JP5579443B2 - マイクロ流体デバイス - Google Patents

マイクロ流体デバイス Download PDF

Info

Publication number
JP5579443B2
JP5579443B2 JP2009545993A JP2009545993A JP5579443B2 JP 5579443 B2 JP5579443 B2 JP 5579443B2 JP 2009545993 A JP2009545993 A JP 2009545993A JP 2009545993 A JP2009545993 A JP 2009545993A JP 5579443 B2 JP5579443 B2 JP 5579443B2
Authority
JP
Japan
Prior art keywords
film
microfluidic device
layer
membrane
melting temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2009545993A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010515924A5 (enExample
JP2010515924A (ja
Inventor
バーロウ,デイビッド
トムソン,デイビッド
マクナマラ,ケン
ポルワート,スチュアート
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Agilent Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agilent Technologies Inc filed Critical Agilent Technologies Inc
Publication of JP2010515924A publication Critical patent/JP2010515924A/ja
Publication of JP2010515924A5 publication Critical patent/JP2010515924A5/ja
Application granted granted Critical
Publication of JP5579443B2 publication Critical patent/JP5579443B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093Microreactors, e.g. miniaturised or microfabricated reactors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00Layered products comprising a layer of synthetic resin
    • B32B27/06Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00Layered products comprising a layer of synthetic resin
    • B32B27/32Layered products comprising a layer of synthetic resin comprising polyolefins
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12Specific details about manufacturing devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0645Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0887Laminated structure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/12Specific details about materials
    • B01L2300/123Flexible; Elastomeric
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0638Valves, specific forms thereof with moving parts membrane valves, flap valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00Properties of the layers or laminate
    • B32B2307/70Other properties
    • B32B2307/726Permeability to liquids, absorption
    • B32B2307/7265Non-permeable
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2323/00Polyalkenes
    • B32B2323/04Polyethylene
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2323/00Polyalkenes
    • B32B2323/10Polypropylene

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Laminated Bodies (AREA)
JP2009545993A 2007-01-16 2008-01-16 マイクロ流体デバイス Active JP5579443B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0700822.0 2007-01-16
GB0700822A GB2445738A (en) 2007-01-16 2007-01-16 Microfluidic device
PCT/GB2008/000143 WO2008087405A1 (en) 2007-01-16 2008-01-16 Microfluidic device

Publications (3)

Publication Number Publication Date
JP2010515924A JP2010515924A (ja) 2010-05-13
JP2010515924A5 JP2010515924A5 (enExample) 2010-12-09
JP5579443B2 true JP5579443B2 (ja) 2014-08-27

Family

ID=37810038

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009545993A Active JP5579443B2 (ja) 2007-01-16 2008-01-16 マイクロ流体デバイス

Country Status (6)

Country Link
US (1) US20100175999A1 (enExample)
EP (1) EP2114570B1 (enExample)
JP (1) JP5579443B2 (enExample)
CN (1) CN101674888B (enExample)
GB (1) GB2445738A (enExample)
WO (1) WO2008087405A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4685329B2 (ja) * 2000-10-24 2011-05-18 ハンス イエンセン ルブリカトーズ アクティーゼルスカブ 分配装置
ES2548567T3 (es) 2004-04-07 2015-10-19 Levine, Robert Aaron Cámara desechable para analizar fluidos biológicos
US8715446B2 (en) * 2004-10-13 2014-05-06 Rheonix, Inc. Latent solvent-based microfluidic apparatus, methods, and applications
US7731901B2 (en) 2005-10-19 2010-06-08 Abbott Laboratories Apparatus and method for performing counts within a biologic fluid sample
GB2445739A (en) 2007-01-16 2008-07-23 Lab901 Ltd Polymeric laminates containing heat seals
ES2352581T3 (es) * 2008-06-02 2011-02-21 Boehringer Ingelheim Microparts Gmbh Estructura de lámina microfluídica para dosificar líquidos.
JP2011030522A (ja) * 2009-08-04 2011-02-17 Aida Engineering Ltd マイクロ流体デバイス
EP2512647A2 (en) * 2009-12-18 2012-10-24 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge
US8720036B2 (en) 2010-03-09 2014-05-13 Netbio, Inc. Unitary biochip providing sample-in to results-out processing and methods of manufacture
KR101796110B1 (ko) 2010-03-09 2017-11-10 네트바이오, 인코포레이티드 샘플 투입 및 결과 발생 처리를 제공하기 위한 단일한 바이오칩 및 이의 제조 방법
CN101823686B (zh) * 2010-04-21 2012-07-04 大连理工大学 一种热塑性聚合物多层微流控芯片封合方法
JP5582049B2 (ja) * 2010-05-31 2014-09-03 横河電機株式会社 化学処理用カートリッジシステム
WO2012028595A1 (de) * 2010-09-01 2012-03-08 Boehringer Ingelheim Microparts Gmbh Verfahren zum herstellen einer mikrofluidischen vorrichtung sowie diesbezügliche laminiereinrichtungen
ES2533839T3 (es) 2010-12-30 2015-04-15 Abbott Point Of Care, Inc. Cartucho de análisis de fluido biológico con porción de manipulación de muestra y porción de cámara de análisis
US20130137144A1 (en) * 2011-06-08 2013-05-30 Bio-Rad Laboratories, Inc. LSG - GXD Division Thermal block with built-in thermoelectric elements
CN103890590B (zh) 2011-08-24 2016-03-09 艾博特健康公司 生物流体样品分析盒
WO2013102071A1 (en) * 2011-12-30 2013-07-04 Abbott Molecular, Inc. Chemical reaction vessels
EP2869922B1 (en) * 2013-01-09 2019-11-20 Tecan Trading AG Disposable cartridge for microfluidics systems
WO2014116979A1 (en) 2013-01-24 2014-07-31 Sabic Innovative Plastics Ip B.V. Microwell plate made from a polyester-polycarbonate
EP2948251A1 (en) 2013-01-24 2015-12-02 SABIC Global Technologies B.V. Microwell plate made from a polyester-polycarbonate
WO2014116951A2 (en) 2013-01-24 2014-07-31 Sabic Innovative Plastics Ip B.V. Polycarbonate microfluidic articles
JP6012518B2 (ja) * 2013-03-21 2016-10-25 株式会社日立ハイテクノロジーズ 生化学カートリッジ用温調機構、温調ブロック及び生化学処理装置
EP3129652A4 (en) 2014-04-11 2018-01-10 President and Fellows of Harvard College High throughput fabrication of soft machines
CN104607256A (zh) * 2014-12-31 2015-05-13 北京同方生物芯片技术有限公司 等离子体辅助热压键合微流控芯片及其制备方法
US9845499B2 (en) * 2016-04-04 2017-12-19 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
US11285478B2 (en) 2016-04-04 2022-03-29 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
AU2017363076B2 (en) 2016-11-17 2021-04-29 Combinati Incorporated Methods and systems for nucleic acid analysis and quantification
EP3384987A3 (en) * 2017-04-03 2018-10-24 CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement Vessel for performing electrochemical measurements and method for manufacturing such vessel
WO2019035079A1 (en) 2017-08-17 2019-02-21 Abbott Point Of Care Inc. DEVICES, SYSTEMS AND METHODS FOR PERFORMING OPTICAL AND ELECTROCHEMICAL ASSAYS
CN110869745B (zh) 2017-08-17 2023-08-11 雅培医护站股份有限公司 用于执行光学测定的设备、系统和方法
CN107739706B (zh) * 2017-09-26 2020-04-14 南京岚煜生物科技有限公司 主动控制流路的多通量微流控核酸检测芯片及其使用方法
DE102018217907B3 (de) * 2018-10-19 2019-12-19 SpinDiag GmbH Probenbehälter
CA3122712A1 (en) 2018-12-10 2020-06-18 Combinati Incorporated Microfluidic array for sample digitization
CN112569881B (zh) * 2020-07-24 2021-07-20 苏州恒瑞宏远医疗科技有限公司 一种反应装置及其加工方法
DE102020202767B3 (de) * 2020-03-04 2021-05-27 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Herstellung eines Verbunds aus Polymersubstraten und gesiegelte mikrofluidische Kartusche
CA3195362A1 (en) 2020-09-28 2022-03-31 Combinati Incorporated Devices and methods for sample processing

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4333968A (en) * 1980-01-25 1982-06-08 Mobil Oil Corporation Thermoplastic packaging films with improved heat-seal characteristics
WO1994026414A1 (en) * 1993-05-17 1994-11-24 Syntex (U.S.A.) Inc. Reaction container for specific binding assays and method for its use
US5500071A (en) * 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5658413A (en) * 1994-10-19 1997-08-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5525405A (en) * 1994-12-14 1996-06-11 E. I. Du Pont De Nemours And Company Adhesiveless aromatic polyimide laminate
JP3839524B2 (ja) * 1995-06-07 2006-11-01 アジレント・テクノロジーズ・インク 小型化全分析システム
US5932799A (en) * 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US6375871B1 (en) * 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US20020150502A1 (en) * 2001-04-03 2002-10-17 Weigl Bernhard H. Surface tension reduction channel
WO2002086333A1 (en) * 2001-04-25 2002-10-31 President And Fellows Of Harvard College Fluidic switches and method for controlling flow in fluidic systems
US20030118804A1 (en) * 2001-05-02 2003-06-26 3M Innovative Properties Company Sample processing device with resealable process chamber
JP2003028877A (ja) * 2001-07-17 2003-01-29 Sekisui Chem Co Ltd 反応チップ用担体及び反応チップ
GB0128350D0 (en) * 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications
JP2003220330A (ja) * 2002-01-31 2003-08-05 Asahi Kasei Corp 透明ポリマーチップ
TWI227196B (en) * 2002-02-22 2005-02-01 Clopay Plastic Prod Co Film, laminated sheet and methods of making same
US20040101657A1 (en) * 2002-08-19 2004-05-27 Moles Donald R. Method of microfluidic construction using composite polymer films
US7431888B2 (en) * 2002-09-20 2008-10-07 The Regents Of The University Of California Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices
CA2772050C (en) * 2002-12-26 2016-09-06 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
EP2574400B1 (en) * 2003-02-05 2016-09-28 Iquum, Inc. Sample processing
AU2004228678A1 (en) * 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same
JP2006076246A (ja) * 2004-09-13 2006-03-23 Rohm Co Ltd 基板の貼り合わせ方法、その貼り合わせ方法を用いたチップ形成方法及びチップ
JP4547216B2 (ja) * 2004-09-17 2010-09-22 東洋製罐株式会社 ガスバリアー性及び層間接着性に優れた多層容器
CA2594483C (en) * 2005-01-28 2014-08-26 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
US20060272716A1 (en) * 2005-05-12 2006-12-07 University Of Washington Method of adhesiveless lamination of polymer films into microfluidic networks with high dimensional fidelity
US20100291588A1 (en) * 2005-06-24 2010-11-18 The Board Of Regents Of The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems

Also Published As

Publication number Publication date
CN101674888A (zh) 2010-03-17
US20100175999A1 (en) 2010-07-15
WO2008087405A1 (en) 2008-07-24
EP2114570B1 (en) 2013-06-05
EP2114570A1 (en) 2009-11-11
JP2010515924A (ja) 2010-05-13
GB2445738A (en) 2008-07-23
CN101674888B (zh) 2012-06-13
GB0700822D0 (en) 2007-02-21

Similar Documents

Publication Publication Date Title
JP5579443B2 (ja) マイクロ流体デバイス
US6527003B1 (en) Micro valve actuator
Prakash et al. Small volume PCR in PDMS biochips with integrated fluid control and vapour barrier
Focke et al. Lab-on-a-Foil: microfluidics on thin and flexible films
US8137624B2 (en) Method and apparatus for attaching a fluid cell to a planar substrate
US6521188B1 (en) Microfluidic actuator
US20040109793A1 (en) Three-dimensional microfluidics incorporating passive fluid control structures
JP5948248B2 (ja) マイクロチップ、及び、マイクロチップの製造方法
WO2008121691A1 (en) Microfluidic array device and system for simultaneous detection of multiple analytes
WO2010121144A1 (en) Devices and methods for interfacing microfluidic devices with macrofluidic devices
Kim et al. Rapid prototyping of multifunctional microfluidic cartridges for electrochemical biosensing platforms
CN105555406A (zh) 用于执行聚合酶链式反应的分析单元、用于运行这样的分析单元的方法以及用于制造这样的分析单元的方法
JP2008008880A (ja) プラスチック製マイクロチップ、及びその製造方法、並びにそれを利用したバイオチップ又はマイクロ分析チップ
KR101853602B1 (ko) 단층 구조의 생체 분자 농축 장치 및 그 제조방법
WO2012085728A1 (en) Microfluidic device with fluid flow control means
Attia et al. Integration of functionality into polymer-based microfluidic devices produced by high-volume micro-moulding techniques
JP2008304352A (ja) 流路デバイス用基板の接合方法および流路デバイス
CN108855264A (zh) 一种多用途多指标微流控芯片
JP2006125990A (ja) 生体物質検査デバイスおよびマイクロリアクタ
US20250121367A1 (en) Method for Sealing Microfluidic Structures by Means of a Hybrid-Foil Membrane
KR100779083B1 (ko) 플라스틱 미세가열 시스템, 그 미세가열 시스템을 이용한랩온어칩, 및 그 미세가열 시스템의 제조방법
JP2007289818A (ja) マイクロリアクタおよびマイクロリアクタを用いたマイクロ総合分析システム
JP2006284451A (ja) 検体中の標的物質を分析するためのマイクロ総合分析システム
TWI275562B (en) Microfluidic device and method for packaging same
Kong Fully Integrated Molecular Diagnostic CD Platform Based on Thermal Control

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100804

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101019

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101019

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20111014

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120515

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20120516

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120809

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130312

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20130613

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140221

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140520

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140613

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140709

R150 Certificate of patent or registration of utility model

Ref document number: 5579443

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250