JP5653917B2 - 神経変性疾患の治療のためのｐｋｃ活性化化合物 - Google Patents

神経変性疾患の治療のためのｐｋｃ活性化化合物 Download PDF

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JP5653917B2
JP5653917B2 JP2011521235A JP2011521235A JP5653917B2 JP 5653917 B2 JP5653917 B2 JP 5653917B2 JP 2011521235 A JP2011521235 A JP 2011521235A JP 2011521235 A JP2011521235 A JP 2011521235A JP 5653917 B2 JP5653917 B2 JP 5653917B2
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acid
compound
pkc
cyclopropanated
methyl ester
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JP2011529503A5 (enExample
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ネルソン、トマス・ジェイ．
アルコン、デニエル・エル．
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ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート
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    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C31/13—Monohydroxylic alcohols containing saturated rings
    • C07C31/133—Monohydroxylic alcohols containing saturated rings monocyclic
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    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
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    • C07C69/608—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11013—Protein kinase C (2.7.11.13)

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JP2011521235A 2008-07-28 2009-07-28 神経変性疾患の治療のためのｐｋｃ活性化化合物 Expired - Fee Related JP5653917B2 (ja)

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US8417208P 2008-07-28 2008-07-28
US61/084,172 2008-07-28
PCT/US2009/051927 WO2010014585A1 (en) 2008-07-28 2009-07-28 Pkc-activating compounds for the treatment of neurodegenerative diseases

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JP2014182597A Division JP2015042643A (ja) 2008-07-28 2014-09-08 神経変性疾患の治療のためのｐｋｃ活性化化合物

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JP2011529503A JP2011529503A (ja) 2011-12-08
JP2011529503A5 JP2011529503A5 (enExample) 2012-09-13
JP5653917B2 true JP5653917B2 (ja) 2015-01-14

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JP2011521235A Expired - Fee Related JP5653917B2 (ja) 2008-07-28 2009-07-28 神経変性疾患の治療のためのｐｋｃ活性化化合物
JP2014182597A Pending JP2015042643A (ja) 2008-07-28 2014-09-08 神経変性疾患の治療のためのｐｋｃ活性化化合物
JP2016051212A Expired - Fee Related JP6449186B2 (ja) 2008-07-28 2016-03-15 神経変性疾患の治療のためのｐｋｃ活性化化合物
JP2018111869A Pending JP2018168170A (ja) 2008-07-28 2018-06-12 神経変性疾患の治療のためのｐｋｃ活性化化合物

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JP2014182597A Pending JP2015042643A (ja) 2008-07-28 2014-09-08 神経変性疾患の治療のためのｐｋｃ活性化化合物
JP2016051212A Expired - Fee Related JP6449186B2 (ja) 2008-07-28 2016-03-15 神経変性疾患の治療のためのｐｋｃ活性化化合物
JP2018111869A Pending JP2018168170A (ja) 2008-07-28 2018-06-12 神経変性疾患の治療のためのｐｋｃ活性化化合物

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US (7) US8163800B2 (enExample)
EP (3) EP3586839A1 (enExample)
JP (4) JP5653917B2 (enExample)
CA (2) CA2731171C (enExample)
ES (1) ES2683021T3 (enExample)
WO (1) WO2010014585A1 (enExample)

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