ES2603061T3 - Interrupción de la percepción de quórum en bacterias mediada por anticuerpos - Google Patents

Interrupción de la percepción de quórum en bacterias mediada por anticuerpos Download PDF

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Publication number
ES2603061T3
ES2603061T3 ES14180831.1T ES14180831T ES2603061T3 ES 2603061 T3 ES2603061 T3 ES 2603061T3 ES 14180831 T ES14180831 T ES 14180831T ES 2603061 T3 ES2603061 T3 ES 2603061T3
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Prior art keywords
seq
amino acid
kynp
hapten
cyclic peptide
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ES14180831.1T
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English (en)
Spanish (es)
Inventor
Kim D. Janda
Gunnar F. Kaufmann
Junguk Park
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Scripps Research Institute
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Scripps Research Institute
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES14180831.1T 2007-10-25 2008-10-24 Interrupción de la percepción de quórum en bacterias mediada por anticuerpos Active ES2603061T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98259307P 2007-10-25 2007-10-25
US982593P 2007-10-25

Publications (1)

Publication Number Publication Date
ES2603061T3 true ES2603061T3 (es) 2017-02-23

Family

ID=40580303

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14180831.1T Active ES2603061T3 (es) 2007-10-25 2008-10-24 Interrupción de la percepción de quórum en bacterias mediada por anticuerpos

Country Status (9)

Country Link
US (2) US9394371B2 (OSRAM)
EP (2) EP2842565B1 (OSRAM)
JP (3) JP5581490B2 (OSRAM)
KR (1) KR101557173B1 (OSRAM)
CN (2) CN101835484B (OSRAM)
AU (1) AU2008317331B2 (OSRAM)
CA (2) CA2975568A1 (OSRAM)
ES (1) ES2603061T3 (OSRAM)
WO (1) WO2009055054A2 (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2911694A4 (en) 2012-10-26 2016-07-13 Sorrento Therapeutics Inc ANTI-INFECTIOUS BINDING PROTEINS THAT BIND TO AIP2
DE102013211850A1 (de) * 2013-06-21 2014-12-24 Gilupi Gmbh Schnelltest zum Nachweisen von Erregermaterial, insbesondere zur Unterstützung der Diagnose einer Sepsis, sowie Kit und Vorrichtung zur Durchführung eines Sepsistests
SG10201800889SA (en) * 2013-08-01 2018-03-28 Univ Catholique Louvain Anti-garp protein and uses thereof
WO2015100225A1 (en) 2013-12-27 2015-07-02 Novus International Inc. Ethoxylated surfactants
PT3101132T (pt) * 2014-01-29 2021-12-31 Km Biologics Co Ltd Anticorpo humano anti-transtirretina
CN106574258B (zh) 2014-01-29 2021-03-30 Km生物医药股份公司 抗-运甲状腺素蛋白人源化抗体
EP3103808B1 (en) * 2014-02-07 2018-08-22 Miyarisan Pharmaceutical Co., Ltd. Peptide having activity of inhibiting production of toxin by bacterium belonging to genus clostridium
US10821167B2 (en) * 2016-02-02 2020-11-03 Unm Rainforest Innovations VLP-based vaccines for targeting Staphylococcus aureus secreted virulence factors
JP7058638B2 (ja) * 2016-08-11 2022-04-22 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ ホスホグリセリン酸ムターゼのペプチド阻害剤および使用方法
AU2018221172A1 (en) * 2017-02-17 2019-09-05 Adimab, Llc Monoclonal antibodies and cocktails for treatment of Ebola infections
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions
BR112020003508A2 (pt) * 2017-08-31 2020-09-01 The Regents Of The University Of California polipeptídeo purificado, formulação tópica, polinucleotídeo isolado, vetor, microrganismo recombinante, composição probiótica tópica, composição medicamentosa, e, métodos de tratamento de um transtorno dermatológico, de tratamento de uma doença ou transtorno de pele e para liberação de fármacos através da pele.
US10501539B2 (en) 2017-09-15 2019-12-10 Lentigen Technology Inc. Compositions and methods for treating cancer with anti-CD19 immunotherapy
US10774135B2 (en) 2017-12-22 2020-09-15 Sorrento Therapeutics, Inc. Variant antibodies that bind AIP2
WO2019159864A1 (ja) 2018-02-13 2019-08-22 住友化学株式会社 組成物および成形体
WO2021030550A1 (en) 2019-08-13 2021-02-18 Mccord Darlene E NON-ACTIVATED, AMORPHOUS, pH NEUTRAL, TWO-PART BEDSIDE-READY CLAY DELIVERY SYSTEM THAT TREATS PATHOGEN INFECTIONS IN HUMANS AND ANIMALS
CN111573853B (zh) * 2020-05-29 2020-11-20 南京大学 一种削减生物法处理废水毒性的方法
EP4423197A4 (en) 2021-10-25 2025-08-27 Darlene E Mccord COATED MEDICINAL CLAY COMPOSITIONS, PHARMACEUTICAL COMPOSITIONS AND DELIVERY OF CATION SOURCES AND METHODS OF USE THEREOF

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69732709T2 (de) * 1996-05-22 2006-06-29 New York University Expressionsblockierung von virulenten faktoren in s. aureus
US6248329B1 (en) * 1998-06-01 2001-06-19 Ramaswamy Chandrashekar Parasitic helminth cuticlin nucleic acid molecules and uses thereof
JP2003532698A (ja) * 2000-05-10 2003-11-05 プリンストン ユニバーシティ 細菌の増殖および病理発生を調節するための化合物ならびに方法
US7786257B2 (en) * 2000-12-18 2010-08-31 University Of Kansas Signal-1/signal-2 bifunctional peptide inhibitors
US6463632B2 (en) * 2001-02-07 2002-10-15 Hans Oetiker Ag Maschinen-Und Apparatefabrik Guide arrangement for tightening tool emplacement in hose clamps provided with plastically deformable ears
CN1164612C (zh) 2001-09-11 2004-09-01 四川新泰克控股有限责任公司 人工组合的抗菌工程多肽及其制备方法
ES2382075T3 (es) * 2002-08-13 2012-06-05 Haptogen Ltd Procedimientos para el tratamiento de una enfermedad bacteriana infecciosa con un anticuerpo contra las moléculas señal derivadas de una antilactona o una lactona

Also Published As

Publication number Publication date
EP2211889B1 (en) 2014-08-20
EP2842565B1 (en) 2016-08-24
US20100291093A1 (en) 2010-11-18
EP2211889A4 (en) 2012-01-11
US20170043020A1 (en) 2017-02-16
KR20100102100A (ko) 2010-09-20
US9394371B2 (en) 2016-07-19
WO2009055054A3 (en) 2009-09-03
EP2842565A1 (en) 2015-03-04
KR101557173B1 (ko) 2015-10-05
CA2975568A1 (en) 2009-04-30
JP6183910B2 (ja) 2017-08-23
CA2703133A1 (en) 2009-04-30
CN101835484B (zh) 2014-07-16
WO2009055054A2 (en) 2009-04-30
AU2008317331B2 (en) 2013-08-29
CN104211775A (zh) 2014-12-17
JP2014221774A (ja) 2014-11-27
JP5581490B2 (ja) 2014-09-03
JP2018021021A (ja) 2018-02-08
CN101835484A (zh) 2010-09-15
EP2211889A2 (en) 2010-08-04
AU2008317331A1 (en) 2009-04-30
JP2011500814A (ja) 2011-01-06
CA2703133C (en) 2017-09-19

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