JP5669748B2 - １１−（２−ピロリジン−１−イル−エトキシ）−１４，１９−ジオキサ−５，７，２６−トリアザ−テトラシクロ［１９．３．１．１（２，６）．１（８，１２）］ヘプタコサ−１（２５），２（２６），３，５，８，１０，１２（２７），１６，２１，２３−デカエンクエン酸塩 - Google Patents
１１−（２−ピロリジン−１−イル−エトキシ）−１４，１９−ジオキサ−５，７，２６−トリアザ−テトラシクロ［１９．３．１．１（２，６）．１（８，１２）］ヘプタコサ−１（２５），２（２６），３，５，８，１０，１２（２７），１６，２１，２３−デカエンクエン酸塩 Download PDFInfo
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- JP5669748B2 JP5669748B2 JP2011540664A JP2011540664A JP5669748B2 JP 5669748 B2 JP5669748 B2 JP 5669748B2 JP 2011540664 A JP2011540664 A JP 2011540664A JP 2011540664 A JP2011540664 A JP 2011540664A JP 5669748 B2 JP5669748 B2 JP 5669748B2
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- citrate
- ray diffraction
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/22—Tricarboxylic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D201/00—Preparation, separation, purification or stabilisation of unsubstituted lactams
- C07D201/02—Preparation of lactams
- C07D201/10—Preparation of lactams from cycloaliphatic compounds by simultaneous nitrosylation and rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12166808P | 2008-12-11 | 2008-12-11 | |
| US61/121,668 | 2008-12-11 | ||
| PCT/SG2009/000473 WO2010068181A1 (en) | 2008-12-11 | 2009-12-09 | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6)1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27)j16,21,23-decaene citrate salt |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511571A JP2012511571A (ja) | 2012-05-24 |
| JP2012511571A5 JP2012511571A5 (enExample) | 2013-01-24 |
| JP5669748B2 true JP5669748B2 (ja) | 2015-02-12 |
Family
ID=41666397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540664A Active JP5669748B2 (ja) | 2008-12-11 | 2009-12-09 | １１−（２−ピロリジン−１−イル−エトキシ）−１４，１９−ジオキサ−５，７，２６−トリアザ−テトラシクロ［１９．３．１．１（２，６）．１（８，１２）］ヘプタコサ−１（２５），２（２６），３，５，８，１０，１２（２７），１６，２１，２３−デカエンクエン酸塩 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8980873B2 (enExample) |
| EP (1) | EP2376499B1 (enExample) |
| JP (1) | JP5669748B2 (enExample) |
| KR (1) | KR101729918B1 (enExample) |
| CN (1) | CN102282148B (enExample) |
| AR (2) | AR074724A1 (enExample) |
| AU (1) | AU2009325147B2 (enExample) |
| BR (1) | BRPI0922736B1 (enExample) |
| CA (1) | CA2746058C (enExample) |
| DK (1) | DK2376499T3 (enExample) |
| ES (1) | ES2536558T3 (enExample) |
| HR (1) | HRP20150428T1 (enExample) |
| IL (3) | IL213418A0 (enExample) |
| MX (1) | MX2011006206A (enExample) |
| MY (1) | MY160005A (enExample) |
| NZ (1) | NZ593223A (enExample) |
| PL (1) | PL2376499T3 (enExample) |
| PT (1) | PT2376499E (enExample) |
| RU (1) | RU2527970C2 (enExample) |
| SG (1) | SG171907A1 (enExample) |
| TW (1) | TWI449705B (enExample) |
| WO (1) | WO2010068181A1 (enExample) |
| ZA (1) | ZA201104032B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011006206A (es) | 2008-12-11 | 2011-07-20 | S Bio Pte Ltd | Sal de citrato de 11-(2-pirrolidin-1-il-etoxi)-14,19-dioxa-5,7,26- triaza-tetraciclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5 ,8,10,12(27),16,21,23-decaeno. |
| EP2376500B1 (en) * | 2008-12-11 | 2015-02-25 | Cti Biopharma Corp. | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene maleate salt |
| PL2837632T3 (pl) | 2012-04-13 | 2017-01-31 | Lianyungang Jinkang Hexin Pharmaceutical Co. Ltd. | Pochodne triazabicyklo[3.2.1]oktanu użyteczne do leczenia chorób proliferacyjnych |
| CN105061467B (zh) * | 2015-08-28 | 2017-08-25 | 苏州立新制药有限公司 | 一种帕克替尼的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728536A (en) | 1993-07-29 | 1998-03-17 | St. Jude Children's Research Hospital | Jak kinases and regulation of Cytokine signal transduction |
| US6136595A (en) | 1993-07-29 | 2000-10-24 | St. Jude Children's Research Hospital | Jak kinases and regulations of cytokine signal transduction |
| HRP20030911A2 (en) * | 2001-05-14 | 2004-02-29 | Pfizer Prod Inc | Citrate salt 5,8,14,-triazatetracyclo (10.3.1.0<sup>2,11</sup>.0<sup>4,9</sup>)-hexadeca-2 (11), 3,5,7,9-pentaene |
| US6433018B1 (en) | 2001-08-31 | 2002-08-13 | The Research Foundation Of State University Of New York | Method for reducing hypertrophy and ischemia |
| KR20040066140A (ko) * | 2001-11-29 | 2004-07-23 | 화이자 프로덕츠 인크. | 5,8,14-트리아자테트라시클로[10.3.1.0(2,11).0(4,9)]헥사데카-2(11),3,5,7,9-펜타엔의 숙신산염 및 그의 제약 조성물 |
| CN101365703B (zh) * | 2005-11-16 | 2013-11-06 | S*Bio私人有限公司 | 杂烷基连接的嘧啶衍生物 |
| MX2011006206A (es) | 2008-12-11 | 2011-07-20 | S Bio Pte Ltd | Sal de citrato de 11-(2-pirrolidin-1-il-etoxi)-14,19-dioxa-5,7,26- triaza-tetraciclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5 ,8,10,12(27),16,21,23-decaeno. |
-
2009
- 2009-12-09 MX MX2011006206A patent/MX2011006206A/es active IP Right Grant
- 2009-12-09 EP EP09788621.2A patent/EP2376499B1/en active Active
- 2009-12-09 MY MYPI2011002647A patent/MY160005A/en unknown
- 2009-12-09 JP JP2011540664A patent/JP5669748B2/ja active Active
- 2009-12-09 US US13/133,297 patent/US8980873B2/en active Active
- 2009-12-09 CN CN200980150325.5A patent/CN102282148B/zh active Active
- 2009-12-09 CA CA2746058A patent/CA2746058C/en active Active
- 2009-12-09 DK DK09788621T patent/DK2376499T3/en active
- 2009-12-09 RU RU2011126173/04A patent/RU2527970C2/ru active
- 2009-12-09 KR KR1020117015738A patent/KR101729918B1/ko active Active
- 2009-12-09 NZ NZ593223A patent/NZ593223A/xx unknown
- 2009-12-09 AU AU2009325147A patent/AU2009325147B2/en active Active
- 2009-12-09 PT PT97886212T patent/PT2376499E/pt unknown
- 2009-12-09 WO PCT/SG2009/000473 patent/WO2010068181A1/en not_active Ceased
- 2009-12-09 ES ES09788621.2T patent/ES2536558T3/es active Active
- 2009-12-09 SG SG2011040060A patent/SG171907A1/en unknown
- 2009-12-09 PL PL09788621T patent/PL2376499T3/pl unknown
- 2009-12-09 BR BRPI0922736-9A patent/BRPI0922736B1/pt active IP Right Grant
- 2009-12-09 HR HRP20150428TT patent/HRP20150428T1/hr unknown
- 2009-12-11 AR ARP090104834A patent/AR074724A1/es not_active Application Discontinuation
- 2009-12-11 TW TW098142605A patent/TWI449705B/zh active
-
2011
- 2011-05-31 ZA ZA2011/04032A patent/ZA201104032B/en unknown
- 2011-06-06 IL IL213418A patent/IL213418A0/en unknown
-
2015
- 2015-02-13 US US14/621,726 patent/US9624242B2/en active Active
-
2017
- 2017-01-26 IL IL250310A patent/IL250310A0/en unknown
-
2019
- 2019-03-20 AR ARP190100701A patent/AR114133A2/es unknown
-
2021
- 2021-12-26 IL IL289379A patent/IL289379A/en unknown
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