AR109857A1 - Anticuerpos anti-chikv y usos de éstos - Google Patents
Anticuerpos anti-chikv y usos de éstosInfo
- Publication number
- AR109857A1 AR109857A1 ARP170102933A ARP170102933A AR109857A1 AR 109857 A1 AR109857 A1 AR 109857A1 AR P170102933 A ARP170102933 A AR P170102933A AR P170102933 A ARP170102933 A AR P170102933A AR 109857 A1 AR109857 A1 AR 109857A1
- Authority
- AR
- Argentina
- Prior art keywords
- monoclonal antibody
- amino acid
- cdrh
- seq
- sequences
- Prior art date
Links
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 6
- 235000001014 amino acid Nutrition 0.000 abstract 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 2
- 235000004279 alanine Nutrition 0.000 abstract 2
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 2
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicación 1: Un anticuerpo monoclonal aislado que se une a CHIKV y que comprende tres Regiones Determinantes de la Complementariedad de Cadena Pesada (CDRH) y tres Regiones Determinantes de la Complementariedad de Cadena Ligera (CDRL), en el que i) dichas CDRH tienen secuencias de aminoácidos de SEQ ID Nº 5, 6 y 7, y dichas CDRL tienen secuencias de aminoácidos de SEQ ID Nº 8, GNT y 10, o ii) dichas CDRH tienen secuencias de aminoácidos de SEQ ID Nº 11, 12 y 13, y dichas CDRL tienen secuencias de aminoácidos de SEQ ID Nº 14, GTS y 16, o iii) dichas CDRH y CDRL tienen secuencias de aminoácidos que se diferencian de las secuencias de i) o ii) por una o dos sustituciones de aminoácidos; y en el que dicho anticuerpo comprende además una región Fc que comprende al menos un residuo seleccionado del grupo que consiste en: iv) una alanina en la posición 434, o v) una alanina en las posiciones 307, 380 y 434, respectivamente, o vi) una glutamina en la posición 250 y una leucina en la posición 428, respectivamente, o vii) una leucina en la posición 428 y una serina en la posición 434, respectivamente, o viii) una tirosina en la posición 252, una treonina en la posición 254 y un ácido glutámico en la posición 256, respectivamente, en el que dichas posiciones de aminoácidos se proporcionan según el índice EU. Reivindicación 26: Una composición farmacéutica que comprende el anticuerpo monoclonal según una cualquiera de las reivindicaciones 1 a 22 y al menos un excipiente. Reivindicación 28: Un método para producir el anticuerpo monoclonal según una cualquiera de las reivindicaciones 1 a 22, en el que dicho método comprende las etapas de: i) cultivar una línea celular que produce dicho anticuerpo monoclonal; ii) purificar el anticuerpo monoclonal producido; y opcionalmente iii) formular dicho anticuerpo monoclonal en una composición farmacéutica. Reivindicación 29: Un polinucleótido que comprende una secuencia que codifica el anticuerpo monoclonal según una cualquiera de las reivindicaciones 1 a 22.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16306374 | 2016-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR109857A1 true AR109857A1 (es) | 2019-01-30 |
Family
ID=57590434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170102933A AR109857A1 (es) | 2016-10-20 | 2017-10-20 | Anticuerpos anti-chikv y usos de éstos |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11286295B2 (es) |
| EP (1) | EP3529271A1 (es) |
| JP (2) | JP7181193B6 (es) |
| CN (2) | CN115873106A (es) |
| AR (1) | AR109857A1 (es) |
| CA (1) | CA3040842A1 (es) |
| EA (1) | EA201990988A1 (es) |
| IL (2) | IL310834A (es) |
| MA (1) | MA46562A (es) |
| TW (2) | TW202300515A (es) |
| UY (1) | UY37449A (es) |
| WO (1) | WO2018073387A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA41517A (fr) | 2015-04-14 | 2017-12-19 | Univ Vanderbilt | Neutralisation du virus du chikungunya à médiation par des anticorps |
| TW202300515A (zh) * | 2016-10-20 | 2023-01-01 | 法商賽諾菲公司 | 抗ｃｈｉｋｖ抗體及其用途 |
| WO2019156758A2 (en) | 2018-01-05 | 2019-08-15 | Vanderbilt University | Antibody-mediated neutralization of chikungunya virus |
| KR102201261B1 (ko) * | 2019-05-15 | 2021-01-11 | 한국생명공학연구원 | 치쿤구니야 바이러스에 특이적인 단일클론 항체 및 이의 용도 |
| CN114656554B (zh) * | 2022-03-07 | 2023-05-23 | 中山大学 | 基孔肯雅热病毒e2蛋白的纳米抗体及其应用 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
| WO1987002671A1 (en) | 1985-11-01 | 1987-05-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
| AU597574B2 (en) | 1986-03-07 | 1990-06-07 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
| US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| LU91067I2 (fr) | 1991-06-14 | 2004-04-02 | Genentech Inc | Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines |
| CA2156725A1 (en) | 1993-02-22 | 1994-09-01 | Warren S. Pear | Production of high titer helper-free retroviruses by transient transfection |
| FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| KR100259828B1 (ko) | 1995-09-11 | 2000-06-15 | 히라타 다다시 | 인체 인터루킨 5 수용체 알파-사슬에 대한 항체 |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| WO1998045322A2 (en) | 1997-04-10 | 1998-10-15 | Royal Netherlands Academy Of Arts And Sciences | Diagnosis method and reagents |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| KR101155191B1 (ko) | 1999-01-15 | 2012-06-13 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
| DE60143544D1 (de) | 2000-12-12 | 2011-01-05 | Medimmune Llc | Moleküle mit längeren halbwertszeiten, zusammensetzungen und deren verwendung |
| AU2005304624B2 (en) | 2004-11-12 | 2010-10-07 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US8546543B2 (en) | 2004-11-12 | 2013-10-01 | Xencor, Inc. | Fc variants that extend antibody half-life |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US8802820B2 (en) * | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| CA2591665C (en) * | 2004-12-20 | 2015-05-05 | Crucell Holland B.V. | Binding molecules capable of neutralizing west nile virus and uses thereof |
| CA2545597A1 (en) | 2006-03-15 | 2007-09-15 | Institut Pasteur | Novel isolated and purified strains of chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof |
| CA2598966A1 (en) | 2007-09-07 | 2009-03-07 | Institut Pasteur | Anti-chikungunya monoclonal antibodies and uses thereof |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| EP4269443A3 (en) | 2007-12-26 | 2023-12-27 | Xencor, Inc. | Fc variants with altered binding to fcrn |
| EA028621B1 (ru) * | 2008-01-17 | 2017-12-29 | Новартис Аг | АНТИТЕЛО ИЛИ ЕГО АНТИГЕНСВЯЗЫВАЮЩИЙ ФРАГМЕНТ, КОТОРЫЙ СПЕЦИФИЧНО СВЯЗЫВАЕТ РЕЦЕПТОРНУЮ ТИРОЗИНКИНАЗУ (TrkB), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ЭТО АНТИТЕЛО ИЛИ ЕГО АНТИГЕНСВЯЗЫВАЮЩИЙ ФРАГМЕНТ, И КОМБИНАЦИЯ, ВКЛЮЧАЮЩАЯ УКАЗАННУЮ КОМПОЗИЦИЮ |
| EP2374816B1 (en) | 2010-04-07 | 2016-09-28 | Agency For Science, Technology And Research | Binding molecules against Chikungunya virus and uses thereof |
| US9441032B2 (en) | 2010-04-07 | 2016-09-13 | Agency For Science, Technology And Research | Binding molecules against Chikungunya virus and uses thereof |
| WO2012106578A1 (en) | 2011-02-04 | 2012-08-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HIV NEUTRALIZING ANTIBODIES HAVING MUTATIONS IN CONSTANT DOMAIN (Fc) |
| GB201112429D0 (en) | 2011-07-19 | 2011-08-31 | Glaxo Group Ltd | Antigen-binding proteins with increased FcRn binding |
| KR20150093834A (ko) | 2012-12-13 | 2015-08-18 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Ｄｎａ 항체 작제물 및 그 이용 방법 |
| EP3021868A4 (en) | 2013-07-19 | 2017-03-01 | Integral Molecular, Inc. | Antibodies against chikungunya virus and uses thereof |
| MA41517A (fr) | 2015-04-14 | 2017-12-19 | Univ Vanderbilt | Neutralisation du virus du chikungunya à médiation par des anticorps |
| TW202300515A (zh) | 2016-10-20 | 2023-01-01 | 法商賽諾菲公司 | 抗ｃｈｉｋｖ抗體及其用途 |
-
2017
- 2017-10-18 TW TW111134308A patent/TW202300515A/zh unknown
- 2017-10-18 TW TW106135643A patent/TWI778985B/zh active
- 2017-10-18 US US15/787,647 patent/US11286295B2/en active Active
- 2017-10-19 WO PCT/EP2017/076792 patent/WO2018073387A1/en active Application Filing
- 2017-10-19 IL IL310834A patent/IL310834A/en unknown
- 2017-10-19 MA MA046562A patent/MA46562A/fr unknown
- 2017-10-19 CA CA3040842A patent/CA3040842A1/en active Pending
- 2017-10-19 EP EP17794260.4A patent/EP3529271A1/en active Pending
- 2017-10-19 CN CN202211721154.0A patent/CN115873106A/zh active Pending
- 2017-10-19 IL IL266082A patent/IL266082B2/en unknown
- 2017-10-19 JP JP2019521142A patent/JP7181193B6/ja active Active
- 2017-10-19 EA EA201990988A patent/EA201990988A1/ru unknown
- 2017-10-19 CN CN201780078371.3A patent/CN110088131B/zh active Active
- 2017-10-20 UY UY0001037449A patent/UY37449A/es unknown
- 2017-10-20 AR ARP170102933A patent/AR109857A1/es unknown
-
2022
- 2022-02-16 US US17/672,871 patent/US20220275063A1/en active Pending
- 2022-11-16 JP JP2022183022A patent/JP2023015301A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN110088131A (zh) | 2019-08-02 |
| CA3040842A1 (en) | 2018-04-26 |
| IL266082B2 (en) | 2024-07-01 |
| US20180127487A1 (en) | 2018-05-10 |
| EP3529271A1 (en) | 2019-08-28 |
| IL266082B1 (en) | 2024-03-01 |
| UY37449A (es) | 2018-05-31 |
| WO2018073387A1 (en) | 2018-04-26 |
| CN110088131B (zh) | 2022-12-06 |
| TWI778985B (zh) | 2022-10-01 |
| CN115873106A (zh) | 2023-03-31 |
| MA46562A (fr) | 2019-08-28 |
| JP2019534001A (ja) | 2019-11-28 |
| TW202300515A (zh) | 2023-01-01 |
| US20220275063A1 (en) | 2022-09-01 |
| US11286295B2 (en) | 2022-03-29 |
| EA201990988A1 (ru) | 2019-09-30 |
| JP2023015301A (ja) | 2023-01-31 |
| IL310834A (en) | 2024-04-01 |
| JP7181193B2 (ja) | 2022-11-30 |
| TW201827461A (zh) | 2018-08-01 |
| IL266082A (en) | 2019-06-30 |
| JP7181193B6 (ja) | 2022-12-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR109857A1 (es) | Anticuerpos anti-chikv y usos de éstos | |
| AR106184A1 (es) | Proteínas de unión a pd-1 y sus métodos de uso | |
| AR127371A2 (es) | Receptores quiméricos de flt3 y métodos para usarlos | |
| AR126242A2 (es) | Tratamiento del cáncer utilizando receptores de antígenos quiméricos | |
| AR124240A2 (es) | Un anticuerpo biespecífico anti-vegf / anti-ang-2, ácido nucleico, vector de expresión, célula huésped y un método de preparación del anticuerpo | |
| PE20221580A1 (es) | Anticuerpos terapeuticos y sus usos | |
| AR110979A1 (es) | Moléculas de unión a cd70 y métodos de uso de las mismas | |
| AR108066A1 (es) | Receptores quiméricos para cll-1 y métodos de uso de los mismos | |
| AR106752A1 (es) | Proteínas de unión a pd1 / ctla4 | |
| AR110017A1 (es) | Anticuerpos de pd-1 y usos de estos | |
| PE20181326A1 (es) | Anticuerpos que se unen especificamente a pd-1 y sus usos | |
| AR102239A1 (es) | Anticuerpos anti-ox40 humanizados y sus usos | |
| CU20190087A7 (es) | Anticuerpos que reconocen tau en los residuos 257-271 o 320-334 de la seq id no: 1 | |
| AR105026A1 (es) | ANTICUERPOS MADURADOS POR AFINIDAD Y HUMANIZADOS PARA FcRH5 Y MÉTODOS PARA SU USO | |
| AR101936A1 (es) | Constructos de anticuerpos de cadena sencilla biespecífica específicos para especies cruzadas optimizadas | |
| PE20181952A1 (es) | Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos | |
| RU2018133708A (ru) | Антитела, обладающие специфичностью к btla, и их использование | |
| AR066164A1 (es) | Proteinas humanas de union a antigenos del factor estimulante de colonias de megacariocitos-macrofagos(gm-csf) | |
| AR074221A1 (es) | Combinaciones antitumorales que contienen anticuerpos que reconocen especificamente cd38 y ciclofosfamida | |
| AR101875A1 (es) | Proteína de unión a antígenos, bi-específicos del receptor anti-cgrp / receptor pac1 y usos de las mismas | |
| ES2687282T3 (es) | Anticuerpos humanizados ANTI-CD134 (OX40) y sus usos | |
| FI3683235T3 (fi) | Anti-IL-33-vasta-aineita ja niiden käyttöjä | |
| AR100573A1 (es) | Anticuerpos anti-il-17, un método para producirlos y utilizarlos | |
| PE20201255A1 (es) | Anticuerpos y conjugados de anticuerpo-farmaco especificos para cd123 y usos de los mismos | |
| AR077973A1 (es) | Anticuerpos anti-cdcp1 humanizados |