IL213418A0 - 11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6)1(8,12)heptacosa-1(25),2(26)3,5,8,10,12 (27) j16,21,23-decaene citrate salt - Google Patents

11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6)1(8,12)heptacosa-1(25),2(26)3,5,8,10,12 (27) j16,21,23-decaene citrate salt

Info

Publication number
IL213418A0
IL213418A0 IL213418A IL21341811A IL213418A0 IL 213418 A0 IL213418 A0 IL 213418A0 IL 213418 A IL213418 A IL 213418A IL 21341811 A IL21341811 A IL 21341811A IL 213418 A0 IL213418 A0 IL 213418A0
Authority
IL
Israel
Prior art keywords
heptacosa
ylethoxy
tetracyclo
triaza
dioxa
Prior art date
Application number
IL213418A
Other languages
English (en)
Original Assignee
S Bio Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S Bio Pte Ltd filed Critical S Bio Pte Ltd
Publication of IL213418A0 publication Critical patent/IL213418A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/22—Tricarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D201/00—Preparation, separation, purification or stabilisation of unsubstituted lactams
    • C07D201/02—Preparation of lactams
    • C07D201/10—Preparation of lactams from cycloaliphatic compounds by simultaneous nitrosylation and rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
IL213418A 2008-12-11 2011-06-06 11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6)1(8,12)heptacosa-1(25),2(26)3,5,8,10,12 (27) j16,21,23-decaene citrate salt IL213418A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12166808P 2008-12-11 2008-12-11
PCT/SG2009/000473 WO2010068181A1 (en) 2008-12-11 2009-12-09 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6)1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27)j16,21,23-decaene citrate salt

Publications (1)

Publication Number Publication Date
IL213418A0 true IL213418A0 (en) 2011-07-31

Family

ID=41666397

Family Applications (3)

Application Number Title Priority Date Filing Date
IL213418A IL213418A0 (en) 2008-12-11 2011-06-06 11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6)1(8,12)heptacosa-1(25),2(26)3,5,8,10,12 (27) j16,21,23-decaene citrate salt
IL250310A IL250310A0 (en) 2008-12-11 2017-01-26 Citrate salt of 11-(2-pyrrolidin-1-yl-ethoxy)-19,14-dioxa-26,7,5-triaza-tetracyclo[1.1.3.19(6,2)1(12,8)]hepatacosa- 1(25),2(26),12,10,8,5,3(27)j23,21,16–Decan
IL289379A IL289379A (en) 2008-12-11 2021-12-26 Citrate salt of 11-(2-pyrrolidin-1-yl-ethoxy)-19,14-dioxa-26,7,5-triaza-tetracyclo[1.1.3.19(6,2)1(12,8)]hepatacosa- 1(25),2(26),12,10,8,5,3(27)j23,21,16–Decan

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL250310A IL250310A0 (en) 2008-12-11 2017-01-26 Citrate salt of 11-(2-pyrrolidin-1-yl-ethoxy)-19,14-dioxa-26,7,5-triaza-tetracyclo[1.1.3.19(6,2)1(12,8)]hepatacosa- 1(25),2(26),12,10,8,5,3(27)j23,21,16–Decan
IL289379A IL289379A (en) 2008-12-11 2021-12-26 Citrate salt of 11-(2-pyrrolidin-1-yl-ethoxy)-19,14-dioxa-26,7,5-triaza-tetracyclo[1.1.3.19(6,2)1(12,8)]hepatacosa- 1(25),2(26),12,10,8,5,3(27)j23,21,16–Decan

Country Status (23)

Country Link
US (2) US8980873B2 (enExample)
EP (1) EP2376499B1 (enExample)
JP (1) JP5669748B2 (enExample)
KR (1) KR101729918B1 (enExample)
CN (1) CN102282148B (enExample)
AR (2) AR074724A1 (enExample)
AU (1) AU2009325147B2 (enExample)
BR (1) BRPI0922736B1 (enExample)
CA (1) CA2746058C (enExample)
DK (1) DK2376499T3 (enExample)
ES (1) ES2536558T3 (enExample)
HR (1) HRP20150428T1 (enExample)
IL (3) IL213418A0 (enExample)
MX (1) MX2011006206A (enExample)
MY (1) MY160005A (enExample)
NZ (1) NZ593223A (enExample)
PL (1) PL2376499T3 (enExample)
PT (1) PT2376499E (enExample)
RU (1) RU2527970C2 (enExample)
SG (1) SG171907A1 (enExample)
TW (1) TWI449705B (enExample)
WO (1) WO2010068181A1 (enExample)
ZA (1) ZA201104032B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2376500T3 (pl) * 2008-12-11 2015-07-31 Cti Biopharma Corp Sól maleinianowa 11-(2-pirrolidyn-1-yloetoksy)-14,19-dioksa-5,7,26 triazatetracyklo[19.3.1.1(2,6).1(8,12)]heptakosa-1(25),2(26),3,5,8,10,12(27),16,21,23-dekaenu
CN102282148B (zh) 2008-12-11 2014-12-24 Cti生物医药有限公司 11-(2-吡咯烷-1-基-乙氧基)-14,19-二氧杂-5,7,26-三氮杂-四环[19.3.1.1(2,6).1(8,12)]二十七碳-1(25),2(26),3,5,8,10,12(27),16,21,23-十烯柠檬酸盐
US9090623B2 (en) 2012-04-13 2015-07-28 Lianyungang Jinkang Hexin Pharmaceutical Co., Ltd. Compound JK12A and preparation thereof
CN105061467B (zh) * 2015-08-28 2017-08-25 苏州立新制药有限公司 一种帕克替尼的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728536A (en) 1993-07-29 1998-03-17 St. Jude Children's Research Hospital Jak kinases and regulation of Cytokine signal transduction
US6136595A (en) 1993-07-29 2000-10-24 St. Jude Children's Research Hospital Jak kinases and regulations of cytokine signal transduction
CA2446988A1 (en) * 2001-05-14 2002-11-21 Pfizer Products Inc. The citrate salt of 5, 8, 14-triazatetracyclo(10.3.1.02,11.04.9)-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof
US6433018B1 (en) 2001-08-31 2002-08-13 The Research Foundation Of State University Of New York Method for reducing hypertrophy and ischemia
IL161326A0 (en) * 2001-11-29 2004-09-27 Pfizer Prod Inc Succinic acid salts of 5,8,14-triazatetracyclo'10.3.1.0<2,11>.0<4,9>-hexadeca-2 (11),3,5,7,9-pentaene and pharmaceutical compositions thereof
CN101360751B (zh) 2005-11-16 2011-09-14 S*Bio私人有限公司 氧连接的嘧啶衍生物
CN102282148B (zh) 2008-12-11 2014-12-24 Cti生物医药有限公司 11-(2-吡咯烷-1-基-乙氧基)-14,19-二氧杂-5,7,26-三氮杂-四环[19.3.1.1(2,6).1(8,12)]二十七碳-1(25),2(26),3,5,8,10,12(27),16,21,23-十烯柠檬酸盐

Also Published As

Publication number Publication date
RU2011126173A (ru) 2013-01-20
WO2010068181A1 (en) 2010-06-17
JP5669748B2 (ja) 2015-02-12
MY160005A (en) 2017-02-15
US8980873B2 (en) 2015-03-17
HRP20150428T1 (xx) 2015-06-19
CN102282148B (zh) 2014-12-24
DK2376499T3 (en) 2015-05-04
US20150322084A1 (en) 2015-11-12
IL289379A (en) 2022-02-01
RU2527970C2 (ru) 2014-09-10
IL250310A0 (en) 2017-03-30
EP2376499B1 (en) 2015-02-25
AU2009325147B2 (en) 2014-08-14
NZ593223A (en) 2013-08-30
PT2376499E (pt) 2015-06-03
JP2012511571A (ja) 2012-05-24
TWI449705B (zh) 2014-08-21
PL2376499T3 (pl) 2015-07-31
CA2746058C (en) 2016-05-17
TW201028426A (en) 2010-08-01
ES2536558T3 (es) 2015-05-26
AR114133A2 (es) 2020-07-22
BRPI0922736A2 (pt) 2017-10-31
KR20110106344A (ko) 2011-09-28
CN102282148A (zh) 2011-12-14
MX2011006206A (es) 2011-07-20
SG171907A1 (en) 2011-07-28
WO2010068181A8 (en) 2011-08-18
AR074724A1 (es) 2011-02-09
HK1161877A1 (en) 2012-08-10
KR101729918B1 (ko) 2017-04-25
CA2746058A1 (en) 2010-06-17
US20110294831A1 (en) 2011-12-01
US9624242B2 (en) 2017-04-18
BRPI0922736A8 (pt) 2021-11-09
BRPI0922736B1 (pt) 2022-02-22
ZA201104032B (en) 2012-08-29
EP2376499A1 (en) 2011-10-19
AU2009325147A1 (en) 2011-06-23

Similar Documents

Publication Publication Date Title
HUS1800031I1 (hu) Dioxa-biciklo[3.2.1.]oktán-2,3,4-triol származékok
IL289379A (en) Citrate salt of 11-(2-pyrrolidin-1-yl-ethoxy)-19,14-dioxa-26,7,5-triaza-tetracyclo[1.1.3.19(6,2)1(12,8)]hepatacosa- 1(25),2(26),12,10,8,5,3(27)j23,21,16–Decan
IL206765A0 (en) 4,5-dihydro-oxazol-2-yl-amine derivatives
AP2414A (en) Fungicidal aqueous compositions for seed treatment.
IL201973A0 (en) 3,3-spiroindolinone derivatives
AP3099A (en) Dioxa-bicyclo[3.2.1]octane-2,3,4-triol de derivatives
IL190997A0 (en) New highly stable aqueous solution, electrode with nanocoating for preparing the solution and method for making this electrode
ZA201001797B (en) 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives
GB2444214B (en) Improved process margin using discrete assist features
IL188431A0 (en) Process for preparing 3-arylmethylthio-and 3-heteroarylmethylthio-4,5-dihydro-
IL210063A (en) נגזרות 3–(3–פירימידין–2–איל–בנזיל)–4,2,1–טריאזולו[3,4 –b]פירידזין כמעכבי met קינאז
AP2283A (en) Stable aqueous suspension.
PL2376500T3 (pl) Sól maleinianowa 11-(2-pirrolidyn-1-yloetoksy)-14,19-dioksa-5,7,26 triazatetracyklo[19.3.1.1(2,6).1(8,12)]heptakosa-1(25),2(26),3,5,8,10,12(27),16,21,23-dekaenu
IL206666A0 (en) N-PHENYLIMIDAZO[1,2-a]PYRIDINE-2-
PL2454266T3 (pl) Sól cytrynianowa 9E-15-(2-pirolidyn-1-ylo-etoksy)-7,12,25-trioksa-19,21,24-triaza-tetracyklo[18.3.1.1(2,5).1(14,18)]heksakoza-1(24),2,4,9,14,16,18(26),20,22-nonaenu
ZA201005346B (en) 3,8-diaminotetrahydroquinoline derivative
ZA200803501B (en) New highly stable aqueous solution, electrode with nanocoating for preparing the solution and method for making this electrode
IL206668A0 (en) N-PHENYLIMIDAZO[1,2-a]PYRIDINE-2-
IL187673A0 (en) Process for preparing 3,3-diarylpropylamines
TH0901005537B (th) 11-(2-ไพร์โรลิดิน-1-อิล-เอทอกซี)-14,19-ไดออกซา-5,7,26-ไตรอะซา-เตตราไซโคล[19.3.1.1(2,6).1(8,12)]เฮปทาโคซา-1(25),2(26),3,5,8,10,12(27),16,21,23-เดคาอีน มาลีเอท ซอลท์
IL209403A0 (en) Fluoro-substituted 3,4-diaryl-4,5-dihydro-1h-pyrazole-1-carboxamidine derivatives having cb1-antagonistic activity
IL180493A (en) Process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid
EP2261203A4 (en) PHENYLCYCLOBUTYLAMID DERIVATIVES AND THEIR STEREOISOMERS AND MANUFACTURING METHODS THEREFOR AND USES THEREOF
GB0504761D0 (en) Alfatie, Coliawel, Omaatie