of glycolysis inhibitors prodrugs and synthesis methods therefore
IL296389A (en) 2020-03-16 2022-11-01 Univ Texas Method of treating viral infections with hexose type monosaccharides and analogs thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1196059A (zh) * 1995-06-23 1998-10-14 牛津糖科学(英国)有限公司 治疗化合物
WO2001082926A1 (en) * 2000-05-01 2001-11-08 Lampidis Theodore J Manipulation of oxidative phosphorylation for hypersensitizing tumor cells to glycolytic inhibitors
US20040167079A1 (en) * 2003-01-10 2004-08-26 George Tidmarsh Treatment of cancer with 2-deoxyglucose
EP1881000A1 (en) * 2006-07-17 2008-01-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Conjugates of 2-fluoro-2-deoxy-glucose and their uses as anti cancer agents

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
JPS56103197A (en) * 1980-01-21 1981-08-18 Wakamoto Pharmaceut Co Ltd Novel d-glucose derivative and antitumor agent containing the same as active constitutent
JPS58167582A (ja) 1982-03-29 1983-10-03 Takeda Chem Ind Ltd 糖ケタ−ルの製造法
US6319695B1 (en) 1991-10-15 2001-11-20 The Scripps Research Insitute Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
EE200200565A (et) 2000-03-31 2004-06-15 Angiogene Pharmaceuticals Ltd. Vaskulaarse kahjustava toimega kombinatsioonravi
CN1541106A (zh) 2001-06-11 2004-10-27 转新疗法公司 用维生素b12和治疗剂联合治疗病毒性、增殖性和炎性疾病的方法
WO2003018598A2 (en) 2001-08-30 2003-03-06 University College Dublin Monosaccharide derivatives
WO2003082301A1 (en) 2002-03-29 2003-10-09 Threshold Pharmaceuticals, Inc. Compositions and methods for treating cancer
CA2431425A1 (en) 2003-06-05 2004-12-05 Angiogene, Inc. Epas1 gene transfer to improve cell therapy
WO2005065721A2 (en) 2003-12-30 2005-07-21 Board Of Regents, The University Of Texas System Use of an anti-inflammatory compound for the reduction of inflammation secondary to the administration of a lipid-nucleic acid complex
WO2006024488A2 (en) 2004-08-30 2006-03-09 Interstitial Therapeutics Medical stent provided with inhibitors of atp synthesis
CN101426508A (zh) 2006-02-24 2009-05-06 得克萨斯系统大学评议会 治疗癌症的己糖化合物
EP1986660A4 (en) 2006-02-24 2009-08-26 Univ Texas HEXOSE COMPOUNDS FOR CANCER TREATMENT
US9149489B2 (en) 2006-04-27 2015-10-06 Board Of Regents, University Of Texas System Inhibitors of glycolysis useful in the treatment of brain tumors
WO2008131024A1 (en) 2007-04-17 2008-10-30 Board Of Regents, The University Of Texas System Iodo-hexose compounds useful to treat cancer
US8927506B2 (en) 2008-07-11 2015-01-06 Board Of Regents, The University Of Texas System Acetates of 2-deoxy monosaccharides with anticancer activity
WO2012142615A2 (en) 2011-04-14 2012-10-18 Board Of Regents, The University Of Texas System Auranofin and auranofin analogs useful to treat proliferative disease and disorders

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1196059A (zh) * 1995-06-23 1998-10-14 牛津糖科学(英国)有限公司 治疗化合物
WO2001082926A1 (en) * 2000-05-01 2001-11-08 Lampidis Theodore J Manipulation of oxidative phosphorylation for hypersensitizing tumor cells to glycolytic inhibitors
US20040167079A1 (en) * 2003-01-10 2004-08-26 George Tidmarsh Treatment of cancer with 2-deoxyglucose
EP1881000A1 (en) * 2006-07-17 2008-01-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Conjugates of 2-fluoro-2-deoxy-glucose and their uses as anti cancer agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Hydrolysis of (2-Deoxy-beta-D-glucopyranosyl)pyridinium Salts;HUANG,X et al;《J.Am.Chem.Soc.》;19951231;第117卷(第43期);第10614-10621页 *

Also Published As

Publication number Publication date
JP5890043B2 (ja) 2016-03-22
LT2310020T (lt) 2017-07-25
HUE033210T2 (hu) 2017-11-28
EP2310020B1 (en) 2017-03-15
ES2628180T3 (es) 2017-08-02
WO2010005799A3 (en) 2010-04-29
PL2310020T3 (pl) 2017-10-31
US20110160151A1 (en) 2011-06-30
JP5677951B2 (ja) 2015-02-25
EP2310020A2 (en) 2011-04-20
CN102149388A (zh) 2011-08-10
JP2011527678A (ja) 2011-11-04
WO2010005799A2 (en) 2010-01-14
DK2310020T3 (en) 2017-06-26
JP2015091849A (ja) 2015-05-14
US8927506B2 (en) 2015-01-06
EP2310020A4 (en) 2012-04-25

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Granted publication date: 20141105