CN102149388B - 具有抗癌活性的新型2-脱氧单糖乙酸酯 - Google Patents

具有抗癌活性的新型2-脱氧单糖乙酸酯 Download PDF

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Publication number
CN102149388B
CN102149388B CN200980135924.XA CN200980135924A CN102149388B CN 102149388 B CN102149388 B CN 102149388B CN 200980135924 A CN200980135924 A CN 200980135924A CN 102149388 B CN102149388 B CN 102149388B
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autophagy
glucose
ddd
cancer
mmol
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Chinese (zh)
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CN102149388A (zh
Inventor
W·普里布
M·塞布尔斯基
I·富克特
S·斯科拉
C·康拉德
T·马登
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University of Texas System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN200980135924.XA 2008-07-11 2009-06-25 具有抗癌活性的新型2-脱氧单糖乙酸酯 Active CN102149388B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7996808P 2008-07-11 2008-07-11
US61/079968 2008-07-11
PCT/US2009/048675 WO2010005799A2 (en) 2008-07-11 2009-06-25 Novel acetates of 2-deoxy monosaccharides with anticancer activity

Publications (2)

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CN102149388A CN102149388A (zh) 2011-08-10
CN102149388B true CN102149388B (zh) 2014-11-05

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CN200980135924.XA Active CN102149388B (zh) 2008-07-11 2009-06-25 具有抗癌活性的新型2-脱氧单糖乙酸酯

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Country Link
US (1) US8927506B2 (enExample)
EP (1) EP2310020B1 (enExample)
JP (2) JP5677951B2 (enExample)
CN (1) CN102149388B (enExample)
DK (1) DK2310020T3 (enExample)
ES (1) ES2628180T3 (enExample)
HU (1) HUE033210T2 (enExample)
LT (1) LT2310020T (enExample)
PL (1) PL2310020T3 (enExample)
WO (1) WO2010005799A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9149489B2 (en) 2006-04-27 2015-10-06 Board Of Regents, University Of Texas System Inhibitors of glycolysis useful in the treatment of brain tumors
WO2010005799A2 (en) 2008-07-11 2010-01-14 Board Of Regents, The University Of Texas System Novel acetates of 2-deoxy monosaccharides with anticancer activity
US20120276108A1 (en) * 2011-01-11 2012-11-01 Intertech Bio Monosaccharide-based compounds for the treatment of proliferative and inflammatory dermatological diseases
WO2012142615A2 (en) * 2011-04-14 2012-10-18 Board Of Regents, The University Of Texas System Auranofin and auranofin analogs useful to treat proliferative disease and disorders
JPWO2013154192A1 (ja) * 2012-04-12 2015-12-21 国立大学法人岐阜大学 梗塞治療用医薬組成物
HUE056881T2 (hu) 2013-04-05 2022-03-28 Univ Texas Antiproliferatív hatású 2-deoxi-monoszaccharid észterek
WO2020035782A1 (en) * 2018-08-13 2020-02-20 Dermin Sp. Z O.O. Molecular probes for analysis of metabolism of glycolysis inhibitors prodrugs and synthesis methods therefore
BR112022018536A2 (pt) * 2020-03-16 2022-11-29 Univ Texas Método para o tratamento de infecções virais com monossacarídeos tipo hexose e seus análogos

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1196059A (zh) * 1995-06-23 1998-10-14 牛津糖科学(英国)有限公司 治疗化合物
WO2001082926A1 (en) * 2000-05-01 2001-11-08 Lampidis Theodore J Manipulation of oxidative phosphorylation for hypersensitizing tumor cells to glycolytic inhibitors
US20040167079A1 (en) * 2003-01-10 2004-08-26 George Tidmarsh Treatment of cancer with 2-deoxyglucose
EP1881000A1 (en) * 2006-07-17 2008-01-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Conjugates of 2-fluoro-2-deoxy-glucose and their uses as anti cancer agents

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JPS56103197A (en) 1980-01-21 1981-08-18 Wakamoto Pharmaceut Co Ltd Novel d-glucose derivative and antitumor agent containing the same as active constitutent
JPS58167582A (ja) 1982-03-29 1983-10-03 Takeda Chem Ind Ltd 糖ケタ−ルの製造法
US6319695B1 (en) 1991-10-15 2001-11-20 The Scripps Research Insitute Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
EE200200565A (et) 2000-03-31 2004-06-15 Angiogene Pharmaceuticals Ltd. Vaskulaarse kahjustava toimega kombinatsioonravi
CA2487038A1 (en) 2001-06-11 2002-12-19 Transition Therapeutics Inc. Combination therapies using vitamin b12 and therapeutic agents for treatment of viral, proliferative and inflammatory diseases
WO2003018598A2 (en) 2001-08-30 2003-03-06 University College Dublin Monosaccharide derivatives
WO2003082301A1 (en) 2002-03-29 2003-10-09 Threshold Pharmaceuticals, Inc. Compositions and methods for treating cancer
CA2431425A1 (en) 2003-06-05 2004-12-05 Angiogene, Inc. Epas1 gene transfer to improve cell therapy
WO2005065721A2 (en) 2003-12-30 2005-07-21 Board Of Regents, The University Of Texas System Use of an anti-inflammatory compound for the reduction of inflammation secondary to the administration of a lipid-nucleic acid complex
US20070292478A1 (en) 2004-08-30 2007-12-20 Popowski Youri Medical Implant Provided with Inhibitors of Atp Synthesis
CA2642189A1 (en) 2006-02-24 2007-09-07 University Of Miami Mannose derivatives for killing tumor cells
CA2643038A1 (en) 2006-02-24 2007-09-07 Board Of Regents, The University Of Texas System Hexose compounds to treat cancer
US9149489B2 (en) 2006-04-27 2015-10-06 Board Of Regents, University Of Texas System Inhibitors of glycolysis useful in the treatment of brain tumors
WO2008131024A1 (en) 2007-04-17 2008-10-30 Board Of Regents, The University Of Texas System Iodo-hexose compounds useful to treat cancer
WO2010005799A2 (en) 2008-07-11 2010-01-14 Board Of Regents, The University Of Texas System Novel acetates of 2-deoxy monosaccharides with anticancer activity
WO2012142615A2 (en) 2011-04-14 2012-10-18 Board Of Regents, The University Of Texas System Auranofin and auranofin analogs useful to treat proliferative disease and disorders

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1196059A (zh) * 1995-06-23 1998-10-14 牛津糖科学(英国)有限公司 治疗化合物
WO2001082926A1 (en) * 2000-05-01 2001-11-08 Lampidis Theodore J Manipulation of oxidative phosphorylation for hypersensitizing tumor cells to glycolytic inhibitors
US20040167079A1 (en) * 2003-01-10 2004-08-26 George Tidmarsh Treatment of cancer with 2-deoxyglucose
EP1881000A1 (en) * 2006-07-17 2008-01-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Conjugates of 2-fluoro-2-deoxy-glucose and their uses as anti cancer agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Hydrolysis of (2-Deoxy-beta-D-glucopyranosyl)pyridinium Salts;HUANG,X et al;《J.Am.Chem.Soc.》;19951231;第117卷(第43期);第10614-10621页 *

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Publication number Publication date
WO2010005799A2 (en) 2010-01-14
EP2310020A2 (en) 2011-04-20
JP5677951B2 (ja) 2015-02-25
WO2010005799A3 (en) 2010-04-29
DK2310020T3 (en) 2017-06-26
JP5890043B2 (ja) 2016-03-22
JP2011527678A (ja) 2011-11-04
LT2310020T (lt) 2017-07-25
US8927506B2 (en) 2015-01-06
EP2310020A4 (en) 2012-04-25
EP2310020B1 (en) 2017-03-15
ES2628180T3 (es) 2017-08-02
PL2310020T3 (pl) 2017-10-31
JP2015091849A (ja) 2015-05-14
CN102149388A (zh) 2011-08-10
US20110160151A1 (en) 2011-06-30
HUE033210T2 (hu) 2017-11-28

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