JP2011529503A5 - - Google Patents
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- JP2011529503A5 JP2011529503A5 JP2011521235A JP2011521235A JP2011529503A5 JP 2011529503 A5 JP2011529503 A5 JP 2011529503A5 JP 2011521235 A JP2011521235 A JP 2011521235A JP 2011521235 A JP2011521235 A JP 2011521235A JP 2011529503 A5 JP2011529503 A5 JP 2011529503A5
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- JP
- Japan
- Prior art keywords
- acid
- compound
- alcohol
- cis
- double bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 119
- 150000001875 compounds Chemical class 0.000 claims description 73
- 239000000194 fatty acid Substances 0.000 claims description 52
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 47
- 229930195729 fatty acid Natural products 0.000 claims description 47
- 102000001708 Protein Isoforms Human genes 0.000 claims description 35
- 108010029485 Protein Isoforms Proteins 0.000 claims description 35
- 102000003923 Protein Kinase C Human genes 0.000 claims description 35
- 108090000315 Protein Kinase C Proteins 0.000 claims description 35
- 150000002191 fatty alcohols Chemical class 0.000 claims description 35
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 claims description 30
- 150000004665 fatty acids Chemical class 0.000 claims description 29
- 125000003700 epoxy group Chemical group 0.000 claims description 26
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 25
- -1 fatty acid esters Chemical class 0.000 claims description 25
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 25
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims description 20
- 101150065749 Churc1 gene Proteins 0.000 claims description 20
- 102100038239 Protein Churchill Human genes 0.000 claims description 20
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 16
- 230000004770 neurodegeneration Effects 0.000 claims description 13
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims description 12
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims description 12
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 12
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 12
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 12
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 12
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 12
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 12
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 11
- VCDLWFYODNTQOT-UHFFFAOYSA-N docosahexaenoic acid methyl ester Natural products CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)OC VCDLWFYODNTQOT-UHFFFAOYSA-N 0.000 claims description 11
- LUYYTKKXYNRVHQ-TYYHYDAASA-N methyl (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoate Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(=O)OC LUYYTKKXYNRVHQ-TYYHYDAASA-N 0.000 claims description 11
- 229940055577 oleyl alcohol Drugs 0.000 claims description 11
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 11
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 10
- 235000021342 arachidonic acid Nutrition 0.000 claims description 10
- 229940114079 arachidonic acid Drugs 0.000 claims description 10
- 229960004488 linolenic acid Drugs 0.000 claims description 10
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims description 9
- TWSWSIQAPQLDBP-CGRWFSSPSA-N (7e,10e,13e,16e)-docosa-7,10,13,16-tetraenoic acid Chemical compound CCCCC\C=C\C\C=C\C\C=C\C\C=C\CCCCCC(O)=O TWSWSIQAPQLDBP-CGRWFSSPSA-N 0.000 claims description 8
- YWWVWXASSLXJHU-AATRIKPKSA-N (9E)-tetradecenoic acid Chemical compound CCCC\C=C\CCCCCCCC(O)=O YWWVWXASSLXJHU-AATRIKPKSA-N 0.000 claims description 8
- 235000021292 Docosatetraenoic acid Nutrition 0.000 claims description 8
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 8
- TWSWSIQAPQLDBP-UHFFFAOYSA-N adrenic acid Natural products CCCCCC=CCC=CCC=CCC=CCCCCCC(O)=O TWSWSIQAPQLDBP-UHFFFAOYSA-N 0.000 claims description 8
- ZQPPMHVWECSIRJ-MDZDMXLPSA-N elaidic acid Chemical compound CCCCCCCC\C=C\CCCCCCCC(O)=O ZQPPMHVWECSIRJ-MDZDMXLPSA-N 0.000 claims description 8
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 8
- SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 claims description 8
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 8
- IKYKEVDKGZYRMQ-PDBXOOCHSA-N (9Z,12Z,15Z)-octadecatrien-1-ol Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCO IKYKEVDKGZYRMQ-PDBXOOCHSA-N 0.000 claims description 7
- QWDCYFDDFPWISL-UHFFFAOYSA-N UNPD207407 Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(=O)OC QWDCYFDDFPWISL-UHFFFAOYSA-N 0.000 claims description 7
- 230000003213 activating effect Effects 0.000 claims description 7
- QWDCYFDDFPWISL-JEBPEJKESA-N cis-5,8,11,14,17-eicosapentaenoic acid methyl ester Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC QWDCYFDDFPWISL-JEBPEJKESA-N 0.000 claims description 7
- YHVNLORIIDPMPQ-RRABGKBLSA-N cyclopropane;(e)-octadec-9-enoic acid Chemical compound C1CC1.CCCCCCCC\C=C\CCCCCCCC(O)=O YHVNLORIIDPMPQ-RRABGKBLSA-N 0.000 claims description 7
- JTSVQVYMBXVLFI-IPASSIEDSA-N methyl (z)-11-[(2r,3s)-3-pentyloxiran-2-yl]undec-9-enoate Chemical compound CCCCC[C@@H]1O[C@@H]1C\C=C/CCCCCCCC(=O)OC JTSVQVYMBXVLFI-IPASSIEDSA-N 0.000 claims description 7
- CCPPLLJZDQAOHD-BEBBCNLGSA-N (-)-vernolic acid Chemical compound CCCCC[C@@H]1O[C@@H]1C\C=C/CCCCCCCC(O)=O CCPPLLJZDQAOHD-BEBBCNLGSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 6
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims description 6
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims description 6
- 229940098330 gamma linoleic acid Drugs 0.000 claims description 6
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims description 6
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims description 6
- CCPPLLJZDQAOHD-UHFFFAOYSA-N vernolic acid Natural products CCCCCC1OC1CC=CCCCCCCCC(O)=O CCPPLLJZDQAOHD-UHFFFAOYSA-N 0.000 claims description 6
- OFIDNKMQBYGNIW-UHFFFAOYSA-N arachidonic acid methyl ester Natural products CCCCCC=CCC=CCC=CCC=CCCCC(=O)OC OFIDNKMQBYGNIW-UHFFFAOYSA-N 0.000 claims description 5
- OFIDNKMQBYGNIW-ZKWNWVNESA-N methyl arachidonate Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC OFIDNKMQBYGNIW-ZKWNWVNESA-N 0.000 claims description 5
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 4
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 4
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 4
- YWWVWXASSLXJHU-UHFFFAOYSA-N 9E-tetradecenoic acid Natural products CCCCC=CCCCCCCCC(O)=O YWWVWXASSLXJHU-UHFFFAOYSA-N 0.000 claims description 4
- 239000005642 Oleic acid Substances 0.000 claims description 4
- 235000021319 Palmitoleic acid Nutrition 0.000 claims description 4
- SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 4
- 239000001294 propane Substances 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000005888 cyclopropanation reaction Methods 0.000 claims 7
- 241000611421 Elia Species 0.000 claims 4
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 claims 3
- DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 claims 2
- URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 claims 2
- QYDYPVFESGNLHU-ZHACJKMWSA-N Methyl (9E)-9-octadecenoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OC QYDYPVFESGNLHU-ZHACJKMWSA-N 0.000 claims 2
- 208000019022 Mood disease Diseases 0.000 claims 2
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 claims 2
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 claims 2
- 235000021281 monounsaturated fatty acids Nutrition 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 1
- 235000020778 linoleic acid Nutrition 0.000 claims 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 1
- 150000004702 methyl esters Chemical class 0.000 claims 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8417208P | 2008-07-28 | 2008-07-28 | |
| US61/084,172 | 2008-07-28 | ||
| PCT/US2009/051927 WO2010014585A1 (en) | 2008-07-28 | 2009-07-28 | Pkc-activating compounds for the treatment of neurodegenerative diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014182597A Division JP2015042643A (ja) | 2008-07-28 | 2014-09-08 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529503A JP2011529503A (ja) | 2011-12-08 |
| JP2011529503A5 true JP2011529503A5 (enExample) | 2012-09-13 |
| JP5653917B2 JP5653917B2 (ja) | 2015-01-14 |
Family
ID=41136734
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011521235A Expired - Fee Related JP5653917B2 (ja) | 2008-07-28 | 2009-07-28 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
| JP2014182597A Pending JP2015042643A (ja) | 2008-07-28 | 2014-09-08 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
| JP2016051212A Expired - Fee Related JP6449186B2 (ja) | 2008-07-28 | 2016-03-15 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
| JP2018111869A Pending JP2018168170A (ja) | 2008-07-28 | 2018-06-12 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014182597A Pending JP2015042643A (ja) | 2008-07-28 | 2014-09-08 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
| JP2016051212A Expired - Fee Related JP6449186B2 (ja) | 2008-07-28 | 2016-03-15 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
| JP2018111869A Pending JP2018168170A (ja) | 2008-07-28 | 2018-06-12 | 神経変性疾患の治療のためのｐｋｃ活性化化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (7) | US8163800B2 (enExample) |
| EP (3) | EP2328572B1 (enExample) |
| JP (4) | JP5653917B2 (enExample) |
| CA (2) | CA2731171C (enExample) |
| ES (1) | ES2683021T3 (enExample) |
| WO (1) | WO2010014585A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090030055A1 (en) * | 2002-07-02 | 2009-01-29 | Thomas Nelson | PKC activation as a means for enhancing sAPPALPHA secretion and improving cognition using bryostatin type compounds |
| EP2328572B1 (en) | 2008-07-28 | 2018-06-13 | Blanchette Rockefeller Neurosciences, Institute | Pkc-activating compounds for the treatment of neurodegenerative diseases |
| EP3536317A1 (en) | 2009-10-30 | 2019-09-11 | Retrotope, Inc. | Alleviating oxidative stress disorders with pufa derivatives |
| CA2790680C (en) * | 2010-02-22 | 2019-02-19 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of protein kinase c epsilon (pkc-epsilon) protein levels |
| CA2804789A1 (en) | 2010-07-08 | 2012-01-12 | Daniel L. Alkon | Pkc activators and anticoagulant in regimen for treating stroke |
| WO2012024630A1 (en) | 2010-08-19 | 2012-02-23 | Blanchette Rockefeller Neurosciences Institute | Treatment of cognitive disorders associated with abnormal dendritic spines using pkc activators |
| AU2012249921B2 (en) | 2011-04-26 | 2017-06-08 | Biojiva Llc | Oxidative retinal diseases |
| AU2012249920B2 (en) * | 2011-04-26 | 2017-06-15 | Biojiva Llc | Disorders implicating PUFA oxidation |
| WO2012148927A2 (en) * | 2011-04-26 | 2012-11-01 | Retrotope, Inc. | Impaired energy processing disorders and mitochondrial deficiency |
| JP6106157B2 (ja) | 2011-04-26 | 2017-03-29 | レトロトップ、 インコーポレイテッドＲｅｔｒｏｔｏｐｅ， Ｉｎｃ． | 神経変性障害および筋疾患に関与するｐｕｆａ |
| EP2764120B1 (en) | 2011-10-05 | 2020-06-10 | Blanchette Rockefeller Neurosciences, Institute | Stimulus-elicited genomic profile markers of a neurodegenerative condition |
| US10821079B2 (en) * | 2011-11-13 | 2020-11-03 | Cognitive Research Enterprises, Inc. | PKC activators and combinations thereof |
| JP6563193B2 (ja) * | 2011-11-13 | 2019-08-21 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | Ｄｃｐｌａのエステル、およびそれを用いた処置の方法 |
| US9512152B2 (en) | 2013-02-15 | 2016-12-06 | Nishizaki Bioinformation Research Institute | Phospholipid compound containing unsaturated fatty acid derivative having cyclopropane ring |
| CA2906164A1 (en) | 2013-03-15 | 2014-09-18 | Daniel L. Alkon | Methods for identifying neuroprotective pkc activators |
| EP4101835A1 (en) | 2013-10-18 | 2022-12-14 | Blanchette Rockefeller Neurosciences Institute | 18f-substituted esters of cyclopropanated unsaturated fatty acids for use in the treatment of neurodegenerative diseases |
| JP2017511387A (ja) | 2014-04-18 | 2017-04-20 | ニューロトロープ バイオサイエンス インコーポレイテッド | 脂質蓄積障害の治療のための方法および組成物 |
| US9413754B2 (en) | 2014-12-23 | 2016-08-09 | Airwatch Llc | Authenticator device facilitating file security |
| WO2016183252A1 (en) | 2015-05-11 | 2016-11-17 | Alkon, Daniel, L. | Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele |
| WO2017053659A1 (en) | 2015-09-23 | 2017-03-30 | Khan Tapan K | Methods for survival and rejuvenation of dermal fibroblasts using pkc activators |
| WO2017062924A1 (en) | 2015-10-08 | 2017-04-13 | Alkon Daniel L | Dosing regimens of pkc activators |
| EP3950649A1 (en) | 2015-11-23 | 2022-02-09 | Retrotope, Inc. | Site-specific isotopic labeling of 1, 4-diene systems |
| JP6912072B2 (ja) * | 2016-12-14 | 2021-07-28 | 国立大学法人山口大学 | 前頭側頭型認知症の予防又は治療用医薬 |
| WO2018187647A1 (en) | 2017-04-06 | 2018-10-11 | Neurotrope Bioscience, Inc. | Methods and compositions for treatment of neurological diseases, disorders, or conditions |
| EP3793543A1 (en) * | 2018-05-18 | 2021-03-24 | Neurotrope Bioscience, Inc. | Methods and compositions for treatment of alzheimer's disease |
| WO2020118282A1 (en) * | 2018-12-07 | 2020-06-11 | The Johns Hopkins University | Methods, compositions and kits for treating multiple sclerosis and other disorders |
| AU2021224854A1 (en) | 2020-02-21 | 2022-10-06 | Biojiva Llc | Processes for isotopic modification of polyunsaturated fatty acids and derivatives thereof |
| US20220133687A1 (en) * | 2020-11-02 | 2022-05-05 | Synaptogenix, Inc. | Methods of treating and preventing neurodegenerative diseases with hgf activating compounds |
| US12109194B2 (en) | 2021-02-05 | 2024-10-08 | Biojiva Llc | Synergistic combination therapy for treating ALS |
| EP4288047A4 (en) * | 2021-02-08 | 2024-12-11 | Synaptogenix, Inc. | Treatment of multiple sclerosis using pkc activators |
| EP4288046A4 (en) * | 2021-02-08 | 2024-12-11 | Synaptogenix, Inc. | TREATMENT OF OPTIC NERVE INFECTION WITH PKC ACTIVATORS |
| WO2023225073A1 (en) * | 2022-05-18 | 2023-11-23 | Virginia Commonwealth University | Methods for treatment of cognitive impairment in cirrhosis patients |
| WO2025056602A1 (en) | 2023-09-11 | 2025-03-20 | Elastin Biosciences Ltd. | Pharmaceutical compositions and use thereof in treatment of conditions and diseases related to elastin deficiency and/or aging |
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-
2009
- 2009-07-28 EP EP09790874.3A patent/EP2328572B1/en not_active Not-in-force
- 2009-07-28 CA CA2731171A patent/CA2731171C/en not_active Expired - Fee Related
- 2009-07-28 WO PCT/US2009/051927 patent/WO2010014585A1/en not_active Ceased
- 2009-07-28 JP JP2011521235A patent/JP5653917B2/ja not_active Expired - Fee Related
- 2009-07-28 US US12/510,681 patent/US8163800B2/en active Active
- 2009-07-28 CA CA2941035A patent/CA2941035A1/en not_active Abandoned
- 2009-07-28 EP EP18172435.2A patent/EP3403650A3/en not_active Withdrawn
- 2009-07-28 EP EP19189948.3A patent/EP3586839A1/en not_active Withdrawn
- 2009-07-28 ES ES09790874.3T patent/ES2683021T3/es active Active
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2012
- 2012-02-21 US US13/401,459 patent/US9119825B2/en active Active
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2014
- 2014-09-08 JP JP2014182597A patent/JP2015042643A/ja active Pending
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2015
- 2015-07-20 US US14/803,762 patent/US10323011B2/en active Active
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2016
- 2016-03-15 JP JP2016051212A patent/JP6449186B2/ja not_active Expired - Fee Related
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2018
- 2018-06-12 JP JP2018111869A patent/JP2018168170A/ja active Pending
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2019
- 2019-05-01 US US16/400,132 patent/US10696644B2/en active Active
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- 2023-10-02 US US18/375,745 patent/US20240025870A1/en not_active Abandoned
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