JP5580535B2 - 癌転移および癌転移に関連する骨量減少を予防および処置するための方法 - Google Patents
癌転移および癌転移に関連する骨量減少を予防および処置するための方法 Download PDFInfo
- Publication number
- JP5580535B2 JP5580535B2 JP2008549592A JP2008549592A JP5580535B2 JP 5580535 B2 JP5580535 B2 JP 5580535B2 JP 2008549592 A JP2008549592 A JP 2008549592A JP 2008549592 A JP2008549592 A JP 2008549592A JP 5580535 B2 JP5580535 B2 JP 5580535B2
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- antibody
- csf
- seq
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75694406P | 2006-01-05 | 2006-01-05 | |
| US60/756,944 | 2006-01-05 | ||
| PCT/US2007/000405 WO2007081879A2 (en) | 2006-01-05 | 2007-01-04 | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012186613A Division JP2012229271A (ja) | 2006-01-05 | 2012-08-27 | 癌転移および癌転移に関連する骨量減少を予防および処置するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009522369A JP2009522369A (ja) | 2009-06-11 |
| JP2009522369A5 JP2009522369A5 (enExample) | 2011-02-10 |
| JP5580535B2 true JP5580535B2 (ja) | 2014-08-27 |
Family
ID=38219019
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008549592A Active JP5580535B2 (ja) | 2006-01-05 | 2007-01-04 | 癌転移および癌転移に関連する骨量減少を予防および処置するための方法 |
| JP2012186613A Pending JP2012229271A (ja) | 2006-01-05 | 2012-08-27 | 癌転移および癌転移に関連する骨量減少を予防および処置するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012186613A Pending JP2012229271A (ja) | 2006-01-05 | 2012-08-27 | 癌転移および癌転移に関連する骨量減少を予防および処置するための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090246208A1 (enExample) |
| EP (2) | EP1984024A2 (enExample) |
| JP (2) | JP5580535B2 (enExample) |
| KR (1) | KR20080083187A (enExample) |
| CN (1) | CN101534858A (enExample) |
| AU (1) | AU2007205048B2 (enExample) |
| BR (1) | BRPI0706314A2 (enExample) |
| CA (1) | CA2636149A1 (enExample) |
| IL (1) | IL192568A0 (enExample) |
| RU (1) | RU2470665C2 (enExample) |
| TW (1) | TW200738262A (enExample) |
| WO (1) | WO2007081879A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8183207B2 (en) | 2008-11-26 | 2012-05-22 | Five Prime Therapeutics, Inc. | Treatment of osteolytic disorders and cancer using CSF1R extracellular domain fusion molecules |
| WO2010062399A2 (en) | 2008-11-26 | 2010-06-03 | Five Prime Therapeutics, Inc. | Csf1r extracellular domain fusion molecules and treatments using same |
| PT2949670T (pt) | 2009-12-10 | 2019-05-20 | Hoffmann La Roche | Anticorpos que se ligam preferencialmente ao domínio extracelular 4 do csf1r e respetiva utilização |
| CA2789071C (en) * | 2010-03-05 | 2018-03-27 | F. Hoffmann-La Roche Ag | Antibodies against human csf-1r and uses thereof |
| WO2011107553A1 (en) | 2010-03-05 | 2011-09-09 | F. Hoffmann-La Roche Ag | Antibodies against human csf-1r and uses thereof |
| CN107011438B (zh) | 2010-05-04 | 2020-11-20 | 戊瑞治疗有限公司 | 结合csf1r的抗体 |
| AU2012285875B2 (en) | 2011-07-18 | 2016-11-10 | Morphosys Ag | Use of c-Fms antagonists |
| WO2013033206A2 (en) * | 2011-08-29 | 2013-03-07 | University Of Rochester | Compositions and methods for inhibiting ccl3 |
| RU2658603C2 (ru) | 2011-12-15 | 2018-06-21 | Ф.Хоффманн-Ля Рош Аг | Антитела против человеческого csf-1r и их применения |
| US20130302322A1 (en) | 2012-05-11 | 2013-11-14 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| CN103044555B (zh) * | 2012-07-05 | 2016-08-31 | 雷克塞德(苏州)生物医药有限公司 | 包含cFms胞外片段的融合蛋白质及其制备方法和应用 |
| SG10201906328RA (en) | 2012-08-31 | 2019-08-27 | Five Prime Therapeutics Inc | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| CA2906394A1 (en) * | 2013-03-15 | 2014-09-18 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the prognosis and treatment of cancer metastasis |
| CN105121466A (zh) | 2013-04-12 | 2015-12-02 | 莫佛塞斯公司 | 靶向m-csf的抗体 |
| AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
| RU2551622C1 (ru) * | 2014-02-20 | 2015-05-27 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ лечения опухолей позвоночника |
| JP6964410B2 (ja) | 2014-06-23 | 2021-11-10 | ファイヴ プライム セラピューティクス インク | コロニー刺激因子1受容体(csf1r)に結合する抗体で疾患を治療する方法 |
| LT3212670T (lt) | 2014-10-29 | 2021-02-10 | Five Prime Therapeutics, Inc. | Kombinuotasis vėžio gydymas |
| ES2843586T3 (es) | 2014-12-22 | 2021-07-19 | Five Prime Therapeutics Inc | Anticuerpos dirigidos contra CSF1R para tratar la SVNP |
| BR112017020952A2 (pt) | 2015-04-13 | 2018-07-10 | Five Prime Therapeutics Inc | método de tratamento de câncer, composição e uso da composição |
| RU2609871C1 (ru) * | 2015-08-10 | 2017-02-06 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Противоопухолевое средство |
| RU2631486C1 (ru) * | 2016-06-17 | 2017-09-22 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" (ФБУН ГНЦ ВБ "Вектор") | Способ получения противоопухолевого средства против метастазов костей в виде конъюгата белка-цитокина и аминобисфосфоната |
| EP3504239B1 (en) | 2016-08-25 | 2024-05-29 | F. Hoffmann-La Roche AG | Intermittent dosing of an anti-csf-1r antibody in combination with macrophage activating agent |
| EP3558360A1 (en) | 2016-12-22 | 2019-10-30 | F. Hoffmann-La Roche AG | Treatment of tumors with an anti-csf-1r antibody in combination with an anti-pd-l1 antibody after failure of anti-pd-l1/pd1 treatment |
| KR20200051024A (ko) | 2017-09-13 | 2020-05-12 | 파이브 프라임 테라퓨틱스, 인크. | 췌장암에 대한 조합 항-csf1r 및 항-pd-1 항체 조합 요법 |
| EP3833762A4 (en) | 2018-08-09 | 2022-09-28 | Verseau Therapeutics, Inc. | Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4485045A (en) * | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4675187A (en) | 1983-05-16 | 1987-06-23 | Bristol-Myers Company | BBM-1675, a new antibiotic complex |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US4676980A (en) * | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US4929700A (en) | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
| DK0457804T3 (da) | 1989-02-10 | 1996-09-23 | Chiron Corp | M-CSF-monoklonale antistoffer, som genkender en neutraliserende, konformational epitop |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| EP0617706B1 (en) | 1991-11-25 | 2001-10-17 | Enzon, Inc. | Multivalent antigen-binding proteins |
| ATE249840T1 (de) * | 1991-12-13 | 2003-10-15 | Xoma Corp | Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung |
| US20020111461A1 (en) | 1999-05-21 | 2002-08-15 | Todd C. Somers | Low molecular weight peptidomimetic growth hormone secretagogues |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6025146A (en) | 1995-06-05 | 2000-02-15 | Chiron Corporation | Identification of M-CSF agonists and antagonists |
| GB9518220D0 (en) | 1995-09-06 | 1995-11-08 | Medical Res Council | Checkpoint gene |
| RU2153358C1 (ru) * | 1999-11-10 | 2000-07-27 | Центральный научно-исследовательский рентгенорадиологический институт МЗ России | Способ лечения остеолитических метастазов |
| US20030199531A1 (en) | 2001-07-19 | 2003-10-23 | Todd Wipke | YIGSR peptidomimetics and methods for using the same |
| JP2005516928A (ja) * | 2001-12-13 | 2005-06-09 | メルク エンド カムパニー インコーポレーテッド | 骨異常のためのビスホスホネート液体製剤 |
| MXPA05003318A (es) * | 2002-09-27 | 2005-09-12 | Zentaris Gmbh | Forma de administracion para peptidos farmaceuticamente activos con liberacion sostenida y metodo para la produccion de los mismos. |
| CA2505994A1 (en) * | 2002-11-15 | 2004-06-03 | Chiron Corporation | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
| PT2311873T (pt) * | 2004-01-07 | 2018-11-20 | Novartis Vaccines & Diagnostics Inc | Anticorpo monoclonal específico para m-csf e respetivos usos |
| JP5457671B2 (ja) * | 2005-07-28 | 2014-04-02 | ノバルティス アーゲー | M−csf特異的モノクローナル抗体およびその使用 |
| NZ572072A (en) * | 2006-04-20 | 2011-09-30 | Janssen Pharmaceutica Nv | Inhibitors of c-fms kinase |
-
2007
- 2007-01-04 RU RU2008132150/15A patent/RU2470665C2/ru not_active IP Right Cessation
- 2007-01-04 KR KR1020087018238A patent/KR20080083187A/ko not_active Abandoned
- 2007-01-04 EP EP07716432A patent/EP1984024A2/en not_active Withdrawn
- 2007-01-04 WO PCT/US2007/000405 patent/WO2007081879A2/en not_active Ceased
- 2007-01-04 AU AU2007205048A patent/AU2007205048B2/en active Active
- 2007-01-04 EP EP13168106.6A patent/EP2705854A1/en not_active Withdrawn
- 2007-01-04 CN CNA2007800067993A patent/CN101534858A/zh active Pending
- 2007-01-04 JP JP2008549592A patent/JP5580535B2/ja active Active
- 2007-01-04 US US12/159,665 patent/US20090246208A1/en not_active Abandoned
- 2007-01-04 BR BRPI0706314-8A patent/BRPI0706314A2/pt not_active IP Right Cessation
- 2007-01-04 CA CA002636149A patent/CA2636149A1/en not_active Abandoned
- 2007-01-05 TW TW096100615A patent/TW200738262A/zh unknown
-
2008
- 2008-07-02 IL IL192568A patent/IL192568A0/en unknown
-
2012
- 2012-08-27 JP JP2012186613A patent/JP2012229271A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007205048A1 (en) | 2007-07-19 |
| EP2705854A1 (en) | 2014-03-12 |
| TW200738262A (en) | 2007-10-16 |
| IL192568A0 (en) | 2011-08-01 |
| US20090246208A1 (en) | 2009-10-01 |
| KR20080083187A (ko) | 2008-09-16 |
| CN101534858A (zh) | 2009-09-16 |
| CA2636149A1 (en) | 2007-07-19 |
| WO2007081879A3 (en) | 2007-09-07 |
| JP2009522369A (ja) | 2009-06-11 |
| EP1984024A2 (en) | 2008-10-29 |
| BRPI0706314A2 (pt) | 2011-03-22 |
| RU2008132150A (ru) | 2010-02-10 |
| WO2007081879A2 (en) | 2007-07-19 |
| RU2470665C2 (ru) | 2012-12-27 |
| AU2007205048B2 (en) | 2013-07-04 |
| JP2012229271A (ja) | 2012-11-22 |
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