JP5581490B2 - 抗体媒介による細菌のクオラムセンシングの破壊 - Google Patents

Info

Publication number

JP5581490B2

JP5581490B2 JP2010531058A JP2010531058A JP5581490B2 JP 5581490 B2 JP5581490 B2 JP 5581490B2 JP 2010531058 A JP2010531058 A JP 2010531058A JP 2010531058 A JP2010531058 A JP 2010531058A JP 5581490 B2 JP5581490 B2 JP 5581490B2

Authority

JP

Japan

Prior art keywords

seq

antibody

amino acid

aureus

molecular entity

Prior art date

2007-10-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

Links

• Espacenet
• Global Dossier
• Discuss

• 230000018612 quorum sensing Effects 0.000 title claims description 26
• 230000001580 bacterial effect Effects 0.000 title description 11
• 230000001404 mediated effect Effects 0.000 title description 5
• 230000002163 immunogen Effects 0.000 claims description 120
• 108010069514 Cyclic Peptides Proteins 0.000 claims description 99
• 102000001189 Cyclic Peptides Human genes 0.000 claims description 99
• 241000124008 Mammalia Species 0.000 claims description 78
• 108090000623 proteins and genes Proteins 0.000 claims description 56
• 239000000203 mixture Substances 0.000 claims description 52
• 235000001014 amino acid Nutrition 0.000 claims description 46
• 125000000539 amino acid group Chemical group 0.000 claims description 46
• 150000001413 amino acids Chemical class 0.000 claims description 44
• 102000004169 proteins and genes Human genes 0.000 claims description 41
• 235000018102 proteins Nutrition 0.000 claims description 40
• 239000000126 substance Substances 0.000 claims description 35
• 208000015181 infectious disease Diseases 0.000 claims description 33
• 230000028993 immune response Effects 0.000 claims description 30
• 229920000642 polymer Polymers 0.000 claims description 30
• 241000191967 Staphylococcus aureus Species 0.000 claims description 27
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 21
• 229960005486 vaccine Drugs 0.000 claims description 19
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
• 238000004519 manufacturing process Methods 0.000 claims description 18
• 230000003472 neutralizing effect Effects 0.000 claims description 13
• 239000003937 drug carrier Substances 0.000 claims description 10
• 229910052799 carbon Inorganic materials 0.000 claims description 7
• 238000001990 intravenous administration Methods 0.000 claims description 7
• 238000007920 subcutaneous administration Methods 0.000 claims description 7
• 238000007912 intraperitoneal administration Methods 0.000 claims description 6
• 239000007927 intramuscular injection Substances 0.000 claims description 5
• DJQYYYCQOZMCRC-UHFFFAOYSA-N 2-aminopropane-1,3-dithiol Chemical group SCC(N)CS DJQYYYCQOZMCRC-UHFFFAOYSA-N 0.000 claims description 4
• 238000010255 intramuscular injection Methods 0.000 claims description 4
• 239000002105 nanoparticle Substances 0.000 claims description 3
• 125000004432 carbon atom Chemical group C* 0.000 claims description 2
• 230000005847 immunogenicity Effects 0.000 claims description 2
• 108090000765 processed proteins & peptides Proteins 0.000 description 96
• 230000011664 signaling Effects 0.000 description 87
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical group NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 72
• 238000000034 method Methods 0.000 description 68
• 230000014509 gene expression Effects 0.000 description 49
• 125000004122 cyclic group Chemical group 0.000 description 46
• 125000005647 linker group Chemical group 0.000 description 46
• 229940024606 amino acid Drugs 0.000 description 45
• 241000699670 Mus sp. Species 0.000 description 43
• 150000002596 lactones Chemical class 0.000 description 42
• 235000013877 carbamide Nutrition 0.000 description 39
• 239000004202 carbamide Chemical group 0.000 description 36
• 210000004027 cell Anatomy 0.000 description 33
• 102000004196 processed proteins & peptides Human genes 0.000 description 33
• 150000003951 lactams Chemical class 0.000 description 31
• 230000015572 biosynthetic process Effects 0.000 description 29
• 150000007523 nucleic acids Chemical class 0.000 description 29
• 102000039446 nucleic acids Human genes 0.000 description 25
• 108020004707 nucleic acids Proteins 0.000 description 25
• 238000003786 synthesis reaction Methods 0.000 description 25
• 241000282414 Homo sapiens Species 0.000 description 24
• 102100030675 ADP-ribosylation factor-like protein 6-interacting protein 4 Human genes 0.000 description 23
• 101710199055 ADP-ribosylation factor-like protein 6-interacting protein 4 Proteins 0.000 description 23
• DUIOPKIIICUYRZ-UHFFFAOYSA-N semicarbazide Chemical group NNC(N)=O DUIOPKIIICUYRZ-UHFFFAOYSA-N 0.000 description 23
• 241000894006 Bacteria Species 0.000 description 22
• 241001465754 Metazoa Species 0.000 description 19
• 230000003053 immunization Effects 0.000 description 19
• 125000003277 amino group Chemical group 0.000 description 18
• 239000003153 chemical reaction reagent Substances 0.000 description 18
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 18
• 239000008194 pharmaceutical composition Substances 0.000 description 18
• 101710092462 Alpha-hemolysin Proteins 0.000 description 17
• 241000192125 Firmicutes Species 0.000 description 17
• 241000699666 Mus <mouse, genus> Species 0.000 description 17
• 201000010099 disease Diseases 0.000 description 17
• 238000002649 immunization Methods 0.000 description 17
• 238000011282 treatment Methods 0.000 description 17
• 238000004458 analytical method Methods 0.000 description 16
• 239000012634 fragment Substances 0.000 description 16
• 150000003349 semicarbazides Chemical class 0.000 description 16
• 239000007924 injection Substances 0.000 description 15
• 238000002347 injection Methods 0.000 description 15
• 229920005989 resin Polymers 0.000 description 15
• 239000011347 resin Substances 0.000 description 15
• OROGUZVNAFJPHA-UHFFFAOYSA-N 3-hydroxy-2,4-dimethyl-2H-thiophen-5-one Chemical compound CC1SC(=O)C(C)=C1O OROGUZVNAFJPHA-UHFFFAOYSA-N 0.000 description 14
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 14
• 239000012591 Dulbecco’s Phosphate Buffered Saline Substances 0.000 description 14
• 229940098773 bovine serum albumin Drugs 0.000 description 13
• 238000006243 chemical reaction Methods 0.000 description 13
• 239000000243 solution Substances 0.000 description 13
• 108020004414 DNA Proteins 0.000 description 12
• 102000053602 DNA Human genes 0.000 description 12
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
• 150000001408 amides Chemical group 0.000 description 12
• 239000000427 antigen Substances 0.000 description 12
• 108091007433 antigens Proteins 0.000 description 12
• 102000036639 antigens Human genes 0.000 description 12
• 125000004429 atom Chemical group 0.000 description 12
• 239000012472 biological sample Substances 0.000 description 12
• 230000001965 increasing effect Effects 0.000 description 12
• 239000000725 suspension Substances 0.000 description 12
• QPIROHVZMLYRNN-YRNJLPRFSA-N 2-[(3s,6s,9s,12s,15r)-15-[[(2s,3r)-2-[[(2s)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-9-benzyl-6-[(2s)-butan-2-yl]-3-(2-methylsulfanylethyl)-2,5,8,11,14-pentaoxo-1-thia-4,7,10,13-tetrazacyclohe Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCSC)C(=O)SC[C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)=O)[C@@H](C)CC)C1=CC=CC=C1 QPIROHVZMLYRNN-YRNJLPRFSA-N 0.000 description 11
• 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 11
• -1 lactam macrocycle Chemical class 0.000 description 11
• 239000002953 phosphate buffered saline Substances 0.000 description 11
• 239000006228 supernatant Substances 0.000 description 11
• 125000003396 thiol group Chemical group [H]S* 0.000 description 11
• 238000013518 transcription Methods 0.000 description 11
• 230000035897 transcription Effects 0.000 description 11
• GFJAORMOUQQBTE-XAQATAOCSA-N (2S,3R)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-N-[(3S,6S,9S,12S,15R)-9-benzyl-6-[(2S)-butan-2-yl]-12-[(4-hydroxyphenyl)methyl]-3-(2-methylsulfanylethyl)-2,5,8,11,14-pentaoxo-1-thia-4,7,10,13-tetrazacyclohexadec-15-yl]-3-hydroxybutanamide Chemical compound CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CSC(=O)[C@H](CCSC)NC1=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O GFJAORMOUQQBTE-XAQATAOCSA-N 0.000 description 10
• 102100028571 Disabled homolog 2-interacting protein Human genes 0.000 description 10
• 238000002965 ELISA Methods 0.000 description 10
• 102100037412 Germinal-center associated nuclear protein Human genes 0.000 description 10
• 241000191940 Staphylococcus Species 0.000 description 10
• 239000013543 active substance Substances 0.000 description 10
• 239000002671 adjuvant Substances 0.000 description 10
• 230000032770 biofilm formation Effects 0.000 description 10
• 239000000412 dendrimer Substances 0.000 description 10
• 229920000736 dendritic polymer Polymers 0.000 description 10
• 230000000694 effects Effects 0.000 description 10
• 238000004128 high performance liquid chromatography Methods 0.000 description 10
• 210000004408 hybridoma Anatomy 0.000 description 10
• 239000002609 medium Substances 0.000 description 10
• 238000002360 preparation method Methods 0.000 description 10
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
• 125000001433 C-terminal amino-acid group Chemical group 0.000 description 9
• 102100033334 E3 ubiquitin-protein ligase Itchy homolog Human genes 0.000 description 9
• 101000997630 Homo sapiens E3 ubiquitin-protein ligase Itchy homolog Proteins 0.000 description 9
• 108060003951 Immunoglobulin Proteins 0.000 description 9
• 125000000729 N-terminal amino-acid group Chemical group 0.000 description 9
• 239000002202 Polyethylene glycol Substances 0.000 description 9
• 239000011324 bead Substances 0.000 description 9
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 9
• 108060003552 hemocyanin Proteins 0.000 description 9
• 102000018358 immunoglobulin Human genes 0.000 description 9
• 238000002823 phage display Methods 0.000 description 9
• 229920001223 polyethylene glycol Polymers 0.000 description 9
• 230000004083 survival effect Effects 0.000 description 9
• QAOILFZLKHORKF-DWKLSMNSSA-N 2-[(3S,6S,9S,12S,15R)-15-[[(2S)-4-amino-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-9-benzyl-3,6-bis(2-methylpropyl)-2,5,8,11,14-pentaoxo-1-thia-4,7,10,13-tetrazacyclohexadec-12-yl]acetic acid Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CSC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(O)=O)NC1=O QAOILFZLKHORKF-DWKLSMNSSA-N 0.000 description 8
• 208000035143 Bacterial infection Diseases 0.000 description 8
• 102000014914 Carrier Proteins Human genes 0.000 description 8
• 108010078791 Carrier Proteins Proteins 0.000 description 8
• 101710191399 Disabled homolog 2-interacting protein Proteins 0.000 description 8
• 101710137272 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 Proteins 0.000 description 8
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 8
• 238000003776 cleavage reaction Methods 0.000 description 8
• 230000021615 conjugation Effects 0.000 description 8
• 235000018417 cysteine Nutrition 0.000 description 8
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 8
• 230000005764 inhibitory process Effects 0.000 description 8
• 229930182817 methionine Natural products 0.000 description 8
• 230000007017 scission Effects 0.000 description 8
• GOMDIOPXFUESDK-NWHYMTRRSA-N (2s)-2-[[(2s)-2-[(2-aminoacetyl)amino]-3-methylbutanoyl]amino]-n-[(2s)-1-[[(3s,6s,9s,12s,15r)-3-benzyl-9,12-bis(hydroxymethyl)-6-(2-methylpropyl)-2,5,8,11,14-pentaoxo-1-thia-4,7,10,13-tetrazacyclohexadec-15-yl]amino]-1-oxopropan-2-yl]butanediamide Chemical compound N1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)CN)C(C)C)CSC(=O)[C@@H]1CC1=CC=CC=C1 GOMDIOPXFUESDK-NWHYMTRRSA-N 0.000 description 7
• LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 7
• 241000283690 Bos taurus Species 0.000 description 7
• 108010001336 Horseradish Peroxidase Proteins 0.000 description 7
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 7
• 108091028043 Nucleic acid sequence Proteins 0.000 description 7
• 241000283973 Oryctolagus cuniculus Species 0.000 description 7
• 235000004279 alanine Nutrition 0.000 description 7
• 238000000429 assembly Methods 0.000 description 7
• 230000000712 assembly Effects 0.000 description 7
• 230000008901 benefit Effects 0.000 description 7
• 210000004369 blood Anatomy 0.000 description 7
• 239000008280 blood Substances 0.000 description 7
• 125000002843 carboxylic acid group Chemical group 0.000 description 7
• 239000000969 carrier Substances 0.000 description 7
• 238000005859 coupling reaction Methods 0.000 description 7
• 238000009472 formulation Methods 0.000 description 7
• 125000000524 functional group Chemical group 0.000 description 7
• 238000011534 incubation Methods 0.000 description 7
• 231100000518 lethal Toxicity 0.000 description 7
• 230000001665 lethal effect Effects 0.000 description 7
• 239000002245 particle Substances 0.000 description 7
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 7
• 229920001184 polypeptide Polymers 0.000 description 7
• 239000000047 product Substances 0.000 description 7
• 238000003753 real-time PCR Methods 0.000 description 7
• 239000007787 solid Substances 0.000 description 7
• 238000012360 testing method Methods 0.000 description 7
• DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 7
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
• 241000283707 Capra Species 0.000 description 6
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 6
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 6
• 241001494479 Pecora Species 0.000 description 6
• 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 description 6
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
• 108091030066 RNAIII Proteins 0.000 description 6
• 241000700159 Rattus Species 0.000 description 6
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
• 206010041925 Staphylococcal infections Diseases 0.000 description 6
• 206010000269 abscess Diseases 0.000 description 6
• 238000002835 absorbance Methods 0.000 description 6
• 230000008878 coupling Effects 0.000 description 6
• 238000010168 coupling process Methods 0.000 description 6
• 230000034994 death Effects 0.000 description 6
• 238000010511 deprotection reaction Methods 0.000 description 6
• 238000002474 experimental method Methods 0.000 description 6
• 239000007928 intraperitoneal injection Substances 0.000 description 6
• 239000000463 material Substances 0.000 description 6
• 230000004044 response Effects 0.000 description 6
• 230000028327 secretion Effects 0.000 description 6
• 238000006467 substitution reaction Methods 0.000 description 6
• 230000001225 therapeutic effect Effects 0.000 description 6
• 238000002255 vaccination Methods 0.000 description 6
• 230000007923 virulence factor Effects 0.000 description 6
• 239000000304 virulence factor Substances 0.000 description 6
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
• 101710093674 Cyclic nucleotide-gated cation channel beta-1 Proteins 0.000 description 5
• 101001057193 Homo sapiens Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Proteins 0.000 description 5
• 101000655540 Homo sapiens Protransforming growth factor alpha Proteins 0.000 description 5
• 108091006905 Human Serum Albumin Proteins 0.000 description 5
• 102000008100 Human Serum Albumin Human genes 0.000 description 5
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 5
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 5
• 102100027240 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Human genes 0.000 description 5
• 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 description 5
• 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 description 5
• 102100032350 Protransforming growth factor alpha Human genes 0.000 description 5
• 102100025946 Transforming growth factor beta activator LRRC32 Human genes 0.000 description 5
• 101710169732 Transforming growth factor beta activator LRRC32 Proteins 0.000 description 5
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 5
• 208000022362 bacterial infectious disease Diseases 0.000 description 5
• 230000008859 change Effects 0.000 description 5
• 150000001875 compounds Chemical class 0.000 description 5
• 150000002148 esters Chemical group 0.000 description 5
• 238000003881 globally optimized alternating phase rectangular pulse Methods 0.000 description 5
• 150000002678 macrocyclic compounds Chemical class 0.000 description 5
• 230000004048 modification Effects 0.000 description 5
• 238000012986 modification Methods 0.000 description 5
• 230000002829 reductive effect Effects 0.000 description 5
• 239000000523 sample Substances 0.000 description 5
• 230000001629 suppression Effects 0.000 description 5
• 150000007970 thio esters Chemical group 0.000 description 5
• 239000003053 toxin Substances 0.000 description 5
• 231100000765 toxin Toxicity 0.000 description 5
• 108700012359 toxins Proteins 0.000 description 5
• 230000003612 virological effect Effects 0.000 description 5
• 238000001262 western blot Methods 0.000 description 5
• 229920001817 Agar Polymers 0.000 description 4
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
• 102100027765 Atlastin-2 Human genes 0.000 description 4
• 101710192135 Atlastin-2 Proteins 0.000 description 4
• 101000800130 Bos taurus Thyroglobulin Proteins 0.000 description 4
• 241001529572 Chaceon affinis Species 0.000 description 4
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
• 108010026206 Conalbumin Proteins 0.000 description 4
• 102000006395 Globulins Human genes 0.000 description 4
• 108010044091 Globulins Proteins 0.000 description 4
• 108010006464 Hemolysin Proteins Proteins 0.000 description 4
• 108010075530 Kunitz Soybean Trypsin Inhibitor Proteins 0.000 description 4
• FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical group OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 4
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 4
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 4
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 4
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 4
• 108010058846 Ovalbumin Proteins 0.000 description 4
• 101100203319 Schizosaccharomyces pombe (strain 972 / ATCC 24843) skh1 gene Proteins 0.000 description 4
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 4
• 108010034949 Thyroglobulin Proteins 0.000 description 4
• 102000009843 Thyroglobulin Human genes 0.000 description 4
• 239000008272 agar Substances 0.000 description 4
• 238000013019 agitation Methods 0.000 description 4
• 239000003242 anti bacterial agent Substances 0.000 description 4
• 230000006907 apoptotic process Effects 0.000 description 4
• 238000013459 approach Methods 0.000 description 4
• 230000036760 body temperature Effects 0.000 description 4
• 210000004899 c-terminal region Anatomy 0.000 description 4
• 238000013461 design Methods 0.000 description 4
• 239000006185 dispersion Substances 0.000 description 4
• 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 4
• 238000011156 evaluation Methods 0.000 description 4
• 239000013604 expression vector Substances 0.000 description 4
• 235000011187 glycerol Nutrition 0.000 description 4
• 230000012010 growth Effects 0.000 description 4
• 239000001963 growth medium Substances 0.000 description 4
• 239000003228 hemolysin Substances 0.000 description 4
• 239000004615 ingredient Substances 0.000 description 4
• 229960000310 isoleucine Drugs 0.000 description 4
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 4
• 230000000670 limiting effect Effects 0.000 description 4
• 239000002502 liposome Substances 0.000 description 4
• 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 4
• 239000000178 monomer Substances 0.000 description 4
• 238000010172 mouse model Methods 0.000 description 4
• 229940092253 ovalbumin Drugs 0.000 description 4
• 150000002923 oximes Chemical class 0.000 description 4
• 238000010647 peptide synthesis reaction Methods 0.000 description 4
• 239000000546 pharmaceutical excipient Substances 0.000 description 4
• 238000003752 polymerase chain reaction Methods 0.000 description 4
• 238000000746 purification Methods 0.000 description 4
• 230000000171 quenching effect Effects 0.000 description 4
• 108020003175 receptors Proteins 0.000 description 4
• 102000005962 receptors Human genes 0.000 description 4
• 206010038351 renal abscess Diseases 0.000 description 4
• 210000003705 ribosome Anatomy 0.000 description 4
• 239000011780 sodium chloride Substances 0.000 description 4
• VUFNRPJNRFOTGK-UHFFFAOYSA-M sodium;1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)C1CCC(CN2C(C=CC2=O)=O)CC1 VUFNRPJNRFOTGK-UHFFFAOYSA-M 0.000 description 4
• 239000002904 solvent Substances 0.000 description 4
• 241000894007 species Species 0.000 description 4
• 229960002175 thyroglobulin Drugs 0.000 description 4
• 210000001519 tissue Anatomy 0.000 description 4
• 231100000331 toxic Toxicity 0.000 description 4
• 230000002588 toxic effect Effects 0.000 description 4
• ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical compound CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 description 4
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 4
• 239000000277 virosome Substances 0.000 description 4
• 230000001018 virulence Effects 0.000 description 4
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 3
• DIYPCWKHSODVAP-UHFFFAOYSA-N 1-[3-(2,5-dioxopyrrol-1-yl)benzoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)C1=CC=CC(N2C(C=CC2=O)=O)=C1 DIYPCWKHSODVAP-UHFFFAOYSA-N 0.000 description 3
• VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 3
• JIOPYMJPNUMIJH-ZZGXNYQGSA-N AP4 hapten Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCSC)C(=O)OC[C@@H](C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)COCCOCCNC(=O)[C@@H](N)CS)[C@@H](C)O)=O)[C@@H](C)CC)C1=CC=CC=C1 JIOPYMJPNUMIJH-ZZGXNYQGSA-N 0.000 description 3
• 108090001008 Avidin Proteins 0.000 description 3
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
• 102100033620 Calponin-1 Human genes 0.000 description 3
• 206010011409 Cross infection Diseases 0.000 description 3
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
• 102000004190 Enzymes Human genes 0.000 description 3
• 108090000790 Enzymes Proteins 0.000 description 3
• 241000588724 Escherichia coli Species 0.000 description 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
• 241000233866 Fungi Species 0.000 description 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
• 101000945318 Homo sapiens Calponin-1 Proteins 0.000 description 3
• 101000835018 Homo sapiens Transcription factor AP-4 Proteins 0.000 description 3
• 101000652736 Homo sapiens Transgelin Proteins 0.000 description 3
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• 206010035226 Plasma cell myeloma Diseases 0.000 description 3
• 238000011804 SKH1 hairless mouse Methods 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 241000295644 Staphylococcaceae Species 0.000 description 3
• 102100026154 Transcription factor AP-4 Human genes 0.000 description 3
• 108010059993 Vancomycin Proteins 0.000 description 3
• 239000002253 acid Substances 0.000 description 3
• 125000003545 alkoxy group Chemical group 0.000 description 3
• 125000003282 alkyl amino group Chemical group 0.000 description 3
• 125000004414 alkyl thio group Chemical group 0.000 description 3
• 210000000628 antibody-producing cell Anatomy 0.000 description 3
• 239000011230 binding agent Substances 0.000 description 3
• 229920001222 biopolymer Polymers 0.000 description 3
• 239000006161 blood agar Substances 0.000 description 3
• 239000011575 calcium Substances 0.000 description 3
• 229910052791 calcium Inorganic materials 0.000 description 3
• 150000001732 carboxylic acid derivatives Chemical class 0.000 description 3
• 239000003795 chemical substances by application Substances 0.000 description 3
• 238000000576 coating method Methods 0.000 description 3
• 230000002860 competitive effect Effects 0.000 description 3
• 230000009260 cross reactivity Effects 0.000 description 3
• 239000012228 culture supernatant Substances 0.000 description 3
• 230000001419 dependent effect Effects 0.000 description 3
• 239000002612 dispersion medium Substances 0.000 description 3
• PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
• 229940079593 drug Drugs 0.000 description 3
• 239000003814 drug Substances 0.000 description 3
• 238000005516 engineering process Methods 0.000 description 3
• 229940088598 enzyme Drugs 0.000 description 3
• 210000000416 exudates and transudate Anatomy 0.000 description 3
• 239000000499 gel Substances 0.000 description 3
• 239000008103 glucose Substances 0.000 description 3
• 101150070420 gyrA gene Proteins 0.000 description 3
• 230000002209 hydrophobic effect Effects 0.000 description 3
• 210000000987 immune system Anatomy 0.000 description 3
• 230000002401 inhibitory effect Effects 0.000 description 3
• 208000014674 injury Diseases 0.000 description 3
• 210000003734 kidney Anatomy 0.000 description 3
• 238000007273 lactonization reaction Methods 0.000 description 3
• 239000011777 magnesium Substances 0.000 description 3
• 229910052749 magnesium Inorganic materials 0.000 description 3
• 210000004962 mammalian cell Anatomy 0.000 description 3
• 201000000050 myeloid neoplasm Diseases 0.000 description 3
• 239000000843 powder Substances 0.000 description 3
• 230000008569 process Effects 0.000 description 3
• 125000006239 protecting group Chemical group 0.000 description 3
• 206010040872 skin infection Diseases 0.000 description 3
• 239000007790 solid phase Substances 0.000 description 3
• 125000006850 spacer group Chemical group 0.000 description 3
• 230000003068 static effect Effects 0.000 description 3
• 239000007929 subcutaneous injection Substances 0.000 description 3
• 238000010254 subcutaneous injection Methods 0.000 description 3
• JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 description 3
• 239000004094 surface-active agent Substances 0.000 description 3
• 150000003573 thiols Chemical group 0.000 description 3
• 231100000419 toxicity Toxicity 0.000 description 3
• 230000001988 toxicity Effects 0.000 description 3
• 230000014616 translation Effects 0.000 description 3
• 230000008733 trauma Effects 0.000 description 3
• 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 3
• 150000003672 ureas Chemical class 0.000 description 3
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 3
• 229960003165 vancomycin Drugs 0.000 description 3
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 3
• 239000003981 vehicle Substances 0.000 description 3
• 239000002023 wood Substances 0.000 description 3
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
• NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 2
• 125000000134 2-(methylsulfanyl)ethyl group Chemical group [H]C([H])([H])SC([H])([H])C([H])([H])[*] 0.000 description 2
• UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 2
• PBVAJRFEEOIAGW-UHFFFAOYSA-N 3-[bis(2-carboxyethyl)phosphanyl]propanoic acid;hydrochloride Chemical compound Cl.OC(=O)CCP(CCC(O)=O)CCC(O)=O PBVAJRFEEOIAGW-UHFFFAOYSA-N 0.000 description 2
• 102000005666 Apolipoprotein A-I Human genes 0.000 description 2
• 108010059886 Apolipoprotein A-I Proteins 0.000 description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 description 2
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
• 241000282693 Cercopithecidae Species 0.000 description 2
• 201000006082 Chickenpox Diseases 0.000 description 2
• 102000009016 Cholera Toxin Human genes 0.000 description 2
• 108010049048 Cholera Toxin Proteins 0.000 description 2
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
• 241000975300 Concholepas concholepas Species 0.000 description 2
• 241000699800 Cricetinae Species 0.000 description 2
• 241000283073 Equus caballus Species 0.000 description 2
• 206010016952 Food poisoning Diseases 0.000 description 2
• 208000019331 Foodborne disease Diseases 0.000 description 2
• 206010017533 Fungal infection Diseases 0.000 description 2
• 108010010803 Gelatin Proteins 0.000 description 2
• 244000068988 Glycine max Species 0.000 description 2
• 235000010469 Glycine max Nutrition 0.000 description 2
• 241000606768 Haemophilus influenzae Species 0.000 description 2
• 244000020551 Helianthus annuus Species 0.000 description 2
• 235000003222 Helianthus annuus Nutrition 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
• 108010028921 Lipopeptides Proteins 0.000 description 2
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
• 239000004472 Lysine Substances 0.000 description 2
• 201000005505 Measles Diseases 0.000 description 2
• 208000005647 Mumps Diseases 0.000 description 2
• 241001529936 Murinae Species 0.000 description 2
• 208000031888 Mycoses Diseases 0.000 description 2
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 2
• NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical class ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 2
• 108010038807 Oligopeptides Proteins 0.000 description 2
• 102000015636 Oligopeptides Human genes 0.000 description 2
• 201000005702 Pertussis Diseases 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
• 208000000474 Poliomyelitis Diseases 0.000 description 2
• 108010039918 Polylysine Proteins 0.000 description 2
• 239000004793 Polystyrene Substances 0.000 description 2
• 241000288906 Primates Species 0.000 description 2
• 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
• 108010065585 RNAIII inhibiting peptide Proteins 0.000 description 2
• 108020004511 Recombinant DNA Proteins 0.000 description 2
• 206010039509 Scab Diseases 0.000 description 2
• 208000034189 Sclerosis Diseases 0.000 description 2
• 108010071390 Serum Albumin Proteins 0.000 description 2
• 102000007562 Serum Albumin Human genes 0.000 description 2
• DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 2
• 101800001707 Spacer peptide Proteins 0.000 description 2
• 241000191963 Staphylococcus epidermidis Species 0.000 description 2
• 241000282898 Sus scrofa Species 0.000 description 2
• 210000001744 T-lymphocyte Anatomy 0.000 description 2
• 206010043376 Tetanus Diseases 0.000 description 2
• 108010055044 Tetanus Toxin Proteins 0.000 description 2
• 101710182223 Toxin B Proteins 0.000 description 2
• 101710195626 Transcriptional activator protein Proteins 0.000 description 2
• 101710162629 Trypsin inhibitor Proteins 0.000 description 2
• 229940122618 Trypsin inhibitor Drugs 0.000 description 2
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
• 206010046980 Varicella Diseases 0.000 description 2
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
• 241000700605 Viruses Species 0.000 description 2
• 230000002159 abnormal effect Effects 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• 150000007513 acids Chemical class 0.000 description 2
• 108010029777 actin interacting protein 1 Proteins 0.000 description 2
• 230000001154 acute effect Effects 0.000 description 2
• IBVAQQYNSHJXBV-UHFFFAOYSA-N adipic acid dihydrazide Chemical compound NNC(=O)CCCCC(=O)NN IBVAQQYNSHJXBV-UHFFFAOYSA-N 0.000 description 2
• 125000005248 alkyl aryloxy group Chemical group 0.000 description 2
• 125000000217 alkyl group Chemical group 0.000 description 2
• RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 description 2
• 230000000844 anti-bacterial effect Effects 0.000 description 2
• 230000000845 anti-microbial effect Effects 0.000 description 2
• 239000003429 antifungal agent Substances 0.000 description 2
• 229940121375 antifungal agent Drugs 0.000 description 2
• 239000011668 ascorbic acid Substances 0.000 description 2
• 235000010323 ascorbic acid Nutrition 0.000 description 2
• 229960005070 ascorbic acid Drugs 0.000 description 2
• 210000003719 b-lymphocyte Anatomy 0.000 description 2
• 230000000721 bacterilogical effect Effects 0.000 description 2
• 230000001588 bifunctional effect Effects 0.000 description 2
• 230000003115 biocidal effect Effects 0.000 description 2
• 229920002988 biodegradable polymer Polymers 0.000 description 2
• 238000012925 biological evaluation Methods 0.000 description 2
• 210000001124 body fluid Anatomy 0.000 description 2
• 239000010839 body fluid Substances 0.000 description 2
• 239000002775 capsule Substances 0.000 description 2
• 150000001721 carbon Chemical group 0.000 description 2
• 150000007942 carboxylates Chemical group 0.000 description 2
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
• NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 2
• 239000011248 coating agent Substances 0.000 description 2
• 239000002299 complementary DNA Substances 0.000 description 2
• 239000013078 crystal Substances 0.000 description 2
• 238000003745 diagnosis Methods 0.000 description 2
• 238000000502 dialysis Methods 0.000 description 2
• 238000010790 dilution Methods 0.000 description 2
• 239000012895 dilution Substances 0.000 description 2
• 206010013023 diphtheria Diseases 0.000 description 2
• 229960003983 diphtheria toxoid Drugs 0.000 description 2
• 238000010494 dissociation reaction Methods 0.000 description 2
• 230000005593 dissociations Effects 0.000 description 2
• 238000012377 drug delivery Methods 0.000 description 2
• 239000012636 effector Substances 0.000 description 2
• 239000000839 emulsion Substances 0.000 description 2
• 150000002170 ethers Chemical group 0.000 description 2
• 239000005038 ethylene vinyl acetate Substances 0.000 description 2
• 239000000284 extract Substances 0.000 description 2
• 238000001914 filtration Methods 0.000 description 2
• 230000006870 function Effects 0.000 description 2
• 239000008273 gelatin Substances 0.000 description 2
• 229920000159 gelatin Polymers 0.000 description 2
• 229940014259 gelatin Drugs 0.000 description 2
• 235000019322 gelatine Nutrition 0.000 description 2
• 235000011852 gelatine desserts Nutrition 0.000 description 2
• 210000004907 gland Anatomy 0.000 description 2
• 150000002334 glycols Chemical class 0.000 description 2
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
• 208000027136 gram-positive bacterial infections Diseases 0.000 description 2
• 229940047650 haemophilus influenzae Drugs 0.000 description 2
• 230000002949 hemolytic effect Effects 0.000 description 2
• 208000002672 hepatitis B Diseases 0.000 description 2
• 229910052739 hydrogen Inorganic materials 0.000 description 2
• NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 2
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 2
• 230000036039 immunity Effects 0.000 description 2
• 229940027941 immunoglobulin g Drugs 0.000 description 2
• 230000016784 immunoglobulin production Effects 0.000 description 2
• 238000001727 in vivo Methods 0.000 description 2
• 230000006698 induction Effects 0.000 description 2
• 239000007951 isotonicity adjuster Substances 0.000 description 2
• 239000007788 liquid Substances 0.000 description 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 210000005075 mammary gland Anatomy 0.000 description 2
• 208000004396 mastitis Diseases 0.000 description 2
• 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 2
• 239000012528 membrane Substances 0.000 description 2
• OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
• LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
• 239000000693 micelle Substances 0.000 description 2
• 244000005700 microbiome Species 0.000 description 2
• 230000003278 mimic effect Effects 0.000 description 2
• 208000010805 mumps infectious disease Diseases 0.000 description 2
• 239000002674 ointment Substances 0.000 description 2
• 229940046166 oligodeoxynucleotide Drugs 0.000 description 2
• 238000004091 panning Methods 0.000 description 2
• 230000001717 pathogenic effect Effects 0.000 description 2
• 239000008188 pellet Substances 0.000 description 2
• 239000012071 phase Substances 0.000 description 2
• 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
• 229920000656 polylysine Polymers 0.000 description 2
• 238000006116 polymerization reaction Methods 0.000 description 2
• 229920002223 polystyrene Polymers 0.000 description 2
• 238000001556 precipitation Methods 0.000 description 2
• 230000000069 prophylactic effect Effects 0.000 description 2
• 230000001681 protective effect Effects 0.000 description 2
• 238000010791 quenching Methods 0.000 description 2
• 238000007363 ring formation reaction Methods 0.000 description 2
• 201000005404 rubella Diseases 0.000 description 2
• 238000012216 screening Methods 0.000 description 2
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 2
• 235000020183 skimmed milk Nutrition 0.000 description 2
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
• 238000010561 standard procedure Methods 0.000 description 2
• 238000003756 stirring Methods 0.000 description 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
• 239000000758 substrate Substances 0.000 description 2
• 208000024891 symptom Diseases 0.000 description 2
• 230000009885 systemic effect Effects 0.000 description 2
• 229940118376 tetanus toxin Drugs 0.000 description 2
• 229960000814 tetanus toxoid Drugs 0.000 description 2
• 150000003568 thioethers Chemical group 0.000 description 2
• 231100000027 toxicology Toxicity 0.000 description 2
• 238000011830 transgenic mouse model Methods 0.000 description 2
• 238000013519 translation Methods 0.000 description 2
• 108091005703 transmembrane proteins Proteins 0.000 description 2
• 102000035160 transmembrane proteins Human genes 0.000 description 2
• 239000002753 trypsin inhibitor Substances 0.000 description 2
• 201000008827 tuberculosis Diseases 0.000 description 2
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
• 241001515965 unidentified phage Species 0.000 description 2
• 239000004474 valine Substances 0.000 description 2
• 239000013598 vector Substances 0.000 description 2
• LLXVXPPXELIDGQ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)benzoate Chemical compound C=1C=CC(N2C(C=CC2=O)=O)=CC=1C(=O)ON1C(=O)CCC1=O LLXVXPPXELIDGQ-UHFFFAOYSA-N 0.000 description 1
• FRQWVAWXEBTURS-UHFFFAOYSA-N (2-nitrophenyl) carbamate Chemical compound NC(=O)OC1=CC=CC=C1[N+]([O-])=O FRQWVAWXEBTURS-UHFFFAOYSA-N 0.000 description 1
• JZTKZVJMSCONAK-INIZCTEOSA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-hydroxypropanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CO)C(O)=O)C3=CC=CC=C3C2=C1 JZTKZVJMSCONAK-INIZCTEOSA-N 0.000 description 1
• UCARTONYOJORBQ-UMSFTDKQSA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-trityloxypropanoic acid Chemical compound C([C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21)OC(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 UCARTONYOJORBQ-UMSFTDKQSA-N 0.000 description 1
• VZQHRKZCAZCACO-PYJNHQTQSA-N (2s)-2-[[(2s)-2-[2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]prop-2-enoylamino]-3-methylbutanoyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCNC(N)=N VZQHRKZCAZCACO-PYJNHQTQSA-N 0.000 description 1
• GPHZOMOHUGDLPM-XAQATAOCSA-N (2s)-2-[[(2s,3s)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2s,3r)-2-[[(2s)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-sulfanylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)C1=CC=CC=C1 GPHZOMOHUGDLPM-XAQATAOCSA-N 0.000 description 1
• QHFKWIKCUHNXAU-UHFFFAOYSA-N (4-nitrophenyl) carbamate Chemical compound NC(=O)OC1=CC=C([N+]([O-])=O)C=C1 QHFKWIKCUHNXAU-UHFFFAOYSA-N 0.000 description 1
• YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
• UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 description 1
• WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
• FPKVOQKZMBDBKP-UHFFFAOYSA-N 1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)C1CCC(CN2C(C=CC2=O)=O)CC1 FPKVOQKZMBDBKP-UHFFFAOYSA-N 0.000 description 1
• JFLSOKIMYBSASW-UHFFFAOYSA-N 1-chloro-2-[chloro(diphenyl)methyl]benzene Chemical compound ClC1=CC=CC=C1C(Cl)(C=1C=CC=CC=1)C1=CC=CC=C1 JFLSOKIMYBSASW-UHFFFAOYSA-N 0.000 description 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
• BWZVCCNYKMEVEX-UHFFFAOYSA-N 2,4,6-Trimethylpyridine Chemical compound CC1=CC(C)=NC(C)=C1 BWZVCCNYKMEVEX-UHFFFAOYSA-N 0.000 description 1
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
• AECGEIVNZGQBJT-UHFFFAOYSA-N 3-tritylsulfanylpropanoic acid Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(SCCC(=O)O)C1=CC=CC=C1 AECGEIVNZGQBJT-UHFFFAOYSA-N 0.000 description 1
• QWVRTSZDKPRPDF-UHFFFAOYSA-N 5-(piperidin-1-ylmethyl)-3-pyridin-3-yl-5,6-dihydro-2h-1,2,4-oxadiazine Chemical compound C1CCCCN1CC(N=1)CONC=1C1=CC=CN=C1 QWVRTSZDKPRPDF-UHFFFAOYSA-N 0.000 description 1
• 101710179738 6,7-dimethyl-8-ribityllumazine synthase 1 Proteins 0.000 description 1
• CJIJXIFQYOPWTF-UHFFFAOYSA-N 7-hydroxycoumarin Natural products O1C(=O)C=CC2=CC(O)=CC=C21 CJIJXIFQYOPWTF-UHFFFAOYSA-N 0.000 description 1
• 102100033639 Acetylcholinesterase Human genes 0.000 description 1
• 108010022752 Acetylcholinesterase Proteins 0.000 description 1
• 108010000239 Aequorin Proteins 0.000 description 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
• 108010032595 Antibody Binding Sites Proteins 0.000 description 1
• 206010053555 Arthritis bacterial Diseases 0.000 description 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
• 241000416162 Astragalus gummifer Species 0.000 description 1
• 208000031504 Asymptomatic Infections Diseases 0.000 description 1
• 108020000946 Bacterial DNA Proteins 0.000 description 1
• 102100026189 Beta-galactosidase Human genes 0.000 description 1
• 241000588832 Bordetella pertussis Species 0.000 description 1
• 208000031462 Bovine Mastitis Diseases 0.000 description 1
• NQUPWEDJRIKTKI-UHFFFAOYSA-N C(N)(OC1=CC=C(C=C1)[N+](=O)[O-])=O.C(=O)(OC(C)(C)C)NCC(CCSC)N Chemical compound C(N)(OC1=CC=C(C=C1)[N+](=O)[O-])=O.C(=O)(OC(C)(C)C)NCC(CCSC)N NQUPWEDJRIKTKI-UHFFFAOYSA-N 0.000 description 1
• 241000700198 Cavia Species 0.000 description 1
• 241000700199 Cavia porcellus Species 0.000 description 1
• 102000008186 Collagen Human genes 0.000 description 1
• 108010035532 Collagen Proteins 0.000 description 1
• 208000035473 Communicable disease Diseases 0.000 description 1
• 229920002261 Corn starch Polymers 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 1
• 238000001712 DNA sequencing Methods 0.000 description 1
• XPDXVDYUQZHFPV-UHFFFAOYSA-N Dansyl Chloride Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(Cl)(=O)=O XPDXVDYUQZHFPV-UHFFFAOYSA-N 0.000 description 1
• CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 1
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• 238000012286 ELISA Assay Methods 0.000 description 1
• BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• 206010018910 Haemolysis Diseases 0.000 description 1
• 108010072039 Histidine kinase Proteins 0.000 description 1
• 206010020565 Hyperaemia Diseases 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 206010023232 Joint swelling Diseases 0.000 description 1
• 150000007649 L alpha amino acids Chemical class 0.000 description 1
• OGNSCSPNOLGXSM-VKHMYHEASA-O L-2,4-diazaniumylbutyrate Chemical compound [NH3+]CC[C@H]([NH3+])C([O-])=O OGNSCSPNOLGXSM-VKHMYHEASA-O 0.000 description 1
• AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
• 150000008575 L-amino acids Chemical class 0.000 description 1
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
• UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 description 1
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 101710186608 Lipoyl synthase 1 Proteins 0.000 description 1
• 101710137584 Lipoyl synthase 1, chloroplastic Proteins 0.000 description 1
• 101710090391 Lipoyl synthase 1, mitochondrial Proteins 0.000 description 1
• 108060001084 Luciferase Proteins 0.000 description 1
• 239000005089 Luciferase Substances 0.000 description 1
• DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 1
• 239000007993 MOPS buffer Substances 0.000 description 1
• 244000246386 Mentha pulegium Species 0.000 description 1
• 235000016257 Mentha pulegium Nutrition 0.000 description 1
• 235000004357 Mentha x piperita Nutrition 0.000 description 1
• RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• 241000699660 Mus musculus Species 0.000 description 1
• 206010030113 Oedema Diseases 0.000 description 1
• AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
• UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 235000019483 Peanut oil Nutrition 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 102000057297 Pepsin A Human genes 0.000 description 1
• 108090000284 Pepsin A Proteins 0.000 description 1
• 108010033276 Peptide Fragments Proteins 0.000 description 1
• 102000007079 Peptide Fragments Human genes 0.000 description 1
• 208000037581 Persistent Infection Diseases 0.000 description 1
• ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
• 108010004729 Phycoerythrin Proteins 0.000 description 1
• 206010035664 Pneumonia Diseases 0.000 description 1
• 241000276498 Pollachius virens Species 0.000 description 1
• 229920002732 Polyanhydride Polymers 0.000 description 1
• 239000004698 Polyethylene Substances 0.000 description 1
• 229920000954 Polyglycolide Polymers 0.000 description 1
• 229920001710 Polyorthoester Polymers 0.000 description 1
• 239000004743 Polypropylene Substances 0.000 description 1
• 241000205160 Pyrococcus Species 0.000 description 1
• 239000012980 RPMI-1640 medium Substances 0.000 description 1
• 238000010240 RT-PCR analysis Methods 0.000 description 1
• CGNLCCVKSWNSDG-UHFFFAOYSA-N SYBR Green I Chemical compound CN(C)CCCN(CCC)C1=CC(C=C2N(C3=CC=CC=C3S2)C)=C2C=CC=CC2=[N+]1C1=CC=CC=C1 CGNLCCVKSWNSDG-UHFFFAOYSA-N 0.000 description 1
• 206010040047 Sepsis Diseases 0.000 description 1
• 206010040070 Septic Shock Diseases 0.000 description 1
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
• 241001147687 Staphylococcus auricularis Species 0.000 description 1
• 241001147736 Staphylococcus capitis Species 0.000 description 1
• 241000191980 Staphylococcus intermedius Species 0.000 description 1
• 241000191978 Staphylococcus simulans Species 0.000 description 1
• 241000191973 Staphylococcus xylosus Species 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 108010090804 Streptavidin Proteins 0.000 description 1
• 206010042343 Subcutaneous abscess Diseases 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
• 208000033809 Suppuration Diseases 0.000 description 1
• 208000002847 Surgical Wound Diseases 0.000 description 1
• BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
• 239000004473 Threonine Substances 0.000 description 1
• 206010044248 Toxic shock syndrome Diseases 0.000 description 1
• 231100000650 Toxic shock syndrome Toxicity 0.000 description 1
• 229920001615 Tragacanth Polymers 0.000 description 1
• 101000980463 Treponema pallidum (strain Nichols) Chaperonin GroEL Proteins 0.000 description 1
• 229940022698 acetylcholinesterase Drugs 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 125000002252 acyl group Chemical group 0.000 description 1
• 230000010933 acylation Effects 0.000 description 1
• 238000005917 acylation reaction Methods 0.000 description 1
• 239000000443 aerosol Substances 0.000 description 1
• 238000001042 affinity chromatography Methods 0.000 description 1
• 150000001294 alanine derivatives Chemical class 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 235000010443 alginic acid Nutrition 0.000 description 1
• 229920000615 alginic acid Polymers 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 150000001336 alkenes Chemical group 0.000 description 1
• 125000002947 alkylene group Chemical group 0.000 description 1
• 150000001371 alpha-amino acids Chemical class 0.000 description 1
• 235000008206 alpha-amino acids Nutrition 0.000 description 1
• AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
• ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
• 150000001409 amidines Chemical class 0.000 description 1
• 150000001412 amines Chemical class 0.000 description 1
• 238000007098 aminolysis reaction Methods 0.000 description 1
• BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
• 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
• 235000011130 ammonium sulphate Nutrition 0.000 description 1
• 230000003698 anagen phase Effects 0.000 description 1
• 238000004873 anchoring Methods 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 230000002788 anti-peptide Effects 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 230000000890 antigenic effect Effects 0.000 description 1
• 239000004599 antimicrobial Substances 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 235000006708 antioxidants Nutrition 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 206010003246 arthritis Diseases 0.000 description 1
• 125000003118 aryl group Chemical group 0.000 description 1
• 235000009582 asparagine Nutrition 0.000 description 1
• 229960001230 asparagine Drugs 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 238000003556 assay Methods 0.000 description 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
• 230000002238 attenuated effect Effects 0.000 description 1
• 230000007921 bacterial pathogenicity Effects 0.000 description 1
• 230000007924 bacterial virulence factor Effects 0.000 description 1
• 230000003385 bacteriostatic effect Effects 0.000 description 1
• 230000004888 barrier function Effects 0.000 description 1
• 235000019445 benzyl alcohol Nutrition 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• 108010005774 beta-Galactosidase Proteins 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 239000007621 bhi medium Substances 0.000 description 1
• 239000003833 bile salt Substances 0.000 description 1
• 229940093761 bile salts Drugs 0.000 description 1
• 238000004166 bioassay Methods 0.000 description 1
• 229920000249 biocompatible polymer Polymers 0.000 description 1
• 239000004621 biodegradable polymer Substances 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• 239000000090 biomarker Substances 0.000 description 1
• 229960002685 biotin Drugs 0.000 description 1
• 235000020958 biotin Nutrition 0.000 description 1
• 239000011616 biotin Substances 0.000 description 1
• OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 1
• 229920001400 block copolymer Polymers 0.000 description 1
• 238000009640 blood culture Methods 0.000 description 1
• 125000005621 boronate group Chemical class 0.000 description 1
• 210000000481 breast Anatomy 0.000 description 1
• 239000000872 buffer Substances 0.000 description 1
• 229940041514 candida albicans extract Drugs 0.000 description 1
• 239000001569 carbon dioxide Substances 0.000 description 1
• 229910002092 carbon dioxide Inorganic materials 0.000 description 1
• 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
• 230000003197 catalytic effect Effects 0.000 description 1
• 238000004113 cell culture Methods 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 230000000739 chaotic effect Effects 0.000 description 1
• 239000002738 chelating agent Substances 0.000 description 1
• 229960004926 chlorobutanol Drugs 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 230000001684 chronic effect Effects 0.000 description 1
• 229920001436 collagen Polymers 0.000 description 1
• 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
• 230000001332 colony forming effect Effects 0.000 description 1
• 238000012875 competitive assay Methods 0.000 description 1
• 239000012141 concentrate Substances 0.000 description 1
• 238000009833 condensation Methods 0.000 description 1
• 230000005494 condensation Effects 0.000 description 1
• 230000001268 conjugating effect Effects 0.000 description 1
• 238000011109 contamination Methods 0.000 description 1
• 238000013270 controlled release Methods 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 239000012050 conventional carrier Substances 0.000 description 1
• 239000008120 corn starch Substances 0.000 description 1
• 239000006071 cream Substances 0.000 description 1
• 239000003431 cross linking reagent Substances 0.000 description 1
• 231100000433 cytotoxic Toxicity 0.000 description 1
• 230000001472 cytotoxic effect Effects 0.000 description 1
• 230000006378 damage Effects 0.000 description 1
• 229920006237 degradable polymer Polymers 0.000 description 1
• 239000007857 degradation product Substances 0.000 description 1
• 238000001514 detection method Methods 0.000 description 1
• 238000002405 diagnostic procedure Methods 0.000 description 1
• 238000010586 diagram Methods 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• 238000009792 diffusion process Methods 0.000 description 1
• UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
• 239000007884 disintegrant Substances 0.000 description 1
• 208000035475 disorder Diseases 0.000 description 1
• 239000012153 distilled water Substances 0.000 description 1
• 238000000119 electrospray ionisation mass spectrum Methods 0.000 description 1
• 238000005538 encapsulation Methods 0.000 description 1
• 239000002158 endotoxin Substances 0.000 description 1
• 230000006353 environmental stress Effects 0.000 description 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 150000004665 fatty acids Chemical class 0.000 description 1
• 239000012091 fetal bovine serum Substances 0.000 description 1
• 230000001605 fetal effect Effects 0.000 description 1
• 239000000706 filtrate Substances 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• 235000019634 flavors Nutrition 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
• 125000001153 fluoro group Chemical group F* 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 150000003948 formamides Chemical class 0.000 description 1
• 238000004108 freeze drying Methods 0.000 description 1
• 239000012737 fresh medium Substances 0.000 description 1
• 230000002538 fungal effect Effects 0.000 description 1
• IECPWNUMDGFDKC-MZJAQBGESA-N fusidic acid Chemical class O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C(O)=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C IECPWNUMDGFDKC-MZJAQBGESA-N 0.000 description 1
• 230000004927 fusion Effects 0.000 description 1
• 108020001507 fusion proteins Proteins 0.000 description 1
• 102000037865 fusion proteins Human genes 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 238000001641 gel filtration chromatography Methods 0.000 description 1
• 239000007903 gelatin capsule Substances 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 230000009643 growth defect Effects 0.000 description 1
• 150000002357 guanidines Chemical class 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 230000003862 health status Effects 0.000 description 1
• 230000008588 hemolysis Effects 0.000 description 1
• 125000001072 heteroaryl group Chemical group 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 235000001050 hortel pimenta Nutrition 0.000 description 1
• 210000005260 human cell Anatomy 0.000 description 1
• 210000004754 hybrid cell Anatomy 0.000 description 1
• 150000002429 hydrazines Chemical class 0.000 description 1
• 150000004678 hydrides Chemical class 0.000 description 1
• 125000001183 hydrocarbyl group Chemical group 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• 229940127121 immunoconjugate Drugs 0.000 description 1
• 230000001031 immunopharmacological effect Effects 0.000 description 1
• 230000003308 immunostimulating effect Effects 0.000 description 1
• 230000001939 inductive effect Effects 0.000 description 1
• 239000003701 inert diluent Substances 0.000 description 1
• 239000012678 infectious agent Substances 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 239000002054 inoculum Substances 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000004255 ion exchange chromatography Methods 0.000 description 1
• 150000002576 ketones Chemical class 0.000 description 1
• 125000000686 lactone group Chemical group 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• 229940067606 lecithin Drugs 0.000 description 1
• 231100000225 lethality Toxicity 0.000 description 1
• 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 208000032839 leukemia Diseases 0.000 description 1
• 229920006008 lipopolysaccharide Polymers 0.000 description 1
• 230000033001 locomotion Effects 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 210000002751 lymph Anatomy 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 description 1
• 238000000691 measurement method Methods 0.000 description 1
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
• UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
• 229940050176 methyl chloride Drugs 0.000 description 1
• STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 description 1
• 229940012189 methyl orange Drugs 0.000 description 1
• 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
• 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
• 229960001047 methyl salicylate Drugs 0.000 description 1
• 229960002216 methylparaben Drugs 0.000 description 1
• 229960003085 meticillin Drugs 0.000 description 1
• 230000000813 microbial effect Effects 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 239000004005 microsphere Substances 0.000 description 1
• 235000013336 milk Nutrition 0.000 description 1
• 239000008267 milk Substances 0.000 description 1
• 210000004080 milk Anatomy 0.000 description 1
• 239000002480 mineral oil Substances 0.000 description 1
• 235000010446 mineral oil Nutrition 0.000 description 1
• 238000012544 monitoring process Methods 0.000 description 1
• 229940035032 monophosphoryl lipid a Drugs 0.000 description 1
• 210000004877 mucosa Anatomy 0.000 description 1
• 125000001446 muramyl group Chemical group N[C@@H](C=O)[C@@H](O[C@@H](C(=O)*)C)[C@H](O)[C@H](O)CO 0.000 description 1
• JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
• 239000007923 nasal drop Substances 0.000 description 1
• 229940100662 nasal drops Drugs 0.000 description 1
• 229930014626 natural product Natural products 0.000 description 1
• 239000006199 nebulizer Substances 0.000 description 1
• 230000001338 necrotic effect Effects 0.000 description 1
• 239000013642 negative control Substances 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 239000000346 nonvolatile oil Substances 0.000 description 1
• 239000002773 nucleotide Substances 0.000 description 1
• 125000003729 nucleotide group Chemical group 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 235000019198 oils Nutrition 0.000 description 1
• 229960003104 ornithine Drugs 0.000 description 1
• 239000007800 oxidant agent Substances 0.000 description 1
• 229910052760 oxygen Inorganic materials 0.000 description 1
• 239000001301 oxygen Substances 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 230000007170 pathology Effects 0.000 description 1
• 239000000312 peanut oil Substances 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 229940111202 pepsin Drugs 0.000 description 1
• 229940023041 peptide vaccine Drugs 0.000 description 1
• 102000013415 peroxidase activity proteins Human genes 0.000 description 1
• 108040007629 peroxidase activity proteins Proteins 0.000 description 1
• 239000008177 pharmaceutical agent Substances 0.000 description 1
• 230000003285 pharmacodynamic effect Effects 0.000 description 1
• 229960003742 phenol Drugs 0.000 description 1
• 235000021317 phosphate Nutrition 0.000 description 1
• 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
• 230000000704 physical effect Effects 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 229920000747 poly(lactic acid) Polymers 0.000 description 1
• 239000004633 polyglycolic acid Substances 0.000 description 1
• 239000004626 polylactic acid Substances 0.000 description 1
• 102000040430 polynucleotide Human genes 0.000 description 1
• 108091033319 polynucleotide Proteins 0.000 description 1
• 239000002157 polynucleotide Substances 0.000 description 1
• 229920005862 polyol Polymers 0.000 description 1
• 150000003077 polyols Chemical class 0.000 description 1
• 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
• 229920001155 polypropylene Polymers 0.000 description 1
• 239000013641 positive control Substances 0.000 description 1
• 230000004481 post-translational protein modification Effects 0.000 description 1
• OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
• 229910052939 potassium sulfate Inorganic materials 0.000 description 1
• 235000011151 potassium sulphates Nutrition 0.000 description 1
• 230000003389 potentiating effect Effects 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• 230000002797 proteolythic effect Effects 0.000 description 1
• 238000011002 quantification Methods 0.000 description 1
• 238000004445 quantitative analysis Methods 0.000 description 1
• 239000002516 radical scavenger Substances 0.000 description 1
• 238000013102 re-test Methods 0.000 description 1
• 239000011541 reaction mixture Substances 0.000 description 1
• 238000011084 recovery Methods 0.000 description 1
• 230000001105 regulatory effect Effects 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 238000011160 research Methods 0.000 description 1
• 108091008020 response regulators Proteins 0.000 description 1
• 108091008146 restriction endonucleases Proteins 0.000 description 1
• PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
• 229920002477 rna polymer Polymers 0.000 description 1
• CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
• 229940081974 saccharin Drugs 0.000 description 1
• 235000019204 saccharin Nutrition 0.000 description 1
• 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
• 229930182490 saponin Natural products 0.000 description 1
• 150000007949 saponins Chemical class 0.000 description 1
• 235000017709 saponins Nutrition 0.000 description 1
• 230000003248 secreting effect Effects 0.000 description 1
• 230000009919 sequestration Effects 0.000 description 1
• 210000002966 serum Anatomy 0.000 description 1
• 230000019491 signal transduction Effects 0.000 description 1
• 238000010898 silica gel chromatography Methods 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
• 238000010532 solid phase synthesis reaction Methods 0.000 description 1
• 239000007921 spray Substances 0.000 description 1
• 230000007480 spreading Effects 0.000 description 1
• 238000003892 spreading Methods 0.000 description 1
• 229940032094 squalane Drugs 0.000 description 1
• 229940031439 squalene Drugs 0.000 description 1
• TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 108010004034 stable plasma protein solution Proteins 0.000 description 1
• 229940037648 staphylococcus simulans Drugs 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 230000001954 sterilising effect Effects 0.000 description 1
• 238000004659 sterilization and disinfection Methods 0.000 description 1
• 210000001562 sternum Anatomy 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 229960005322 streptomycin Drugs 0.000 description 1
• 125000001424 substituent group Chemical group 0.000 description 1
• 229940124530 sulfonamide Drugs 0.000 description 1
• 150000003456 sulfonamides Chemical class 0.000 description 1
• 150000003871 sulfonates Chemical class 0.000 description 1
• 150000003457 sulfones Chemical class 0.000 description 1
• 150000003462 sulfoxides Chemical class 0.000 description 1
• 229910052717 sulfur Inorganic materials 0.000 description 1
• 239000011593 sulfur Substances 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 1
• 208000011580 syndromic disease Diseases 0.000 description 1
• 238000001308 synthesis method Methods 0.000 description 1
• QIQOHIJCQZFSMB-UHFFFAOYSA-N tert-butyl n-(2-amino-4-methylsulfanylbutyl)carbamate Chemical compound CSCCC(N)CNC(=O)OC(C)(C)C QIQOHIJCQZFSMB-UHFFFAOYSA-N 0.000 description 1
• IPIBDQMAIDPJBU-QMMMGPOBSA-N tert-butyl n-[(2s)-1-hydroxy-4-methylsulfanylbutan-2-yl]carbamate Chemical compound CSCC[C@@H](CO)NC(=O)OC(C)(C)C IPIBDQMAIDPJBU-QMMMGPOBSA-N 0.000 description 1
• RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
• 229940033663 thimerosal Drugs 0.000 description 1
• 150000003585 thioureas Chemical class 0.000 description 1
• 239000000196 tragacanth Substances 0.000 description 1
• 235000010487 tragacanth Nutrition 0.000 description 1
• 229940116362 tragacanth Drugs 0.000 description 1
• HMJQKIDUCWWIBW-PVQJCKRUSA-N trifluoroalanine Chemical compound OC(=O)[C@@H](N)C(F)(F)F HMJQKIDUCWWIBW-PVQJCKRUSA-N 0.000 description 1
• 231100000588 tumorigenic Toxicity 0.000 description 1
• 230000000381 tumorigenic effect Effects 0.000 description 1
• ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
• HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
• 208000019206 urinary tract infection Diseases 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 238000001291 vacuum drying Methods 0.000 description 1
• 230000035899 viability Effects 0.000 description 1
• 238000012800 visualization Methods 0.000 description 1
• 239000012138 yeast extract Substances 0.000 description 1