JP2011529503A5 - - Google Patents
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- JP2011529503A5 JP2011529503A5 JP2011521235A JP2011521235A JP2011529503A5 JP 2011529503 A5 JP2011529503 A5 JP 2011529503A5 JP 2011521235 A JP2011521235 A JP 2011521235A JP 2011521235 A JP2011521235 A JP 2011521235A JP 2011529503 A5 JP2011529503 A5 JP 2011529503A5
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- Japan
- Prior art keywords
- acid
- compound
- alcohol
- cis
- double bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 119
- 150000001875 compounds Chemical class 0.000 claims description 73
- 239000000194 fatty acid Substances 0.000 claims description 52
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 47
- 229930195729 fatty acid Natural products 0.000 claims description 47
- 102000001708 Protein Isoforms Human genes 0.000 claims description 35
- 108010029485 Protein Isoforms Proteins 0.000 claims description 35
- 102000003923 Protein Kinase C Human genes 0.000 claims description 35
- 108090000315 Protein Kinase C Proteins 0.000 claims description 35
- 150000002191 fatty alcohols Chemical class 0.000 claims description 35
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 claims description 30
- 150000004665 fatty acids Chemical class 0.000 claims description 29
- 125000003700 epoxy group Chemical group 0.000 claims description 26
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 25
- -1 fatty acid esters Chemical class 0.000 claims description 25
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 25
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims description 20
- 101150065749 Churc1 gene Proteins 0.000 claims description 20
- 102100038239 Protein Churchill Human genes 0.000 claims description 20
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 16
- 230000004770 neurodegeneration Effects 0.000 claims description 13
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims description 12
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims description 12
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 12
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 12
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 12
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 12
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 12
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 12
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 11
- VCDLWFYODNTQOT-UHFFFAOYSA-N docosahexaenoic acid methyl ester Natural products CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)OC VCDLWFYODNTQOT-UHFFFAOYSA-N 0.000 claims description 11
- LUYYTKKXYNRVHQ-TYYHYDAASA-N methyl (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoate Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(=O)OC LUYYTKKXYNRVHQ-TYYHYDAASA-N 0.000 claims description 11
- 229940055577 oleyl alcohol Drugs 0.000 claims description 11
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 11
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 10
- 235000021342 arachidonic acid Nutrition 0.000 claims description 10
- 229940114079 arachidonic acid Drugs 0.000 claims description 10
- 229960004488 linolenic acid Drugs 0.000 claims description 10
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims description 9
- TWSWSIQAPQLDBP-CGRWFSSPSA-N (7e,10e,13e,16e)-docosa-7,10,13,16-tetraenoic acid Chemical compound CCCCC\C=C\C\C=C\C\C=C\C\C=C\CCCCCC(O)=O TWSWSIQAPQLDBP-CGRWFSSPSA-N 0.000 claims description 8
- YWWVWXASSLXJHU-AATRIKPKSA-N (9E)-tetradecenoic acid Chemical compound CCCC\C=C\CCCCCCCC(O)=O YWWVWXASSLXJHU-AATRIKPKSA-N 0.000 claims description 8
- 235000021292 Docosatetraenoic acid Nutrition 0.000 claims description 8
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 8
- TWSWSIQAPQLDBP-UHFFFAOYSA-N adrenic acid Natural products CCCCCC=CCC=CCC=CCC=CCCCCCC(O)=O TWSWSIQAPQLDBP-UHFFFAOYSA-N 0.000 claims description 8
- ZQPPMHVWECSIRJ-MDZDMXLPSA-N elaidic acid Chemical compound CCCCCCCC\C=C\CCCCCCCC(O)=O ZQPPMHVWECSIRJ-MDZDMXLPSA-N 0.000 claims description 8
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 8
- SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 claims description 8
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 8
- IKYKEVDKGZYRMQ-PDBXOOCHSA-N (9Z,12Z,15Z)-octadecatrien-1-ol Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCO IKYKEVDKGZYRMQ-PDBXOOCHSA-N 0.000 claims description 7
- QWDCYFDDFPWISL-UHFFFAOYSA-N UNPD207407 Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(=O)OC QWDCYFDDFPWISL-UHFFFAOYSA-N 0.000 claims description 7
- 230000003213 activating effect Effects 0.000 claims description 7
- QWDCYFDDFPWISL-JEBPEJKESA-N cis-5,8,11,14,17-eicosapentaenoic acid methyl ester Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC QWDCYFDDFPWISL-JEBPEJKESA-N 0.000 claims description 7
- YHVNLORIIDPMPQ-RRABGKBLSA-N cyclopropane;(e)-octadec-9-enoic acid Chemical compound C1CC1.CCCCCCCC\C=C\CCCCCCCC(O)=O YHVNLORIIDPMPQ-RRABGKBLSA-N 0.000 claims description 7
- JTSVQVYMBXVLFI-IPASSIEDSA-N methyl (z)-11-[(2r,3s)-3-pentyloxiran-2-yl]undec-9-enoate Chemical compound CCCCC[C@@H]1O[C@@H]1C\C=C/CCCCCCCC(=O)OC JTSVQVYMBXVLFI-IPASSIEDSA-N 0.000 claims description 7
- CCPPLLJZDQAOHD-BEBBCNLGSA-N (-)-vernolic acid Chemical compound CCCCC[C@@H]1O[C@@H]1C\C=C/CCCCCCCC(O)=O CCPPLLJZDQAOHD-BEBBCNLGSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 6
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims description 6
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims description 6
- 229940098330 gamma linoleic acid Drugs 0.000 claims description 6
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims description 6
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims description 6
- CCPPLLJZDQAOHD-UHFFFAOYSA-N vernolic acid Natural products CCCCCC1OC1CC=CCCCCCCCC(O)=O CCPPLLJZDQAOHD-UHFFFAOYSA-N 0.000 claims description 6
- OFIDNKMQBYGNIW-UHFFFAOYSA-N arachidonic acid methyl ester Natural products CCCCCC=CCC=CCC=CCC=CCCCC(=O)OC OFIDNKMQBYGNIW-UHFFFAOYSA-N 0.000 claims description 5
- OFIDNKMQBYGNIW-ZKWNWVNESA-N methyl arachidonate Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC OFIDNKMQBYGNIW-ZKWNWVNESA-N 0.000 claims description 5
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 4
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 4
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 4
- YWWVWXASSLXJHU-UHFFFAOYSA-N 9E-tetradecenoic acid Natural products CCCCC=CCCCCCCCC(O)=O YWWVWXASSLXJHU-UHFFFAOYSA-N 0.000 claims description 4
- 239000005642 Oleic acid Substances 0.000 claims description 4
- 235000021319 Palmitoleic acid Nutrition 0.000 claims description 4
- SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 4
- 239000001294 propane Substances 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000005888 cyclopropanation reaction Methods 0.000 claims 7
- 241000611421 Elia Species 0.000 claims 4
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 claims 3
- DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 claims 2
- URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 claims 2
- QYDYPVFESGNLHU-ZHACJKMWSA-N Methyl (9E)-9-octadecenoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OC QYDYPVFESGNLHU-ZHACJKMWSA-N 0.000 claims 2
- 208000019022 Mood disease Diseases 0.000 claims 2
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 claims 2
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 claims 2
- 235000021281 monounsaturated fatty acids Nutrition 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 1
- 235000020778 linoleic acid Nutrition 0.000 claims 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 1
- 150000004702 methyl esters Chemical class 0.000 claims 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8417208P | 2008-07-28 | 2008-07-28 | |
| US61/084,172 | 2008-07-28 | ||
| PCT/US2009/051927 WO2010014585A1 (en) | 2008-07-28 | 2009-07-28 | Pkc-activating compounds for the treatment of neurodegenerative diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014182597A Division JP2015042643A (ja) | 2008-07-28 | 2014-09-08 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529503A JP2011529503A (ja) | 2011-12-08 |
| JP2011529503A5 true JP2011529503A5 (enExample) | 2012-09-13 |
| JP5653917B2 JP5653917B2 (ja) | 2015-01-14 |
Family
ID=41136734
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011521235A Expired - Fee Related JP5653917B2 (ja) | 2008-07-28 | 2009-07-28 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
| JP2014182597A Pending JP2015042643A (ja) | 2008-07-28 | 2014-09-08 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
| JP2016051212A Expired - Fee Related JP6449186B2 (ja) | 2008-07-28 | 2016-03-15 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
| JP2018111869A Pending JP2018168170A (ja) | 2008-07-28 | 2018-06-12 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014182597A Pending JP2015042643A (ja) | 2008-07-28 | 2014-09-08 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
| JP2016051212A Expired - Fee Related JP6449186B2 (ja) | 2008-07-28 | 2016-03-15 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
| JP2018111869A Pending JP2018168170A (ja) | 2008-07-28 | 2018-06-12 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (7) | US8163800B2 (enExample) |
| EP (3) | EP3586839A1 (enExample) |
| JP (4) | JP5653917B2 (enExample) |
| CA (2) | CA2731171C (enExample) |
| ES (1) | ES2683021T3 (enExample) |
| WO (1) | WO2010014585A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090030055A1 (en) * | 2002-07-02 | 2009-01-29 | Thomas Nelson | PKC activation as a means for enhancing sAPPALPHA secretion and improving cognition using bryostatin type compounds |
| CA2731171C (en) * | 2008-07-28 | 2016-10-18 | Blanchette Rockefeller Neurosciences Institute | Pkc-activating compounds for the treatment of neurodegenerative diseases |
| EP2493296B1 (en) | 2009-10-30 | 2019-01-09 | Retrotope, Inc. | Alleviating oxidative stress disorders with pufa derivatives |
| CA2790680C (en) * | 2010-02-22 | 2019-02-19 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of protein kinase c epsilon (pkc-epsilon) protein levels |
| CA2804789A1 (en) * | 2010-07-08 | 2012-01-12 | Daniel L. Alkon | Pkc activators and anticoagulant in regimen for treating stroke |
| US9597312B2 (en) | 2010-08-19 | 2017-03-21 | Cognitive Research Enterprises, Inc. | Treatment of cognitive disorders associated with abnormal dendritic spines using PKC activators |
| US10154983B2 (en) | 2011-04-26 | 2018-12-18 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating PUFAs |
| WO2012148927A2 (en) * | 2011-04-26 | 2012-11-01 | Retrotope, Inc. | Impaired energy processing disorders and mitochondrial deficiency |
| ES2859753T3 (es) | 2011-04-26 | 2021-10-04 | Retrotope Inc | Trastornos que implican la oxidación de PUFA |
| EP2701697B1 (en) | 2011-04-26 | 2020-03-25 | Retrotope, Inc. | Oxidative retinal diseases |
| US20140235496A1 (en) | 2011-10-05 | 2014-08-21 | Blanchette Rockefeller Neurosciences Drive | Stimulus-elicited genomic profile markers of a neurodegenerative condition |
| CA2856235A1 (en) | 2011-11-13 | 2013-05-16 | Blanchette Rockefeller Neurosciences Institute | Esters of dcpla for the treatment of neurodegenerative disorders |
| EP2776018B1 (en) | 2011-11-13 | 2021-08-25 | Cognitive Research Enterprises, Inc. | Pkc activators and combinations thereof |
| WO2014126191A1 (ja) * | 2013-02-15 | 2014-08-21 | 株式会社西崎創薬研究所 | シクロプロパン環を有する不飽和脂肪酸誘導体を含むリン脂質化合物 |
| WO2014145316A1 (en) | 2013-03-15 | 2014-09-18 | Alkon Daniel L | Methods for identifying neuroprotective pkc activators |
| PL3057934T3 (pl) | 2013-10-18 | 2019-09-30 | Blanchette Rockefeller Neurosciences Institute | Halogenowane estry cyklopropanowanych nienasyconych kwasów tłuszczowych do zastosowania w leczeniu chorób neurodegeneracyjnych |
| MX2016013680A (es) | 2014-04-18 | 2017-07-05 | Neurotrope Bioscience Inc | Métodos y composiciones para el tratamiento de trastornos por el almacenamiento de lípidos. |
| US9413754B2 (en) | 2014-12-23 | 2016-08-09 | Airwatch Llc | Authenticator device facilitating file security |
| WO2016183252A1 (en) | 2015-05-11 | 2016-11-17 | Alkon, Daniel, L. | Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele |
| US20180256537A1 (en) | 2015-09-23 | 2018-09-13 | Tapan K. Khan | Methods for survival and rejuvenation of dermal fibroblasts using pkc activators |
| US20180311209A1 (en) | 2015-10-08 | 2018-11-01 | Cognitive Research Enterprises, Inc. | Dosing regimens of pkc activators |
| KR102643910B1 (ko) | 2015-11-23 | 2024-03-06 | 레트로토프 인코포레이티드 | 1,4-다이엔 시스템에 대한 부위 특이적인 동위원소 표지법 |
| JP6912072B2 (ja) * | 2016-12-14 | 2021-07-28 | 国立大学法人山口大学 | 前頭側頭型認知症の予防又は治療用医薬 |
| WO2018187647A1 (en) | 2017-04-06 | 2018-10-11 | Neurotrope Bioscience, Inc. | Methods and compositions for treatment of neurological diseases, disorders, or conditions |
| EP3964210A1 (en) * | 2018-05-18 | 2022-03-09 | Neurotrope Bioscience, Inc. | Methods and compositions for treatment of alzheimer's disease |
| WO2020118282A1 (en) * | 2018-12-07 | 2020-06-11 | The Johns Hopkins University | Methods, compositions and kits for treating multiple sclerosis and other disorders |
| WO2021168311A1 (en) | 2020-02-21 | 2021-08-26 | Retrotope, Inc. | Processes for isotopic modification of polyunsaturated fatty acids and derivatives thereof |
| US20220133687A1 (en) * | 2020-11-02 | 2022-05-05 | Synaptogenix, Inc. | Methods of treating and preventing neurodegenerative diseases with hgf activating compounds |
| US12109194B2 (en) | 2021-02-05 | 2024-10-08 | Biojiva Llc | Synergistic combination therapy for treating ALS |
| WO2022170232A1 (en) * | 2021-02-08 | 2022-08-11 | Synaptogenix, Inc. | Treatment of multiple sclerosis using pkc activators |
| EP4288046A4 (en) * | 2021-02-08 | 2024-12-11 | Synaptogenix, Inc. | TREATMENT OF OPTIC NERVE INFECTION WITH PKC ACTIVATORS |
| WO2023225073A1 (en) * | 2022-05-18 | 2023-11-23 | Virginia Commonwealth University | Methods for treatment of cognitive impairment in cirrhosis patients |
| WO2025056602A1 (en) | 2023-09-11 | 2025-03-20 | Elastin Biosciences Ltd. | Pharmaceutical compositions and use thereof in treatment of conditions and diseases related to elastin deficiency and/or aging |
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| DE69233767D1 (de) | 1991-12-06 | 2009-09-17 | Max Planck Gesellschaft | Verwendung von Protein-Kinasen zur Diagnose und Behandlung der Alzheimer-Krankheit |
| US5766846A (en) | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
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- 2009-07-28 US US12/510,681 patent/US8163800B2/en active Active
- 2009-07-28 EP EP19189948.3A patent/EP3586839A1/en not_active Withdrawn
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- 2009-07-28 JP JP2011521235A patent/JP5653917B2/ja not_active Expired - Fee Related
- 2009-07-28 EP EP09790874.3A patent/EP2328572B1/en not_active Not-in-force
- 2009-07-28 CA CA2941035A patent/CA2941035A1/en not_active Abandoned
- 2009-07-28 WO PCT/US2009/051927 patent/WO2010014585A1/en not_active Ceased
- 2009-07-28 ES ES09790874.3T patent/ES2683021T3/es active Active
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