CN101674888B - 微流体器件 - Google Patents

微流体器件 Download PDF

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Publication number
CN101674888B
CN101674888B CN2008800065615A CN200880006561A CN101674888B CN 101674888 B CN101674888 B CN 101674888B CN 2008800065615 A CN2008800065615 A CN 2008800065615A CN 200880006561 A CN200880006561 A CN 200880006561A CN 101674888 B CN101674888 B CN 101674888B
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CN
China
Prior art keywords
layer
film
films
relatively
thermoplastic polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2008800065615A
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English (en)
Chinese (zh)
Other versions
CN101674888A (zh
Inventor
戴维·巴洛
戴维·汤姆森
肯·马克拿玛瑞
斯图尔特·保尔沃特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Lab901 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of CN101674888A publication Critical patent/CN101674888A/zh
Application granted granted Critical
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/726—Permeability to liquids, absorption
    • B32B2307/7265—Non-permeable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2323/00—Polyalkenes
    • B32B2323/04—Polyethylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2323/00—Polyalkenes
    • B32B2323/10—Polypropylene

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Laminated Bodies (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN2008800065615A 2007-01-16 2008-01-16 微流体器件 Active CN101674888B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0700822.0 2007-01-16
GB0700822A GB2445738A (en) 2007-01-16 2007-01-16 Microfluidic device
PCT/GB2008/000143 WO2008087405A1 (en) 2007-01-16 2008-01-16 Microfluidic device

Publications (2)

Publication Number Publication Date
CN101674888A CN101674888A (zh) 2010-03-17
CN101674888B true CN101674888B (zh) 2012-06-13

Family

ID=37810038

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008800065615A Active CN101674888B (zh) 2007-01-16 2008-01-16 微流体器件

Country Status (6)

Country Link
US (1) US20100175999A1 (enExample)
EP (1) EP2114570B1 (enExample)
JP (1) JP5579443B2 (enExample)
CN (1) CN101674888B (enExample)
GB (1) GB2445738A (enExample)
WO (1) WO2008087405A1 (enExample)

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US8715446B2 (en) * 2004-10-13 2014-05-06 Rheonix, Inc. Latent solvent-based microfluidic apparatus, methods, and applications
US7731901B2 (en) 2005-10-19 2010-06-08 Abbott Laboratories Apparatus and method for performing counts within a biologic fluid sample
GB2445739A (en) 2007-01-16 2008-07-23 Lab901 Ltd Polymeric laminates containing heat seals
ES2352581T3 (es) * 2008-06-02 2011-02-21 Boehringer Ingelheim Microparts Gmbh Estructura de lámina microfluídica para dosificar líquidos.
JP2011030522A (ja) * 2009-08-04 2011-02-17 Aida Engineering Ltd マイクロ流体デバイス
CN102762289B (zh) 2009-12-18 2016-08-03 艾博特健康公司 生物流体分析卡盒
US8720036B2 (en) 2010-03-09 2014-05-13 Netbio, Inc. Unitary biochip providing sample-in to results-out processing and methods of manufacture
EP3690433B9 (en) * 2010-03-09 2022-12-21 ANDE Corporation Biochip with reagent storage
CN101823686B (zh) * 2010-04-21 2012-07-04 大连理工大学 一种热塑性聚合物多层微流控芯片封合方法
JP5582049B2 (ja) * 2010-05-31 2014-09-03 横河電機株式会社 化学処理用カートリッジシステム
US9522520B2 (en) 2010-09-01 2016-12-20 Boehringer Ingelheim Microparts Gmbh Process for producing a microfluidic apparatus and related laminating devices
CN103282123B (zh) 2010-12-30 2015-05-06 艾博特健康公司 带有样品处理区和分析室区的生物液体分析卡式盒
US20130137144A1 (en) * 2011-06-08 2013-05-30 Bio-Rad Laboratories, Inc. LSG - GXD Division Thermal block with built-in thermoelectric elements
US8797527B2 (en) 2011-08-24 2014-08-05 Abbott Point Of Care, Inc. Biologic fluid sample analysis cartridge
US20130171724A1 (en) * 2011-12-30 2013-07-04 Abbott Molecular Inc. Chemical reaction vessels
JP6033959B2 (ja) * 2013-01-09 2016-11-30 テカン・トレーディング・アクチェンゲゼルシャフトＴＥＣＡＮ Ｔｒａｄｉｎｇ ＡＧ マイクロ流体システム用使い捨てカートリッジ
CN104955575A (zh) 2013-01-24 2015-09-30 沙特基础全球技术有限公司 由聚酯-聚碳酸酯制成的微流体装置和微孔
EP2948252A1 (en) 2013-01-24 2015-12-02 SABIC Global Technologies B.V. Microwell plate made from a polyester-polycarbonate
WO2014116955A1 (en) 2013-01-24 2014-07-31 Sabic Innovative Plastics Ip B.V. Microwell plate made from a polyester-polycarbonate
JP6012518B2 (ja) * 2013-03-21 2016-10-25 株式会社日立ハイテクノロジーズ 生化学カートリッジ用温調機構、温調ブロック及び生化学処理装置
WO2016003519A2 (en) 2014-04-11 2016-01-07 President And Fellows Of Harvard College High throughput fabrication of soft machines
CN104607256A (zh) * 2014-12-31 2015-05-13 北京同方生物芯片技术有限公司 等离子体辅助热压键合微流控芯片及其制备方法
US11285478B2 (en) 2016-04-04 2022-03-29 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
US9845499B2 (en) * 2016-04-04 2017-12-19 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
CN115044655A (zh) 2016-11-17 2022-09-13 康比纳提公司 用于核酸分析和定量的方法和系统
EP3384987A3 (en) * 2017-04-03 2018-10-24 CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement Vessel for performing electrochemical measurements and method for manufacturing such vessel
EP3669179B1 (en) 2017-08-17 2023-07-19 Abbott Point Of Care Inc Systems for performing optical and electrochemical assays
CN110869745B (zh) 2017-08-17 2023-08-11 雅培医护站股份有限公司 用于执行光学测定的设备、系统和方法
CN107739706B (zh) * 2017-09-26 2020-04-14 南京岚煜生物科技有限公司 主动控制流路的多通量微流控核酸检测芯片及其使用方法
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CA3122712A1 (en) 2018-12-10 2020-06-18 Combinati Incorporated Microfluidic array for sample digitization
CN112569881B (zh) * 2020-07-24 2021-07-20 苏州恒瑞宏远医疗科技有限公司 一种反应装置及其加工方法
DE102020202767B3 (de) * 2020-03-04 2021-05-27 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Herstellung eines Verbunds aus Polymersubstraten und gesiegelte mikrofluidische Kartusche
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US20050089449A1 (en) * 2001-11-27 2005-04-28 Lab 901 Ltd Apparatus and methods for microfluidic applications
CN1767897A (zh) * 2003-02-05 2006-05-03 伊库姆公司 试样处理细管

Also Published As

Publication number Publication date
JP5579443B2 (ja) 2014-08-27
EP2114570A1 (en) 2009-11-11
CN101674888A (zh) 2010-03-17
GB0700822D0 (en) 2007-02-21
EP2114570B1 (en) 2013-06-05
US20100175999A1 (en) 2010-07-15
JP2010515924A (ja) 2010-05-13
GB2445738A (en) 2008-07-23
WO2008087405A1 (en) 2008-07-24

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C53 Correction of patent of invention or patent application
CB03 Change of inventor or designer information

Inventor after: Barlow David

Inventor after: Thomson David

Inventor after: Macnamara Ken

Inventor after: Polwart Stuart

Inventor before: Barlow David

Inventor before: Wenstrup Leo

Inventor before: Macnamara Ken

Inventor before: Polwart Stuart

COR Change of bibliographic data

Free format text: CORRECT: INVENTOR; FROM: BARLOW DAVID THOMPSON DAVID MACNAMARA KEN POLWART STUART TO: BARLOW DAVID THOMSON DAVID MACNAMARA KEN POLWART STUART

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Effective date: 20130712

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Patentee after: Anjelen Sci. & Tech. Inc.

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Patentee before: Lab901 Limited