JP5609834B2 - リパーゼ阻害剤 - Google Patents
リパーゼ阻害剤 Download PDFInfo
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Description
本発明のリパーゼ阻害剤の投与量は、年齢、性別などを考慮して適宜増減できるが、通常成人で1日、原生薬換算量として100mg〜50gの範囲で用いることができ、好ましくは、500mg〜30gである。
実施例
モッカを細切後、10倍量の50%エタノールを加え、沸騰後約80℃で30分間ジムロート冷却管を用いて還流抽出し、濾過後エバポレーターを用いてエタノールを留去し、さらに、水分含量が30〜65%程度になるよう濃縮を行うことにより、エキスを得た。
基質溶液(0.2 mM 4-methylumbelliferyl oleate,シグマ社)50μlに実施例で得た各生薬エキス(2.5% DMSOで溶解)25μL及び酵素溶液(100U/mL pancreatic lipase,TypeVI-S from porcine pancreas,シグマ社)25μlを添加した。37℃で15分間反応させた後、0.1M塩酸(国産化学社)150μL及び0.1Mクエン酸ナトリウム(和光純薬工業社)25μLを加え、励起波長320nm、蛍光波長450 nmにおける蛍光を測定した。なお、各生薬エキスは最終濃度として12.5、25、50及び100μg/mLの各濃度で添加した。
結果を表1、図1及び図2に示した。阻害率は下記式にて算出した。
Es:サンプルの蛍光強度
Esblank:サンプルブランクの蛍光強度
Ec:対照の蛍光強度
Ecblank:対照ブランクの蛍光強度
ob/obマウス(6週齢、雄性、日本チャールスリバー社)に実施例で得たソボクエキスを300mg/kg(乾燥エキス換算)の用量で1日1回8週間経口投与した。最終投与後、18〜20時間絶食した。マウスから血液を採取し、遠心分離(3000rpm、20℃、15分)により血清を分離した。血清中のトリグリセライド濃度、遊離脂肪酸濃度及び総コレステロール濃度は、トリグリセライドE−テストワコー、NEFAC−テストワコー及びコレステロールE−テストワコー(いずれも和光純薬工業社)を用いて定量した。
表2及び図3から明らかなように、ソボクはob/obマウスの血清脂質上昇を有意に抑制し、高脂血症や肥満を予防または改善することが明らかになった。
Claims (3)
- モッカ、フクボンシ、オンジ及びシソヨウからなる群から選ばれる1種又は2種以上を配合することを特徴とするリパーゼ阻害剤(ただし、肥満の予防又は改善剤を除く)。
- 高脂血症の予防又は改善剤である請求項1記載のリパーゼ阻害剤。
- 高脂血症が高トリグリセライド血症である請求項2記載のリパーゼ阻害剤。
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JP2011206870A JP5609834B2 (ja) | 2004-04-09 | 2011-09-22 | リパーゼ阻害剤 |
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JP2005111714A Division JP4929611B2 (ja) | 2004-04-09 | 2005-04-08 | リパーゼ阻害剤 |
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JP2013237658A (ja) * | 2012-05-17 | 2013-11-28 | Ominedo Yakuhin Kogyo Kk | アディポネクチン産生促進用組成物 |
CN102846867A (zh) * | 2012-09-29 | 2013-01-02 | 陕西中医学院制药厂 | 用于治疗感冒及各种疮疖肿痛的中药制剂及其制备方法 |
CN104225127A (zh) * | 2013-06-15 | 2014-12-24 | 陈合成 | 一种治疗咽喉肿痛的方法 |
KR101672274B1 (ko) * | 2013-10-28 | 2016-11-04 | 한국 한의학 연구원 | 자화지정 추출물 또는 자화지정, 도인, 계지, 및 감초 복합 추출물을 포함하는 지질 관련 심혈관 질환 및 비만의 예방 또는 치료용 조성물 |
CN104367632A (zh) * | 2014-11-21 | 2015-02-25 | 范影 | 一种治疗感冒的小验方 |
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JPS58172320A (ja) * | 1982-04-02 | 1983-10-11 | Zeria Shinyaku Kogyo Kk | 抗高脂血症剤及びその製造方法 |
JPS6140763A (ja) * | 1984-08-02 | 1986-02-27 | Osaka Chem Lab | 抗肥満食品 |
JP3590908B2 (ja) * | 1993-06-28 | 2004-11-17 | 株式会社キリン堂 | αーアミラーゼインヒビター活性又はチロシナーゼインヒビター活性を有する酵素阻害剤およびその製造方法 |
JPH09176019A (ja) * | 1995-12-26 | 1997-07-08 | Suntory Ltd | 糖質分解消化酵素阻害剤並びにこれを配合した医薬品および飲食品 |
JPH10287575A (ja) * | 1997-04-09 | 1998-10-27 | Ranka Aayurubeedick Haabu Yakuhin Kk | 抗肥満剤 |
JP2000102383A (ja) * | 1998-09-30 | 2000-04-11 | Nisshin Sugar Mfg Co Ltd | シソ抽出物を有効成分とするα−グルコシダーゼ阻害剤および同阻害剤を含有する糖組成物ならびに飲食物 |
JP2002138045A (ja) * | 2000-10-30 | 2002-05-14 | Ichimaru Pharcos Co Ltd | 前駆脂肪細胞分化誘導剤 |
JP2003113106A (ja) * | 2001-10-01 | 2003-04-18 | Pola Chem Ind Inc | 熱産生タンパク質発現促進剤及びそれを含有する組成物 |
JP3615512B2 (ja) * | 2001-11-12 | 2005-02-02 | 日華化学株式会社 | リパーゼ活性賦活剤、該リパーゼ活性賦活剤を含有する皮膚外用剤、痩身用皮膚外用剤及び痩身用浴用剤 |
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