ES2536558T3 - Sal citrato de 11-(2-pirrolidin-1-il-etoxi)-14,19-dioxa-5,7,26-triaza-tetraciclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-deceno - Google Patents

Sal citrato de 11-(2-pirrolidin-1-il-etoxi)-14,19-dioxa-5,7,26-triaza-tetraciclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-deceno Download PDF

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Publication number
ES2536558T3
ES2536558T3 ES09788621.2T ES09788621T ES2536558T3 ES 2536558 T3 ES2536558 T3 ES 2536558T3 ES 09788621 T ES09788621 T ES 09788621T ES 2536558 T3 ES2536558 T3 ES 2536558T3
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Spain
Prior art keywords
tetracycle
heptacosa
triaza
dioxa
decene
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ES09788621.2T
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English (en)
Inventor
Brian Dymock
Cheng Hsia Angeline Lee
Anthony Deodaunia William
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CTI Biopharma Corp
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CTI Biopharma Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/22—Tricarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D201/00—Preparation, separation, purification or stabilisation of unsubstituted lactams
    • C07D201/02—Preparation of lactams
    • C07D201/10—Preparation of lactams from cycloaliphatic compounds by simultaneous nitrosylation and rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Una sal citrato de 11-(2-pirrolidin-1-il-etoxi)-14,19-dioxa-5,7,26-triaza-tetraciclo[19.3.1.1(2,6).1(8,12)]heptacosa- 1(25),2(26),3,5,8,10,12(27),16,21,23-deceno.
ES09788621.2T 2008-12-11 2009-12-09 Sal citrato de 11-(2-pirrolidin-1-il-etoxi)-14,19-dioxa-5,7,26-triaza-tetraciclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-deceno Active ES2536558T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12166808P 2008-12-11 2008-12-11
US121668P 2008-12-11
PCT/SG2009/000473 WO2010068181A1 (en) 2008-12-11 2009-12-09 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6)1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27)j16,21,23-decaene citrate salt

Publications (1)

Publication Number Publication Date
ES2536558T3 true ES2536558T3 (es) 2015-05-26

Family

ID=41666397

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09788621.2T Active ES2536558T3 (es) 2008-12-11 2009-12-09 Sal citrato de 11-(2-pirrolidin-1-il-etoxi)-14,19-dioxa-5,7,26-triaza-tetraciclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-deceno

Country Status (24)

Country Link
US (2) US8980873B2 (es)
EP (1) EP2376499B1 (es)
JP (1) JP5669748B2 (es)
KR (1) KR101729918B1 (es)
CN (1) CN102282148B (es)
AR (2) AR074724A1 (es)
AU (1) AU2009325147B2 (es)
BR (1) BRPI0922736B1 (es)
CA (1) CA2746058C (es)
DK (1) DK2376499T3 (es)
ES (1) ES2536558T3 (es)
HK (1) HK1161877A1 (es)
HR (1) HRP20150428T1 (es)
IL (3) IL213418A0 (es)
MX (1) MX2011006206A (es)
MY (1) MY160005A (es)
NZ (1) NZ593223A (es)
PL (1) PL2376499T3 (es)
PT (1) PT2376499E (es)
RU (1) RU2527970C2 (es)
SG (1) SG171907A1 (es)
TW (1) TWI449705B (es)
WO (1) WO2010068181A1 (es)
ZA (1) ZA201104032B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5669748B2 (ja) 2008-12-11 2015-02-12 シーティーアイ・バイオファーマ・コーポレーションＣＴＩ ＢｉｏＰｈａｒｍａ Ｃｏｒｐ． １１−（２−ピロリジン−１−イル−エトキシ）−１４，１９−ジオキサ−５，７，２６−トリアザ−テトラシクロ［１９．３．１．１（２，６）．１（８，１２）］ヘプタコサ−１（２５），２（２６），３，５，８，１０，１２（２７），１６，２１，２３−デカエンクエン酸塩
US8987243B2 (en) * 2008-12-11 2015-03-24 Cti Biopharma Corp. 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-maleate salt
KR101673979B1 (ko) 2012-04-13 2016-11-08 리안윤강 진강 해신 파머수티컬 코. 엘티디. 화합물 jk12a 및 그 제조
CN105061467B (zh) * 2015-08-28 2017-08-25 苏州立新制药有限公司 一种帕克替尼的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728536A (en) 1993-07-29 1998-03-17 St. Jude Children's Research Hospital Jak kinases and regulation of Cytokine signal transduction
US6136595A (en) 1993-07-29 2000-10-24 St. Jude Children's Research Hospital Jak kinases and regulations of cytokine signal transduction
JP4137645B2 (ja) * 2001-05-14 2008-08-20 ファイザー・プロダクツ・インク ５，８，１４−トリアザテトラシクロ［１０．３．１．０２，１１．０４，９］−ヘキサデカ−２（１１），３，５，７，９−ペンタンのクエン酸塩及びその医薬組成物
US6433018B1 (en) 2001-08-31 2002-08-13 The Research Foundation Of State University Of New York Method for reducing hypertrophy and ischemia
ES2258652T3 (es) * 2001-11-29 2006-09-01 Pfizer Products Inc. Sales de succinato de 5,8,14-triazatetraciclo(10.3.1.02,11.04,9)-hexadeca-2(11),3,5,7,9-pentaeno y composiciones farmaceuticas de los mismos.
WO2007058628A1 (en) * 2005-11-16 2007-05-24 S*Bio Pte Ltd Heteroalkyl linked pyrimidine derivatives
JP5669748B2 (ja) 2008-12-11 2015-02-12 シーティーアイ・バイオファーマ・コーポレーションＣＴＩ ＢｉｏＰｈａｒｍａ Ｃｏｒｐ． １１−（２−ピロリジン−１−イル−エトキシ）−１４，１９−ジオキサ−５，７，２６−トリアザ−テトラシクロ［１９．３．１．１（２，６）．１（８，１２）］ヘプタコサ−１（２５），２（２６），３，５，８，１０，１２（２７），１６，２１，２３−デカエンクエン酸塩

Also Published As

Publication number Publication date
BRPI0922736B1 (pt) 2022-02-22
PL2376499T3 (pl) 2015-07-31
KR20110106344A (ko) 2011-09-28
US20150322084A1 (en) 2015-11-12
TW201028426A (en) 2010-08-01
US20110294831A1 (en) 2011-12-01
BRPI0922736A8 (pt) 2021-11-09
AU2009325147A1 (en) 2011-06-23
BRPI0922736A2 (pt) 2017-10-31
ZA201104032B (en) 2012-08-29
MX2011006206A (es) 2011-07-20
NZ593223A (en) 2013-08-30
RU2011126173A (ru) 2013-01-20
CA2746058A1 (en) 2010-06-17
AU2009325147B2 (en) 2014-08-14
JP2012511571A (ja) 2012-05-24
AR074724A1 (es) 2011-02-09
WO2010068181A1 (en) 2010-06-17
AR114133A2 (es) 2020-07-22
DK2376499T3 (en) 2015-05-04
MY160005A (en) 2017-02-15
SG171907A1 (en) 2011-07-28
TWI449705B (zh) 2014-08-21
IL250310A0 (en) 2017-03-30
WO2010068181A8 (en) 2011-08-18
HRP20150428T1 (en) 2015-06-19
CA2746058C (en) 2016-05-17
CN102282148B (zh) 2014-12-24
JP5669748B2 (ja) 2015-02-12
US8980873B2 (en) 2015-03-17
EP2376499A1 (en) 2011-10-19
CN102282148A (zh) 2011-12-14
US9624242B2 (en) 2017-04-18
EP2376499B1 (en) 2015-02-25
PT2376499E (pt) 2015-06-03
IL213418A0 (en) 2011-07-31
RU2527970C2 (ru) 2014-09-10
IL289379A (en) 2022-02-01
HK1161877A1 (en) 2012-08-10
KR101729918B1 (ko) 2017-04-25

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